He nui loa anei kou mau protein pale ma kou kino? E aʻo kākou e pili ana i ka Polyclonal Gammopathy ma nā ʻōlelo maʻalahi!

Ua haʻi aku anei kekahi kauka iā ʻoe he kiʻekiʻe loa kou pae o kekahi mau protein pale (immunoglobulins) i loko o kou koko? He mea maʻamau ke manaʻo iki i ka makaʻu ke lohe ʻoe i kekahi mea e like me ia. Akā, mai hopohopo. I kēia lā, e kamaʻilio mākou e pili ana i kahi maʻi i kapa ʻia ʻo "Polyclonal Gammopathy." E wehewehe mākou i ke ʻano o ia mea, no ke aha e hana ai, a me nā mea hiki iā ʻoe ke hana e pili ana i ia mea ma ke ʻano maʻalahi a maʻalahi hoʻi e hoʻomaopopo.

He aha kēia Polyclonal Gammopathy?

I ka ʻōlelo maʻalahi, ʻo ka polyclonal gammopathy kahi kūlana kahi e hana ai kekahi mau hunaola pale i loko o kou koko i nā antibodies he nui loa, a i ʻole immunoglobulins, kahi ʻano protein e kōkua i ko mākou kino e pale iā lākou iho mai ka maʻi. E noʻonoʻo i kēia mau antibodies e like me nā koa pale ponoʻī o ke kino. ʻO lākou ka poʻe e hakakā nei i nā maʻi a me nā germs ke komo mai lākou.

No laila, ʻo ka huaʻōlelo "polyclonal" ʻo ia hoʻi, hui pū nā ʻano like ʻole o nā cell immune a hana i nā ʻano antibodies like ʻole. Ua like ia me nā hui like ʻole e hana pū ana, ʻaʻole wale nā ​​​​ʻano koa like.

No ke aha kēia e hana nei? Pehea ka hopena o kēia iaʻu?

Inā loaʻa iā ʻoe ka polyclonal gammopathy, ʻo ia hoʻi ua overactive kāu ʻōnaehana pale . Me he mea lā e makaʻala mau ana. ʻO ke kumu nui o kēia, ʻo ia ka loaʻa mau ʻana o kāu ʻōnaehana pale i nā hōʻailona mai kahi maʻi a i ʻole kahi maʻi autoimmune, e haʻi ana iā ia e "hana i nā antibodies, hana i nā antibodies."

ʻO ia hoʻi, hiki i ka polyclonal gammopathy ke lilo i hōʻailona o kahi maʻi ʻē aʻe . No ka laʻana, inā loaʻa iā ʻoe ka maʻi kanesa, a inā he maʻi akepaʻa kou, a inā he maʻi autoimmune kou e like me ka rheumatoid arthritis, loaʻa paha iā ʻoe kēia polyclonal gammopathy. No laila, ke ʻike nā kauka i kēia, ʻimi lākou, "No ke aha i hoʻoulu ʻia ai ka ʻōnaehana pale?"

He aha ka ʻokoʻa ma waena o ka polyclonal a me ka monoclonal gammopathy?

Me he mea lā he hohonu iki kēia, akā e maʻalahi kākou. Aia ʻelua ʻano o nā hunaola koko keʻokeʻo i loko o ko kākou koko i kapa ʻia ʻo 'nā hunaola B' a me 'nā hunaola plasma'. ʻO kēia nā mea e hana ai i nā antibodies ('Immunoglobulins') a kākou i kamaʻilio ai ma mua.

• Polyclonal Gammopathy: Maanei, hui pū nā 'B cell' a me nā 'plasma cell' e hana i nā ʻano antibodies like ʻole. E like me nā hale hana like ʻole e hana i nā ʻano waiwai like ʻole.
• ʻO ka Gammopathy Monoclonal:ʻO ka mea e hana ʻia ma ʻaneʻi, ʻo ia wale nō nā 'plasma cells' e hōʻiliʻili a hana nui i hoʻokahi ʻano antibody, i kapa ʻia ʻo 'M protein'. He ʻano ʻokoʻa iki kēia. Hiki ke pili kēia me nā maʻi kanesa e like me 'Multiple Myeloma'. Eia nō naʻe, hiki i kekahi poʻe ke loaʻa i kahi maʻi i kapa ʻia ʻo 'Monoclonal Gammopathy of Undetermined Significance' (MGUS). Inā hana ʻia kēlā, e nānā pinepine kāu kauka iā ʻoe e ʻike inā e ulu ana ke kanesa. No laila he mea maikaʻi ke makaʻala i kēlā.

He mea nui: ʻAʻole maʻamau ka maʻi kanesa ka polyclonal gammopathy. He pane ia o ka ʻōnaehana pale kino.

Aia kekahi mau inoa ʻē aʻe no kēia?

