E aʻo kākou e pili ana i kekahi mau pilikia me ka ʻōnaehana glandular o kou kino? - Multiple Endocrine Neoplasia (MEN)

Ua like ko kākou kino me kahi mīkini kupaianaha, ʻeā? I mea e hana pono ai kēia mīkini, pono kēlā me kēia ʻāpana e hana pū a hoʻonohonoho pono. Aia kahi ʻōnaehana koʻikoʻi loa i loko o ko kākou kino, i kapa ʻia ʻo ka ʻōnaehana endocrine . Hoʻopuka nā glands i loko o kēia ʻōnaehana i nā hormones e kāohi ana i nā hana he nui i loko o ko kākou kino. Eia naʻe, i kekahi manawa hiki i kēia ʻōnaehana ke hele hewa. I kēia lā e kamaʻilio mākou e pili ana i kahi kūlana kakaikahi akā koʻikoʻi loa e makaʻala. ʻO ia ka Multiple Endocrine Neoplasia , i ʻike ʻia hoʻi ʻo `(MEN)` no ka pōkole.

No laila he aha kēia ʻōnaehana endocrine?

I ka ʻōlelo maʻalahi, ʻo kā mākou ʻōnaehana endocrine kahi pūnaewele o nā glands a me nā ʻōkana i loko o ko mākou kino. ʻO kēia nā mea e hana i nā kemika i kapa ʻia he hormones a hoʻokuʻu iā lākou i loko o ke kahe koko. E noʻonoʻo i kēia mau hormones e like me nā ʻelele liʻiliʻi e lawe ana i nā leka i loko o ko mākou kino. Ke haʻi aku nei kēia mau leka i ko mākou mau ʻōkana, ʻili, a me nā ʻiʻo i ka mea e hana ai a me ka wā e hana ai.

Aia kekahi mau kelepa nui a me nā ʻōkana e pili ana i kā mākou ʻōnaehana endocrine:

• Hypothalamus: Aia kēia ma ke kumu o ko kākou lolo. Hoʻomalu ia i nā mea he nui i loko o ka ʻōnaehana endocrine.
• ʻO ke kelepa pituitary: ʻO kēia kelepa liʻiliʻi, i pili i ka hypothalamus, hana i nā hormones e kaohi i nā kelepa ʻē aʻe he nui, e like me ke kelepa thyroid, nā kelepa adrenal, nā ovaries, a me nā testicles.
• ʻO ka thyroid: ʻO kēia ʻāpana ʻano pepeke ma ke alo o ka ʻāʻī e kaohi i ka metabolism o ko mākou kino, ʻo ia ke ʻano o kā mākou hoʻohana ʻana i ka ikehu mai ka meaʻai a mākou e ʻai ai.
• Nā kelepa parathyroid: ʻO kēia mau kelepa liʻiliʻi ʻehā, aia ma kahi kokoke i ka kelepa thyroid, e kaohi i nā pae o ka calcium a me ka phosphorus i loko o ko mākou kino.
• Nā kelepa adrenal: ʻO kēia mau kelepa ʻelua, aia ma luna o nā puʻupaʻa, kaohi i ka metabolism, ke koko, ka ulu ʻana o ka moekolohe, a me ka pane ʻana i ke kaumaha.
• Pineal gland: Hoʻopuka kēia gland i ka hormone melatonin a hoʻokele i kā mākou pōʻaiapuni hiamoe.
• ʻAnakena: Maanei e hana ʻia ai ka insulin. He mea nui loa ia no ka metabolism a me ke kaohi ʻana i ke kō koko. He ʻāpana nō hoʻi ia o kā mākou ʻōnaehana hoʻoheheʻe.
• ʻOvaries: ʻO kēia kahi e hana ʻia ai nā hormones wahine estrogen, progesterone, a me testosterone.
• Nā ho'āʻo: ʻOiai e hana ana i ka sperm i loko o nā kāne, hana ʻia ka hormone testosterone ma aneʻi.

