Loaʻa iā ʻoe a i ʻole kekahi āu i ʻike ai ka anemia hemolytic i hoʻokumu ʻia e kahi hemahema enzyme i kapa ʻia ʻo pyruvate kinase deficiency? He kūlana kakaikahi kēia. I kēlā mau hihia, ua kuhikuhi paha kāu kauka iā ʻoe i kahi pila i kapa ʻia ʻo Mitapivat. Hiki iā ʻoe ke manaʻo iki i ka huikau ke lohe ʻoe i kēia inoa. No laila, i kēia lā e kamaʻilio maʻalahi a me ke aloha e pili ana i kēia lāʻau lapaʻau i kapa ʻia ʻo Mitapivat (inoa inoa PYRUKYND).
I ka ʻōlelo maʻalahi, he aha kēia Mitapivat?
He lāʻau lapaʻau kūikawā ʻo Mitapivat i hāʻawi ʻia e mālama i ka anemia hemolytic i hoʻokumu ʻia e kahi maʻi i kapa ʻia ʻo pyruvate kinase deficiency. I kēia manawa ke noʻonoʻo nei paha ʻoe, "He aha ka anemia hemolytic?"
He mea maʻalahi loa ia. Loaʻa iā mākou kahi ʻano koko i kapa ʻia he mau koko ʻulaʻula i loko o ko mākou kino. Lawe kēia mau koko i ka oxygen ma loko o ko mākou kino. ʻO ka maʻamau, ola kēia mau koko ʻulaʻula no kahi o 120 mau lā. Eia naʻe, i loko o ke kino o ke kanaka me ka hemahema o ka pyruvate kinase, haki kēia mau koko ʻulaʻula a luku ʻia ma mua iki, me ka wikiwiki. ʻO ia ka mea i kapa ʻia ʻo ka anemia hemolytic.
No laila, ʻo ka mea a Mitapivat e hana ai, ʻo ia ke kāohi i ka haki wikiwiki ʻana o nā hunaola koko ʻulaʻula. I ka pololei, hāʻawi ia i kēlā mau hunaola i ka ikehu a hoʻonui i ko lākou ola . He aha ka hana a kēia?
- Hoʻonui ʻia ka nui o nā hunaola koko ʻulaʻula i loko o ke kino.
- Ua hoʻemi ʻia nā hōʻailona o ka anemia e like me ka luhi, ka luhi pinepine, a me ka pōkole o ka hanu .
- Ua emi pū ka pono no ke kahe koko pinepine ʻana.
ʻO ia hoʻi, e kōkua kēia lāʻau lapaʻau i ka hoʻomaikaʻi ʻana i kou ola .
Nā mea e pono ai ʻoe e haʻi i kāu kauka ma mua o ka lawe ʻana i kēia lāʻau lapaʻau
Ma mua o ka hoʻohana ʻana i kekahi lāʻau lapaʻau, he mea nui loa ia e hāʻawi i kāu kauka i kahi wehewehe piha o kou kūlana olakino. Ma mua o kou hoʻomaka ʻana e lawe iā Mitapivat, e hōʻoia e haʻi i kāu kauka inā loaʻa iā ʻoe kekahi o kēia mau kūlana:
- Maʻi akepaʻa: Inā loaʻa iā ʻoe kekahi maʻi akepaʻa ma mua, e ʻoluʻolu e haʻi mai iā mākou.
- Nā maʻi ʻaleʻale :Inā loaʻa iā ʻoe kahi maʻi alerika iā Mitapivat, kekahi lāʻau lapaʻau ʻē aʻe, meaʻai, nā kala, a i ʻole nā mea hoʻomalu, e ʻoluʻolu e hoʻomaopopo iā mākou.
- Hāpai keiki : Inā hāpai ʻoe a i ʻole e hoʻāʻo nei e hāpai koke, e kamaʻilio me kāu kauka e pili ana i ia mea.
- Inā he makuahine hānai waiū ʻoe: Inā he makuahine hānai waiū ʻoe, pono ʻoe e haʻi aku i ke kauka.
Ma muli o kēia ʻike, e hoʻoholo kāu kauka inā kūpono kēia lāʻau lapaʻau iā ʻoe a i ʻole pono e hoʻololi i ka dosage.
Pehea e hoʻohana pono ai i ka lāʻau lapaʻau?
No ka loaʻa ʻana o ka hopena maikaʻi loa mai ka lāʻau lapaʻau, he mea nui loa ia e hoʻohana pono.
