Koj tus menyuam puas kub taub hau tas li? Puas yog vim muaj SAIDs (Systemic Autoinflammatory Diseases)?

Auj, koj tus me nyuam puas kub taub hau ntau zaus niaj hnub no? Tsuas yog thaum koj xav tias koj zoo dua lawm, puas rov qab kub dua? Qee zaum qhov ua rau qhov no yuav tsis yog tus kab mob lossis cov kab mob me me. Hnub no peb yuav tham txog ib qho mob uas nyuaj me ntsis, tab sis nws tseem ceeb heev uas yuav tsum paub txog. Qhov no hu ua SAIDs, uas sawv cev rau Systemic Autoinflammatory Diseases . Yav dhau los, qhov no hu ua '(Periodic Fever Syndromes)' lossis '(Recurrent Fever Syndromes)'.

SAIDs yog dab tsi? Cia peb nkag siab yooj yim.

Hais yooj yim xwb, cov kab mob SAIDs yog ib pawg kab mob uas tshwm sim los ntawm kev ua haujlwm tsis zoo lossis teeb meem hauv peb lub cev tiv thaiv kab mob . Qhov no yog vim li cas ib tug menyuam yaus thiaj li kub taub hau ntau zaus txawm tias tsis muaj kev kis kab mob (xws li tus kab mob lossis cov kab mob me me).

Qhov tseem ceeb tshaj plaws yog tias cov mob no hu ua SAIDs yuav tsum tsis txhob raug yuam kev nrog '(Autoimmune Diseases)' (piv txwv li '(Rheumatoid Arthritis)' lossis '(Lupus)' uas koj yuav tau hnov ​​​​txog. Hauv cov kab mob '(Autoimmune)', vim muaj qee qhov yuam kev hauv peb lub cev '(adaptive immune system)', lub cev ntawd tawm tsam nws cov hlwb noj qab haus huv. Tab sis hauv SAIDs, qee yam txawv tshwm sim.

Cov kab mob SAIDs tsis tshua muaj ntau dua li cov kab mob autoimmune. Lawv feem ntau yog los ntawm noob caj noob ces thiab yog los ntawm kev hloov pauv caj ces .

Feem ntau, tab sis tsis yog txhua lub sijhawm, cov tsos mob ntawm SAID pib thaum ib tug me nyuam tseem hluas heev, txawm tias yog thaum nws tseem yog menyuam mos lossis menyuam yaus . Koj tus menyuam yuav muaj "lub sijhawm" kub taub hau thiab lwm yam tsos mob nrog rau tus mob no. Nyob nruab nrab ntawm cov sijhawm no, koj tus menyuam yuav tsis muaj tsos mob li. Txawm hais tias tsis muaj kev kho rau SAIDs, feem ntau muaj kev kho mob los pab tswj koj tus menyuam cov tsos mob.

Cov hom SAIDs tseem ceeb yog dab tsi?

Cov kws tshawb nrhiav tau txheeb xyuas txog li 60 hom kab mob SAIDs, thiab tseem muaj cov tshiab tshwm sim. Nov yog qee hom kab mob SAIDs uas feem ntau pom:

• Kab mob ua npaws Mediterranean hauv tsev neeg (FMF): Qhov no yog cov kab mob ua npaws uas rov tshwm sim ntau tshaj plaws uas tau txais los ntawm noob caj noob ces. Nws tuaj yeem ua rau mob plab, hauv siab, thiab pob qij txha rau cov menyuam yaus.
• Mob ua npaws tas li, mob aphthous-stomatitis, mob pharyngitis, mob adenitis (PFAPA): Qhov no feem ntau pib rau cov menyuam yaus ua ntej hnub nyoog 4 xyoos. Qee zaum, tus mob tuaj yeem zoo dua tom qab hnub nyoog 10 xyoos.
• Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): Qhov no tuaj yeem tshwm sim thaum yau, thaum hluas, lossis txawm tias thaum laus.
• Mevalonate kinase deficiency (MKD): Yav tas los hu ua "Hyper-IgD syndrome", qhov no feem ntau pib ua ntej tus menyuam muaj ib xyoos.
• Cov kab mob autoinflammatory cuam tshuam nrog NLRP3:Qhov no yav tas los hu ua `(Cryopyrin-associated periodic syndromes - CAPS)`. Muaj peb hom kab mob me me hauv qhov no.
• Kab mob Still uas pib thaum laus (AOSD): Raws li lub npe qhia, qhov no yog ib hom kab mob "Systemic Juvenile Idiopathic Arthritis (JIA)" uas pib thaum yau.
• Kab mob NOD-2-associated granulomatous disease (Blau syndrome): Qhov no feem ntau pib ua ntej hnub nyoog 4 xyoos. Nws feem ntau cuam tshuam rau daim tawv nqaij, qhov muag, thiab pob qij txha ntawm tus menyuam.

