He ʻano ʻē anei kou puʻuwai? E aʻo kākou e pili ana iā Dofetilide!

Ua haʻi aku ke kauka iā ʻoe he pilikia me kou puʻuwai, ʻo ia hoʻi, ka wikiwiki o kou puʻuwai? Ua manaʻo paha ʻoe i kahi makaʻu iki, ʻeā? ʻO Dofetilide kahi ʻano lāʻau lapaʻau i hāʻawi ʻia i kēlā mau manawa. No laila, i kēia lā e kamaʻilio mākou e pili ana i kēia lāʻau lapaʻau i kapa ʻia ʻo Dofetilide, me he mea lā e haʻi aku ana mākou i kahi hoaaloha.

He aha ka Dofetilide?

I ka ʻōlelo maʻalahi, he lāʻau antiarrhythmic ʻo Dofetilide. ʻO ke ʻano kēia he mea kōkua ia i ka hoʻomaʻamaʻa ʻana i kou ʻano puʻuwai. Loaʻa pinepine ia ma ke ʻano o kahi capsule. Lawe pinepine ʻia i hoʻokahi a ʻelua paha i ka lā. Ua ʻike paha ʻoe iā ia ma lalo o ka inoa inoa ʻo Tikosyn®.

Akā, hoʻokahi mea e hoʻomanaʻo ai. ʻO ka nui o kēia lāʻau lapaʻau, ʻo ia hoʻi, ka nui i hāʻawi ʻia iā ʻoe e inu, hiki ke ʻokoʻa mai kēlā kanaka a kēia kanaka . Inā e lawe ana kāu hoaaloha i kēia lāʻau lapaʻau, ʻaʻole e hāʻawi ʻia iā ʻoe ka nui like me ka mea i hāʻawi ʻia iā ia. E loiloi ke kauka i kou kūlana a kuhikuhi i ka nui kūpono nou (e like me `125 mcg, 250 mcg` a i ʻole `500 mcg`). ʻO `(mcg)` ke kū nei no nā micrograms.

I nā hihia hea e hoʻohana ʻia ai ʻo Dofetilide?

Hoʻohana nui ʻia kēia lāʻau lapaʻau e mālama i kekahi mau pilikia o ka puʻuwai a pale iā lākou mai ka hoʻi hou ʻana.

Nā maʻi ʻōuli o ka puʻuwai

• ʻO ka Atrial Fibrillation (Afib): ʻO kēia ka manawa e kuʻi wikiwiki ai nā keʻena o luna o kou puʻuwai (i kapa ʻia hoʻi ʻo atria) a ʻano ʻē, ma mua o ke ʻano mele. E noʻonoʻo e like me ka pahu i manaʻo ʻia e hoʻokani ʻia ma kekahi ʻano, akā kuʻi ia ma waho o ke mele a lilo i pupule. Ua kapa ʻia kēia ʻo "Afib".
• Atrial Flutter: ʻO kēia kekahi ʻano puʻuwai ʻē aʻe e kū nei ma nā keʻena o luna o ka puʻuwai. Ua like iki ia me ka "Afib", akā aia kekahi mau ʻokoʻa iki.

He mea nui: Ma kēia mau kūlana ʻelua, lilo ka hana o ka puʻuwai i mea ʻano ʻē, no laila ʻaʻole paha e hoʻopuka pono ʻia ke koko. Hiki i kēia ke alakaʻi i nā pilikia like ʻole. No laila, hana kēia lāʻau lapaʻau ma ka hoʻoponopono ʻana i kēlā ʻano ʻē a me ka hana hou ʻana i ka puʻuwai.

Nā hoʻohana "Ma waho o ka lepili"

I kekahi manawa, kuhikuhi nā kauka iā Dofetilide no nā maʻi puʻuwai ʻē aʻe ma waho aʻe o kona hoʻohana mua ʻana. Ua kapa ʻia kēia he hoʻohana "off-label". ʻO ia hoʻi, ʻike nā kauka hiki i ka lāʻau lapaʻau ke kōkua i kēlā mau maʻi, akā ʻaʻole i ʻae mua ʻia no kēlā mau maʻi.

