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Ola Palekana5 Iulai 2026🔄 Updated: 14 Iul. 2026⏱ 11 min

He aha ka HNPCC (Hereditary Nonpolyposis Colorectal Cancer)? Aia kekahi moʻolelo o ke kanesa i loko o kou ʻohana?

Dr. Priya Sammani, MBBS, PG Dip. FMMedical Verification

I kekahi manawa ʻike mākou he nui nā lālā o ka ʻohana e loaʻa ana i ke ʻano like o ka maʻi kanesa. A i ʻole ua ʻōlelo ʻia he ʻoi aku ka nui o ka pilikia o ka loaʻa ʻana o ka maʻi i nā lālā o ka ʻohana hoʻokahi. ʻO ia ka mea a mākou e kamaʻilio ai i kēia lā. ʻOiai he kumuhana paʻakikī kēia, e hoʻāʻo kākou e hoʻomaopopo maʻalahi.

He aha nā HNPCC a me Lynch Syndrome?

I ka ʻōlelo maʻalahi, ʻo ka HNPCC (Hereditary Nonpolyposis Colorectal Cancer) kahi ʻano maʻi kanesa colorectal i hoʻokumu ʻia e nā hoʻololi genetic. ʻO kēia no ka mea ʻo kekahi mau genes a mākou e hoʻoilina ai mai ko mākou mau mākua e ʻoi aku ka nui o ka hiki ke hoʻomohala i nā hunaola kanesa.

Ua lohe paha ʻoe i ka Lynch syndrome, i kapa ʻia hoʻi ʻo Lynch syndrome . He pili maoli ka HNPCC a me ka Lynch syndrome, akā ʻaʻole like loa lāua. Ke kapa nei mākou iā HNPCC ma ke ʻano he maʻi kanesa e pili ana i ka Lynch syndrome i ʻike ʻia ma mua o 50 mau makahiki. Hiki i kēia ke komo pū me ka maʻi kanesa colon, akā, ʻo nā maʻi kanesa o ka uhi o ka uterus (endometrium), ka ʻōpū liʻiliʻi, ka ureter, a me ka pelvis renal. I ka HNPCC, ʻo ka maʻi kanesa ka mea maʻamau ma ka ʻaoʻao ʻākau o ka colon.

Pehea ka maʻamau o ka HNPCC?

ʻO HNPCC ka helu ma waena o 2% a me 4% o nā maʻi ʻaʻai colorectal āpau. Hiki ke loaʻa i kēlā me kēia makahiki, akā ʻike pinepine ʻia nā hōʻailona a ʻike ʻia ka maʻi ma mua o 50 mau makahiki.

He aha nā hōʻailona o ka HNPCC?

I nā pae mua, ʻaʻole paha e hōʻike ka HNPCC i kekahi mau hōʻailona. ʻO ke ʻano kēia, hiki i ke kanesa ke ulu i loko o kou kino me ka ʻole o kou manaʻo i kekahi mea. Akā i ka ulu ʻana o ke kanesa, hiki iā ʻoe ke ʻike i nā hōʻailona e like me:

ʻEha ka ʻōpū a pehu paha.
ʻAʻohe ʻono o ka meaʻai.
Koko i loko o ka ʻōpala. (He hōʻailona koʻikoʻi loa kēia, mai hoʻowahāwahā!)
Luhi mau ka manaʻo (Fatigue).
Ka pohō kaumaha me ke kumu ʻole.

He aha nā kumu o ka HNPCC?

E like me kā mākou i ʻōlelo ai ma mua, ua hoʻokumu ʻia ka HNPCC e nā hoʻololi ʻana o nā genes i hoʻoilina ʻia mai ko mākou mau mākua. Ke hoʻoili ʻia kēia mau kīnā genetic mai kēlā hanauna a i kēia hanauna, piʻi ka pilikia o ka loaʻa ʻana o ka maʻi kanesa i loko o kēlā ʻohana. Kāhea mākou i kēia he 'family cancer syndrome'.

