Loaʻa iā ʻoe kēia mau hōʻailona ʻē? E kamaʻilio kākou e pili ana i ka Carcinoid Syndrome!

I kekahi manawa, ʻaʻole mākou i ʻike pono i ka mea e hana nei i loko o ko mākou kino, ʻeā? Ua ʻike anei ʻoe i ka ʻulaʻula koke, ka paʻakikī o ka hanu ʻana, ka ʻeha o ka ʻōpū, a me ka maʻi kahe? ʻAʻole kēia he mau mea wale nō. I kekahi manawa he mau hōʻailona kēia o kahi maʻi laha ʻole i kapa ʻia ʻo Carcinoid Syndrome. E kamaʻilio kākou e pili ana i kēia i kēia lā.

He aha ka Carcinoid Syndrome?

I ka ʻōlelo maʻalahi, ʻo ka carcinoid syndrome kahi hōʻiliʻili o nā hōʻailona i hoʻokumu ʻia e kahi ʻano ulu ʻana o ka maʻi kanesa i loko o kou kino i kapa ʻia ʻo nā neuroendocrine tumors (NETs) . ʻO kēia mau cell neuroendocrine kahi ʻano kūikawā o nā cell i komo i loko o kā mākou ʻōnaehana nerve a me nā hormonal. Loaʻa nā NETs i ka wā e māhele koke ai kēia mau cell a hoʻonui koke, e hana ana i nā tumors.

I kēia manawa, ke noʻonoʻo nei paha ʻoe inā he maʻi kēia e hoʻopilikia ana i nā mea āpau. ʻAʻole, he ʻano laha ʻole ia. Ua hōʻike ʻia nā noiʻi e pili ana i hoʻokahi o ka ʻelima mau kānaka me nā ʻōpū neuroendocrine (NET) e hoʻomohala i ka maʻi carcinoid. ʻAʻole maʻamau ka NET, me ka manaʻo ʻia he 5 i loko o 100,000 ma ʻAmelika Hui Pū ʻIa.

Hoʻokuʻu kēia mau NET, ʻoiai nā mea i loko o kou ʻōpū gastrointestinal a i ʻole nā ​​māmā, i nā nui o nā hormones e like me ka serotonin a me nā kemika ʻē aʻe i loko o ke kino i ka manawa hoʻokahi. ʻO ia ka manawa e ʻike ʻia ai nā hōʻailona o ka carcinoid syndrome. I kekahi manawa, ʻike mua ʻoe he NET kāu ma hope o ka ʻike ʻia ʻana o nā hōʻailona o kēia syndrome.

He mea kākaʻikahi loa, inā ʻaʻole i ʻike pono ʻia a mālama ʻia kēia maʻi carcinoid, hiki iā ia ke alakaʻi i kahi pilikia weliweli i ke ola i kapa ʻia ʻo 'carcinoid crisis.' No laila, he mea nui loa ka makaʻala i kēia.

He aha nā hōʻailona o ka Carcinoid Syndrome?

E nānā kākou i nā hōʻailona maʻamau o kēia maʻi. E nānā inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona, ​​pākahi:

• ʻUlaʻula: Hiki ke lilo i mea ʻoluʻolu ʻole kēia. Ua like ia me ka ʻulaʻula ke hilahila ʻoe, akā inā hana pinepine ia me ke kumu ʻole, pono ʻoe e hopohopo.
• ʻUhaʻi a me ka pōkole o ka hanu (dyspnea): Manaʻo paha ia he paʻakikī ke hanu, a i ʻole e like me ke kani ʻūlū e puka mai ana mai ka umauma mai.
• ʻŌpū ʻeha a me ka maʻi pahū pinepine: ʻEha ʻōpū me ka maʻi pahū mau a koʻikoʻi. I kekahi manawa he paʻakikī ke kāohi.
• Nā ʻōpala momona e ʻala maikaʻi ʻole: Hiki ke ʻano ʻaila ka ʻōpala a he ʻala ʻē.
• ʻEdema a i ʻole ka pehu ʻana o kou mau wāwae a me kou mau wāwae:Hiki i kēia ke lilo i hōʻailona o ka hāʻule ʻana o ka puʻuwai, no laila he mea nui e ʻimi koke i ke kōkua lapaʻau.
• Hoʻemi ʻia ka makemake moekolohe a i ʻole ka hana erectile i nā kāne: Hiki i kekahi poʻe ke ʻike i kēia mau kūlana.
• Melemele o ka ʻili a me ke keʻokeʻo o nā maka (Jaundice): ʻO kēia ka mea a mākou e kapa nei he 'jaundice'. He pilikia paha ia o ke akepaʻa.
• Pōʻino a nāwaliwali paha: Hiki i kēia ke hōʻailona o ke koko haʻahaʻa.
• Ke manaʻo nei e holo wikiwiki ana kou puʻuwai: Hiki paha iā ʻoe ke manaʻo e wikiwiki ana kou umauma.

Inā hoʻomau ʻoe i kekahi a ʻoi aku paha o kēia mau hōʻailona, ​​e ʻike pono i ke kauka e kūkākūkā iā lākou. Hiki i kēia ke lilo i mau hōʻailona o nā kūlana ʻē aʻe, akā he mea nui e hōʻoia i loaʻa iā ʻoe ka carcinoid syndrome.

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No ke aha e kū mai ai kēia maʻi carcinoid?

E like me kaʻu i ʻōlelo ai ma mua, loaʻa ka maʻi carcinoid inā loaʻa iā ʻoe nā ʻōpū neuroendocrine (NETs). ʻO kēia mau NETs he mau ʻōpū e ulu ana mai nā pūnaewele kūikawā i loko o kāu ʻōnaehana neuroendocrine. Hoʻopuka a hoʻokuʻu kēia mau pūnaewele i nā hormones i loko o ke kino.

ʻO ka maʻamau, hiki i kēia mau NET ke ulu ma nā wahi e like me kou ʻōpū gastrointestinal, nā māmā, a me ka pancreas. Eia nō naʻe, ʻo ka maʻi carcinoid ka mea i hoʻokumu pinepine ʻia e nā NET i loko o ke ʻōpū gastrointestinal a i ʻole nā ​​māmā e hoʻokuʻu koke ana i nā nui o nā hormones (ʻoi aku ka serotonin) i loko o ke koko.

E noʻonoʻo e like me kahi paipu e hoʻohuli mālie ana i ka wai, hoʻokuʻu pinepine kēia mau cell i nā hormones i nā nui liʻiliʻi. Akā i ka wā e hana ʻia ai kahi NET, ua like ia me ka hoʻohuli koke ʻia ʻana o ka paipu, a puka mai ka nui o nā hormones i ka manawa hoʻokahi. ʻO ia ka manawa e ʻike ʻia ai nā hōʻailona o kēia syndrome.

ʻO wai ka mea i ʻoi aku ka nui o ka pilikia o ka hoʻomohala ʻana i ka carcinoid syndrome?

ʻO ke kumu pilikia nui no kēia, ʻo ia ka loaʻa ʻana o kahi puʻupuʻu neuroendocrine (NET) i loko o kou ʻōpū gastrointestinal a i ʻole nā ​​māmā . I nā huaʻōlelo ʻē aʻe, ʻaʻole ulu ka carcinoid syndrome me ka ʻole o kahi NET.

ʻO ia hoʻi, inā ua ʻike ʻia ʻoe me NETs, ​​​​pono ʻoe e hopohopo e pili ana i kēia maʻi. I kekahi manawa, inā ua loaʻa i kekahi o ka ʻohana nā NETs, ​​​​hiki iā ia ke lilo i mea pilikia i kekahi ʻano, akā he mea kakaikahi loa ia.

He aha nā pilikia e hiki ke loaʻa mai ka Carcinoid Syndrome?