ʻO nā maʻi ʻē aʻe like ʻole o ka puʻuwai:

• Ventricular Tachycardia: Ma kēia, kuʻi wikiwiki loa nā keʻena haʻahaʻa o ka puʻuwai.
• Nā Tachycardias Supraventricular: He puʻuwai wikiwiki hoʻi kēia e kū nei ma nā keʻena o luna o ka puʻuwai. Aia kekahi mau ʻano ʻē aʻe ma waho aʻe o `(Afib)` a me `(Atrial Flutter).`
• ʻO Wolff-Parkinson-White Syndrome: He ʻano kēia e kuʻi wikiwiki ai ka puʻuwai ma muli o kahi ala uila keu i loko o ka puʻuwai.

Pehea e hoʻomaka ai e lawe iā Dofetilide?

He mea kūikawā iki kēia. Ke hoʻomaka ʻoe e lawe iā Dofetilide, pono ʻoe e noho ma ka haukapila no ʻekolu a ʻehā lā . He mea kupanaha paha kēia, ʻeā? ʻO ke kumu, makemake nā kauka e nānā i ke ʻano o ka hopena o ka lāʻau lapaʻau i kou puʻuwai a inā paha e loaʻa iā ʻoe kekahi mau pilikia hou. E hoʻohana pū lākou i kēia manawa e ʻike ai i ka nui kūpono nou. ʻOiai ʻoe ma ka haukapila, hiki iā lākou ke hoʻololi i ka nui o ka lāʻau lapaʻau i hāʻawi ʻia iā ʻoe. Mai hopohopo, no kou palekana kēia mau mea a pau.

Pehea e lawe ai iā Dofetilide ma ka home?

Ma hope o kou hoʻi ʻana i ka home mai ka haukapila, e hōʻike maopopo ana ka lepili i hāʻawi ʻia iā ʻoe i ka nui o ka lāʻau e lawe ai a me ka nui o nā manawa e pono ai ʻoe e lawe i ka lā.

He mea nui loa e hoʻomanaʻo i kēia mau mea:

• E lawe i ka lāʻau lapaʻau e like me ka ʻōlelo a ke kauka. Mai hoʻonui a hoʻēmi paha i ka nui.
• E lawe i ka lāʻau lapaʻau i ka manawa like i kēlā me kēia lā. Inā he kakahiaka, e lawe i ke kakahiaka, inā he pō, e lawe i ka pō. Mai hoʻololi i ka manawa.
• ʻOiai inā ʻoe e ʻoluʻolu ana, mai hoʻōki i ka lawe ʻana i ka lāʻau. E hoʻomau i ka lawe ʻana iā ia a hiki i ka wā e ʻōlelo ai kāu kauka.
• Hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau me ka meaʻai a i ʻole me ka ʻole o ka meaʻai.
• Mai hōʻalo i kāu lāʻau lapaʻau.
• E lawe wale i ka nui i kauoha ʻia e ke kauka.

Inā he mau nīnau kāu e pili ana i kāu lāʻau lapaʻau a pehea e loaʻa ai kahi hoʻopihapiha, mai makaʻu e nīnau i kāu kauka a kauka lāʻau paha. Inā he mea āu i maopopo ʻole ai, e noi iā lākou e wehewehe.

He aha kaʻu e haʻi aku ai i kaʻu kauka ma mua o ka lawe ʻana iā Dofetilide?

Ma mua o ke kuhikuhi ʻana i kēia lāʻau lapaʻau iā ʻoe, he mea nui e haʻi i kāu kauka i kēia mau mea:

• Ua loaʻa paha iā ʻoe kahi hopena maʻi i ka dofetilide? Inā pēlā, e wehewehe mai i ka mea i hana ʻia.
• E papa inoa i nā lāʻau lapaʻau āpau āu e lawe nei (kauoha, over-the-counter (OTC), nā huaora, a me nā mea hoʻohui lāʻau). Mai hoʻomaka i nā lāʻau lapaʻau a i ʻole nā ​​​​mea hoʻohui hou me ka ʻole o ka nīnau mua ʻana i kāu kauka.
• E haʻi mai iā mākou inā he maʻi puʻuwai kou, ʻoiai he maʻi puʻuwai i kapa ʻia ʻo 'Long QT Syndrome' , a inā he maʻi puʻupaʻa a maʻi akepaʻa paha kou, a inā he haʻahaʻa kou pae o ka potassium a i ʻole ka magnesium i loko o kou koko.
• E hōʻoia e haʻi mai iā mākou inā ʻoe e hāpai ana, e hoʻāʻo ana e hāpai, a i ʻole e hānai waiū ana .

