Tshuaj kho mob plab o thiab mob plab zom mov tsis zoo! Cia peb kawm txog cov tshuaj Proton Pump Inhibitors (PPIs)!

Koj puas feem ntau mob plab lossis mob hauv siab? Los yog tus kws kho mob hais tias "gastritis"? Ib hom tshuaj uas cov kws kho mob feem ntau sau rau hauv cov xwm txheej zoo li no hu ua '(Proton Pump Inhibitors)'. Yog tias peb hais ncaj qha, peb yuav hu nws ua "tshuaj rau gastritis." Yog li, hnub no peb yuav tham txog '(Proton Pump Inhibitors)' lossis PPIs luv.

Vim li cas peb thiaj xav tau cov tshuaj PPI no? Ua li cas rau cov kua qaub hauv plab?

Hais yooj yim xwb, '(Proton Pump Inhibitors)' yog ib hom tshuaj uas txo cov kua qaub uas tsim tawm hauv koj lub plab, uas yog, cov kua qaub hauv plab . Tam sim no koj yuav xav tias, "Auj, lub ntsiab lus ntawm cov kua qaub hauv plab yog dab tsi? Nws tsis zoo." Qhov ntawd tsis yog qhov tseeb. Cov kua qaub hauv plab yog qhov tseem ceeb heev rau peb lub cev. Nws yog cov kua qaub no uas pab peb zom cov zaub mov uas peb noj. Tsis yog li ntawd xwb, tab sis cov kua qaub hauv plab no kuj pab rhuav tshem cov kab mob phem uas peb tsis paub tias noj nrog zaub mov.

Txawm li cas los xij, qee zaum teeb meem pib thaum cov kua qaub hauv plab nce ntau dhau, lossis thaum cov kua qaub mus rau qhov chaw txawv ntawm qhov nws yuav tsum tau ua. Nws zoo li cov lus hais tias "Yog tias nws nce ntxiv, txawm tias cov kua txiv hmab txiv ntoo yuav lom." Qhov ntawd yog thaum cov kab mob hauv plab ('ulcers'), lossis raws li peb hu lawv, "gastritis ulcers" tuaj yeem tshwm sim. Lwm yam xws li mob siab thiab saj qaub hauv caj pas kuj tuaj yeem tshwm sim. Qhov ntawd yog thaum cov tshuaj no hu ua PPIs pab peb. Lawv tshwj xeeb tshaj yog siv rau cov teeb meem mus sij hawm ntev ntsig txog cov kua qaub hauv plab.

Cov tshuaj PPIs no siv rau cov kab mob dab tsi?

Cov kws kho mob feem ntau siv cov tshuaj no (Proton Pump Inhibitors) los kho cov mob xws li kev puas tsuaj thiab o rau cov feem ntawm peb lub cev zom zaub mov, uas yog cov hnyuv thiab txoj hlab pas, uas tshwm sim los ntawm cov kua qaub hauv plab. Cia peb saib lawv yog dab tsi:

• GERD lossis Kab Mob Rov Qab Mob Hnyuv Ntev: Koj puas feem ntau mob plab? Koj puas muaj qhov saj qaub hauv koj lub caj pas? GERD yog li ntawd. Hais yooj yim, nws yog cov kua qaub hauv koj lub plab uas nce mus rau hauv koj lub caj pas. Qhov no tuaj yeem ua rau lub txheej ntawm koj lub caj pas puas tsuaj, uas tseem hu ua erosive esophagitis. PPIs ua haujlwm los ntawm kev txo cov kua qaub hauv plab thiab muab sijhawm rau koj lub caj pas kom zoo.
• Mob plab thiab mob plab hnyuv hauv plab thiab duodenum: Mob plab thiab mob plab hnyuv hauv plab thiab duodenum yog cov mob plab uas tuaj yeem tshwm sim los ntawm cov kua qaub hauv plab, uas tuaj yeem ua rau lub txheej tiv thaiv ntawm lub plab puas tsuaj. Lawv kuj tuaj yeem ua rau mob plab hnyuv hauv thawj ntu ntawm txoj hnyuv me (hu ua duodenum). PPIs tuaj yeem pab kho cov mob plab hnyuv no. Tsis tas li ntawd, qee cov tshuaj tua kab mob, tshwj xeeb tshaj yog cov tshuaj nonsteroidal anti-inflammatory drugs (NSAIDs), muaj feem cuam tshuam nrog kev pheej hmoo ntawm kev mob plab hnyuv. Cov kev tshawb fawb qhia tau tias kwv yees li 30% ntawm cov neeg uas noj NSAIDs tsis tu ncua mob plab hnyuv. PPIs tuaj yeem pab tiv thaiv thiab kho cov mob plab hnyuv.
• Kev kis tus kab mob H. pylori:Nov yog ib hom kab mob uas nyob tau hauv peb lub plab. Cov kab mob no kuj tseem ua rau mob plab. Thaum kho tus kab mob H. pylori, cov kws kho mob muab PPIs nrog rau cov tshuaj tua kab mob. Qhov no yog vim PPIs hloov qib pH ntawm lub plab, ua rau nws yooj yim dua rau cov tshuaj tua kab mob tua cov kab mob.
• Zollinger-Ellison syndrome: Qhov no yog ib qho mob tsis tshua muaj. Hauv qhov mob no, qee hom qog nqaij hlav ('qog nqaij hlav') tshwm sim hauv lub cev thiab ua rau lub cev tsim cov tshuaj hormones ntau dhau uas ua rau lub plab kua qaub. Qhov no ua rau lub plab kua qaub ntau dhau. PPIs kuj tseem siv los kho qhov mob no.

