He aha nā lāʻau lapaʻau no ke Kanesa Colon Stage IV?

He mea paʻakikī ke wehewehe i ka makaʻu a me ka haʻalulu e hele mai me ka ʻike ʻia ʻana o ka maʻi kanesa Stage IV. He mea maʻamau ke noʻonoʻo, "Ua pau anei i kēia manawa?" Akā e ʻae mai iaʻu e haʻi aku iā ʻoe, ʻaʻole. Ua holomua nui ka ʻepekema lapaʻau. ʻOiai i kēia pae, he nui nā lāʻau lapaʻau e hiki ke kōkua iā ʻoe e ola lōʻihi, e kāohi i kāu mau hōʻailona, ​​a noho olakino. E kamaʻilio kākou e pili ana i kēia me ka maʻalahi, ma ke ʻano hiki iā ʻoe ke hoʻomaopopo.

He aha ke ʻano o ka 'Stage IV'?

I ka ʻōlelo maʻalahi, ʻo ke ʻano o ka Pae IV ua pālahalaha ke kanesa ma ʻō aku o ka kolona , ​​kahi i hoʻomaka ai. ʻO ka hapa nui o kēia i ke akepaʻa . Hiki iā ia ke pālahalaha i nā māmā, ka uhi o ka ʻōpū, a i ʻole nā ​​​​kikowaena lymph ma nā wahi ʻē aʻe o ke kino.

Hiki ke paʻakikī ke loaʻa kahi lāʻau lapaʻau piha i kēia pae. Eia nō naʻe, inā ua laha ka maʻi ʻaʻai i kekahi mau wahi wale nō, i kekahi manawa hiki ke hana ʻoki kino e wehe loa i kēlā mau wahi a hoʻōla i ka maʻi. No laila, ʻoi aku ka maikaʻi o ke ʻike ʻana i ke kauka loea i ka mālama ʻana i kēia ʻano maʻi. ʻO ka lāʻau āu e loaʻa ai e hilinaʻi ʻia ma nā kumu he nui, me kahi i laha ai ka maʻi ʻaʻai, kou makahiki, a me kou olakino holoʻokoʻa.

Aia kekahi mau ʻano lapaʻau nui i hoʻohana ʻia:

• ʻoki kino
• Kemoterapia
• Hoʻōla radiation
• ʻO ka hoʻopau ʻana a me ka cryotherapy
• Nā lāʻau lapaʻau i kuhikuhi ʻia
• Hoʻōla lāʻau pale

I ka manawa pinepine, hāʻawi ʻia ʻoe ma mua o hoʻokahi o kēia mau lāʻau lapaʻau, a i ʻole ka hui pū ʻana o kekahi mau mea.

He aha ka mea e hana ʻia me ke ʻoki kino?

Inā ua pālahalaha ke kanesa i kou akepaʻa a i ʻole kou māmā, hiki ke hana ʻia ke ʻoki kino i kekahi manawa. E like me kaʻu i ʻōlelo ai ma mua, inā ua kaupalena ʻia ke kanesa, hiki i ke ʻoki kino ke wehe iā ia a hiki iā ʻoe ke hoʻōla piha . I nā hihia ʻē aʻe, hiki ke kōkua ke ʻoki kino i ka hōʻemi ʻana i nā hōʻailona i hoʻokumu ʻia e ke kanesa, e like me ka ʻeha a me ke ālai ʻana o ka ʻōpū.

I ka wā o ke ʻoki kino, wehe ke kauka i ka ʻāpana o ka kolona, ​​ke akepaʻa, a i ʻole ka māmā kahi i loaʻa ai ke kanesa. I ka manawa like, wehe ʻia nā lymph node a puni ia. ʻO kēia no ka mea hiki i nā hunaola kanesa ke laha maʻalahi i nā ʻāpana ʻē aʻe o ke kino ma o kēia mau lymph node.

Ma hope o ka wehe ʻana i ka ʻāpana kanesa o ka kolona, ​​e hoʻopili hou ke kauka i nā wēlau ʻelua o ke kolona i koe. A laila hiki iā ʻoe ke neʻe i ka ʻōpū ma ke ʻano maʻamau. Eia nō naʻe, i kekahi manawa inā ʻaʻole hiki kēia pilina, pono paha ʻoe e hana i kahi colostomy . Pili kēia i ka hoʻopili ʻana i kekahi wēlau o ke kolona i kahi lua i hana ʻia ma ka ʻili o ka ʻōpū. Puka mai ka ʻōpala ma o kēlā lua. Hōʻiliʻili ʻia ka ʻōpala i loko o kahi ʻeke i hoʻopili ʻia iā ia.

