Ua lohe paha ʻoe i ka Lynch Syndrome? He mea hou paha kēia inoa iā ʻoe. Akā, he ʻano genetic ia i hoʻoili ʻia mai kēlā hanauna a i kēia hanauna e hoʻonui nui ai i ko kākou pilikia o ka loaʻa ʻana o ka maʻi kanesa. Hoʻonui kēia i ka pilikia o ka loaʻa ʻana o ka maʻi kanesa, ʻoiai ma mua o 50 mau makahiki. He mea maʻamau ke manaʻo iki i ka makaʻu ke lohe ʻoe i nā huaʻōlelo "hiki paha iā ʻoe ke loaʻa i ka maʻi kanesa". Akā, ʻo ka mea nui loa, ʻo ia ka ʻike pono e pili ana i ia mau ʻano. No laila, i kēia lā e kamaʻilio maʻalahi mākou e pili ana i kēia, ma ke ʻano hiki iā ʻoe ke hoʻomaopopo.
I ka ʻōlelo maʻalahi, he aha ka Lynch Syndrome?
E noʻonoʻo ua like ko kākou kino me kahi mīkini paʻakikī e hana ana e like me kahi puke kuhikuhi nui (DNA). Ua like ko kākou mau genes me nā leka ma kēia puke kuhikuhi. I kekahi manawa, aia nā hewa ma kēia puke kuhikuhi, a i ʻole 'nā hewa kikokiko'. I ka lāʻau lapaʻau, ua kapa ʻia kēia he mau hoʻololi genetic.
ʻO ka maʻi Lynch kahi maʻi i hoʻokumu ʻia e kahi hoʻololi genetic. Loaʻa i ko mākou kino kahi ʻano gene kūikawā e ʻike a hoʻoponopono i nā hewa i loko o kā mākou DNA. Ua kapa ʻia kēia ʻo ka gene "mismatch repair (MMR)". Ua like ia me kahi "hui hoʻoponopono" i loko o ko mākou kino. ʻO kahi kanaka me ka maʻi Lynch he kīnā i loko o kekahi o nā genes i loko o kēia "hui hoʻoponopono". No laila, ʻaʻole i hoʻoponopono pono ʻia nā hewa i loko o ka DNA. Hōʻiliʻili nā cell me kēia mau hewa a i ka hala ʻana o ka manawa, ʻoi aku ka nui o ko lākou lilo ʻana i maʻi kanesa.
Hiki i kēia maʻi ke hoʻopilikia i kekahi. No ka mea, he maʻi hoʻoilina ia. I kekahi manawa hiki iā ʻoe ke hoʻoilina i kēia gene kīnā mai kou makuahine a makua paha. He mea kākaʻikahi loa, hiki ke hana ʻia kēia hoʻololi hoʻoilina i loko o ke kino o ke kanaka hou me ka ʻole o kekahi o ka ʻohana. Inā ʻoe e nānā i nā helu helu ma kahi ʻāina e like me ʻAmelika, ua manaʻo ʻia he hoʻokahi i loko o 279 mau kānaka i loaʻa i kēia maʻi.
He aha nā hōʻailona e hiki i kekahi me ka Lynch syndrome ke ʻike?
ʻO ka mea nui e hoʻomaopopo ma ʻaneʻi, ʻaʻohe hōʻailona kikoʻī o ka maʻi Lynch. Akā, he hōʻailona ia o nā maʻi ʻaʻai i hoʻokumu ʻia e ke ʻano. ʻO ka mea maʻamau o kēia mau mea, ʻo ia ke kanesa colorectal.
