He lāʻau lapaʻau hou e hoʻopaneʻe ana i ka maʻi diabetes type 1: E aʻo kākou e pili ana iā Tzield (Teplizumab)

Aia kekahi o kou ʻohana i loaʻa i ka maʻi diabetes type 1? A i ʻole ua haʻi aku kekahi kauka iā ʻoe e pilikia ana ʻoe i ka loaʻa ʻana o ka maʻi? Inā pēlā, i kēia lā ke kamaʻilio nei mākou e pili ana i kahi lāʻau hou e hiki ke hoʻopaneʻe i ka hoʻomaka ʻana o nā hōʻailona diabetes i kekahi mau makahiki. He mea kēia i lawe mai i ka manaʻolana nui i nā poʻe he nui. E nānā kākou i ke ʻano o kēia lāʻau a pehea e hana ai.

ʻO ka maʻi diabetes ʻano 1 a me ke kuleana o ka lāʻau lapaʻau ʻo Tzield

ʻO ka mea mua, e hoʻomaopopo wale kākou i ke ʻano o ka maʻi diabetes type 1. He maʻi autoimmune maoli nō ia. I ka ʻōlelo maʻalahi, ʻo ka ʻōnaehana pale, e like me ka 'pūʻali koa' e pale ana i ko mākou kino mai nā maʻi, hoʻomaka hewa i ka hoʻouka ʻana i kā mākou mau cell maikaʻi ponoʻī. I ka maʻi diabetes type 1, hana ʻia kēia 'hoʻouka' ma nā cell beta i loko o kā mākou pancreas.

E noʻonoʻo i kēia mau pūnaewele beta e like me nā hale hana liʻiliʻi e hana ana i kahi hormone i kapa ʻia ʻo insulin, he mea nui ia no ko kākou kino. Kōkua ka Insulin i nā pūnaewele e hoʻololi i ke kō (glucose) i loko o ka meaʻai a kākou e ʻai ai i ikehu. No laila, ke luku ka ʻōnaehana pale i kēia mau pūnaewele beta, e emi mālie ana ka hana ʻana o ka insulin.

ʻAʻole e hiki koke mai kēia luku. E hiki mai ana ia ma nā pae ʻekolu.

• Pae 1: Hoʻomaka ka ʻōnaehana pale e hoʻouka i nā cell beta, akā hana mau lākou i ka insulin i lawa.
• Pae 2: Piʻi ka pōʻino o nā pūnaewele Beta, hoʻomaka ke kiʻekiʻe o ke kō koko e lilo i mea ʻē iki, akā ʻaʻohe hōʻailona waho.
• Pae 3: Ua luku ʻia ka hapa nui o nā hunaola beta, a ʻaʻole hiki i ke kino ke hana i ka insulin lawa. Piʻi nui ke kiʻekiʻe o ke kō koko. ʻO kēia ka manawa e ʻike ʻia ai nā hōʻailona o ka maʻi diabetes, e like me ka makewai nui a me ka mimi pinepine.

ʻO kēia kahi e komo mai ai kahi lāʻau i kapa ʻia ʻo Tzield (teplizumab-mzwv) . He lāʻau lapaʻau biologic ʻo Tzield. Hiki iā ia ke hoʻolohi i ka wikiwiki o ka hoʻouka ʻana o ka ʻōnaehana pale i nā cell beta o ka poʻe me ka maʻi diabetes pae 2 type 1. ʻO ke ʻano kēia hiki iā ia ke hoʻopaneʻe i ka holomua o ka maʻi i ke pae 3, i ka wā e ʻike ʻia ai nā hōʻailona a pono nā pana insulin i kēlā me kēia lā.

He lāʻau lapaʻau kēia i hāʻawi ʻia ma o kahi aʻa (intravenous infusion, a i ʻole IV) . Hāʻawi ʻia kēia papa hana i hoʻokahi manawa i ka lā no 14 mau lā i ka lālani.

He kūpono anei kēia lāʻau lapaʻau Tzield iaʻu?