Mai hopohopo, no ka hapa nui o nā kānaka, he manawa pōkole kēia colostomy. Ke ho'ōla ʻia nā ʻeha o loko ma hope o ke ʻoki ʻana, hiki ke wehe ʻia a hiki iā ʻoe ke loaʻa hou nā neʻe ʻōpū maʻamau.

I kekahi manawa, inā wehe ʻia kahi ʻāpana nui o ka kolona, ​​pili ka hopena o ka ʻōpū liʻiliʻi i ka ʻili o ka ʻōpū. Ua kapa ʻia kēia he ileostomy . Eia nō naʻe, aia paha kekahi ʻeha ma hope o ke ʻoki ʻana. Hiki iā ʻoe ke loaʻa i ka maʻi pākī a i ʻole ka paʻa ʻana o ka ʻōpū. E nalo aku kēia mau hopena ʻaoʻao ma hope o kekahi manawa.

Inā ua ālai ʻia ka ʻōpū e ka maʻi ʻaʻai, hiki ke hoʻokomo ʻia kahi ʻōmole liʻiliʻi i kapa ʻia he stent e wehe mau ai.

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He aha ka chemotherapy?

ʻO ka Chemotherapy, a i ʻole 'chemo' e like me kā mākou e kapa nei, he ʻano lāʻau lapaʻau ikaika ia i hāʻawi ʻia e pepehi i nā hunaola kanesa. Hiki ke hāʻawi ʻia kēia lāʻau lapaʻau ma ke ʻano intravenous a i ʻole he pila.

Hāʻawi ʻia ka chemotherapy ma nā ʻano nui he nui:

• Ma mua o ke ʻoki ʻana, hiki ke hoʻēmi ʻia nā ʻōpū kanesa i mea e maʻalahi ai ka wehe ʻana.
• Ma hope o ke ʻoki ʻana, e luku i nā hunaola kanesa e koe ana i loko o ke kino.
• Ma ke ʻano he lāʻau lapaʻau nui no ka poʻe hiki ʻole ke hana ʻoki kino.

Aia kekahi mau ʻano lāʻau chemo i hāʻawi ʻia no ke kanesa colon pae 4. I kekahi manawa ʻoi aku ma mua o hoʻokahi o kēia mau lāʻau i hāʻawi ʻia i ka hui pū ʻana. Eia kekahi, hāʻawi ʻia ka chemo i ka hui pū ʻana me ka 'targeted therapy', a mākou e kamaʻilio ai ma hope.

ʻO kahi mea a ka poʻe he nui e makaʻu nei i ka lohe ʻana e pili ana i ka chemo, ʻo ia ka nalowale ʻana o ko lākou lauoho. Eia naʻe,ʻAʻole maʻamau ka chemotherapy no ka maʻi ʻaʻai colon e hoʻoulu i ka hāʻule ʻana o ka lauoho. Mai hopohopo i kēia mau hopena ʻaoʻao. Hiki i kāu kauka ke kōkua iā ʻoe e hoʻokele iā lākou a hoʻolilo iā lākou i ʻoluʻolu. E nalo mālie kēia mau hopena ʻaoʻao ke pau kāu lāʻau.

Inā ua pālahalaha ke kanesa i ke akepaʻa, hiki ke hāʻawi ʻia ka chemotherapy me ka hoʻohana ʻana i kahi ʻano hana kūikawā i kapa ʻia ʻo "hepatic artery infusion chemotherapy." ʻO kēia ke komo ʻana i ka chemotherapy pololei i loko o ke kīʻaha koko nui e hoʻolako ana i ke koko i ke akepaʻa me ka hoʻohana ʻana i kahi pamu. No ka mea, hele pololei ka lāʻau lapaʻau i ke akepaʻa ma mua o ka hele ʻana ma ke kino holoʻokoʻa, hiki i kēia ʻano hana ke hōʻemi i nā hopena ʻaoʻao a hāʻawi i kahi mahele kiʻekiʻe o ka lāʻau lapaʻau.

ʻO ka radiation therapy a me nā ʻano hana ʻē aʻe

Hoʻōla Pāhawewe

Pili kēia i ka hoʻohana ʻana i nā kukuna X-ikehu kiʻekiʻe e luku i nā hunaola kanesa. ʻOiai ʻaʻole paha e hoʻōla loa kēia lāʻau i ke kanesa pae 4, hiki iā ia ke kōkua i ka hoʻēmi ʻana i ka puʻupuʻu a hōʻemi i nā hōʻailona e like me ka ʻeha . Hāʻawi pinepine ʻia kēia lāʻau i 5 mau lā o ka pule no kekahi mau pule.

