Koj lub cev puas tawv tsis muaj laj thawj? Cia peb tham txog tus mob Stiff Person Syndrome!

Puas muaj tej lub sij hawm koj xav tias koj cov leeg nqaij nruj tsis paub meej, lossis koj cov leeg nqaij co mob heev? Tej lub sij hawm nws tuaj yeem tshwm sim thaum koj hnov ​​​​​​lub suab nrov lossis ib tug neeg tsoo koj. Yog tias tej yam no tshwm sim ntau zaus, nws yog ib lub tswv yim zoo los saib xyuas nws. Hnub no peb yuav tham txog ib qho mob tsis tshua muaj uas tuaj yeem ua rau muaj cov tsos mob zoo sib xws. Qhov ntawd hu ua Stiff Person Syndrome (SPS) .

Tus Neeg Mob Stiffness Syndrome yog dab tsi?

Hais yooj yim xwb, Kab Mob Stiff Person Syndrome (SPS) yog ib qho mob tsis tshua muaj ntawm lub paj hlwb . Nws tshwm sim thaum peb lub cev tiv thaiv kab mob, uas tiv thaiv peb ntawm kab mob, ua yuam kev tawm tsam peb cov hlwb paj hlwb noj qab haus huv. Nws yog ib qho mob autoimmune. Qhov no ua rau cov leeg nqaij hauv koj lub plab, tshwj xeeb tshaj yog koj lub plab, hauv siab, thiab nraub qaum , ua rau tawv lossis tawv . Raws li lub sijhawm dhau mus, qhov tawv thiab mob ntswj no tuaj yeem kis mus rau koj ob txhais ceg thiab lwm cov leeg. Qhov no tuaj yeem ua rau nws nyuaj rau taug kev, ua rau koj ntog ntau zaus, thiab ua rau koj yuav raug mob ntau dua.

Qhov no yav tas los hu ua "stiff man syndrome," tab sis tam sim no lub npe ntawd tau hloov lawm vim tias tus kab mob no tuaj yeem cuam tshuam rau txhua tus neeg, tsis hais hnub nyoog lossis poj niam txiv neej.

Kev kuaj pom tias muaj tus mob no tuaj yeem ua rau koj ntxhov siab me ntsis. Tab sis koj pab neeg kho mob yuav tsim ib txoj kev npaj kho mob uas ua haujlwm rau koj thiab koj cov tsos mob. Qhov no tuaj yeem txawv ntawm ib tus neeg mus rau ib tus neeg. Qhov tseem ceeb tshaj plaws yog mus ntsib koj cov kws kho mob tsis tu ncua, nrhiav kev txhawb nqa uas koj xav tau, thiab sim ua kom koj noj qab nyob zoo.

Cov tsos mob ntawm tus mob Stiff Person Syndrome (SPS) yog dab tsi?

Muaj ob qho tsos mob tseem ceeb ntawm tus kab mob no:

• Cov leeg nqaij tawv lossis tawv.
• Mob nqaij ntshiv mob heev.

Txawm hais tias cov tsos mob no tuaj yeem pib thaum twg los tau, tab sis feem ntau lawv tshwm sim ntawm hnub nyoog 30 thiab 40 xyoo .

Cov tsos mob ntawm tus kab mob Stiff Person Syndrome tuaj yeem kis mus rau lwm qhov ntawm lub cev thiab hnyav zuj zus tuaj. Rau qee tus neeg, nws yuav siv sijhawm ntau lub hlis mus rau ntau xyoo kom cov tsos mob tshwm sim. Rau lwm tus, cov tsos mob yuav zoo li qub tau ntau xyoo. Rau qee tus neeg, cov tsos mob yuav maj mam hnyav zuj zus thiab ua rau nws ua tsis tau tej yam txhua hnub.