Cov tshuaj no hu ua PPIs ua haujlwm li cas? Zoo kawg nkaus li, puas yog?

Xav txog tias muaj ib lub "tshuab" me me hauv peb lub plab uas ua kua qaub. Peb hu lub tshuab no ua "lub twj tso kua qaub hydrogen-potassium ATPase", lossis luv ua "lub twj tso kua proton". Ib yam li lub twj tso kua dej rub dej los rau saum, lub twj tso kua proton no yog qhov ua cov txheej txheem tshuaj lom neeg uas xav tau los ua kua qaub hauv plab.

Yog li, cov tshuaj '(Proton Pump Inhibitors)' lossis PPIs ua yog ib ntus tsis pub lub twj proton ua haujlwm . Qhov ntawd yog, lawv "txwv" nws, uas yog, lawv cuam tshuam rau nws. Tom qab ntawd cov kua qaub hauv plab yuav txo qis.

Tiamsis qhov no tsis tau txwv tsis pub cov kua qaub hauv plab tsim tawm tag nrho, puas yog? Koj tseem muaj cov kua qaub txaus los zom cov zaub mov. Yog tias koj noj PPI li tsib hnub sib law liag, cov kua qaub hauv plab yuav raug txo kom tsawg li 65%. Cov kua qaub seem 35% txaus los zom cov zaub mov.

Cov PPI no yog dab tsi?

Qee cov tshuaj PPI no koj yuav tau yuav yam tsis tas yuav muaj daim ntawv yuav tshuaj (OTC) ntawm lub tsev muag tshuaj yam tsis tas yuav muaj daim ntawv yuav tshuaj, tab sis qee cov tshuaj muaj zog dua yuav tsum tau muaj daim ntawv yuav tshuaj los ntawm kws kho mob (Rx xwb).

Cov tshuaj PPI uas noj tau nrog lossis tsis muaj daim ntawv qhia los ntawm kws kho mob (OTC thiab Rx):

• Esomeprazole (Nexium®)
• Lansoprazole (Prevacid®)
• Omeprazole (Prilosec®)
• Omeprazole/sodium bicarbonate (Zegerid®)

Cov tshuaj PPI uas tsuas muaj tau nrog daim ntawv yuav tshuaj los ntawm kws kho mob xwb (Rx xwb):

• Dexlansoprazole (Dexilant®)
• Pantoprazole (Protonix®)
• Rabeprazole (AcipHex®)

Kuv yuav noj cov tshuaj no li cas? Kuv yuav tsum noj ntau npaum li cas?

Cov tshuaj no muaj ob hom: ntsiav tshuaj los yog tshuaj ntsiav. Koj noj lawv ntawm qhov ncauj. Qee hom tshuaj ntsiav muaj hmoov uas tuaj yeem sib tov rau hauv cov khoom noj, xws li kua txiv applesauce, thiab tom qab ntawd noj. Qhov no yog ib qho kev pab zoo rau cov neeg uas muaj teeb meem nqos cov tshuaj.