No laila he aha ka Multiple Endocrine Neoplasia (MEN)?

ʻO ka Multiple Endocrine Neoplasia (MEN) kahi maʻi genetic laha ʻole kahi e ulu ai nā ʻōpū ma mua o hoʻokahi o nā glands a me nā ʻiʻo o ka ʻōnaehana endocrine, a mākou i kūkākūkā ai ma mua. I kekahi manawa hiki i kēia mau ʻōpū ke lilo i maʻi kanesa.

ʻElua ʻano nui o kēia kūlana `(MEN)`:

1. ʻO ka neoplasia endocrine lehulehu ʻano 1 (MEN ʻano 1): He kūlana kēia e ulu ai nā ʻōpū he nui i nā kelepa like ʻole o ka ʻōnaehana endocrine. Ua kapa ʻia kēia ʻo MEN-1 a me ka maʻi Wermer.

2. ʻO ka neoplasia endocrine lehulehu ʻano 2 (MEN ʻano 2): He ʻano maʻi kanesa genetic kēia e hoʻopilikia ai i kekahi mau glands. Hoʻomohala ka poʻe me MEN2 i kahi ʻano maʻi kanesa thyroid i kapa ʻia ʻo medullary thyroid cancer (MTC) . Loaʻa iā lākou kahi pilikia kiʻekiʻe o ka hoʻomohala ʻana i nā tumors ma nā glands ʻē aʻe o ka ʻōnaehana endocrine. Ua kapa ʻia kēia ʻo MEN-2 a me Sipple syndrome.

No ke aha lā e kū mai ai kēia kūlana `(MEN)`?

Hoʻokumu ʻia kēia mau ʻano ʻelua ʻo "MEN" e nā loli i loko o kā mākou mau genes , ʻo ia hoʻi, nā mutations . E noʻonoʻo he mea like ko ko mākou kino me kahi puke kuhikuhi, ʻo ia hoʻi, nā genes. Inā hewa kekahi leka ma kēia puke kuhikuhi, ʻo ia hoʻi, inā ua loli kahi gene, hiki ke hoʻopilikia ʻia kekahi o nā hana o ke kino.

• (MEN ʻano 1) i hoʻokumu ʻia e kahi mutation i loko o ka gene `MEN1` . ʻO kēia gene `MEN1` he gene hoʻopau tumor . ʻO ia hoʻi, he gene e kōkua ana i ka hoʻomalu ʻana i ka mahele cell a pale i ka hoʻokumu ʻana o nā tumors. Inā ʻaʻole hana pono kēia gene, hiki i kekahi mau cell ke ulu ma waho o ke kaohi a hana i nā tumors.
• (MEN ʻano 2) i hoʻokumu ʻia e kahi mutation i loko o ka gene `RET` . ʻO kēia gene `RET` kahi gene e pili ana i ka ulu ʻana o ka maʻi kanesa. Ke hoʻololi ʻia kēia gene, ulu nā pūnaewele i loko o kekahi mau ʻōkana a me nā glands me ke kāohi ʻole a hana i nā puʻupuʻu.

Hiki ke hoʻoilina ʻia kēia mau hoʻololi genetic mai nā mākua a i ʻole hiki ke hana maʻamau i ka wā o ka ulu ʻana o ka fetal. Inā loaʻa i kekahi makua ka MEN, aia ma kahi o 50% ka manawa e loaʻa ai i kahi keiki.

E aʻo iki kākou e pili ana i ke ʻano `(MEN)` ʻano 1 (`MEN ʻano 1`)

Hoʻomohala nā kānaka me ka MEN type 1 i nā puʻupuʻu ma kekahi mau glands o ka ʻōnaehana endocrine. ʻO nā wahi i hoʻopilikia pinepine ʻia:

• Nā kelepa parathyroid: ʻO kēia ka mea maʻamau.
• ʻO ke ala Gastroenteropancreatic: ʻO ia hoʻi, hiki ke hana ʻia nā ʻōpū i loko o ka pancreas, ka ʻōpū, a me nā ʻāpana ʻē aʻe o ka ʻōnaehana hoʻoheheʻe, e like me ka duodenum.
• ʻŌpū pituitary.