ʻAʻole wale ka maʻi Carcinoid he mau hōʻailona, ​​hiki iā ia ke alakaʻi i kekahi mau pilikia koʻikoʻi. ʻO kekahi o ia ʻano maʻi ʻo ia ke ʻano hoʻoweliweli i ke ola i kapa ʻia ʻo 'carcinoid crisis' aʻu i ʻōlelo ai ma mua.

E nānā kākou i kekahi mau pilikia hou aʻe:

• Maʻi puʻuwai Carcinoid:He mea kākaʻikahi nō hoʻi kēia, akā hiki ke hoʻoweliweli i ke ola. Hoʻopilikia nā hormones i hoʻokuʻu ʻia e NETs i ka uhi o kou mau keʻena puʻuwai, nā valves, a me nā kīʻaha koko. Hiki i kēia ke alakaʻi i ka hāʻule ʻana o ka puʻuwai.
• ʻO ka fibrosis Mesenteric: Hiki i nā NET ke hoʻoulu i ka mumū a me ka ʻeha o ka mesentery, ke ʻiʻo e hoʻopili ai i kou mau ʻōpū i kou paia ʻōpū. Hiki i kēia ke hoʻopilikia i ka hana o ka ʻōpū.
• Kaumaha: Hiki i ka maʻi Carcinoid ke hoʻopilikia i ka hiki o kou kino ke hoʻohana i kahi waikawa amino koʻikoʻi i kapa ʻia ʻo tryptophan. Kōkua ʻo Tryptophan i ka hana ʻana i ka serotonin. ʻO ka Serotonin kahi kemika lolo e kaohi i nā mea e like me ko mākou ʻano, ke ʻano, a me ka hiamoe. No laila, hiki i nā pae serotonin haʻahaʻa ke alakaʻi i ke kaumaha.

ʻO ke kūlana weliweli i kapa ʻia ʻo ka pilikia carcinoid

He pilikia kakaikahi loa ka pilikia carcinoid akā he mea hoʻoweliweli paha i ke ola . Hiki ke hana ia ma muli o ke ʻoki kino, nā kaʻina hana lapaʻau ʻē aʻe, a i ʻole kahi ʻeha mai kahi ulia.

ʻO nā ʻano o kēia:

• Nā loli nui i ke koko: Hiki i ke koko ke hāʻule koke i lalo loa (hypotension) a piʻi paha i luna loa.
• ʻUla nui: Lilo koke ke kino holoʻokoʻa i ʻulaʻula a wela paha.
• Paʻakikī ka hanu ʻana (Dyspnea): Hiki ke loaʻa ka pōkole nui o ka hanu.
• Huikau: Manaʻo paha ʻoe me he mea lā e hoʻopilikia ʻia ana kou ʻike.

He mea nui loa ia no kekahi me ka carcinoid syndrome a i ʻole kahi neuroendocrine tumor (NET) e lawe i kahi kāleka e hōʻike ana i ko lākou kūlana. Hiki i kēia ke kōkua nui inā pono lākou i ka mālama olakino ulia pōpilikia. Eia kekahi, inā e hana ʻoe i ke ʻoki kino, he mea nui e haʻi i kāu mau kauka e pili ana i kēia kūlana. A laila hiki iā lākou ke hāʻawi iā ʻoe i ka lāʻau lapaʻau ma mua a i ka wā o ke ʻoki kino e hōʻemi i ka pilikia o kahi 'carcinoid crisis'.

Pehea e ʻike ʻia ai ka Carcinoid Syndrome?

Hoʻohana nā kauka i kekahi mau hoʻokolohua e ʻike ai i kēia maʻi. E nānā kākou i ke ʻano o ia mau mea:

• Hoʻāʻo mimi: Nānā kēia i nā pae o kekahi mau hormones i loko o kou mimi, ʻo ia hoʻi kahi huahana o ka serotonin i kapa ʻia ʻo 5-HIAA (5-hydroxyindoleacetic acid) .
• Hoʻokolohua kino a me ka mōʻaukala lapaʻau: Hiki ke like nā hōʻailona o ka carcinoid syndrome me nā maʻi ʻē aʻe i ʻoi aku ka koʻikoʻi, no laila e nīnau kāu kauka iā ʻoe i nā kikoʻī e pili ana i kāu mau hōʻailona, ​​​​pehea ka lōʻihi o ko lākou noho ʻana, a inā paha e ʻoi aku ka ʻino.
• Nā hoʻāʻo koko:Nānā kēia i nā pae o nā mea i hoʻokuʻu ʻia i loko o ke koko mai kou mau ʻōpū a me nā ʻiʻo. Inā piʻi koke a hāʻule paha nā pae o kekahi mau mea, hiki ke lilo i hōʻailona o ka maʻi. No ka laʻana, nānā lākou i kahi māka i kapa ʻia ʻo Chromogranin A.
• ʻO ke scan Neuroendocrine Positron Emission Tomography (PET): He scan kūikawā kēia e hoʻohana ana i kahi dye i kapa ʻia ʻo gallium 68 dotatate e ʻike ai i kahi o nā tumors neuroendocrine (NETs).
• CT scan: Hoʻohana ka CT scan i nā kukuna X a me kahi kamepiula e hana i nā kiʻi ʻekolu-dimensional (3D) o kou mau kino a me nā iwi. Hiki i kēia ke kōkua i ka hoʻoholo ʻana i kahi a me ka nui o nā puʻupuʻu.
• ʻO ke scan Ultrasound: Hoʻohana kēia i nā nalu kani e hana i nā kiʻi o nā ʻōpū.
• MRI scan (Magnetic Resonance Imaging (MRI): Hoʻohana kēia i kahi magnet nui, nā nalu lekiō, a me kahi kamepiula e hana i nā kiʻi kikoʻī o loko o ke kino.
• Endoscopy: Ma kēia hoʻāʻo, hoʻokomo ke kauka i kahi ʻōmole lōʻihi a lahilahi me kahi kāmela a me ke kukui i loko o kou kino e nānā iā ia. No ka laʻana, hiki ke hoʻohana ʻia kēia kaʻina hana e nānā i ka ʻōpū a i ʻole nā ​​​​​​naʻau.

He aha nā lāʻau lapaʻau no ka Carcinoid Syndrome?

Hoʻokumu ʻia ka maʻi Carcinoid e nā ʻōpū neuroendocrine (NETs). No laila, ke mālama ʻia kēlā mau ʻōpū, mālama ʻia nō hoʻi ka maʻi.

Aia kekahi mau ʻano lapaʻau nui:

• ʻOki kino: Hiki ke wehe loa ʻia nā puʻupuʻu neuroendocrine a hoʻemi ʻia paha ko lākou nui. Aia ke ʻano o ke ʻoki kino i ka wahi a me ka nui o ka puʻupuʻu.
• Nā analog Somatostatin: He ʻano lāʻau lapaʻau kūikawā kēia. Hiki i kēia mau lāʻau lapaʻau ke pale i kou kino mai ka hana ʻana i ka nui o ka hormone. Hiki iā lākou ke kōkua i ka kaohi ʻana i ka ulu ʻana o nā puʻupuʻu ke laha nā hunaola kanesa i nā ʻāpana ʻē aʻe o ke kino (metastasis). ʻO nā laʻana e komo pū me nā lāʻau lapaʻau i kapa ʻia ʻo Octreotide a me Lanreotide .
• Lapaʻau i kuhikuhi ʻia: He ʻano lapaʻau kūikawā kēia i hoʻohana ʻia e pepehi i nā hunaola kanesa. Ma kēia, hāʻawi ʻia nā lāʻau lapaʻau e kuhikuhi i nā genes kikoʻī a i ʻole nā ​​​​protein i loko o nā hunaola kanesa.
• Kemoterapi: Hoʻohana kēia i nā lāʻau lapaʻau e pepehi i nā hunaola kanesa. ʻAʻole like ka hana a kemoterapi no nā ʻano NET āpau.
• Embolization: Ma kēia ʻano hana, ua ālai ʻia ke kīʻaha koko e hoʻolako ana i ke koko i ka puʻupuʻu, e luku ana i ka puʻupuʻu. He lāʻau lapaʻau kēia i hoʻohana kūikawā ʻia no nā NET i loko o ke akepaʻa.