ʻO ka maʻi kanesa ʻohana nui e hoʻoulu ai i ka HNPCC ʻo ia ka maʻi Lynch . Hoʻokumu ʻia ia e nā mutations i loko o nā genes MLH1, MSH2, MSH6, PMS2, a me EPCAM . ʻO ka hana a kēia mau genes ka hoʻoponopono ʻana i nā hewa e kū mai ana i ka wā o ka hana hou ʻana o ka DNA i ka wā e māhelehele ai kā mākou mau cell. E noʻonoʻo, inā ʻaʻole hana pono kēia mau genes, ʻaʻole i hoʻoponopono ʻia kēlā mau hewa. A laila ʻoi aku ka kiʻekiʻe o ka manawa e lilo ai nā cell maʻamau i mau cell cancer.

He maʻi lele anei ka HNPCC?

ʻAʻole, ʻaʻole he maʻi lele ka HNPCC. ʻO ke ʻano kēia, ʻaʻole ia e laha mai kekahi kanaka a i kekahi kanaka ma ka hoʻopā ʻana a i ʻole ka ʻūhā ʻana. Eia nō naʻe, ʻo ka hoʻololi ʻana o ka gene e hoʻoulu ai i ka HNPCC ua hoʻoili ʻia mai kēlā hanauna a i kēia hanauna . No laila, hiki i kekahi mau lālā o nā ʻohana me kēia hoʻololi ʻana o ka gene ke loaʻa i ka maʻi ʻaʻai colon a i ʻole nā maʻi ʻaʻai ʻē aʻe e pili ana me ka Lynch syndrome.

ʻO ka mea nui, ʻo kēia gene hemahema a me ka pilikia o ka hoʻomohala ʻana i ka HNPCC hiki ke hoʻoili ʻia mai nā mākua a i nā keiki.

Pehea e ʻike ai nā kauka i ka maʻi ʻaʻai colon?

Hana pinepine nā kauka i kahi hoʻokolohua kino e nānā i ka maʻi ʻaʻai kolona. A laila paipai lākou i kahi colonoscopy , ʻo ia hoʻi ke hoʻokomo ʻana i kahi ʻōmole liʻiliʻi i hoʻomālamalama ʻia ma kou anus e nānā i loko o kou kolona.

Inā loaʻa i kekahi o kou ʻohana ka HNPCC, pono ʻoe e haʻi i kāu kauka . He mea nui loa ia.

He aha nā hoʻokolohua e hana ʻia e hōʻoia i ka HNPCC?

Hiki i kāu kauka ke ʻōlelo aku i ka hoʻāʻo ʻana i ka genetic e hoʻoholo ai inā loaʻa iā ʻoe ka mutation gene e pili ana me ka Lynch syndrome. E nīnau pū kāu kauka e pili ana i:

Ua loaʻa anei i kekahi o kou ʻohana pili (makuahine, makuakāne, kaikaina) ka maʻi ʻaʻai kolona? ʻOi loa aku inā ua ʻike ʻia ma mua o 50 mau makahiki.
Hoʻomaopopo pū ia ʻaʻole ʻoe e loaʻa i kahi maʻi kanesa colon hoʻoilina ʻē aʻe i kapa ʻia ʻo Familial Adenomatous Polyposis (FAP) , i hoʻokumu ʻia e kahi mutation genetic ʻokoʻa ma mua o HNPCC.

He mea pono anei ke ʻoki kino no ka HNPCC?

ʻAe, mālama pinepine ʻia ka HNPCC me ke ʻoki kino. Ua kapa ʻia kēia ʻoki kino he colectomy . Pili ia i ka wehe ʻana i kahi hapa a i ʻole ka ʻōpū nui āpau. Aia kekahi mau ʻano ʻoki kino:

ʻO ka colectomy hapa a i ʻole ka colectomy segmental: Ma kēia, ʻo ka ʻāpana wale nō o ke kolona me ka maʻi kanesa e wehe ʻia.
Proctectomy: ʻO kēia ka wehe ʻana i ka kolona a me ka rectum.
ʻO ka colectomy holoʻokoʻa: Ma kēia, ua wehe ʻia ke kolona holoʻokoʻa.

He aha nā lāʻau ʻē aʻe i loaʻa no ka HNPCC?