ʻO ka hapa nui o ka manawa, ʻo nā puʻupuʻu e ulu ana me ka MEN type 1 ʻaʻole ia he maʻi kanesa (benign) . Eia nō naʻe, hiki i kekahi mau puʻupuʻu ke lilo i maʻi kanesa (malignant).Hiki iā ia ke laha (metastasize) i nā ʻāpana ʻē aʻe o ke kino. Hoʻokuʻu pinepine nā kelepa i loaʻa nā puʻupuʻu i ka nui o ka hormone i loko o ke koko. ʻO kēia ke kumu o nā ʻano hōʻailona like ʻole a me nā pilikia olakino.

Ua ʻike nā kauka ma mua o 20 mau ʻano o nā puʻupuʻu endocrine a me nā non-endocrine i nā poʻe me ka MEN type 1. Aia kekahi mau ʻano puʻupuʻu ʻē aʻe i emi iki ka maʻamau, e like me:

• ʻO nā puʻupuʻu neuroendocrine e ulu ana i loko o ka thymus (kahi lymph node i loko o ka umauma) a me ka bronchi (nā ala ea i loko o nā māmā).
• Hoʻokumu ʻia nā ʻōpū Adrenocortical i loko o ka papa waho o nā kelepa adrenal.
• Nā puʻupuʻu momona (Lipomas) e hana ʻia ma lalo o ka ʻili.
• Ka maʻi ʻaʻai umauma.
• ʻO nā puʻupuʻu e like me ka meningiomas a me ka ependymomas e hiki ke hana i loko o ka lolo a i ʻole ke kaula spinal.

He aha nā hōʻailona o ka `(MEN type 1)`?

Hiki ke ʻokoʻa loa nā hōʻailona o ka MEN type 1 mai kēlā kanaka a kēia kanaka. Aia ia i nā glands i hoʻopilikia ʻia a me ka nui o ka hormone a lākou e hana ai. ʻAʻohe hōʻailona o kekahi poʻe, ʻo kekahi poʻe he mau hōʻailona iki, a ʻo kekahi poʻe he mau hōʻailona koʻikoʻi, a hiki ke hoʻoweliweli i ke ola. Hiki ke ʻokoʻa nā hōʻailona mai kēlā kanaka a kēia kanaka, ʻoiai i loko o ka ʻohana hoʻokahi, ʻoiai ma waena o nā māhoe.

E nānā kākou i kekahi o nā ʻano nui o nā puʻupuʻu a me kā lākou mau hōʻailona pili:

• Ma muli o nā pilikia me nā kelepa parathyroid (hyperparathyroidism):

90% o ka poʻe me ka `(MEN type 1)` e loaʻa i kēia maʻi i ka hiki ʻana i 50 makahiki. I kēia, lilo nā kelepa parathyroid i mea hana nui.

• Nā hōʻailona ʻoluʻolu: ʻeha nā hono, nāwaliwali o nā ʻiʻo, luhi, kaumaha, paʻakikī i ka noʻonoʻo ʻana, nalowale o ka makemake e ʻai.
• Nā hōʻailona koʻikoʻi: ka nausea, ka luaʻi ʻana, ka huikau, ka poina ʻana, ka makewai nui a me ka mimi pinepine ʻana, ka paʻa ʻana o ka ʻōpū, ka ʻeha o ka iwi.

• Ma muli o nā puʻupuʻu i loko o ka pancreas a me ka hapa mua o ka ʻōpū liʻiliʻi (Gastrinomas):

Ma kahi o 40% o nā pākeke me MEN type 1 e loaʻa i nā ʻōpū i kapa ʻia ʻo gastrinomas. Hoʻopuka kēia i kahi hormone i kapa ʻia ʻo gastrin, ka mea e hoʻoulu ai i ka ʻōpū e hana i ka nui o ka waikawa.