Cov leeg nqaij tawv

Feem ntau, thawj cov tsos mob uas koj pom nrog tus kab mob Stiff Person Syndrome yog cov leeg nqaij tawv hauv lub cev . Qhov no txhais tau tias nyob rau hauv thaj chaw xws li lub plab, hauv siab, thiab nraub qaum. Qhov kev tawv nqaij no tuaj yeem ua rau mob thiab tsis xis nyob. Cov tsos mob no tuaj yeem tuaj thiab mus yam tsis muaj laj thawj pom tseeb. Tus mob kuj tseem tuaj yeem cuam tshuam rau caj npab thiab ceg. Thaum qhov kev tawv nqaij nce ntxiv, qee tus neeg yuav tsim cov qauv tsis zoo uas ua rau nws nyuaj rau taug kev lossis txav mus los.

Cov leeg nqaij ntswj

Cov leeg nqaij mob yog lwm yam tsos mob tseem ceeb ntawm tus mob no. Cov no tuaj yeem cuam tshuam rau tag nrho lub cev, lossis lawv tuaj yeem nyob rau hauv ib cheeb tsam tshwj xeeb. Cov kev mob no tuaj yeem kav ntev li ob peb feeb, feeb, lossis txawm tias teev. Xav txog, thaum koj sawv ntsug xwb, koj ceg lossis nraub qaum yuav nruj thiab khaus. Nws yog ib qho kev paub mob heev.

Dab tsi yog cov ua rau muaj tus mob Stiff Person Syndrome (SPS)?

Muaj ntau yam ua rau cov tsos mob xws li cov leeg nqaij ntswj tuaj yeem tshwm sim tam sim ntawd:

• Ib lub suab nrov tam sim ntawd. Xav txog seb koj puas taug kev hauv txoj kev thiab lub tsheb cia li nias nws lub suab, lossis yog tias muaj ib yam dab tsi hauv tsev poob rau hauv av nrog lub suab nrov nrov.
• Kev kov lossis kev txhawb zog. Yog tias muaj ib tug neeg kov koj tam sim ntawd, ces muab koj puag.
• Kev hloov pauv ntawm qhov kub thiab txias, tshwj xeeb yog qhov chaw txias. Yog tias koj mus rau qhov chaw txias tam sim ntawd, lossis yog tias dej txias poob rau ntawm koj lub cev.
• Tej xwm txheej ntxhov siab. Lub sijhawm chim siab thiab ntshai.

Vim tias cov leeg nqaij no tuaj yeem tshwm sim rau lub sijhawm tsis paub tseeb, qee tus neeg uas muaj tus kab mob Stiff Person Syndrome muaj kev ntxhov siab thiab agoraphobia . Agoraphobia yog kev ntshai heev ntawm kev mus rau qhov chaw muaj neeg coob coob, mus sab nraum zoov, lossis tawm hauv tsev. Vim tias thaum nyob sab nraum zoov, nws nyuaj rau khiav tawm ntawm cov kev xav no.

Dab tsi ua rau muaj tus mob Stiff Person Syndrome (SPS)?

Cov kws tshawb nrhiav tseem tsis tau paub meej tias yog dab tsi ua rau muaj tus kab mob no, tab sis lawv ntseeg tias nws yog ib qho mob autoimmune, uas txhais tau tias peb lub cev lub cev tiv thaiv kab mob tawm tsam cov hlwb noj qab haus huv.

Kev tshawb fawb tau qhia tias muaj cov tshuaj tiv thaiv kab mob (antibodies ) koom nrog. Muaj ntau tus neeg uas muaj tus kab mob Stiff Person Syndrome muaj cov tshuaj tiv thaiv kab mob tiv thaiv ib qho enzyme hu ua Glutamic Acid Decarboxylase (GAD) . Cov enzyme no (GAD) pab ua cov neurotransmitter gamma-aminobutyric acid (GABA) . Cov neurotransmitter no (GABA) pab tswj cov leeg nqaij ua haujlwm.