Ua ntej noj tshuaj, koj yuav tsum nyeem cov lus qhia ntawm lub pob kom zoo zoo.Thaum ntawd koj yuav tau txais cov txiaj ntsig tseeb tshaj plaws. Muaj qee cov tshuaj PPI uas koj yuav tsum noj ib nrab teev lossis ib teev ua ntej noj mov, thaum koj lub plab khoob. Thaum koj noj thaum ntawd, cov tshuaj muaj sijhawm ua haujlwm ua ntej koj lub plab pib tsim cov kua qaub thaum koj noj mov.

Tsuas yog koj tus kws kho mob thiaj li qhia tau koj tias koj xav tau tshuaj ntau npaum li cas ('koob tshuaj') thiab koj yuav tsum noj pes tsawg zaus hauv ib hnub. Nws yuav sau ntawv kom koj noj tshuaj uas yuav tswj tau koj cov tsos mob nrog rau qhov tsawg kawg nkaus ntawm kev phiv. Rau qee tus neeg, noj ib lub tshuaj ua ntej noj tshais txaus. Rau lwm tus, noj ob zaug hauv ib hnub, ua ntej noj tshais thiab ua ntej noj hmo, tej zaum yuav txaus. Qee zaum, noj txhua ob hnub tuaj yeem txaus.

Nyob rau lub sijhawm ntev mus, tej zaum koj yuav tau txo qhov koob tshuaj ntawm koj cov tshuaj. Koj tus kws kho mob yuav qhia koj txog qhov no thiab.

Cov tshuaj PPIs no siv sijhawm ntev npaum li cas thiaj ua haujlwm tau?

Tom qab noj tshuaj PPI, nws yuav siv sijhawm txij li 24 teev mus rau plaub hnub kom hnov ​​​​​​nws cov txiaj ntsig tag nrho.

Yog tias koj cia li muaj mob plab lossis mob hauv siab thiab xav tau kev pab sai sai, nws zoo dua los siv cov tshuaj antacid (xws li Digene, Acidex) lossis cov tshuaj histamine blocker (H2 blocker) (xws li Pepcid® lossis Tagamet®) dua li PPIs. Xav txog tias koj cia li muaj mob plab tom qab noj zaub mov ntsim. Tom qab ntawd, noj cov tshuaj no yuav pab tau koj hauv ob peb feeb lossis ob peb teev. Txawm li cas los xij, nws cov txiaj ntsig tsis kav ntev npaum li PPIs.

Cov tshuaj PPI zoo tshaj yog tias koj muaj teeb meem kua qaub hauv plab mus ntev.

Puas muaj tej yam tshwm sim thaum siv cov PPIs no?

Feem ntau cov neeg tsis muaj teeb meem loj thaum noj cov tshuaj PPI. Txawm li cas los xij, zoo li lwm yam tshuaj, lawv tuaj yeem ua rau muaj qee qhov kev phiv. Cov no suav nrog:

• Mob plab
• Kab mob cem quav
• Mob raws plab
• kiv taub hau
• Qhov ncauj qhuav
• Mob taub hau
• Ua npaws
• O/Roj
• Mob taub hau me ntsis
• Khaus thiab pob khaus
• Ntuav

Txawm hais tias PPIs feem ntau suav tias muaj kev nyab xeeb, cov kws tshawb fawb tau pom tias lawv tuaj yeem ua rau muaj qee qhov kev pheej hmoo, tshwj xeeb tshaj yog thaum siv rau lub sijhawm ntev . Cia peb saib seb lawv yog dab tsi:

• Kev kis kab mob Clostridioides difficile (C. diff): PPIs tuaj yeem hloov qhov sib npaug ntawm cov kab mob zoo thiab cov kab mob phem hauv koj txoj hnyuv, ua rau koj muaj feem yuav kis tau kab mob zoo li C. diff.
• Pob Txha: PPIs tuaj yeem txo koj lub cev lub peev xwm los nqus calcium, ib qho mineral uas pab kom peb cov pob txha muaj zog. Lub Koom Haum Saib Xyuas Khoom Noj thiab Tshuaj hauv Tebchaws Meskas (FDA) ceeb toom tias PPIs yuav ua rau muaj kev pheej hmoo ntawm pob txha tawg hauv lub duav, dab teg, lossis tus txha nraub qaum.
• Kab mob raum:Cov no tuaj yeem ua rau muaj kev pheej hmoo ntawm kev mob raum ntev (CKD), lossis ua rau cov mob uas twb muaj lawm hnyav zuj zus.
• Kev tsis txaus noj haus: PPIs tuaj yeem txo koj txoj hnyuv me lub peev xwm los nqus magnesium lossis vitamin B12. Magnesium yog ib qho mineral uas pab peb cov leeg thiab cov hlab ntsha ua haujlwm tau zoo. Vitamin B12 yog qhov tseem ceeb rau peb lub paj hlwb thiab cov qe ntshav liab.