Inā ua pālahalaha ke kanesa colon (metastasized) i nā ʻāpana ʻē aʻe o ke kino, hiki i kāu kauka ke ʻōlelo i nā lāʻau lapaʻau e like me:

Chemotherapy: ʻO kēia ka hāʻawi ʻana i nā lāʻau lapaʻau e luku i nā hunaola kanesa.
Immunotherapy: ʻO kēia ka hoʻoulu ʻana i ka ʻōnaehana pale o ko mākou kino ponoʻī e hakakā i nā hunaola kanesa.

Makemake pinepine nā kauka i ka immunotherapy no ka mea ʻoi aku ka maikaʻi o ia a he emi nā hopena ʻaoʻao.

Hiki ke pale ʻia ka HNPCC?

Hoʻokumu ʻia kēia mau maʻi kanesa ʻohana e nā hoʻololi hoʻoilina i hoʻoilina ʻia. No laila, ʻaʻohe ala e pale aku ai i kēia mau hoʻololi hoʻoilina mai ka hanana ʻana . Eia nō naʻe, inā loaʻa i kekahi o kou ʻohana ka Lynch syndrome a i ʻole HNPCC, he mea nui loa ia e kamaʻilio me kāu kauka e pili ana i ka pono e hana i ka hoʻāʻo hoʻoilina.

ʻO ka nānā mau ʻana a, inā pono, ʻo ke ʻoki pale ʻana hiki ke hōʻemi i ka pilikia o ka make i nā poʻe me HNPCC.

Pehea e ʻike ai iaʻu inā aia wau i ka pilikia o ka loaʻa ʻana o ka HNPCC?

Inā hōʻoia ka hoʻāʻo ʻana i ka genetic he hoʻololi gene kou e pili ana me ka Lynch syndrome, hiki i kāu kauka ke ʻōlelo aku i ka nānā ʻana no ke kanesa colorectal e hoʻomaka ana i kou mau makahiki 20. Inā ʻike mua ʻia ke kanesa, ʻoi aku ka kiʻekiʻe o ka manawa kūpono o ka mālama ʻana.

Inā loaʻa iaʻu ka HNPCC, he aha hou aʻe kaʻu e manaʻo ai?

Inā loaʻa iā ʻoe ka HNPCC, ʻoi aku paha kou pilikia o ka loaʻa ʻana o nā maʻi ʻaʻai ʻē aʻe e pili ana i ka HNPCC. No laila, hiki i kāu kauka ke nānā pinepine iā ʻoe no kēia mau ʻano maʻi ʻaʻai:

Ka maʻi ʻaʻai lolo
Ka maʻi ʻaʻai puʻupaʻa
Ka maʻi ʻaʻai ate
Ka maʻi ʻōpū
Ka maʻi ʻōpū
Ka maʻi ʻili
Ka maʻi ʻaʻai ʻōpū/Endometrial

Hiki ke ho'ōla ʻia ka HNPCC?

ʻAʻole hiki ke ho'ōla piha ʻia ka maʻi Lynch no ka mea he maʻi hoʻoilina ia. Eia nō naʻe, hiki i ke ʻoki ʻana e wehe i ka kolone holoʻokoʻa (colectomy holoʻokoʻa) ke mālama i ka HNPCC a pale i ka ulu ʻana o ka maʻi ʻaʻai kolone .

He aha ka wānana no nā poʻe me HNPCC?

Ma kahi o 60% o ka poʻe i ʻike ʻia me HNPCC e ola mau ana ma hope o ʻelima mau makahiki . ʻO ia hoʻi, he 60 mai loko mai o 100 mau maʻi e ola mau ana i ʻelima mau makahiki ma hope o ko lākou hōʻoia ʻana i ka HNPCC. ʻO ka nui o ke ola ʻana he 10 makahiki no ka poʻe me Lynch syndrome ma waena o 70% a me 88%. He mea weliweli paha kēia mau helu helu, akā e hoʻomanaʻo me ka ʻike mua ʻana a me ka mālama kūpono, hiki ke kāohi nui ʻia kēia kūlana .

Pehea e hiki ai iaʻu ke mālama iaʻu iho inā loaʻa iaʻu ka HNPCC?