Hiki i ka maʻi diabetes ʻano 1 ke hoʻopilikia i kekahi i kēlā me kēia makahiki a me kekahi ʻano nohona. He kūpono paha ka lāʻau lapaʻau Tzield iā ʻoe inā ʻoe e hoʻokō i kēia mau pae hoʻohālikelike:

• Inā loaʻa iā ʻoe ka maʻi diabetes type 1 o ke kahua 2 .
• Iā ʻoeInā ʻaʻohe ou maʻi diabetes type 2 .
• Inā he 8 ou makahiki a ʻoi paha .

No ka hōʻoia ʻana inā loaʻa iā ʻoe ka maʻi diabetes type 1 i ka lua o ka pae, e hana kāu kauka i kekahi mau hoʻokolohua koko kūikawā. ʻO ka mea nui o kēia mau mea he hoʻokolohua e nānā i nā autoantibodies e kūʻē i nā cell beta a me kahi hoʻokolohua hoʻomanawanui kō waha . E nānā pū lākou i kāu helu cell koko a me nā enzymes ate e ʻike inā palekana kēia lāʻau lapaʻau iā ʻoe.

Pehea i aʻo ʻia ai nā hopena o ka lāʻau Tzield?

Ua mālama ʻia kekahi noiʻi lapaʻau kūikawā i kapa ʻia ʻo TN-10 e noiʻi i nā pono a me nā pilikia o kēia lāʻau. ʻO ka nīnau nui i nīnau ʻia, "Hiki iā Tzield ke hoʻōki a hoʻopaneʻe paha i ka holomua o ka maʻi diabetes type 1 i ke kahua 3 i nā poʻe i ka pilikia kiʻekiʻe?"

Ua māhele ʻia nā mea komo i ʻelua mau pūʻulu. Ua hāʻawi ʻia kekahi hui i ka lāʻau Tzield. Ua hāʻawi ʻia kekahi hui i kahi placebo . ʻO ia hoʻi, he wai saline i like me ka lāʻau akā ʻaʻohe lāʻau lapaʻau i loko. ʻAʻole ʻike nā maʻi a me nā kauka i ka mea nāna e loaʻa.

Hiki iā ʻoe ke ʻike maʻalahi i ke kūpono a me nā hōʻole no ke komo ʻana i ke aʻo ʻana mai ka papa ma lalo nei.

He aha nā hopena o ke aʻo ʻana?

Ma hope o 14 mau lā o ka mālama ʻana, ua nānā ʻia kēia poʻe no kahi o 5 mau makahiki. He mea hoʻoikaika maoli nā hopena.

I ka ʻōlelo maʻalahi, ua hala ma kahi o 4 mau makahiki no ka poʻe e lawe ana iā Tzield e hoʻomohala i nā hōʻailona, ​​​​ʻoiai ʻo ka poʻe e lawe ana i ka placebo ua hoʻomohala i nā hōʻailona ma kahi o 2 mau makahiki. ʻOiai i loko o ka makahiki mua o ka mālama ʻana, he kakaikahi wale nō ka poʻe e lawe ana iā Tzield i ʻike i ka ʻoi aku ka ʻino o ko lākou maʻi. I ka hopena o ke aʻo ʻana, 57% o ka poʻe e lawe ana iā Tzield ua olakino a ʻaʻohe hōʻailona o ka maʻi diabetes. Akā he 28% wale nō o ka poʻe e lawe ana i ka placebo i hana.

He aha nā hopena ʻaoʻao o Tzield?

E like me nā lāʻau lapaʻau āpau, hiki iā Tzield ke loaʻa nā hopena ʻaoʻao. Akā, mai hopohopo, hiki ke mālama ʻia ka hapa nui o kēia mau mea.

Nā hopena ʻaoʻao maʻamau:

• ʻŌhūhū ʻili: Hiki i kēia ke hōʻailona o kahi maʻi ʻaleka. ʻO ka hapa nui o ka manawa, ʻaʻole ia he mea koʻikoʻi a e nalo wale nō ia. E mālama i ka ʻili i ka pulu a pale i ke kahakaha ʻana. Hiki i nā mea e like me ka holoi ʻana me ka wai anuanu a i ʻole ka ʻauʻau ʻana i ka oatmeal ke kōkua. E kamaʻilio me kāu kauka e pili ana i kēia. E kuhikuhi ʻo ia i ka lāʻau lapaʻau inā pono. Eia nō naʻe , inā hele pū ka ʻōhūhū me ka pehu ʻana o ke alelo a i ʻole ka puʻu, a inā pilikia ʻoe i ka hanu ʻana, e hele koke i ka lumi pilikia (ETU) o kahi haukapila.