Cov tsos mob ntawm SAIDs yog dab tsi?

Cov tsos mob ntawm SAIDs feem ntau pib thaum yau. Cov tsos mob tseem ceeb thiab feem ntau yog kub taub hau tas li . Thaum lub sijhawm kub taub hau, tib neeg feem ntau tuaj yeem noj qab nyob zoo thiab tsis muaj tsos mob. Txawm li cas los xij, tej zaum yuav muaj lwm cov tsos mob uas tshwj xeeb rau txhua hom SAID. Cia peb saib seb lawv yog dab tsi:

• FMF: Qhov no tuaj yeem ua rau o thiab mob hnyav rau hauv lub plab, hauv siab, thiab pob qij txha ntawm tus menyuam . Kuj tseem yuav muaj pob khaus rau ntawm ob txhais ceg qis lossis pob luj taws.
• PFAPA: Qhov no tuaj yeem ua rau mob caj pas, mob qhov ncauj, thiab cov qog ntshav hauv caj dab o . Piv txwv li, yog tias koj tus menyuam muaj cov tsos mob xws li mob tonsillitis thiab mob qhov ncauj ntau zaus, nws yuav yog PFAPA.
• KEV NTSUAM: Qhov no tuaj yeem ua rau mob khaub thuas thiab mob nqaij hauv lub cev/lub cev thiab caj npab . Nws kuj tseem tuaj yeem ua rau muaj pob liab mob uas pib ntawm caj npab thiab ceg thiab nthuav mus rau hauv lub cev.
• MKD: Qhov no tuaj yeem ua rau muaj cov tsos mob xws li mob khaub thuas, mob taub hau, mob plab, tsis xav noj mov, thiab cov tsos mob zoo li mob khaub thuas .
• Cov kab mob NLRP3: Cov mob no tuaj yeem ua rau tawv nqaij tawm pob, mob taub hau, mob nqaij, mob pob qij txha, thiab mob qhov muag liab/mob qhov muag .
• AOSD: Qhov no yog ib qho mob uas feem ntau ua rau tawv nqaij khaus, mob pob qij txha, thiab mob nqaij . Ib txhia neeg kuj yuav mob caj pas, mob plab, qaug zog, thiab tsis muaj zog.
• Kab mob Blau: Qhov no tuaj yeem ua rau mob tawv nqaij ntawm koj tus menyuam caj npab, ceg, lossis nruab nrab ntawm nws lub cev . Nws kuj tseem tuaj yeem ua rau mob pob qij txha thiab mob qhov muag .

Cov ua rau muaj SAIDs yog dab tsi?

Ntau yam kab mob SAIDs yog cov kab mob caj ces . Uas yog, ib qho kev hloov pauv tshwj xeeb (variant) hauv ib qho gene tshwj xeeb ua rau txhua tus mob. Xav txog tias peb lub cev muaj ib pawg lus qhia (genes) uas qhia peb yuav ua li cas ua txhua txoj haujlwm, yog li ntawd yog tias ib tsab ntawv hauv phau ntawv ntawd tsis raug, nws tuaj yeem ua rau lwm yam haujlwm tsis raug.

Nov yog cov hom SAIDs tseem ceeb thiab cov noob caj noob ces cuam tshuam nrog lawv:

• FMF:Tus gene 'MEFV' yog tus uas qhia txog yuav ua li cas thiaj ua tau cov protein '(pyrin)'.
• PFAPA: Qhov ua rau qhov no tseem tsis tau txiav txim siab .
• TRAPS: Tus gene `TNFRSF1A`. Qhov no qhia kom muaj ib qho protein hu ua `(tumor necrosis factor receptor - TNFR)`.
• MDK: Tus gene hu ua 'MVK'. Qhov no qhia kom muaj ib qho protein hu ua '(mevalonic kinase)'.
• Cov kab mob NLRP3: Lub noob caj noob ces 'NLRP3'. Qhov no qhia kom muaj cov protein hu ua '(cryopyrin)'.
• AOSD: Qhov ua rau qhov no tseem tsis tau pom .
• Kab mob Blau: Tus gene 'NOD2'. Qhov no qhia kom muaj cov protein hu ua '(NOD2)'.