ʻAe, hoʻohana nā kauka i kekahi mau inoa ʻē aʻe no ke ʻano polyclonal gammopathy. ʻO nā mea nui:

• Hypergammaglobulinemia: Pili kēia i ka hoʻonui ʻia o ka nui o ka gamma globulin (kahi ʻano antibody) i loko o ke koko.
• Maʻi Polyclonal: He inoa ʻē aʻe kēia.

He aha nā kumu o ka Polyclonal Gammopathy?

Ke noiʻi nei nā loea i ke kumu kikoʻī o kēia ʻano. Eia nō naʻe, ʻoi aku ka maʻamau i nā poʻe me kekahi mau maʻi, nā maʻi autoimmune, a i ʻole nā ​​​​maʻi ʻaʻai koko. I kekahi manawa, hiki i kekahi mau lāʻau lapaʻau i lawe ʻia no nā kūlana ʻē aʻe ke hoʻonui i ka pilikia.

He aha nā hōʻailona o kēia maʻi?

ʻO ka hapa nui o ka manawa, ʻaʻole hana ka polyclonal gammopathy i kekahi mau hōʻailona kikoʻī. Hiki iā ʻoe ke loaʻa nā hōʻailona ma muli o ka maʻi kumu i hoʻokumu ai i ka gammopathy.

E noʻonoʻo ʻoe ua loaʻa iā ʻoe ka maʻi niumonia me ke kuni kiʻekiʻe a me ke kuni. A laila e hōʻike ʻoe i nā hōʻailona e pili ana i kēlā maʻi niumonia. Ke mālama nei ke kauka iā ia, hiki iā ia ke hana i kahi hoʻāʻo koko a loaʻa kēia kūlana polyclonal gammopathy ma ka manawa kūpono. ʻO ia hoʻi, loaʻa pinepine ia i ka wā e ʻimi nei ʻoe i kahi mea ʻē aʻe.

He mea kēia i laha ʻia e kahi maʻi a bacteria paha?

ʻAʻole. ʻAʻole i hoʻokumu pololei ʻia ka Polyclonal gammopathy e kahi maʻi a bacteria paha. He pane ia o ka ʻōnaehana pale . Eia nō naʻe, hiki ke hoʻokumu ʻia ka polyclonal gammopathy e kahi maʻi viral a bacteria paha. ʻO ia hoʻi, hoʻoulu ka maʻi a bacteria paha i ka ʻōnaehana pale.

Pehea e ʻike ai nā kauka i kēia? (Diagnosis)

Hoʻohana nui nā kauka i kahi hoʻāʻo koko kūikawā e ʻike ai i ka polyclonal gammopathy. Ua kapa ʻia kēia ʻo Serum Protein Electrophoresis (SPEP) .

Inā ua ʻike mua kāu kauka iā ʻoe me kahi maʻi autoimmune, ka maʻi ʻaʻai, ka maʻi akepaʻa, a i ʻole ke kanesa, a i ʻole kānalua ʻoe he ʻano maʻi like ia, hiki iā ia ke hana i kēia hoʻāʻo 'SPEP' e ʻike pono ai pehea e pane mai ai kāu ʻōnaehana pale.

Pehea e hiki ai i ka hoʻāʻo `SPEP` ke kōkua i ka loaʻa ʻana o kēia?

He mea maʻalahi loa ia. Lawe ke kauka i kahi hāpana koko mai ou aku. A laila, ma ka hale hana hoʻokolohua, hoʻohana lākou i kēia ʻano hana i kapa ʻia ʻo `SPEP` e hoʻokaʻawale i nā ʻano protein like ʻole i loko o kou koko a nānā i ko lākou pae.

Hiki i kēia mau pae protein ke haʻi nui i kāu kauka e pili ana i ke olakino o kāu ʻōnaehana pale . No ka laʻana, hiki iā lākou ke hāʻawi iā ʻoe i nā hōʻailona e pili ana inā he maʻi ate kou (hiki ke hana i ka polyclonal gammopathy), a inā he maʻi a maʻi kanesa paha kāu.

Aia kekahi mau hoʻokolohua ʻē aʻe e ʻike ai i kēia?

ʻAe. I kekahi manawa, inā kānalua kāu kauka he maʻi kou o kou ʻōnaehana nerve waena, e like me ka meningitis, hiki iā ia ke hoʻāʻo i kāu wai cerebrospinal (CSF) , no ka mea, hiki i kēlā mau maʻi ke hana i ka polyclonal gammopathy.

He aha nā lāʻau lapaʻau no kēia?

ʻO ka mea nui e hoʻomaopopo ai ma ʻaneʻi, ʻo ka polyclonal gammopathy he pane ia o ka ʻōnaehana pale, ʻaʻole ia he maʻi ponoʻī. No laila, ʻaʻohe lāʻau lapaʻau pololei no kēia ʻano.

E mālama kāu kauka i ke kūlana kumu i hoʻoulu ai i ka hana nui o ka ʻōnaehana pale. No ka laʻana, inā he maʻi ia, e mālama ʻia ka maʻi. Inā he maʻi autoimmune ia, e hāʻawi ʻia ka lāʻau kūpono.