Hiki ke pale ʻia ka Carcinoid Syndrome?

ʻOiaʻiʻo,ʻAʻohe ala e pale aku ai i ka maʻi carcinoid no ka mea pili ia me nā ʻōpū neuroendocrine (NETs). ʻOiai ʻaʻohe ala i ʻike ʻia e pale aku ai i ka ulu ʻana o nā NETs, ​​ʻaʻohe ala e pale aku ai i nā hōʻailona e loaʻa mai ana mai ia mau mea.

Eia nō naʻe, inā ʻike ʻoe he NET kāu, ʻo ka ʻike ʻana i nā hōʻailona o ka carcinoid syndrome i ka wā mua a me ka hoʻomaka ʻana i ka lāʻau lapaʻau hiki ke hōʻemi i ka pilikia o nā pilikia.

Pehea wau e mālama ai iaʻu iho? / Pehea wau e mālama ai i nā hōʻailona?

Inā loaʻa iā ʻoe ka maʻi carcinoid, loaʻa paha iā ʻoe kahi maʻi neuroendocrine (NET). No laila, inā loaʻa iā ʻoe nā hōʻailona o ka maʻi carcinoid, e haʻi koke i kāu kauka. Hiki iā lākou ke loiloi i kou kūlana a ʻōlelo i nā hoʻokolohua e pono ai e ʻike inā loaʻa iā ʻoe kahi NET.

ʻO nā hōʻailona nui ʻekolu o ka carcinoid syndrome ka ʻulaʻula, ka hanu ʻana, a me ka maʻi pākī. Eia kekahi mau mea hiki iā ʻoe ke hana e kōkua i ka mālama ʻana i kēia mau mea:

• Ka Holoi ʻana: ʻO kēia ka pane a kou ʻōnaehana nerve i ke kaumaha kino a noʻonoʻo paha. No ka hōʻemi ʻana i kēia, e hanu hohonu, e holoi i kou maka a me kou umauma me kahi lole pulu, a i ʻole e kiʻi i ka ea hou ma waho. Hiki i ka pale ʻana i ka waiʻona ke kōkua.
• ʻUmiʻumi: No ka pōkole o ka hanu, e hoʻāʻo e inu i ke kī lāʻau a hoʻohana paha i kahi inhaler a vaporizer paha . Inā ʻoe e puhipaka, e hoʻāʻo e haʻalele. Hiki i ka puhipaka ke hoʻāla hou aku i kou mau alaloa.
• Ka maʻi kahe: Inā he pilikia ka maʻi kahe iā ʻoe, e kamaʻilio me kāu kauka e pili ana i nā ala e hōʻemi ai i kona pinepine a me ke koʻikoʻi. Aia nā lāʻau lapaʻau kūikawā i hoʻolālā ʻia e kāohi i ka maʻi kahe i hoʻokumu ʻia e ka carcinoid syndrome. Eia kekahi, hiki i nā meaʻai momona, nā mea ʻala, a me nā meaʻai waiū ke hoʻonui i kēia kūlana no kekahi poʻe. No laila e makaʻala i kāu mea e ʻai ai.

Āhea wau e ʻike ai i ke kauka? / Āhea wau e hele ai i kahi lumi pilikia?

Inā e ʻoi aku ka ʻino o kāu mau hōʻailona o ka carcinoid syndrome, e ʻike pono i ke kauka. Inā ʻoe e mālama ʻia nei no NET, e haʻi i kāu kauka inā ʻike ʻoe i kekahi mau loli hou i kou kino e like paha me nā hōʻailona NET. ʻAʻole paha e pili kēia mau loli i kāu hōʻailona NET, akā ʻo ke ala maikaʻi loa e ʻike pono ai, ʻo ia ke kamaʻilio me kāu kauka. Eia kekahi, inā e ʻoi aku ka ʻino o kāu mau hōʻailona a i ʻole nā ​​​​hopena ʻaoʻao mai kāu lāʻau lapaʻau, e haʻi i kāu kauka.