Inā loaʻa iā ʻoe kekahi mau hōʻailona hou o ke kanesa colon, e haʻi koke i kāu kauka . No ke kōkua ʻana i ka pale ʻana i ke kanesa colon, hiki iā ʻoe ke hana i kēia mau mea:

E pale i ka puhipaka.
E ʻai i ka meaʻai olakino.
E hoʻoikaika kino i nā manawa a pau.
E kiʻi i nā hoʻokolohua maʻi kanesa a pau i ʻōlelo ʻia e kāu kauka.
E kaupalena i ka inu ʻana i ka waiʻona.
E mālama i ke kaumaha olakino.

Aia anei ka pilikia o ka loaʻa ʻana o ka HNPCC i kaʻu keiki?

Inā loaʻa iā ʻoe ka maʻi Lynch, he 50% ka manawa kūpono o kāu keiki e hoʻoilina i ka hoʻololi ʻana o ka gene e hoʻokumu ai. ʻO ke ʻano kēia inā he ʻelua kāu mau keiki, hiki i kekahi ke hoʻoilina i ka gene a ʻaʻole paha kekahi. Inā hoʻoilina ʻia kēlā ʻano hoʻololi ʻana o ka gene, ʻoi aku ka nui o ka pilikia o kēlā keiki i ka loaʻa ʻana o ka HNPCC.

Ua like anei nā maʻi ʻaʻai kolona FAP a me HNPCC?

ʻO ka HNPCC a me ka FAP (Familial Adenomatous Polyposis) he mau maʻi ʻaʻai kolona genetic, akā ua hoʻokumu ʻia lākou e nā mutations i nā genes like ʻole .

Hoʻomohala ka poʻe me FAP i nā polyps he nui i loko o ko lākou kolona. I kekahi manawa he mau tausani o kēia mau ulu liʻiliʻi i kapa ʻia he polyps. Eia nō naʻe, ʻaʻole nui nā polyps i loaʻa i ka poʻe me HNPCC, a i kekahi manawa hiki i ka maʻi kanesa ke ulu me ka ʻole o nā polyps. ʻO nā polyps e ulu ana ma HNPCC he pālahalaha maʻamau.

ʻO nā polyp e ulu ana ma kēia mau kūlana ʻelua ua manaʻo ʻia he precancerous , ʻo ia hoʻi hiki iā lākou ke lilo i ka maʻi kanesa i loko o kahi manawa pōkole.

ʻO nā mea nui a mākou e hoʻomanaʻo ai mai kēia moʻolelo, ʻo ia

ʻO ka HNPCC (Hereditary Nonpolyposis Colorectal Cancer) kahi ʻano maʻi ʻaʻai colorectal i hoʻokumu ʻia e kahi kīnā genetic i hoʻoili ʻia i nā hanauna. Pili pū ia me ka Lynch syndrome.

Inā he moʻolelo ʻohana no ka maʻi kanesa, he mea nui loa e kamaʻilio me kāu kauka e pili ana i ia mea.
ʻOiai inā ʻaʻohe ou hōʻailona, inā ʻoe i ka pilikia , e hana i nā hoʻokolohua maʻamau.
Inā ʻike ʻia i ka wā mua, ʻoi aku ka maikaʻi o ka holomua ʻana o ka lāʻau.
ʻAʻole he maʻi lele ka HNPCC, akā hiki ke hoʻoilina ʻia ma ke ʻano genetic.
He mea nui loa ke ola i kahi nohona olakino a hahai i nā ʻōlelo a ke kauka.

Inā he mau nīnau hou aku kāu e pili ana i kēia, mai makaʻu e nīnau i kāu kauka. E kōkua lākou iā ʻoe.

HNPCC , Lynch syndrome, maʻi ʻaʻai colorectal, maʻi ʻaʻai colon, maʻi ʻaʻai rectal, nā hoʻololi genetic, maʻi ʻaʻai hoʻoilina, nānā ʻana i ke kanesa, colonoscopy, ʻoki kino, chemotherapy, immunotherapy

⚠️ Important: The medical articles and information on Nirogi Lanka are for general awareness only, and are by no means a substitute for professional medical advice, diagnosis, or treatment. For any medical problem you have, consult a qualified physician immediately.