• Nā Hōʻailona: ʻEha ʻōpū, maʻi kahe, puʻuwai ʻeha (reflux acid), ʻōpū ʻeha (peptic ulcers).
• ʻO kekahi puʻupuʻu i ʻike ʻia ma kēia māhele ʻo ia ka insulinoma . Hoʻopuka kēia i ka insulin, hiki ke hoʻoulu i ke kō koko haʻahaʻa (hypoglycemia).
• Nā hōʻailona: huikau, haʻalulu, hou, pōloli nui, hoʻomaha ʻole, puʻuwai wikiwiki, nā loli ʻike maka no ka manawa pōkole.

• Ma muli o nā maʻi pituitary (prolactinomas):

Ma kahi o 25% o ka poʻe me ka MEN type 1 e loaʻa i nā puʻupuʻu pituitary. ʻO ka mea maʻamau ka prolactinomas, nāna e hana i ka hormone prolactin .

• Nā hōʻailona i nā wahine: nā hana hewa o ka menstruation a i ʻole ka pau ʻana o ka menstruation (amenorrhea), paʻakikī i ka hāpai ʻana i nā keiki, ka hoʻokuʻu ʻana o ka waiū mai nā nipples i ka wā ʻaʻole hāpai a hānai waiū paha (galactorrhea), hoʻemi ʻia ka makemake moekolohe.
• Nā hōʻailona i nā kāne: Ka emi ʻana o ka makemake moekolohe ma muli o ka emi ʻana o ka pae testosterone, ka erectile dysfunction (ED), a me ka paʻakikī i ka hāpai ʻana i nā keiki.
• Inā nui ka puʻupuʻu: ʻeha poʻo, nausea/luaʻi, loli ka ʻike (ʻike pālua, emi ka ʻike ʻaoʻao).

He mea nui: ʻAʻole e ʻike nā kānaka a pau i nā hōʻailona like. ʻAʻole pau kēia papa inoa. Nui nā ʻano puʻupuʻu ʻē aʻe e hiki ke ulu i ka MEN type 1.

E aʻo pū kākou e pili ana i ke ʻano `(MEN)` ʻano 2 (`MEN ʻano 2`)

Loaʻa i nā kānaka a pau me ka MEN type 2 kahi ʻano maʻi thyroid i kapa ʻia ʻo medullary thyroid cancer (MTC) . Hoʻomohala ʻia kēia ʻano maʻi kanesa i loko o kahi ʻano cell kūikawā i loko o ka thyroid gland i kapa ʻia ʻo C cells. Hoʻopuka kēia mau cell i kahi hormone i kapa ʻia ʻo calcitonin. Hiki i ka MTC ke pālahalaha i nā lymph nodes a me nā ʻōpū ʻē aʻe. ʻO ka lāʻau lapaʻau nui ka wehe ʻana i ka thyroid gland (thyroidectomy).

Eia kekahi, hiki i nā poʻe me ka `(MEN type 2)` ke loaʻa i kekahi a i ʻole nā ​​​​​​kūlana ʻelua:

• Pheochromocytoma: He puʻupuʻu laha ʻole kēia e ulu ana ma ka ʻaoʻao waena o kekahi a i ʻole nā ​​kelepa adrenal ʻelua (adrenal medulla). ʻO ka hapa nui o ka manawa, ʻaʻole kēia he maʻi kanesa. Ma kahi o 10%-15% o nā hihia hiki ke lilo i maʻi kanesa a laha.
• Hyperparathyroidism: Piʻi ka nui o ka calcium koko ma muli o ka hana nui ʻana o ka hormone parathyroid (PTH) e nā kelepa parathyroid.

He aha nā hōʻailona o ka `(MEN type 2)`?

He ʻokoʻa nō hoʻi nā hōʻailona ma ʻaneʻi. ʻO ka maʻamau, hoʻokumu ʻia nā hōʻailona e nā pae kiʻekiʻe o nā hormones i hana ʻia e ke kanesa (MTC) a me kekahi mau puʻupuʻu.