- He pila kēia lāʻau lapaʻau āu e lawe ai ma ka waha. E ho'āʻo e lawe iā ia i ka manawa like i kēlā me kēia lā , e like me ke kauoha a kāu kauka.
- E ale i ka papa me ka wai. Mai uhaʻi, kuʻi, a nau paha i ka papa.
- E hoʻomau i ka lawe ʻana i kēia lāʻau a hiki i ka wā e ʻōlelo ai kāu kauka e hoʻōki. Mai hoʻōki koke, ʻoiai inā ua maikaʻi kou manaʻo.
- Pono paha ka mālama kūikawā inā hāʻawi ʻia kēia lāʻau lapaʻau i nā keiki. No laila, e hahai i nā ʻōlelo a ke kauka e like me ia.
He aha kāu e hana ai inā lawe ʻoe i ka nui o ka lāʻau lapaʻau? (Overdosage)
E noʻonoʻo ua lawe hewa ʻoe i kēia lāʻau lapaʻau ma mua o ka nui i kuhikuhi ʻia. Inā hana ʻia kēlā, mai hoʻokaʻulua. E hele koke i ka Emergency Treatment Unit (ETU) kokoke loa. A i ʻole, e kelepona i ke National Poisons Information Centre ma ka Colombo National Hospital no ka ʻōlelo aʻoaʻo.
Ua kuhikuhi ʻia kēia lāʻau lapaʻau nou wale nō. Mai kaʻana like me kekahi, ʻoiai inā he mau hōʻailona like me kāu.
He aha inā e hala iaʻu kahi mahele o ka lāʻau lapaʻau?
Me ka nui o ke ola, i kekahi manawa e poina paha ʻoe i kahi mahele o ka lāʻau lapaʻau. Inā hana ʻia kēlā, eia ka mea e hana ai:
- E lawe i kāu lāʻau lapaʻau i ka wā e hoʻomanaʻo ai ʻoe.
- Eia nō naʻe, inā ʻoe e poina i kahi mahele lāʻau ma mua o 4 mau hola, e hōʻalo loa i kēlā mahele lāʻau. E lawe i kāu mahele lāʻau aʻe i ka manawa i hoʻonohonoho ʻia.
- Mai lawe i ka pālua o ka lāʻau e hana ai no kahi lāʻau i hala ʻole no kekahi kumu.
Nā lāʻau lapaʻau ʻē aʻe e launa pū me kēia lāʻau lapaʻau
Hiki i kekahi mau lāʻau lapaʻau āu e lawe ai ke launa pū me Mitapivat. Hiki i kēia ke hoʻololi i ke ʻano o ka hana a Mitapivat a hoʻonui paha i nā hopena ʻaoʻao. No laila, e hōʻoia e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe ai (me nā huaora, nā lāʻau lapaʻau lāʻau, a me nā lāʻau lapaʻau i kuhikuhi ʻia e nā kauka ʻē aʻe).E haʻi i kāu kauka.
Aia ma lalo iho kekahi mau lāʻau lapaʻau e hiki ke launa pū me Mitapivat.
| Māhele lāʻau lapaʻau | Nā Laʻana |
|---|---|
| ʻO kekahi mau lāʻau lapaʻau no nā maʻi fungal | ʻO Fluconazole, Itraconazole, Ketoconazole |
| ʻEfavirenz (he lāʻau lapaʻau no ka maʻi HIV) | Efavirenz |
| ʻO nā hormones Estrogen a me progestin | Nā lāʻau hoʻomalu hānau, ka lāʻau lapaʻau hormone |
| Midazolam | He lāʻau lapaʻau i hoʻohana ʻia e hōʻoluʻolu a hoʻomaha paha |
| ʻO Rifampin | He lāʻau antibiotic i hāʻawi ʻia no nā maʻi e like me ka maʻi puʻupuʻu |
Mea nui: ʻAʻole piha kēia papa inoa. E haʻi i kāu kauka inā ʻoe e puhipaka ana, inu waiʻona, a hoʻohana paha i nā lāʻau ʻē aʻe.
Nā mea e makaʻala ai i ka wā e lawe ai i ka lāʻau lapaʻau
ʻOiai ʻoe e lawe ana i kēia lāʻau lapaʻau, e nānā mau kāu kauka i kou olakino.
- E hele i nā manawa i hoʻonohonoho ʻia ma ke keʻena lapaʻau. He mea nui loa kēia e ʻike ai i kou ʻano a inā e hana ana ka lāʻau.
- Inā ʻaʻole hoʻomaikaʻi kou mau ʻōuli, a inā e ʻoi aku ka ʻino, e haʻi i kāu kauka.