I ka manawa hea e hele ai i kahi Emergency Treatment Unit (ETU)

Inā waiho ʻole ʻia ka maʻi carcinoid i ka mālama ʻole ʻia, hiki i nā hōʻailona ke ʻoi aku ka ʻino i ka hala ʻana o ka manawa a lilo i mea hoʻoweliweli ola i kapa ʻia ʻo 'carcinoid crisis.' No laila, e hele koke i kahi keʻena pilikia o ka haukapila inā loaʻa iā ʻoe:

• Inā he palpitations kou a he ʻeha paha ka umauma.
• Inā loaʻa iā ʻoe ka maʻi pākī nui no kekahi mau lā.
• Inā loaʻa iā ʻoe ka ʻeha nui o ka ʻōpū.
• Inā ʻoe e manaʻo ua nāwaliwali.
• Inā loaʻa iā ʻoe ka ʻulaʻula koke a koʻikoʻi o ka maka, ka ʻāʻī, a me ka umauma (ʻulaʻula koke).

He aha nā nīnau e pono iaʻu e nīnau aku i kaʻu kauka?

Hiki i ka maʻi Carcinoid ke hōʻailona he loaʻa iā ʻoe kahi puʻupuʻu neuroendocrine (NET). No laila, inā he mau nīnau kāu e pili ana i ka maʻi carcinoid, nui paha kāu mau nīnau e pili ana i nā NET. Eia kekahi mau nīnau hiki iā ʻoe ke nīnau i kāu kauka:

• Inā loaʻa iaʻu ka maʻi carcinoid, pehea lā wau e ʻike ai inā he maʻi neuroendocrine koʻu?
• Inā he puʻupuʻu koʻu, ma hea ia i loko o koʻu kino?
• He aha nā lāʻau lapaʻau no koʻu puʻupuʻu?
• He aha nā hopena ʻaoʻao o ka lāʻau lapaʻau?
• Hiki ke ho'ōla loa ʻia ka puʻupuʻu neuroendocrine i hoʻoulu ai i koʻu carcinoid syndrome?
• Hiki ke hoʻi mai ka maʻi carcinoid ma hope o ka mālama ʻia ʻana o kaʻu puʻupuʻu neuroendocrine?

Leka Hoʻihoʻi Hope Loa

He ʻano laha ʻole ka Carcinoid Syndrome i hiki ke loaʻa i kekahi me ka neuroendocrine tumor (NET). I ka manawa pinepine, ʻike mua ka poʻe me ka carcinoid syndrome he NET ko lākou. I kekahi manawa, ʻike mua ka poʻe he NET ko lākou ma hope o ka ʻike ʻia ʻana me ka carcinoid syndrome.

ʻO ka mea maikaʻi loa, hiki ke mālama ʻia nā NET. ʻO ka ʻike ʻana he carcinoid syndrome kou ka hana mua e ʻike ai inā he maʻi kanesa kou, a inā pēlā, pehea e mālama ai. No laila, inā ua ʻike ʻia ʻoe me ka carcinoid syndrome, mai makaʻu e kamaʻilio me kāu kauka a nīnau i nā hana aʻe e hōʻoia ai inā he NET kāu. ʻO ka mea nui loa, ʻo ia ka loaʻa ʻana o ka maʻi a me ka mālama ʻia i ka wā mua.

E hoʻomanaʻo, ʻaʻole ʻoe hoʻokahi. I ke kūlana e like me kēia, he mea nui loa e hahai i nā ʻōlelo aʻoaʻo lapaʻau a ʻimi i ke kākoʻo o kou ʻohana.

ʻO ka maʻi Carcinoid, nā puʻupuʻu neuroendocrine, NETs, ​​​​serotonin, nā hōʻailona, ​​​​ka maʻi kanesa, nā hormones