• Nā hōʻailona o ka maʻi ʻaʻai thyroid medullary (MTC):
• He puʻu ma ke alo o ka ʻāʻī, ʻeha ka ʻāʻī, loli ka leo (hoarseness), ʻū, paʻakikī ke ale, paʻakikī ke hanu.

• Nā hōʻailona i hoʻokumu ʻia e ka Pheochromocytoma: (ʻike ʻia ma kahi o 50% o nā hihia)
• ʻIke wale ʻia nā hōʻailona ke hana nui kēia mau puʻupuʻu i nā hormones, e like me ka adrenaline. ʻAʻole hana kekahi mau puʻupuʻu i nā hormones a ʻaʻole paha e hōʻike i kekahi mau hōʻailona.
• Nā hōʻailona maʻamau (e hele pinepine mai a hele aku i nā manawa like ʻole): ke koko kiʻekiʻe (hypertension), ka ʻeha poʻo, ka hou nui ʻana me ke kumu ʻole, ka puʻuwai wikiwiki a i ʻole ka puʻuwai kūpono ʻole, nā haʻalulu.

• Nā hōʻailona i hoʻokumu ʻia e ka hyperparathyroidism:
• E like me ka `(MEN type 1)`, hiki ke loaʻa nā hōʻailona e like me ka ʻeha o nā hono, ka nāwaliwali o nā ʻiʻo, ka luhi, ke kaumaha, ka paʻakikī i ka noʻonoʻo ʻana, ka nalowale o ka makemake e ʻai, ka nausea, ka luaʻi ʻana, ka makewai nui a me ka mimi pinepine ʻana, ka paʻa ʻana o ka ʻōpū, a me ka ʻeha o ka iwi.

ʻO wai ka mea hiki ke loaʻa i kēia maʻi `(MEN)`? Pehea ka maʻamau o ia mea?

Hiki i ke kūlana `(MEN)` ke hoʻopilikia like i nā kāne a me nā wahine. ʻOkoʻa loa nā makahiki i ʻike ʻia ai ke kūlana `(MEN type 1)`. Ua ʻike ʻia i nā keiki he 8 makahiki a me nā pākeke he 80 makahiki.

He maʻi laha ʻole ka `(MEN)`.

• Hoʻopilikia ka maʻi ʻano 1 (MEN) i hoʻokahi i loko o 30,000 mau kānaka.
• Hoʻopilikia ka maʻi ʻano 2 i hoʻokahi i loko o 35,000 mau kānaka.

Manaʻo kekahi poʻe noiʻi he ʻoi aku ka nui o ka poʻe me kēia mau kūlana ma muli o ka hōʻoia ʻole ʻia a i ʻole ka kuhi hewa ʻana.

Pehea e ʻike ai nā kauka i ke kūlana `(MEN)`? (Diagnosis)

Hiki ke paʻakikī iki ka ʻike ʻana i ke kūlana `(MEN)`, no ka mea, hoʻopilikia ia i nā kelepa like ʻole.

• Ka ʻike ʻana o `(MEN ʻano 1)`:

ʻIke pinepine ʻia ke kanaka me ka MEN ʻano 1 inā loaʻa iā lākou ma ka liʻiliʻi ʻelua o nā puʻupuʻu endocrine nui ʻekolu i ʻōlelo ʻia ma luna (nā puʻupuʻu parathyroid, nā puʻupuʻu pituitary, a/a i ʻole nā ​​puʻupuʻu o ke ala gastrointestinal), a i ʻole inā loaʻa iā lākou kekahi o kēlā mau puʻupuʻu a loaʻa i kahi lālā o ka ʻohana ka MEN ʻano 1.

• Nā hoʻāʻo:
• Nā hoʻāʻo koko: E nānā i nā pae kiʻekiʻe o kekahi mau hormones (e.g. parathyroid hormone (PTH), calcium).
• Nā hoʻāʻo kiʻi: Hiki i kēia ke kōkua i ka ʻike ʻana i nā wahi o nā puʻupuʻu, e like me ka CT scan (computed tomography scan) a i ʻole MRI (magnetic resonance imaging scan).
• Hoʻāʻo hoʻoilina: Nānā i kahi mutation i loko o ka gene `MEN1`.