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Ola Palekana5 Iulai 2026

He aha ka HNPCC (Hereditary Nonpolyposis Colorectal Cancer)? Aia kekahi moʻolelo o ke kanesa i loko o kou ʻohana?

Dr. Priya SammaniMedical Verification

⏱ 11 min read

I kekahi manawa ʻike mākou he nui nā lālā o ka ʻohana e loaʻa ana i ke ʻano like o ka maʻi kanesa. A i ʻole ua ʻōlelo ʻia he ʻoi aku ka nui o ka pilikia o ka loaʻa ʻana o ka maʻi i nā lālā o ka ʻohana hoʻokahi. ʻO ia ka mea a mākou e kamaʻilio ai i kēia lā. ʻOiai he kumuhana paʻakikī kēia, e hoʻāʻo kākou e hoʻomaopopo maʻalahi.

He aha nā HNPCC a me Lynch Syndrome?

I ka ʻōlelo maʻalahi, ʻo ka HNPCC (Hereditary Nonpolyposis Colorectal Cancer) kahi ʻano maʻi kanesa colorectal i hoʻokumu ʻia e nā hoʻololi genetic. ʻO kēia no ka mea ʻo kekahi mau genes a mākou e hoʻoilina ai mai ko mākou mau mākua e ʻoi aku ka nui o ka hiki ke hoʻomohala i nā hunaola kanesa.

Ua lohe paha ʻoe i ka Lynch syndrome, i kapa ʻia hoʻi ʻo Lynch syndrome . He pili maoli ka HNPCC a me ka Lynch syndrome, akā ʻaʻole like loa lāua. Ke kapa nei mākou iā HNPCC ma ke ʻano he maʻi kanesa e pili ana i ka Lynch syndrome i ʻike ʻia ma mua o 50 mau makahiki. Hiki i kēia ke komo pū me ka maʻi kanesa colon, akā, ʻo nā maʻi kanesa o ka uhi o ka uterus (endometrium), ka ʻōpū liʻiliʻi, ka ureter, a me ka pelvis renal. I ka HNPCC, ʻo ka maʻi kanesa ka mea maʻamau ma ka ʻaoʻao ʻākau o ka colon.

Pehea ka maʻamau o ka HNPCC?

ʻO HNPCC ka helu ma waena o 2% a me 4% o nā maʻi ʻaʻai colorectal āpau. Hiki ke loaʻa i kēlā me kēia makahiki, akā ʻike pinepine ʻia nā hōʻailona a ʻike ʻia ka maʻi ma mua o 50 mau makahiki.

He aha nā hōʻailona o ka HNPCC?

I nā pae mua, ʻaʻole paha e hōʻike ka HNPCC i kekahi mau hōʻailona. ʻO ke ʻano kēia, hiki i ke kanesa ke ulu i loko o kou kino me ka ʻole o kou manaʻo i kekahi mea. Akā i ka ulu ʻana o ke kanesa, hiki iā ʻoe ke ʻike i nā hōʻailona e like me:

ʻEha ka ʻōpū a pehu paha.
ʻAʻohe ʻono o ka meaʻai.
Koko i loko o ka ʻōpala. (He hōʻailona koʻikoʻi loa kēia, mai hoʻowahāwahā!)
Luhi mau ka manaʻo (Fatigue).
Ka pohō kaumaha me ke kumu ʻole.

He aha nā kumu o ka HNPCC?

E like me kā mākou i ʻōlelo ai ma mua, ua hoʻokumu ʻia ka HNPCC e nā hoʻololi ʻana o nā genes i hoʻoilina ʻia mai ko mākou mau mākua. Ke hoʻoili ʻia kēia mau kīnā genetic mai kēlā hanauna a i kēia hanauna, piʻi ka pilikia o ka loaʻa ʻana o ka maʻi kanesa i loko o kēlā ʻohana. Kāhea mākou i kēia he 'family cancer syndrome'.