No laila, eia kekahi mau hōʻailona maʻamau e pili ana i ka maʻi ʻaʻai colorectal:
| Hōʻailona | Wehewehena |
|---|---|
| Koko i loko o ka ʻōpala | He ʻulaʻula a ʻeleʻele paha ka ʻōpala me ke koko i hui pū ʻia. |
| ʻEha ʻōpū a i ʻole ka nausea | ʻEha pinepine a ʻeha paha ka ʻōpū. |
| Hoʻololi i nā ʻano hana ʻōpū | Ka hoʻomaka koke ʻana o ka paʻa ʻana o ka ʻōpū a i ʻole ka maʻi kahe, a i ʻole nā ʻōpala lahilahi ma mua o ka maʻamau. |
| Luhi pinepine | Luhi mau ʻoiai ka hoʻomaha maikaʻi. |
| Pehu a pehu paha | Manaʻo piha a pehu paha ma hope o ka ʻai iki ʻana. |
| Ka luaʻi a i ʻole ka luaʻi | Ka luaʻi a i ʻole ka luaʻi ʻana me ke kumu ʻole. |
ʻO ka mea nui, ʻaʻole loaʻa i nā kānaka a pau kēia mau hōʻailona. I kekahi manawa, ʻaʻole paha e hōʻike ka maʻi kanesa i kekahi mau hōʻailona a hiki i ka wā e holomua loa ai. No laila, inā hoʻomau ʻoe i kekahi a ʻoi aku paha o kēia mau hōʻailona, e ʻike pono i kāu kauka no ka ʻōlelo aʻo.
He aha nā ʻano maʻi kanesa e hiki ke ulu ma muli o kēia maʻi?
ʻAʻole ʻo Lynch syndrome kahi maʻi e wehe ai i ka puka i hoʻokahi ʻano maʻi kanesa. Hoʻonui ia i ka pilikia o ka loaʻa ʻana o ka maʻi kanesa ma nā ʻāpana like ʻole o ke kino. Hiki ke ʻokoʻa nā ʻōpū i ka pilikia ma muli o ka gene hewa. ʻO `MLHL`, `MSH2`, `MSH6`, `PMS2` a me `EPCAM` nā genes nui ʻelima i pili.
Aia ma lalo iho kekahi mau ʻano maʻi kanesa e hoʻonui ai ka pilikia o ka maʻi Lynch syndrome.
| ʻAno maʻi kanesa | ʻĀpana kino pili |
|---|---|
| Ka maʻi ʻaʻai kolona a me ka rectum | ʻŌnaehana hoʻoheheʻe |
| Ka maʻi ʻaʻai ʻōpū/Endometrial | ʻŌnaehana hānau wahine |
| Ka maʻi ʻōpū | ʻŌnaehana hānau wahine |
| Ka maʻi ʻōpū | ʻŌnaehana hoʻoheheʻe |
| Ka maʻi ʻōpū liʻiliʻi | ʻŌnaehana hoʻoheheʻe |
| Ka maʻi ʻaʻai pancreatic | ʻŌnaehana hoʻoheheʻe |
| Ka maʻi ʻaʻai o ke ala mimi kiʻekiʻe | ʻŌnaehana mimi |
| Ka maʻi ʻaʻai lolo | ʻŌnaehana nerve |
| Ka maʻi ʻili | ʻIli |
He ʻokoʻa iki nā maʻi ʻaʻai kolona i hoʻokumu ʻia e ka Lynch syndrome. Ulu wikiwiki lākou ma mua o nā maʻi ʻaʻai e ulu maʻamau.ʻOiai he 10 mau makahiki ka lilo ʻana o ka polyp liʻiliʻi o ke kanaka maʻamau i maʻi kanesa, he hoʻokahi a ʻelua paha makahiki no kekahi me Lynch syndrome.
Eia kekahi, ma muli o kēia kūlana, ʻoi aku ka nui o ka pilikia o ke kanaka i loaʻa i ka maʻi kanesa colorectal a ua hoʻōla ʻia e hoʻomohala hou i ke ʻano maʻi like.
E noʻonoʻo, aia ma kahi o 15% ka pilikia o ka ulu hou ʻana o ke kanesa i loko o 10 mau makahiki ma hope o ka wehe ʻia ʻana o ke kanesa mua ma ke ʻoki ʻana. Hiki ke piʻi kēia pilikia i 40% ma hope o 20 mau makahiki, a i 60% ma hope o 30 mau makahiki. Hōʻike kēia i ke koʻikoʻi o ka nānā mau ʻana.
Pehea e hoʻoili ʻia ai kēia ma o nā hanauna?
ʻO ka maʻi Lynch kahi maʻi i hoʻoili ʻia mai kēlā hanauna a i kēia hanauna ma ke ʻano "autosomal dominant". ʻO ke ʻano o kēia, inā hoʻokahi wale nō makua , ʻo ka makuahine a i ʻole ka makuakāne paha, he 50% ka manawa e hoʻoilina ai ke keiki. ʻO ke ʻano o kēia, he 50% ka manawa e hoʻoilina ai kēlā me kēia keiki a he 50% ka manawa e hoʻoilina ʻole ai.