ʻO ka Ablation a me ka Cryotherapy

Hoʻohana pinepine ʻia kēia mau ʻano ʻelua e luku i nā hunaola kanesa i pālahalaha i ke ake. Hoʻohana ka Ablation i ka wela , ʻoiai ʻo ka cryotherapy e hoʻohana i ke anu loa . Me ka hoʻohana ʻana i kahi CT a i ʻole ultrasound scan, hoʻouna ke kauka i kahi mea lahilahi e like me ke nila i ka puʻupuʻu a hoʻomehana a hoʻopaʻahau paha iā ia e luku i nā hunaola kanesa.

ʻO ka Lapaʻau i Hoʻolālā ʻia a me ka Immunotherapy - Nā Lapaʻau Hou Loa

ʻO kēia nā ʻano hana ʻelua hou loa a kūleʻa loa i ka mālama ʻana i ka maʻi kanesa.

Nā Lapaʻau i Hoʻolālā ʻia

I ka ʻōlelo maʻalahi, kuhikuhi pono kēia mau lāʻau i nā hunaola kanesa. Ke ālai nei lākou i nā mea e pono ai nā hunaola kanesa e ulu a laha. He mea liʻiliʻi loa kēia e hōʻino ai i nā hunaola olakino.

• Nā lāʻau anti-angiogenesis: Hana kēia ma ke kāohi ʻana i ka ulu ʻana o nā kīʻaha koko hou e hānai ana i ke kanesa. Ua like ia me ke kāohi ʻana i ke kanesa mai ka ʻai ʻana. ʻO Bevacizumab (Avastin) lāua ʻo Ramucirumab (Cyramza) kekahi mau lāʻau.
• Nā mea pale EGFR: ʻO nā lāʻau lapaʻau e like me Cetuximab (Erbitux) a me Panitumumab (Vectibix) e ālai i kahi protein i kapa ʻia ʻo EGFR e kōkua ana i ka ulu ʻana o nā hunaola kanesa. Eia nō naʻe, i mea e hana ai kēia mau lāʻau lapaʻau, pono i ke kanesa nā mutations i loko o kekahi mau genes (KRAS, NRAS, BRAF). E hoʻāʻo kāu kauka e ʻike inā kūpono kēia mau lāʻau lapaʻau iā ʻoe.
• Nā lāʻau lapaʻau ʻē aʻe: Loaʻa pū kekahi mau lāʻau lapaʻau hou e like me Encorafenib (Braftovi) a me Entrectinib (Rozlytrek) i kēia lā e pili ana i nā maʻi kanesa me nā hoʻololi genetic kikoʻī e like me BRAF, NTRK, a me RET.

Hoʻōla lāʻau pale

He lāʻau lapaʻau kupaianaha loa kēia. ʻO kāu hana ma ʻaneʻi , ʻo ia ka hoʻoulu ʻana i ka ʻōnaehana pale o kou kino ponoʻī a hoʻohana iā ia e hakakā i nā hunaola kanesa.

Loaʻa i ko kākou ʻōnaehana pale kino nā protein i kapa ʻia ʻo PD-1 e hana ana e like me nā paleki. Hoʻohana nā hunaola kanesa i kēia mau paleki e pale aku i ka ʻōnaehana pale. Hana nā lāʻau lapaʻau pale e like me Nivolumab (Opdivo) a me Pembrolizumab (Keytruda) ma ka hoʻopau ʻana i kēia mau paleki. ʻAe kēia i ka ʻōnaehana pale kino e ʻike a hoʻouka i ke kanesa.

He mea nui: Hiki i ka immunotherapy ke hoʻoulu i ka ʻōnaehana pale e lilo i mea hana nui, i kekahi manawa e hoʻouka ana i nā ʻōpū olakino i loko o ke kino (e like me nā māmā, ke akepaʻa, nā ʻōpū). No laila , he mea nui e hōʻike koke i nā hōʻailona hou āu e ulu ai i ka wā o ka mālama ʻana i kāu kauka.

ʻO kāu hoʻolālā lapaʻau

ʻO ke ʻano o ka lāʻau lapaʻau āu e loaʻa ai ma muli o nā kumu he nui. E hana kāu kauka i kahi hoʻolālā lapaʻau e pili pono ana iā ʻoe, e noʻonoʻo ana i nā kumu e like me kahi i laha ai ke kanesa, kou mau makahiki, kou olakino holoʻokoʻa, a me nā ʻano genetic o ke kanesa.

Loaʻa paha iā ʻoe ka manawa kūpono e komo i nā hoʻokolohua lapaʻau e hoʻāʻo ai i nā lāʻau lapaʻau hou a me nā lāʻau lapaʻau a puni ka honua. He manawa kūpono kēia e hoʻāʻo ai i kahi lāʻau lapaʻau hou. E kamaʻilio pū me kāu kauka e pili ana i kēlā.