Tiamsis cov kws tshawb nrhiav tseem tsis tau nkag siab tag nrho tias cov enzyme '(GAD)' cuam tshuam li cas rau kev loj hlob thiab kev nce qib ntawm Stiff Person Syndrome. Ib qho uas yuav tsum nco ntsoov yog tias muaj cov tshuaj tiv thaiv '(GAD)' hauv koj lub cev tsis tau txhais hais tias koj muaj Stiff Person Syndrome. Ib feem pua ​​me me ntawm cov pej xeem feem ntau yuav muaj cov tshuaj tiv thaiv '(GAD)' no hauv lawv lub cev yam tsis muaj kev phiv.

Ntxiv rau GAD, lwm cov tshuaj tiv thaiv kab mob xws li glycine receptor, amphiphysin, thiab DPPX (dipeptidyl peptidase-like protein 6) tau pom tias muaj feem cuam tshuam nrog tus kab mob. Tsis tas li ntawd, qee tus neeg mob yuav tsis muaj cov tshuaj tiv thaiv kab mob no. Kev tshawb fawb ntxiv tseem tab tom ua mus kom paub seb lwm cov tshuaj tiv thaiv kab mob twg yuav koom nrog.

Cov yam ua rau muaj tus mob Stiff Person Syndrome (SPS) yog dab tsi?

Kab mob Stiff person syndrome feem ntau tshwm sim ob npaug rau cov poj niam . Nws kuj tseem tuaj yeem tshwm sim nrog lwm yam kab mob autoimmune. Piv txwv li:

• Kab mob ntshav qab zib hom 1
• Kab mob thyroid autoimmune
• Vitiligo
• Kev mob ntshav tsis txaus
• Kab mob celiac

Kab mob Stiff Person Syndrome (SPS) muaj ntau npaum li cas?

Qhov no yog ib qho mob tsis tshua muaj . Lawv hais tias tsuas muaj ib tug ntawm ib lab tus tib neeg muaj tus kab mob no. Qhov ntawd txhais tau tias nws yog ib qho mob tsis tshua muaj.

Yuav kuaj mob li cas rau tus mob Stiff Person Syndrome (SPS)?

Tus kws kho mob yuav kuaj mob no los ntawm cov tsos mob tshwj xeeb, kev kuaj mob, thiab kev kuaj mob. Lawv yuav nug koj txog koj cov tsos mob, kuaj lub cev, thiab kuaj lub paj hlwb.

Yog tias tus kws kho mob xav tias muaj tus kab mob Stiff Person Syndrome, lawv yuav ua cov kev kuaj mob xws li:

• Kev kuaj ntshav tiv thaiv kab mob: Qhov no pab kuaj seb puas muaj cov tshuaj tiv thaiv kab mob rau (GAD) (lossis lwm yam tshuaj tiv thaiv kab mob) thiab txiav txim siab seb puas muaj lwm yam mob.
• Electromyography (EMG): Qhov no ntsuas qhov ua haujlwm hluav taws xob ntawm koj cov leeg. Qhov no tuaj yeem pab tshem tawm lwm yam ua rau koj cov tsos mob.
• Kev tho qhov mob ntawm lub duav (qhov tho qhov mob ntawm tus txha caj qaum): Hauv qhov kev kuaj no, tus kws kho mob siv ib rab koob los kuaj cov kua dej ntawm koj tus txha caj qaum thiab kuaj nws rau cov tshuaj tiv thaiv kab mob rau GAD. Qhov no kuj tseem ceeb heev kom tshem tawm lwm yam mob.

Kab mob Stiff Person Syndrome yuav nyuaj rau kuaj mob vim tias nws tsis tshua muaj thiab nws cov tsos mob zoo ib yam li lwm yam kab mob autoimmune, xws li ankylosing spondylitis thiab multiple sclerosis.

Puas muaj hom mob Stiff Person Syndrome (SPS)?