No laila, inā ua ʻike ʻia ʻoe a i ʻole kekahi o kou ʻohana me ka Lynch syndrome, he mea nui loa ia e hoʻomaopopo i ke koena o kou ʻohana. ʻOi aku hoʻi kou mau kaikaina, nā keiki, a me nā mākua e pono e haʻi ʻia e pili ana i kēia pilikia. ʻO ka kuhikuhi ʻana iā lākou i ka hoʻāʻo genetic a me ke aʻo ʻana e hoʻopakele paha i ko lākou ola.
Pehea e ʻike ai au inā loaʻa iaʻu kēia maʻi? He aha nā hoʻokolohua e pono iaʻu e hana?
ʻO ke ala maikaʻi loa e hōʻoia ai inā loaʻa iā ʻoe ka Lynch syndrome, ʻo ia ka hana ʻana i ka hoʻāʻo genetic . ʻO ka maʻamau, pili kēia i ka lawe ʻana i kahi hāpana koko. A i ʻole e lawe ʻia kahi swab buccal mai loko mai o kou waha. Hiki i kēia hoʻāʻo ke ʻike pololei inā loaʻa iā ʻoe kahi mutation i loko o nā genes a mākou i kamaʻilio ai ma mua, e like me MLHL a me MSH2.
Inā ua ʻike ʻia ʻoe me ka Lynch syndrome, ʻo ka mea nui aʻe e hiki mai ana, ʻo ia ka loaʻa ʻana o nā hoʻokolohua maʻamau e ʻike mua i ka maʻi kanesa. E hoʻomohala kāu kauka i kahi papa hana hoʻokolohua kūpono iā ʻoe.
| Hoʻāʻo | Pehea e hana ai a me ka manawa i ʻōlelo ʻia |
|---|---|
| Kolonoskopi | ʻO ka colonoscopy kahi hana e hoʻokomo ʻia ai kahi ʻōmole lahilahi me kahi kāmela ma o ka anus e nānā i ka colon. Manaʻo pinepine ʻia i kēlā me kēia makahiki a ʻelua paha . |
| ʻO ka Ultrasound Transvaginal | No nā wahine, ua ʻōlelo ʻia kahi hoʻokolohua pelvic, ʻo ia hoʻi ke hoʻokomo ʻana i kahi mea scan ma o ka vagina a me ka nānā ʻana i ka uterus a me nā ovaries, i kēlā me kēia makahiki a ʻelua paha . |
| Ka nānā ʻana i ka mimi | E loaʻa i kahi ʻike kumu o nā maʻi ʻaʻai e pili ana i nā puʻupaʻa ma o ka hoʻāʻo ʻana i kahi hāpana mimi. He mea kūpono ke hana i kēia i kēlā me kēia makahiki . |
| Endoscopy luna | He ʻōmole me kahi kāmela i hoʻokomo ʻia ma ka waha e nānā i ka ʻōpū a me ka ʻaoʻao o luna o ka ʻōpū liʻiliʻi. Manaʻo ʻia i kēlā me kēia 3-5 mau makahiki . |
| Biopsy | Inā loaʻa kahi ʻiʻo kānalua a i ʻole kahi puʻupuʻu i ka wā o ka hoʻāʻo ʻana ma luna, e lawe ʻia kahi hāpana liʻiliʻi a hoʻāʻo ʻia no nā hunaola kanesa. |
Pehea e mālama ʻia ai ka Lynch syndrome?
ʻAʻohe lāʻau lapaʻau i kēia manawa no ke ʻano genetic Lynch syndrome. No laila, ʻo ke kumu nui o ka mālama ʻana, ʻo ia ka ʻike ʻana a me ka wehe ʻana i nā hunaola kanesa mai ke kino ma ke ʻoki ʻana. Inā hiki ke ʻike ʻia a wehe ʻia ke kanesa ma mua o ka laha ʻana i nā ʻāpana ʻē aʻe o ke kino, ua holomua loa nā hopena.