He aha nā lāʻau lapaʻau e pono ʻole ke lawe pū ʻia me Dofetilide?

Inā ʻoe e lawe nei i kēia mau lāʻau lapaʻau, hiki i ka lawe ʻana iā Dofetilide ke lilo i mea weliweli loa.No laila, inā ʻoe e hoʻohana nei i kahi lāʻau lapaʻau e like me kēia, pono ʻoe e haʻi aku i kāu kauka. A laila ʻaʻole ia e hāʻawi iā ʻoe iā Dofetilide.

• ʻO Cimetidine (e.g. Tagamet®)
• ʻO Cisapride
• Dolutegravir (`Dolutegravir` - e like me `Tivicay®`)
• Verapamil (`Verapamil` - e laʻa. `Calan®`)
• ʻO Ketoconazole
• ʻO Itraconazole (e.g. Sporanox®)
• ʻO Trimethoprim (ʻO Trimethoprim) - e.g. ʻO Proloprim®
• ʻO Trimethoprim me ka sulfamethoxazole (e.g., Bactrim®, Septra®)
• ʻO Hydrochlorothiazide (`Hydrochlorothiazide` - e.g. `Microzide®`)
• Ziprasidone
• ʻO nā antidepressants Tricyclic e like me amitriptyline
• ʻO Promethazine
• ʻO Prochlorperazine (e.g., Compro®)
• Kuinidina
• ʻO Disopyramide (e.g., Norpace®)
• Sotalol (`Sotalol` - e laʻa. `Betapace®`)

Nā lāʻau lapaʻau ʻē aʻe e launa pū me Dofetilide

Aia kekahi mau lāʻau lapaʻau ʻē aʻe e hiki ke launa pū me Dofetilide. ʻO ke ʻano kēia inā ʻoe e lawe pū i kēia mau lāʻau lapaʻau, hiki iā lākou ke hoʻololi i ke ʻano o ka hana ʻana o Dofetilide a hoʻonui paha i kona mau hopena ʻaoʻao. No laila, inā ʻoe e lawe ana i kekahi o nā lāʻau lapaʻau i helu ʻia ma lalo nei, e kamaʻilio me kāu kauka ma mua o ka hoʻomaka ʻana iā Dofetilide.

• Amiodarone (`Amiodarone` - e laʻa. `Cordarone®`)
• ʻO Digoxin (`Digoxin` - e.g. `Lanoxin®`)
• ʻO Metformin (ʻo ia hoʻi ʻo Glucophage®)
• ʻO Megestrol
• ʻO Diltiazem (e.g. Cardizem®)
• ʻO Zafirlukast
• Kuina
• ʻO Fluconazole
• ʻErythromycin (ʻErythromycin) - e.g. `PCE®`
• ʻO Clarithromycin
• ʻO nā lāʻau antibiotic fluoroquinolone e like me Norfloxacin a me Moxifloxacin
• ʻO nā SSRI (Selective Serotonin Reuptake Inhibitors) e like me Fluoxetine, Sertraline, Paroxetine (e.g. Paxil®)
• ʻO nā diuretics (nā lāʻau lapaʻau e wehe i ka wai mai ke kino) e like me Furosemide, Triamterene, a me Amiloride
• Nā mea hoʻopaʻa protease (nā lāʻau lapaʻau no nā maʻi e like me ka HIV) e like me Indinavir

E makaʻala wale nō: E like me kekahi mau lāʻau lapaʻau, ʻo ka inu ʻana i ka wai pomegerane (he hua e like me ka pomegerane) hiki ke hoʻonui i ka pae o ka lāʻau dofetilide i loko o kou kino. Hiki ke lilo kēia i mea weliweli. No laila, e nīnau i kāu kauka inā he mea maikaʻi ke inu i ka wai pomegerane i ka wā e lawe ana i kēia lāʻau lapaʻau.

He aha kāu e hana ai inā e poina ʻoe i kahi mahele o ka lāʻau lapaʻau?

Inā hana kēia, e lawe i ka lāʻau i hala ʻole i ka wā e hoʻomanaʻo ai ʻoe . Eia nō naʻe, inā kokoke ka manawa no kāu lāʻau aʻe i kou hoʻomanaʻo ʻana, e kāpae i ka lāʻau i hala ʻole a lawe i kāu lāʻau aʻe i ka manawa i hoʻonohonoho ʻia. Mai lawe pālua i ka lāʻau. Inā ʻaʻole ʻoe maopopo i ka mea e hana ai, e kamaʻilio me kāu kauka a kauka lāʻau paha.