ʻO ka maʻi kanesa ʻohana nui e hoʻoulu ai i ka HNPCC ʻo ia ka maʻi Lynch . Hoʻokumu ʻia ia e nā mutations i loko o nā genes MLH1, MSH2, MSH6, PMS2, a me EPCAM . ʻO ka hana a kēia mau genes ka hoʻoponopono ʻana i nā hewa e kū mai ana i ka wā o ka hana hou ʻana o ka DNA i ka wā e māhelehele ai kā mākou mau cell. E noʻonoʻo, inā ʻaʻole hana pono kēia mau genes, ʻaʻole i hoʻoponopono ʻia kēlā mau hewa. A laila ʻoi aku ka kiʻekiʻe o ka manawa e lilo ai nā cell maʻamau i mau cell cancer.

He maʻi lele anei ka HNPCC?

ʻAʻole, ʻaʻole he maʻi lele ka HNPCC. ʻO ke ʻano kēia, ʻaʻole ia e laha mai kekahi kanaka a i kekahi kanaka ma ka hoʻopā ʻana a i ʻole ka ʻūhā ʻana. Eia nō naʻe, ʻo ka hoʻololi ʻana o ka gene e hoʻoulu ai i ka HNPCC ua hoʻoili ʻia mai kēlā hanauna a i kēia hanauna . No laila, hiki i kekahi mau lālā o nā ʻohana me kēia hoʻololi ʻana o ka gene ke loaʻa i ka maʻi ʻaʻai colon a i ʻole nā maʻi ʻaʻai ʻē aʻe e pili ana me ka Lynch syndrome.

ʻO ka mea nui, ʻo kēia gene hemahema a me ka pilikia o ka hoʻomohala ʻana i ka HNPCC hiki ke hoʻoili ʻia mai nā mākua a i nā keiki.

Pehea e ʻike ai nā kauka i ka maʻi ʻaʻai colon?

Hana pinepine nā kauka i kahi hoʻokolohua kino e nānā i ka maʻi ʻaʻai kolona. A laila paipai lākou i kahi colonoscopy , ʻo ia hoʻi ke hoʻokomo ʻana i kahi ʻōmole liʻiliʻi i hoʻomālamalama ʻia ma kou anus e nānā i loko o kou kolona.

Inā loaʻa i kekahi o kou ʻohana ka HNPCC, pono ʻoe e haʻi i kāu kauka . He mea nui loa ia.

He aha nā hoʻokolohua e hana ʻia e hōʻoia i ka HNPCC?

Hiki i kāu kauka ke ʻōlelo aku i ka hoʻāʻo ʻana i ka genetic e hoʻoholo ai inā loaʻa iā ʻoe ka mutation gene e pili ana me ka Lynch syndrome. E nīnau pū kāu kauka e pili ana i:

Ua loaʻa anei i kekahi o kou ʻohana pili (makuahine, makuakāne, kaikaina) ka maʻi ʻaʻai kolona? ʻOi loa aku inā ua ʻike ʻia ma mua o 50 mau makahiki.
Hoʻomaopopo pū ia ʻaʻole ʻoe e loaʻa i kahi maʻi kanesa colon hoʻoilina ʻē aʻe i kapa ʻia ʻo Familial Adenomatous Polyposis (FAP) , i hoʻokumu ʻia e kahi mutation genetic ʻokoʻa ma mua o HNPCC.

He mea pono anei ke ʻoki kino no ka HNPCC?

ʻAe, mālama pinepine ʻia ka HNPCC me ke ʻoki kino. Ua kapa ʻia kēia ʻoki kino he colectomy . Pili ia i ka wehe ʻana i kahi hapa a i ʻole ka ʻōpū nui āpau. Aia kekahi mau ʻano ʻoki kino:

ʻO ka colectomy hapa a i ʻole ka colectomy segmental: Ma kēia, ʻo ka ʻāpana wale nō o ke kolona me ka maʻi kanesa e wehe ʻia.
Proctectomy: ʻO kēia ka wehe ʻana i ka kolona a me ka rectum.
ʻO ka colectomy holoʻokoʻa: Ma kēia, ua wehe ʻia ke kolona holoʻokoʻa.

He aha nā lāʻau ʻē aʻe i loaʻa no ka HNPCC?