Muaj ntau hom kab mob sib txawv ntawm cov kab mob no:

• Kab mob Classic Stiff Person Syndrome: Qhov no yog hom kab mob uas feem ntau pom. Feem ntau nws cuam tshuam nrog cov tshuaj tiv thaiv GAD, tab sis kev tshawb fawb pom tias lwm cov tshuaj tiv thaiv kuj koom nrog.
• Cov kev hloov pauv ntawm tus neeg mob tawv nqaij:Hauv qab no, muaj cov kev hloov pauv uas tsuas cuam tshuam rau qee qhov ntawm lub cev xwb, lossis uas qhia ntau cov tsos mob xws li poob kev tswj hwm thaum taug kev ('ataxia').
• Kab mob hlwb uas ua rau lub hlwb tsis khov thiab mob myoclonus (PERM): PERM yog ib hom kab mob uas ua rau tus neeg mob tsis khov hnyav dua. Nws tuaj yeem ua rau tsis nco qab, muaj teeb meem txav lub qhov muag, ataxia, thiab ua haujlwm tsis zoo ntawm lub cev. Kev ua haujlwm tsis zoo ntawm lub cev yuav tsum tau mus pw hauv tsev kho mob rau cov neeg uas muaj PERM.

Yuav kho tus mob Stiff Person Syndrome (SPS) li cas?

Muaj ob txoj kev tseem ceeb los kho qhov no:

• Cov tshuaj thiab kev kho mob los tswj cov tsos mob.
• Kev kho mob tiv thaiv kab mob, lossis kev kho mob hloov kho kab mob.

Cov kev xaiv kho mob sib txawv nyob ntawm koj cov tsos mob. Lub hom phiaj tseem ceeb ntawm kev kho mob yog los tswj txoj kev uas koj cov tsos mob cuam tshuam rau koj thiab txhim kho koj txoj kev txav mus los thiab kev xis nyob.

Koj pab neeg kho mob yuav muaj ntau tus kws tshwj xeeb, xws li:

• Cov kws kho mob hlwb, tshwj xeeb tshaj yog cov kws kho mob hlwb.
• Cov kws kho mob ua haujlwm thiab cov kws kho lub cev.
• Cov kws tshwj xeeb hauv kev kho mob lub cev thiab kev kho kom rov zoo.
• Cov kws kho kev hais lus.
• Cov kws tshwj xeeb txog kev noj qab haus huv ntawm lub hlwb, piv txwv li cov kws kho mob hlwb.

Cov tshuaj thiab kev kho mob

Cov tshuaj zoo li no tuaj yeem pab txo cov leeg nqaij tawv, mob, thiab mob nqaij ntshiv:

• Benzodiazepines: Cov no yog ib pawg tshuaj siv los kho ntau yam mob, suav nrog kev ntxhov siab, qaug dab peg, thiab pw tsis tsaug zog. Lawv cuam tshuam rau cov neurotransmitter (GABA) signaling. Cov kws kho mob feem ntau sau diazepam ua thawj txoj kev kho mob rau Stiff Person Syndrome.
• Cov tshuaj ua kom cov leeg nqaij so: Cov tshuaj xws li Baclofen tuaj yeem pab txo cov leeg nqaij ntswj. Lawv ua rau cov leeg nqaij so thiab txo qhov mob.
• Cov tshuaj kho mob neuropathic: Cov tshuaj xws li gabapentin thiab pregabalin kuj cuam tshuam rau GABA signaling thiab pab nrog cov tsos mob.

Lwm yam kev kho mob uas yuav pab tswj cov tsos mob muaj xws li:

• Kev kho lub cev lossis kev kho mob ua haujlwm.
• Zaws.
• Hydrotherapy (kev kho mob hauv dej).
• Kev kho cua sov.
• Kev siv koob txhaj tshuaj.

Kev kho mob tiv thaiv kab mob

Muaj qee qhov pov thawj tias kev kho mob immunoglobulin (IVIg) uas siv rau hauv cov hlab ntsha (tseem yog ib hom kev kho mob immunotherapy) tuaj yeem pab txo cov tsos mob ntawm Stiff Person Syndrome. IVIg muaj cov immunoglobulins (cov tshuaj tiv thaiv kab mob ntuj) uas tau pub los ntawm ntau txhiab tus neeg uas muaj lub cev tiv thaiv kab mob zoo.