Nws yog ib qho tseem ceeb uas yuav tsum nkag siab tias thaum cov no yog los ntawm cov yam ntxwv caj ces, nws tsis yog niam txiv lub txim. Cov no yog cov txheej txheem ntawm lub cev uas nyuaj heev.

Cov teeb meem uas tshwm sim los ntawm SAIDs

Nws yog ib qho tseem ceeb heev uas yuav tsum tau kho kom zoo rau cov mob no. Vim tias, yog tias kev o ntawm lub cev tseem txuas ntxiv mus, nws tuaj yeem ua rau muaj mob hu ua '(Amyloidosis). '(Amyloidosis)' yog cov protein uas tso rau hauv lub raum . Qhov no tuaj yeem ua rau lub raum puas tsuaj mus tas li . Yog li ntawd, yog tias muaj cov tsos mob, nws yog ib qho tseem ceeb uas yuav tsum nrhiav kev pab kho mob tam sim ntawd.

Yuav txheeb xyuas cov SAIDs li cas?

Yog hais qhov tseeb, kev kuaj mob SAIDs yuav nyuaj me ntsis vim tias cov tsos mob yuav zoo ib yam li lwm yam mob hnyav, xws li lupus lossis lymphoma. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum mus ntsib kws kho mob uas tau kawm tshwj xeeb txog cov kab mob o (tus kws kho mob rheumatologist) kom kuaj mob thiab tswj koj tus menyuam tus mob kom raug.

Koj tus menyuam tus kws kho mob pob qij txha yuav siv ntau yam los kuaj mob SAIDs. Nws yuav nug txog koj tus menyuam cov tsos mob thiab seb puas muaj leej twg hauv koj tsev neeg tau muaj cov mob no (keeb kwm tsev neeg). Tus kws kho mob yuav xav tias koj tus menyuam muaj Periodic Fever Syndrome yog tias:

• Yog koj kub taub hau tas li
• Yog leej twg hauv tsev neeg muaj keeb kwm ntawm kev kub taub hau tsis tu ncua zoo li no
• Yog koj yog ib tug neeg uas muaj tus mob kub taub hau zoo li no

Siv cov kev ntsuam xyuas twg?

Koj tus kws kho mob yuav pom zoo kom ua ntau yam kev kuaj mob kom paub tseeb tias muaj mob. Tej zaum yuav muaj xws li:

• Kev kuaj hauv chav kuaj: Kev kuaj xws li `(C-reactive protein - CRP)` thiab `(Complete Blood Count - CBC)` tuaj yeem kuaj xyuas seb puas muaj kev o hauv lub cev. Cov kev kuaj no `(zoo)` thaum muaj kub taub hau, thiab rov qab mus rau qhov qub thaum kub taub hau ploj mus.
• Kev kuaj zis:Yuav kuaj cov protein hauv zis seb puas muaj protein ntau hauv cov zis. Hauv MKD, yuav kuaj cov organic acid hauv zis seb puas muaj mevalonic acid ntau.
• Kev kuaj noob caj noob ces: Qhov no tuaj yeem kuaj xyuas seb puas muaj cov noob caj noob ces sib txawv. Txawm li cas los xij, qee tus menyuam uas muaj SAIDs yuav tsis pom cov noob caj noob ces sib txawv. Yog li ntawd, txawm tias cov txiaj ntsig ntawm kev kuaj yog "tsis zoo", qhov ua tau ntawm SAID tsis tuaj yeem raug tshem tawm.

Yuav kho cov kab mob SAID li cas?

Kev kho mob rau SAIDs sib txawv nyob ntawm hom thiab qhov hnyav ntawm tus kab mob . Txawm hais tias cov kab mob no tsis tuaj yeem kho tau tag nrho, cov tsos mob ntawm tus menyuam tuaj yeem tswj tau zoo nrog kev siv tshuaj . Piv txwv li, yog tias koj tus menyuam tsuas yog mob khaub thuas no ob peb zaug hauv ib xyoos, cov tshuaj tua kab mob thiab cov tshuaj nonsteroidal anti-inflammatory (NSAIDs) feem ntau tuaj yeem tswj cov tsos mob. Txawm li cas los xij, yog tias tus kab mob hnyav dua, tus kws kho mob yuav qhia lwm txoj kev kho mob.