Inā ua pālahalaha ke kanesa colon (metastasized) i nā ʻāpana ʻē aʻe o ke kino, hiki i kāu kauka ke ʻōlelo i nā lāʻau lapaʻau e like me:

Chemotherapy: ʻO kēia ka hāʻawi ʻana i nā lāʻau lapaʻau e luku i nā hunaola kanesa.
Immunotherapy: ʻO kēia ka hoʻoulu ʻana i ka ʻōnaehana pale o ko mākou kino ponoʻī e hakakā i nā hunaola kanesa.

Makemake pinepine nā kauka i ka immunotherapy no ka mea ʻoi aku ka maikaʻi o ia a he emi nā hopena ʻaoʻao.

Hiki ke pale ʻia ka HNPCC?

Hoʻokumu ʻia kēia mau maʻi kanesa ʻohana e nā hoʻololi hoʻoilina i hoʻoilina ʻia. No laila, ʻaʻohe ala e pale aku ai i kēia mau hoʻololi hoʻoilina mai ka hanana ʻana . Eia nō naʻe, inā loaʻa i kekahi o kou ʻohana ka Lynch syndrome a i ʻole HNPCC, he mea nui loa ia e kamaʻilio me kāu kauka e pili ana i ka pono e hana i ka hoʻāʻo hoʻoilina.

ʻO ka nānā mau ʻana a, inā pono, ʻo ke ʻoki pale ʻana hiki ke hōʻemi i ka pilikia o ka make i nā poʻe me HNPCC.

Pehea e ʻike ai iaʻu inā aia wau i ka pilikia o ka loaʻa ʻana o ka HNPCC?

Inā hōʻoia ka hoʻāʻo ʻana i ka genetic he hoʻololi gene kou e pili ana me ka Lynch syndrome, hiki i kāu kauka ke ʻōlelo aku i ka nānā ʻana no ke kanesa colorectal e hoʻomaka ana i kou mau makahiki 20. Inā ʻike mua ʻia ke kanesa, ʻoi aku ka kiʻekiʻe o ka manawa kūpono o ka mālama ʻana.

Inā loaʻa iaʻu ka HNPCC, he aha hou aʻe kaʻu e manaʻo ai?

Inā loaʻa iā ʻoe ka HNPCC, ʻoi aku paha kou pilikia o ka loaʻa ʻana o nā maʻi ʻaʻai ʻē aʻe e pili ana i ka HNPCC. No laila, hiki i kāu kauka ke nānā pinepine iā ʻoe no kēia mau ʻano maʻi ʻaʻai:

Ka maʻi ʻaʻai lolo
Ka maʻi ʻaʻai puʻupaʻa
Ka maʻi ʻaʻai ate
Ka maʻi ʻōpū
Ka maʻi ʻōpū
Ka maʻi ʻili
Ka maʻi ʻaʻai ʻōpū/Endometrial

Hiki ke ho'ōla ʻia ka HNPCC?

ʻAʻole hiki ke ho'ōla piha ʻia ka maʻi Lynch no ka mea he maʻi hoʻoilina ia. Eia nō naʻe, hiki i ke ʻoki ʻana e wehe i ka kolone holoʻokoʻa (colectomy holoʻokoʻa) ke mālama i ka HNPCC a pale i ka ulu ʻana o ka maʻi ʻaʻai kolone .

He aha ka wānana no nā poʻe me HNPCC?

Ma kahi o 60% o ka poʻe i ʻike ʻia me HNPCC e ola mau ana ma hope o ʻelima mau makahiki . ʻO ia hoʻi, he 60 mai loko mai o 100 mau maʻi e ola mau ana i ʻelima mau makahiki ma hope o ko lākou hōʻoia ʻana i ka HNPCC. ʻO ka nui o ke ola ʻana he 10 makahiki no ka poʻe me Lynch syndrome ma waena o 70% a me 88%. He mea weliweli paha kēia mau helu helu, akā e hoʻomanaʻo me ka ʻike mua ʻana a me ka mālama kūpono, hiki ke kāohi nui ʻia kēia kūlana .

Pehea e hiki ai iaʻu ke mālama iaʻu iho inā loaʻa iaʻu ka HNPCC?