• Ka ʻike ʻana o `(MEN ʻano 2)`:

Ua ʻike ʻia ke kanaka me ka MEN type 2 inā loaʻa iā lākou ka maʻi kanesa thyroid medullary (MTC) me ka pheochromocytoma a/a i ʻole hyperplasia a adenoma paha o nā kelepa parathyroid.

• Nā hoʻāʻo:
• Nā hoʻāʻo koko: E nānā i nā pae hormone e like me ka calcitonin (no MTC), ka hormone parathyroid (PTH), a me nā catecholamines (no pheochromocytoma).
• Nā hoʻāʻo kiʻi: Hoʻohana ʻia ke ʻano 'CT scan' a i ʻole 'MRI scan'.
• Hoʻāʻo hoʻoilina: Nānā i kahi mutation i loko o ka gene `RET`.

He aha nā lāʻau lapaʻau no ka `(MEN)`?

ʻO ka mālama ʻana i ka MEN e hilinaʻi wale ʻia ma nā kelepa endocrine a me nā ʻōpū i hoʻopilikia ʻia. ʻO ka maʻamau, pili ia i kahi hui kauka multidisciplinary, me nā endocrinologists , nā kauka ʻokiʻoki , a me nā oncologists .

Aia paha kekahi mau koho lapaʻau:

• Lāʻau lapaʻau: E kāohi i nā hōʻailona a hōʻemi i nā hopena o nā hormones keu.
• ʻO ke ʻoki kino: E wehe i ka puʻupuʻu a i ʻole ke kelepaʻu holoʻokoʻa i hoʻopilikia ʻia (e.g., ke kelepaʻu thyroid).
• Lapaʻau hoʻololi hormone: Inā wehe ʻia kahi gland endocrine ma ke ʻoki ʻana, hoʻokele ʻia nā hormones i hana ʻia e ia ma waho.
• Lāʻau lapaʻau no ke kanesa: Inā ua pālahalaha ke kanesa i nā wahi ʻē aʻe (metastasized), e hana ʻia nā lāʻau lapaʻau e like me ka chemotherapy a me ka radiation therapy .

No ka mea, he ʻokoʻa kēlā me kēia maʻi `(MEN)`, ʻokoʻa ka hoʻolālā lapaʻau e pono ai no kēlā me kēia. Mai makaʻu e kamaʻilio me kāu kauka e pili ana i nā koho lapaʻau i kūpono loa iā ʻoe.

Hiki ke ho'ōla loa ʻia ke ʻano o ka maʻi `(MEN)`? Hiki ke pale ʻia?

ʻO ka mea pōʻino, ʻaʻohe lāʻau lapaʻau no ke kūlana `(MEN)` i kēia manawa. Eia nō naʻe, hiki ke mālama ʻia . Mālama nā kauka i nā loli i kēlā me kēia gland me ke ʻoki kino a i ʻole ka lāʻau lapaʻau e like me ka mea kūpono i ka manawa.

ʻAʻole hiki ke pale aku i ka ulu ʻana o ka `(MEN)`, no ka mea, ua hoʻokumu ʻia e kahi hoʻololi genetic. Hiki ke hoʻoilina ʻia kēia mau hoʻololi genetic mai nā mākua mai a i ʻole e hana wale ʻia i ka wā embryonic.

Eia nō naʻe, inā ua ʻike ʻia kahi lālā o ka ʻohana pili (makua, kaikaina) me MEN, he mea nui e kamaʻilio me kāu kauka e pili ana i ka hoʻāʻo genetic no MEN. ʻO ka hana ʻana pēlā e hiki ke kōkua i ka ʻike mua ʻana i nā puʻupuʻu inā loaʻa iā ʻoe ke ʻano.