He aha nā pōmaikaʻi o Dofetilide?

Hiki iā Dofetilide ke kōkua i ka kaohi ʻana i kekahi o nā puʻuwai puʻuwai kūpono ʻole i loko o kou puʻuwai, kahi e maʻalahi ai kou ola. Eia nō naʻe, he mea nui e hoʻomanaʻo ʻaʻole ia e ho'ōla loa i ka maʻi.

He aha nā hopena ʻaoʻao o Dofetilide?

E like me nā lāʻau lapaʻau āpau, hiki iā Dofetilide ke hana i kekahi mau hopena ʻaoʻao. ʻAʻole loaʻa i nā kānaka a pau, akā he mea maikaʻi ke makaʻala iā lākou.

Nā hopena ʻaoʻao liʻiliʻi e hiki ke loaʻa:

• ʻEha umauma
• ʻEha poʻo (ʻeha poʻo)
• ʻO ka poniuniu (vertigo)
• Ka luaʻi (manaʻo e like me ka luaʻi ʻana)
• Ka maʻi ʻōpū (ʻeha ʻōpū)
• ʻEha ʻōpū

He mea e makaʻala loa ai:

Hāʻawi ʻia ʻo Dofetilide e hoʻoponopono i kahi puʻuwai puʻuwai kūpono ʻole, akā aia kahi pilikia o kekahi ʻano puʻuwai puʻuwai kūpono ʻole me kēia lāʻau lapaʻau. ʻOi aku ka nui, hiki ke loaʻa kahi puʻuwai wikiwiki i nā keʻena haʻahaʻa o ka puʻuwai (`ventricular tachycardia`) i kapa ʻia ʻo "Torsades de Pointes" .

ʻO kēia ke kumu nui e pono ai ʻoe e hoʻokomo ʻia i ka haukapila a hoʻomaka i ka lawe ʻana i ka lāʻau lapaʻau! Makemake nā kauka e nānā pono iā ʻoe no kēia puʻuwai puʻuwai weliweli a kūpono ʻole.

ʻEhia ka manawa e ʻoi aku ai koʻu maikaʻi ma hope o ka hoʻomaka ʻana i ka lāʻau lapaʻau?

ʻElua a ʻekolu hola paha ka lōʻihi o ka hana ʻana o Dofetilide. Eia nō naʻe, inā ʻoe e ʻoluʻolu ana, mai hoʻōki i ka lawe ʻana i ka lāʻau a hiki i ka wā e ʻōlelo aku ai kāu kauka. E hoʻomau i ka lawe ʻana.

Pehea e hiki ai iaʻu ke mālama i koʻu olakino i ka wā e lawe ana iā Dofetilide?

Aia kekahi mau mea e pono ai ʻoe e hana ma kāu ʻaoʻao i ka wā e lawe ana i kēia lāʻau.

• E hōʻoia e hele i kāu mau hālāwai āpau me kāu kauka, me nā hoʻokolohua lab. ʻO ia ka manawa e ʻike ai ʻoe pehea e hoʻopilikia ai ka lāʻau lapaʻau iā ʻoe.
• Pono paha ʻoe e hana i kahi hoʻāʻo electrocardiogram (EKG) i kēlā me kēia ʻeono mahina . E nānā kēia i ka wikiwiki a me ke kuʻi ʻana o kou puʻuwai.
• Hiki paha iā lākou ke kauoha i nā hoʻāʻo koko e ʻike ai inā pono e hoʻololi ʻia ka nui o ka lāʻau.
• E heluhelu mau i ka pepa ʻike e hele pū mai me kāu lāʻau lapaʻau, ʻoiai inā he mau loli hou i kāu lāʻau lapaʻau a i ʻole ke kūlana olakino. E nīnau i kāu kauka lāʻau inā he mau nīnau kāu.