Nov yog qee cov kev kho mob zoo li no:

• FMF: Qhov no kho tau nrog cov tshuaj hu ua '(Colchicine)' kom txo qhov o. Yog tias koj noj tsis tau '(Colchicine)', koj tuaj yeem sim siv hom tshuaj '(Biologic)' hu ua '(Canakinumab)'.
• PFAPA: Qhov mob PFAPA uas rov huam tuaj yeem luv dua los ntawm kev muab tshuaj steroids (feem ntau yog prednisone). Ib txhia menyuam yaus tau tswj tau lawv cov tsos mob los ntawm kev siv cimetidine, ib yam tshuaj siv los kho cov qhov txhab hauv plab.
• TRAPS: Cov tshuaj '(Canakinumab)' zoo heev rau TRAPS. Tsis tas li ntawd, cov tshuaj tiv thaiv kev o xws li '(Glucocorticoids)' kuj tseem tuaj yeem pab txo cov tsos mob.
• MKD: '(Canakinumab)' yog ib txoj kev xaiv zoo rau kev kho mob MKD. Kev siv '(NSAIDs)' lossis '(Steroids)' thaum lub sijhawm kub taub hau kuj tseem yuav pab tau.
• Cov kab mob NLRP3: Lwm cov tshuaj "Immunomodulators" xws li "Canakinumab" thiab "Rilonacept" thiab "Anakinra" tau siv los kho cov kab mob NLRP3 tau zoo.
• AOSD: Muaj ntau hom tshuaj tiv thaiv kev o uas siv rau AOSD. Cov no suav nrog `(Steroids)`, `(Disease-Modifying Anti-Rheumatic Drugs - DMARDs)`, thiab `(Biologics)`.
• Kab mob Blau: Nyob ntawm seb tus menyuam cov tsos mob li cas, tej zaum yuav sim siv cov tshuaj immunosuppressants, cov tshuaj tumor necrosis factor (TNF) inhibitors, thiab/lossis cov tshuaj pleev qhov muag.

Puas yog SAIDs mob zoo dua nws tus kheej?

Qee cov kab mob SAIDs yuav kav ntev mus ib sim neej . Lwm cov yuav kav ntev li ob peb xyoos thiab zoo dua thaum laus. Txawm hais tias qee cov mob yuav kav ntev mus ib sim neej, qhov zaus ntawm kev kub taub hau yuav txo qis raws sijhawm thiab cov tsos mob yuav tsis hnyav heev . Koj tus kws kho mob tuaj yeem muab cov ntaub ntawv tshwj xeeb rau koj txog koj tus menyuam tus mob.

Kev saib xyuas ib tug me nyuam uas muaj SAID yuav nyuaj heev. Tej zaum koj twb muaj SAID lawm, tab sis koj siv tau koj tej kev paub dhau los los pab koj tus me nyuam saib xyuas thiab pab lawv daws qhov teeb meem no mus tas li.

Qhov tseem ceeb tshaj plaws yog nrhiav kev kho mob los ntawm cov kws tshwj xeeb uas paub zoo txog cov teeb meem ntawm SAIDs. Lawv tuaj yeem pab tswj koj tus menyuam cov tsos mob thiab pab lawv muaj lub neej thaum yau zoo tshaj plaws.

Tej yam tseem ceeb tshaj plaws uas yuav tsum nco ntsoov (Cov Lus Coj Mus Tsev)

Zoo, yog li cia peb sau qee yam uas koj yuav tsum nco ntsoov los ntawm qhov peb tau tham txog.

• Yog koj tus menyuam kub taub hau tas li, tsis paub vim li cas , nrog kws kho mob tham txog qhov no. Qhov no yuav yog ib qho cim qhia tias koj muaj mob SAID.
• Cov kab mob SAIDs yog ib qho teeb meem ntawm lub cev tiv thaiv kab mob uas muaj los ntawm lub cev , tsis yog ib yam kab mob sib kis uas feem ntau tshwm sim.
• Cov no txawv ntawm cov kab mob "Autoimmune" .
• Feem ntau, cov no yog tshwm sim los ntawm cov yam ntxwv caj ces .
• Nws yog ib qho tseem ceeb uas yuav tsum mus ntsib kws kho mob Rheumatologist kom paub tseeb tias koj mob dab tsi.
• Kev kho mob tuaj yeem tswj cov tsos mob tau zoo .
• Kev kho mob thaum ntxov yog qhov tseem ceeb kom tiv thaiv kev puas tsuaj rau lub raum.

Yog koj muaj lus nug ntxiv txog qhov no, tsis txhob ntshai nug koj tus kws kho mob hauv tsev neeg lossis kws kho menyuam yaus. Lawv yuav pab tau koj ntxiv.

SAIDs , mob kub taub hau los ntawm noob caj ces, mob kub taub hau ntau zaus, mob kub taub hau rau menyuam yaus, lub cev tiv thaiv kab mob, cov kab mob caj ces, kws kho mob pob qij txha