• Nā hunaola koko keʻokeʻo haʻahaʻa (Lymphopenia): Hiki ke emi iki kou helu hunaola koko keʻokeʻo i nā lā mua o ka mālama ʻana. ʻAʻole paha kēia e hoʻopilikia iā ʻoe, akā hiki iā ia ke hoʻonui i kou loaʻa ʻana i nā maʻi. E hoʻi hou kēia i ka maʻamau i loko o kekahi mau pule. E nānā mau kāu kauka iā ʻoe no kēia.

• ʻEha poʻo: Hiki ke loaʻa kahi ʻeha poʻo iki. Nalo pinepine ia ma kona iho. Inā hoʻomau ka ʻeha poʻo a lilo paha i mea koʻikoʻi, e haʻi i kāu kauka.

Nā hopena ʻaoʻao koʻikoʻi e makaʻala ai:

• ʻO ka maʻi hoʻokuʻu Cytokine:No ka mea, ʻo nā lāʻau lapaʻau e hoʻopilikia i ka ʻōnaehana pale, e like me Tzield, hiki i kekahi manawa ke hoʻokuʻu i ka nui o nā mea pale i kapa ʻia ʻo cytokines i loko o ke koko i ka manawa hoʻokahi. Hiki ke hana i kēia i nā lā mua o ka mālama ʻana. Hiki ke loaʻa nā hōʻailona e like me ke kuni, ka nausea, ka ʻeha kino, a me ka luhi nui. E hāʻawi kāu kauka iā ʻoe i nā lāʻau lapaʻau ʻē aʻe (e like me ka paracetamol) ma mua o ka mālama ʻana e hōʻemi i kēia mau mea. Inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona, ​​e haʻi koke i kāu kauka.

• Ka emi nui ʻana o ka helu o nā hunaola koko keʻokeʻo: Inā lilo kēia ʻano i mea koʻikoʻi, hiki iā ia ke alakaʻi i nā maʻi koʻikoʻi. Inā loaʻa iā ʻoe nā hōʻailona o ka maʻi e like me ke kuni, ke anu, ke kuni, a me ka luhi nui , e haʻi koke i kāu kauka.

ʻAʻole kēia nā hopena ʻaoʻao āpau o Tzield. Inā loaʻa iā ʻoe kekahi mau hōʻailona e hoʻopilikia nei iā ʻoe, e ʻike pono i kāu kauka no ka ʻōlelo aʻo lapaʻau.

Pehea ʻoe e ʻike ai inā e hana ana ka lāʻau lapaʻau?

ʻO ke kumu o Tzield ka hoʻopaneʻe ʻana i ka hoʻomaka ʻana o nā hōʻailona. No laila, ʻaʻole paha ʻoe e ʻike i ka ʻokoʻa nui ma hope o ka lawe ʻana i ka lāʻau lapaʻau. He lāʻau lapaʻau hoʻokahi kēia no 14 lā. Ma hope o kēlā, e nānā mau kāu kauka i kāu maʻi diabetes e ʻike pehea ia. Mai hoʻōki i ka lawe ʻana i ka lāʻau lapaʻau a hoʻololi paha i ka papa hana me ka ʻole o ka ʻōlelo aʻoaʻo a kāu kauka.

Aia kekahi pilikia me nā lāʻau lapaʻau ʻē aʻe?

Ma mua o kou hoʻomaka ʻana i ka lāʻau Tzield, he mea nui loa ia e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei (me nā huaora, nā mea hoʻopihapiha, nā lāʻau Ayurvedic a i ʻole nā ​​​​lāʻau lapaʻau).

ʻO ka mea nui, pono ʻoe e makaʻala e pili ana i ka loaʻa ʻana o nā lāʻau pale i ka wā e lawe ana iā Tzield. Hiki i kekahi mau lāʻau pale ke emi iki ka maikaʻi, a ʻo kekahi paha he palekana ʻole. No laila , ma mua o ka loaʻa ʻana o kekahi lāʻau pale, e haʻi i kāu kauka e lawe ana ʻoe iā Tzield.