He aha ka mea e hana ʻia ke noho pū ʻoe me `(MEN)`? (Wānana)

ʻO ka wānana no MEN e pili ana i kekahi mau kumu:

• Pehea ka wikiwiki o ka ʻike ʻia ʻana o `(MEN)`.
• He aha nā kelepa endocrine i hoʻopilikia ʻia?
• Inā he maʻi kanesa ka puʻupuʻu a ʻaʻole paha.
• ʻAno lapaʻau i hoʻohana ʻia.
• Ua kapa ʻia inā ua pālahalaha kahi puʻupuʻu kanesa i nā ʻāpana ʻē aʻe o ke kino (metastasized).

Inā ua ʻike ʻia ʻoe me MEN, hiki i kāu kauka ke hāʻawi iā ʻoe i ka manaʻo maikaʻi loa e pili ana i kāu lāʻau lapaʻau a me ke ala e hiki ai.

I ka manawa hea e ʻike ai i ke kauka a me nā nīnau koʻikoʻi e nīnau ai

Inā ua ʻike ʻia ʻoe me MEN, pono ʻoe e ʻike pinepine i kāu kauka e nānā i kou kūlana a e hōʻoia i ka hana pono ʻana o kāu lāʻau lapaʻau.

Eia kekahi, inā he '(MEN)' ko kekahi lālā pili o kou ʻohana, e kamaʻilio me kāu kauka e pili ana i ka hoʻāʻo ʻana i ka genetic, e like me ka mea i ʻōlelo ʻia ma mua.

Inā loaʻa iā ʻoe ka `(MEN)`, he mea kōkua paha ke nīnau i kāu kauka i nā nīnau e like me kēia:

• He aha ke ʻano o nā `(KĀNE)` aʻu?
• Pehea ka hopena o (MEN) i koʻu kino?
• He aha nā hōʻailona e pono iaʻu e makaʻala?
• He aha nā koho lapaʻau e loaʻa iaʻu?
• He aha nā pōmaikaʻi a me nā pōʻino o nā ʻano lapaʻau like ʻole?
• ʻEhia ka lōʻihi o ka manawa e holomua ai ka lāʻau lapaʻau?
• Pono anei e hoʻāʻo ʻia ke koena o koʻu ʻohana no (MEN)?

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai (Leka Lawe-Home)

He maʻi laha ʻole ka Multiple endocrine neoplasia (MEN). Eia kekahi, no ka mea hiki i ka MEN ke hana i nā ʻano hōʻailona like ʻole a ʻaʻole like ke ʻano o kēlā me kēia kanaka, hiki i kekahi manawa ke paʻakikī ke ʻike inā loaʻa iā ʻoe.

Inā loaʻa iā ʻoe kekahi mau hōʻailona hou e hopohopo nei iā ʻoe, a inā ʻike ʻoe i kekahi mau loli i kou kino, ʻo ka mea maikaʻi loa e hana ai, ʻo ia ke ʻike i ke kauka.

ʻOiai kekahi mau hihia o ka `(MEN)` e kū wale ana, hiki nō hoʻi ke holo i loko o nā ʻohana. Inā loaʻa i kekahi o kou ʻohana pili ʻo `(MEN)`, he mea nui loa ia e loaʻa ka hoʻāʻo genetic e ʻike ai inā ʻoe i ka pilikia. E kamaʻilio me kāu kauka e pili ana i nā nīnau āu e pili ana i kou pilikia o ka loaʻa ʻana o `(MEN)`. Aia lākou ma laila e kōkua iā ʻoe. Mai makaʻu, mai makaʻu, a mai makaʻu e nīnau.

ʻO ka neoplasia endocrine lehulehu, MEN, ʻōnaehana endocrine, hormones, tumors, maʻi ʻaʻai, MEN ʻano 1, MEN ʻano 2, parathyroid, pituitary, pancreas, thyroid, MTC, pheochromocytoma, kūlana genetic, nā hōʻailona, ​​​​​​ʻike, lāʻau lapaʻau