Nā mea hou aʻe hiki iā ʻoe ke hana:

• Inā ʻoe e hana nei i kekahi hana ʻoki kino, hana niho, a i ʻole ka mālama ʻana i ka pilikia, e haʻi i ke kauka a kauka niho paha e lawe ana ʻoe iā Dofetilide.
• Pono paha ʻoe e kau i kahi kāleka hōʻoia e haʻi ana e lawe ana ʻoe iā Dofetilide.
• Mai ho'ōki i ka lawe ʻana i kēia lāʻau me ka ʻole o ke noi ʻana aku i kāu kauka.
• E hahai i nā ʻōlelo aʻo a kāu kauka e pili ana i ka meaʻai a me ka mea inu, ʻoiai hoʻi nā mea inu ʻona.
• E mālama mau i ka lawa o ka lāʻau lapaʻau me ʻoe. Ma mua o ka hele ʻana i ka hoʻomaha a i ʻole ka huakaʻi, e nānā inā ua emi kāu lāʻau lapaʻau. A i ʻole, ʻaʻole paha ʻoe e loaʻa iā ia i kahi pilikia.

Āhea ʻoe e ʻike ai i ke kauka?

Inā ʻike ʻoe i kekahi o kēia mau hōʻailona, ​​e kāhea koke aku i kāu kauka a i ʻole e hele i kahi lumi pilikia:

• Ka puʻuwai wikiwiki a kūpono ʻole paha.
• Ke manaʻo nei e kuʻi wikiwiki ana kou puʻuwai, ke holo wikiwiki nei kou puʻuwai.
• ʻEha ka umauma.
• Ka poniuniu a i ʻole ka manaʻo māmā ke poʻo ('lightheadedness').
• Paʻakikī ka hanu ʻana.
• Ka maʻi pākī nui.
• Ka luaʻi ʻana me ka nalowale o ka makemake.
• Ka hou ʻana maʻamau ʻole.
• Hoʻonui ʻia ka make wai no ka wai.
• ʻŌhūhū ʻili.

ʻOiai inā he mau hopena ʻino ʻole e like me kēia, e kamaʻilio me kāu kauka inā hoʻopilikia lākou iā ʻoe:

• ʻEha poʻo.
• ʻAʻole hiki ke hiamoe.
• Nā hopena ʻaoʻao ʻē aʻe e hoʻopilikia iā ʻoe.

Ma hea e hiki ai iaʻu ke kūʻai iā Dofetilide?

ʻAʻole loaʻa ka Dofetilide ma nā hale kūʻai lāʻau lapaʻau āpau. No laila, e kelepona i kāu hale kūʻai lāʻau lapaʻau kokoke loa e ʻike inā loaʻa iā lākou. Inā pilikia ʻoe i ka loaʻa ʻana o ka lāʻau lapaʻau, e kamaʻilio me kāu kauka.

Pehea e mālama ai iā Dofetilide?

• E mālama iā Dofetilide i loko o kahi pahu i pani paʻa ʻia, ma ka mahana o ka lumi, ma kahi maloʻo .
• Mai waiho i ka lā pololei a i ʻole ma nā wahi wela.
• Mai mālama i kēia lāʻau lapaʻau ma nā wahi me ka makū kiʻekiʻe, e like me ka lua. Hiki i ka makū ke hoʻopau i nā waiwai o ka lāʻau lapaʻau.
• E mālama ʻaʻole i kēia lāʻau lapaʻau wale nō, akā, i nā lāʻau lapaʻau ʻē aʻe a pau mai ka hiki ʻana aku o nā keiki.
• Mai kaʻana like i kāu lāʻau lapaʻau me kekahi.
• Mai hoʻohana i ka lāʻau lapaʻau i pau ka lā. Loaʻa i kekahi mau pūʻolo lāʻau kahi lā palena pau i paʻi ʻia ma luna o lākou. A i ʻole, inā ʻaʻole ʻoe maopopo i ka makahiki o ka lāʻau lapaʻau, e kelepona i kāu hale kūʻai lāʻau lapaʻau a nīnau.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai

Hiki ke hoʻoluhi nui ʻia ka ʻike ʻana he pilikia kou no ka puʻuwai. Eia nō naʻe, inā ua kuhikuhi kāu kauka iā Dofetilide nou, hiki iā ia ke kōkua iā ʻoe. ʻO ka mea nui loa, ʻo ia ka hahai pono ʻana i nā kuhikuhi a ke kauka a me nā kuhikuhi ma ka pūʻolo lāʻau. Inā he mau nīnau a hopohopo paha kāu e pili ana i kēia lāʻau, mai kānalua e nīnau i kāu kauka a kauka lāʻau paha. E hiki iā lākou ke kōkua iā ʻoe.

ʻO Dofetilide, Palpitations puʻuwai, Arrhythmia, Atrial fibrillation, Atrial flutter, Tikosyn, Maʻi puʻuwai