Inā loaʻa iā ʻoe kekahi mau hōʻailona hou o ke kanesa colon, e haʻi koke i kāu kauka . No ke kōkua ʻana i ka pale ʻana i ke kanesa colon, hiki iā ʻoe ke hana i kēia mau mea:

E pale i ka puhipaka.
E ʻai i ka meaʻai olakino.
E hoʻoikaika kino i nā manawa a pau.
E kiʻi i nā hoʻokolohua maʻi kanesa a pau i ʻōlelo ʻia e kāu kauka.
E kaupalena i ka inu ʻana i ka waiʻona.
E mālama i ke kaumaha olakino.

Aia anei ka pilikia o ka loaʻa ʻana o ka HNPCC i kaʻu keiki?

Inā loaʻa iā ʻoe ka maʻi Lynch, he 50% ka manawa kūpono o kāu keiki e hoʻoilina i ka hoʻololi ʻana o ka gene e hoʻokumu ai. ʻO ke ʻano kēia inā he ʻelua kāu mau keiki, hiki i kekahi ke hoʻoilina i ka gene a ʻaʻole paha kekahi. Inā hoʻoilina ʻia kēlā ʻano hoʻololi ʻana o ka gene, ʻoi aku ka nui o ka pilikia o kēlā keiki i ka loaʻa ʻana o ka HNPCC.

Ua like anei nā maʻi ʻaʻai kolona FAP a me HNPCC?

ʻO ka HNPCC a me ka FAP (Familial Adenomatous Polyposis) he mau maʻi ʻaʻai kolona genetic, akā ua hoʻokumu ʻia lākou e nā mutations i nā genes like ʻole .

Hoʻomohala ka poʻe me FAP i nā polyps he nui i loko o ko lākou kolona. I kekahi manawa he mau tausani o kēia mau ulu liʻiliʻi i kapa ʻia he polyps. Eia nō naʻe, ʻaʻole nui nā polyps i loaʻa i ka poʻe me HNPCC, a i kekahi manawa hiki i ka maʻi kanesa ke ulu me ka ʻole o nā polyps. ʻO nā polyps e ulu ana ma HNPCC he pālahalaha maʻamau.

ʻO nā polyp e ulu ana ma kēia mau kūlana ʻelua ua manaʻo ʻia he precancerous , ʻo ia hoʻi hiki iā lākou ke lilo i ka maʻi kanesa i loko o kahi manawa pōkole.

ʻO nā mea nui a mākou e hoʻomanaʻo ai mai kēia moʻolelo, ʻo ia

ʻO ka HNPCC (Hereditary Nonpolyposis Colorectal Cancer) kahi ʻano maʻi ʻaʻai colorectal i hoʻokumu ʻia e kahi kīnā genetic i hoʻoili ʻia i nā hanauna. Pili pū ia me ka Lynch syndrome.

Inā he moʻolelo ʻohana no ka maʻi kanesa, he mea nui loa e kamaʻilio me kāu kauka e pili ana i ia mea.
ʻOiai inā ʻaʻohe ou hōʻailona, inā ʻoe i ka pilikia , e hana i nā hoʻokolohua maʻamau.
Inā ʻike ʻia i ka wā mua, ʻoi aku ka maikaʻi o ka holomua ʻana o ka lāʻau.
ʻAʻole he maʻi lele ka HNPCC, akā hiki ke hoʻoilina ʻia ma ke ʻano genetic.
He mea nui loa ke ola i kahi nohona olakino a hahai i nā ʻōlelo a ke kauka.

Inā he mau nīnau hou aku kāu e pili ana i kēia, mai makaʻu e nīnau i kāu kauka. E kōkua lākou iā ʻoe.

HNPCC , Lynch syndrome, maʻi ʻaʻai colorectal, maʻi ʻaʻai colon, maʻi ʻaʻai rectal, nā hoʻololi genetic, maʻi ʻaʻai hoʻoilina, nānā ʻana i ke kanesa, colonoscopy, ʻoki kino, chemotherapy, immunotherapy

⚠️ Important: The medical articles and information on Nirogi Lanka are for general awareness only, and are by no means a substitute for professional medical advice, diagnosis, or treatment. For any medical problem you have, consult a qualified physician immediately.

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