ʻOiai e mālama ana i ke kūlana kumu, e nānā hou kāu kauka i kāu mau pae immunoglobulin e ʻike inā ua emi a nalowale paha ka polyclonal gammopathy.

Hiki ke pale ʻia ka ulu ʻana o ka Polyclonal Gammopathy?

ʻO ka mea pōʻino, ʻaʻole i loaʻa i nā kānaka noiʻi kahi ala e pale aku ai i kēia maʻi. No ka mea, pinepine ia ma ke ʻano he hopena ʻaoʻao o kahi maʻi ʻē aʻe, ʻo ka mea maikaʻi loa e hana ai, ʻo ia ke pale aku i ka maʻi kumu.

Pehea e ʻike ai au inā pilikia wau i ka loaʻa ʻana o kēia maʻi?

Inā loaʻa iā ʻoe kekahi mau maʻi olakino, ʻoi aku kou pilikia o ka loaʻa ʻana o ka polyclonal gammopathy. ʻO kekahi o kēia mau kūlana:

• Nā kūlana Autoimmune: ʻO nā hiʻohiʻona e pili ana i ka lupus, ka rheumatoid arthritis, a me ka maʻi Sjogren.
• Nā maʻi koko: No ka laʻana, ʻo Sickle Cell Anemia.
• Nā maʻi ʻaʻai koko: e like me ka leukemia a me ka lymphoma.
• Nā maʻi ʻaʻai ʻē aʻe: Ka maʻi ʻaʻai puʻupaʻa, Ka maʻi ʻaʻai akepaʻa, Ka maʻi ʻaʻai māmā, Ka maʻi ʻaʻai ovarian.
• Nā maʻi: Ka maʻi HIV, Malaria, Mononucleosis, Pneumonia, Tuberculosis.
• Nā maʻi o ke akepaʻa: Hepatitis Autoimmune, Cirrhosis, Hepatitis Viral.
• Inā ua hōʻike ʻia ʻoe i ka asbestos .

Inā loaʻa iā ʻoe kekahi o kēia mau kūlana, a inā paha e manaʻo ʻoe e ʻoi aku ka ʻino o kāu mau hōʻailona, ​​e kamaʻilio me kāu kauka. Hiki iā ia ke hoʻāʻo iā ʻoe no ka polyclonal gammopathy, inā pono.

He aha kaʻu e manaʻo ai inā loaʻa iaʻu ka Polyclonal Gammopathy?

Inā loaʻa iā ʻoe ka polyclonal gammopathy, aia paha ʻoe i kahi pilikia iki o nā maʻi a me ka anemia. Akā ʻo ka nūhou maikaʻi, me ka mālama pono ʻana i ka maʻi kumu i hoʻokumu ai i ka gammopathy, hiki i ka gammopathy a me nā pilikia pili ke nalo aku.

Hiki ke hana ʻia kēia kūlana ma mua o hoʻokahi manawa?

ʻAe, hiki i ka polyclonal gammopathy ke hana hou ma mua o hoʻokahi manawa, no ka mea, inā hoʻi hou ke kumu kumu, hiki nō hoʻi i kēia pane pale kino ke hana hou.

Inā loaʻa iaʻu kēia maʻi, pehea lā wau e mālama ai iaʻu iho?

ʻO ka mea nui loa, ʻo ia ka hahai pono ʻana i nā ʻōlelo a kāu kauka. ʻOi aku hoʻi nā mea e pili ana i ka pale ʻana iā ʻoe iho mai nā maʻi. Eia kekahi laʻana, ʻo nā mea maʻalahi e like me ke kau ʻana i ka pale maka i ka wā e hele ai i nā wahi piha kanaka a me ka holoi pinepine ʻana i kou mau lima hiki ke hana i kahi ʻokoʻa nui.

Leka Lawe-Home

ʻAe, mai nā mea a mākou i kūkākūkā ai, lana koʻu manaʻo ua loaʻa iā ʻoe kahi manaʻo maikaʻi e pili ana i ka Polyclonal Gammopathy a i ʻole Hypergammaglobulinemia.

• I ka ʻōlelo maʻalahi, ʻo ia hoʻi ke hana nei kāu ʻōnaehana pale i nā immunoglobulins (antibodies) he nui loa .
• Hōʻike kēia e hana ikaika loa ana kāu ʻōnaehana pale . Pono ke kumu no kēlā.
• E mālama kāu kauka i ke kūlana kumu i hoʻokumu i kēia, a e hoʻomaikaʻi pinepine kēia gammopathy.

No laila, mai hopohopo no ka mea aia kekahi mea e like me kēia ma kahi hōʻike. E kamaʻilio me kāu kauka a e hoʻomaopopo pono i ka mea e hana nei a me nā mea e pono ai ke hana. Makemake au iā ʻoe i ke olakino maikaʻi!

`polyclonal gammopathy, hypergammaglobulinemia, immunoglobulin, antibody, ʻōnaehana pale, SPEP, pūnaewele B, pūnaewele plasma