Pono kēia i kahi hui kauka multidisciplinary. No ka laʻana, hana pū nā gastroenterologists, nā kauka ʻokiʻoki, nā gynecologic oncologists, a me nā oncologists e mālama i kēia maʻi.
Koho kekahi poʻe, ʻoiai nā wahine i hoʻopau i ko lākou mau ʻohana, e hana i kahi hysterectomy a i ʻole oophorectomy ma mua o ka ulu ʻana o kekahi maʻi e hōʻemi i ko lākou pilikia o ka loaʻa ʻana o ka maʻi ʻōpū a i ʻole ka maʻi ovarian i ka wā e hiki mai ana. Pēlā nō, ʻo ka poʻe i loaʻa i ka pilikia kiʻekiʻe o ka maʻi ʻaʻai colon e koho paha e hana i kahi colectomy. He mau hoʻoholo pilikino loa kēia, a pono e hana ʻia ma hope o ke kūkākūkā nui ʻana me kāu kauka.
He like anei ka Lynch syndrome a me ka HNPCC?
Ua lohe paha ʻoe i ka inoa ʻo 'HNPCC (Hereditary Non-Polyposis Colorectal Cancer)'. Hoʻohana pinepine ʻia ʻo Lynch syndrome a me HNPCC me ke ʻano like ʻole, akā aia kahi ʻokoʻa loea ma waena o nā mea ʻelua.
I ka ʻōlelo maʻalahi, hoʻohana ʻia ka inoa HNPCC ma muli o ka mōʻaukala ʻohana. ʻO ia hoʻi, inā ua loaʻa i kekahi mau lālā o kahi ʻohana kēia ʻano maʻi kanesa, ua ʻōlelo ʻia ua loaʻa i kēlā ʻohana ka HNPCC. Akā ʻo Lynch syndrome ka inoa i hāʻawi ʻia ma hope o ka ʻike ʻia ʻana o ka mutation gene kikoʻī e kumu ai. No laila, hiki i nā lālā āpau o kahi ʻohana me HNPCC ke loaʻa ka mutation gene syndrome Lynch. Eia kekahi, ʻo ke kanaka e hoʻomohala i kahi mutation gene hou me ka ʻole o kekahi mea ʻē aʻe o ka ʻohana hiki ke ʻōlelo ʻia he Lynch syndrome.
ʻAʻohe mea makemake e lohe i nā huaʻōlelo, "He maʻi kanesa kou." Pono paha kekahi me Lynch syndrome e lohe i kēlā mau ʻōlelo i kekahi manawa o ko lākou ola. Akā, ʻaʻole ia ka hopena o ka honua. Inā ʻike ʻoe i kou kūlana, e hana pū me kāu kauka, a loaʻa nā hoʻokolohua maʻamau no ke kanesa, hiki ke ʻike ʻia a hoʻōla ʻia kekahi kanesa i kona wā mua loa. ʻO ka ʻike mua ʻana a me ka mālama ʻana ke ala maikaʻi loa e ola ai i kahi ola olakino a hauʻoli.
Leka Lawe-Home
- ʻO ka Lynch syndrome kahi maʻi genetic i hoʻoili ʻia i nā hanauna a hoʻonui i ka pilikia o ka maʻi kanesa.
- Inā hoʻokahi wale nō makua i loaʻa kēia ʻano kīnā, he 50% ka manawa kūpono o ke keiki e hoʻoilina iā ia.
- Inā ua ʻike ʻia ʻoe a i ʻole kekahi o kou ʻohana me kēia maʻi, he mea nui loa ia e hoʻomaopopo i nā ʻohana pili ʻē aʻe e pili ana i ia mea.
- ʻOiai ʻaʻole hiki ke ho'ōla ʻia kēia maʻi hoʻoilina, ʻo ke ala maikaʻi loa e pale aku ai a ʻike mua paha i ka maʻi kanesa, ʻo ia ke hele i nā hoʻokolohua lapaʻau maʻamau.
- Hiki i ka ʻike mua ʻana a me ka mālama ʻana i ka maʻi kanesa ke loaʻa nā hopena holomua loa a hiki iā ʻoe ke ola i kahi ola olakino.
- E kūkākūkā mau me kāu kauka e hoʻonohonoho i kahi papa hana hoʻāʻo e kūpono iā ʻoe a e hoʻoponopono i kekahi mau hopohopo.
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