Qhov kev sib txuas ntawm PPIs thiab cov yam txaus ntshai no tseem tab tom kawm. Txawm li cas los xij, cov kws kho mob feem ntau pom zoo kom siv cov tshuaj tsawg kawg nkaus thiab rau lub sijhawm luv tshaj plaws kom txog thaum koj cov tsos mob zoo dua. Qhov no yuav txo qhov kev pheej hmoo ntawm cov yam txaus ntshai no.

Kuv yuav tsum mus ntsib kuv tus kws kho mob thaum twg?

Yog tias tus kws kho mob tau sau ntawv kom koj noj cov tshuaj PPI, nco ntsoov nug koj tus kws kho mob yog tias koj muaj lus nug txog kev noj tshuaj, thaum twg yuav tsum tsis txhob noj, lossis yuav ua li cas kom txo qhov ntau npaum li cas.

Yog koj noj cov tshuaj PPI uas tsis tas yuav muaj ntawv yuav tshuaj los ntawm lub tsev muag tshuaj thiab xav tias koj xav tau lawv txhua hnub los tswj koj cov tsos mob, koj tseem yuav tsum mus ntsib kws kho mob. Nws tuaj yeem qhia koj txog qhov ntau npaum li cas thiab lub sijhawm ntev npaum li cas uas koj yuav tsum noj tshuaj.

Tsis tas li ntawd, yog tias koj ntsib ib qho ntawm cov kev mob tshwm sim txaus ntshai no, mus ntsib kws kho mob tam sim ntawd:

• Kev ua xua (mob tawv nqaij, liab, o)
• Cov cim qhia tias lub raum puas lawm (tso zis tsawg dua li yav dhau los, o ntawm tes thiab taw, pob luj taws)
• Cov tsos mob ntawm qhov tsis txaus magnesium (ntshai, lub plawv dhia tsis xwm yeem, cov leeg nqaij co)
• Cov tsos mob ntawm qhov tsis muaj vitamin B12 (mob hauv tes thiab taw, loog, tingling, kiv taub hau, tsis meej pem)
• Yog tias daim tawv nqaij liab, ua pob liab, lossis zoo li nws tab tom tev tawv
• Yog koj raws plab hnyav heev
• Yog koj kub taub hau

Yog li, cov lus kawg coj mus tsev yog dab tsi?

Muaj cov kua qaub hauv plab ntau dhau, lossis muaj nws nyob rau qhov chaw tsis raug, tuaj yeem ua rau mob heev. Nws kuj tseem tuaj yeem ua rau koj lub cev zom zaub mov puas tsuaj. Zoo hmoo, muaj ntau yam tshuaj uas tuaj yeem pab tau yog tias koj muaj cov tsos mob no.

Rau kev pab luv luv, cov tshuaj antacid lossis H2 blocker zoo tshaj plaws. Tab sis yog tias koj mob siab heev lossis muaj mob plab, koj tus kws kho mob yuav sau ntawv rau ib hom PPI. Cov tshuaj no tau muaj ntau xyoo thiab suav tias yog kev kho mob zoo thiab muaj kev nyab xeeb. Muaj ntau tus neeg pom kev pab los ntawm cov tshuaj no.

Qhov tseem ceeb tshaj plaws yog tias cov tshuaj no tsuas yog siv raws li tus kws kho mob qhia, raws li qhov ntau npaum li cas thiab rau lub sijhawm uas tau teem tseg.Yog koj sim siv nws raws li koj xav tau, tej teeb meem yuav tshwm sim. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum mloog tus kws kho mob hais thiab noj tshuaj raws li qhov koj xav tau.

Cov tshuaj PPIs, mob plab zom mov tsis zoo, mob plab o, kua qaub rov qab los, mob plab, omeprazole, pantoprazole