- E noi ʻia paha ʻoe e hana i ka hana koko i kou wā e lawe ana i kēia lāʻau. Mai hōʻalo i kēia mau hoʻokolohua a e hana mau iā lākou.
He aha nā hopena ʻaoʻao e hiki mai ana?
E like me nā lāʻau lapaʻau āpau, hiki iā Mitapivat ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole loaʻa i nā kānaka a pau. Hiki i kekahi mau hopena ʻaoʻao ke koʻikoʻi, no laila he mea nui e makaʻala iā lākou.
| Ka hopena ʻaoʻao | Wehewehena |
|---|---|
| Nā hopena ʻaoʻao e pono e hōʻike koke ʻia i kāu kauka | |
| Nā hopena alerika | ʻŌhūhū ʻili, maneʻo, pehu o ka maka, lehelehe, alelo a i ʻole ka puʻu, paʻakikī ke hanu. |
| Ka hoʻonui ʻia ʻana o ka anemia hemolytic | Manaʻo nui i ka luhi/luhi ma mua o ka maʻamau, poniuniu, ʻeha poʻo, paʻakikī ka hanu ʻana, mimi ʻeleʻele, melemele o ka ʻili a i ʻole nā maka. |
| Nā hōʻailona o ka hōʻeha o ke akepaʻa | ʻEha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū, nalowale ka makemake e ʻai, nausea, ʻōpala ʻeleʻele, mimi melemele a ʻeleʻele paha, melemele o ka ʻili a i ʻole nā maka, nāwaliwali kūikawā. |
| E haʻi i kāu kauka inā hoʻomau a hoʻopilikia paha. | |
| ʻEha hope | |
| ʻEha hui | |
ʻAʻole i hoʻokomo ʻia nā hopena ʻaoʻao āpau i loko o kēia papa inoa. Inā loaʻa iā ʻoe kekahi mau hōʻailona ʻē aʻe, ʻano ʻē, e kamaʻilio me kāu kauka e pili ana iā lākou.
Pehea e mālama pono ai i ka lāʻau lapaʻau?
- E mālama i kahi hiki ʻole i nā keiki a me nā holoholona ke kiʻi aku .
- E mālama ma ka mahana o ka lumi (ma waena o 20 a me 25 kekelē Celsius).
- E mālama i ka lāʻau lapaʻau i loko o ka pahu kumu i loaʻa ai.
- Mai hoʻohana i nā lāʻau lapaʻau i pau ka lā . E hoʻolei aku iā lākou me ka palekana.
I ka wā e hoʻopau ai i nā lāʻau lapaʻau i pau ka lā a i ʻole nā lāʻau lapaʻau i makemake ʻole ʻia, ʻoi aku ka maikaʻi o ke kūkākūkā ʻana me kāu kauka. ʻOi aku ka maikaʻi o ka hoʻolei ʻana iā lākou i loko o ka ʻōpala. Inā pēlā, e lawe i nā pila mai loko mai o ka ʻōmole, e kāwili iā lākou me kahi mea e like me ke kope kope i hoʻohana ʻia, ka lepo, a i ʻole ka ʻōpala pōpoki, a waiho i loko o kahi ʻeke i hoʻopaʻa pono ʻia a hoʻolei iā lākou i loko o ka ʻōpala.
Leka Lawe-Home
- ʻO Mitapivat kahi lāʻau lapaʻau kūikawā e mālama ai i ka anemia hemolytic i hoʻokumu ʻia e ka hemahema o ka pyruvate kinase.
- E lawe mau i kēia lāʻau lapaʻau e like me ke kauoha a kāu kauka, i ka manawa kūpono. Mai uhaʻi, kuʻi, a nau paha i nā papa.
- E hāʻawi i kāu kauka i ka wehewehe piha o nā lāʻau lapaʻau ʻē aʻe, nā huaora, a me nā kūlana olakino ʻē aʻe āu e lawe nei.
- E ʻimi koke i ke kōkua lapaʻau inā loaʻa iā ʻoe kekahi mau hopena koʻikoʻi, e like me nā hopena alerika a i ʻole nā hōʻailona o ka hōʻino ʻia o ke ake.
- Ua kuhikuhi ʻia kēia lāʻau lapaʻau nou wale nō. Mai kaʻana like me nā poʻe ʻē aʻe.
- Inā he mau hopohopo kāu e pili ana i kēia lāʻau lapaʻau, e kamaʻilio me kāu kauka.
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