Puas kho tau tus mob Stiff Person Syndrome (SPS)?

Tam sim no, tsis muaj tshuaj kho tau tus mob Stiff Person Syndrome. Kev kho mob tsuas yog pab tswj cov tsos mob xwb.

Yuav ua li cas thiaj paub tias tus mob Stiff Person Syndrome (SPS) yuav zoo li cas?

Qhov no yog ib qho mob uas yuav mob mus tas li (mob ntev) . Qhov kev xav ntawm ib tus neeg mus rau ib tus neeg yuav txawv nyob ntawm ntau yam:

• Qhov hnyav ntawm cov tsos mob.
• Qhov ceev ntawm tus kab mob kis mus.
• Kev kho mob no ua tau zoo npaum li cas?

Nws yog ib qho tseem ceeb uas yuav tsum pib kho sai li sai tau thaum cov tsos mob pib tshwm sim. Qhov no tuaj yeem pab tiv thaiv lossis txo qhov kev kis tus kab mob thiab pab tiv thaiv cov teeb meem mus sij hawm ntev. Txawm hais tias ntau tus neeg pom kev zoo los ntawm kev siv tshuaj, qee zaum nws yuav nyuaj rau tswj cov yam ua rau cov leeg nqaij ntswj.

Kev taug kev tej zaum yuav nyuaj zuj zus tuaj raws sijhawm. Lub peev xwm ua tej yam txhua hnub kuj tseem yuav maj mam txo qis. Thaum tus kab mob loj zuj zus, qhov kev pheej hmoo ntawm kev ntog yuav nce ntxiv. Tej zaum koj yuav tsum siv tus pas nrig, tus pas nrig taug kev, lossis txawm tias lub rooj zaum muaj log.

Puas tiv thaiv tau tus kab mob Stiff Person Syndrome (SPS)?

Vim qhov no yog ib yam kab mob autoimmune, tsis muaj dab tsi koj ua tau los tiv thaiv nws .

Kuv yuav saib xyuas kuv tus kheej li cas yog tias kuv muaj tus mob Stiff Person Syndrome (SPS)?

Yog tias ua tau, sim nrhiav ib tus kws kho mob uas tshwj xeeb hauv kev tshawb fawb thiab kho tus mob Stiff Person Syndrome. Tus mob no tsis tshua muaj, yog li nws tuaj yeem nyuaj me ntsis. Yog tias koj xav tau kev kho mob zoo tshaj plaws thiab muaj lub neej zoo tshaj plaws, koj yuav tsum hais tawm thiab mob siab rau nws.

Nws yog ib qho uas cov neeg uas muaj tus kab mob no feem ntau muaj teeb meem kev noj qab haus huv ntawm lub hlwb, xws li kev ntxhov siab lossis kev nyuaj siab . Yog tias koj tab tom muaj cov tsos mob no, nws yog ib qho tseem ceeb uas yuav tsum tham nrog koj tus kws kho mob lossis tus kws tshaj lij kev noj qab haus huv ntawm lub hlwb, xws li tus kws kho mob hlwb.

Yog koj thiab koj tsev neeg ua tau, koj tuaj yeem koom nrog ib pawg neeg txhawb nqa uas koj tuaj yeem ntsib lwm tus uas nkag siab txog koj tej kev paub dhau los.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Yog tias koj muaj tus mob Stiff Person Syndrome, koj yuav tsum ntsib nrog koj pab neeg kho mob tsis tu ncua kom pom tias koj txoj kev kho mob puas ua tiav thiab saib xyuas kev loj hlob ntawm koj cov tsos mob.

Yog koj pom cov tsos mob tshiab lossis muaj cov kev mob tshwm sim los ntawm cov tshuaj, qhia rau koj tus kws kho mob.

Kuv yuav tsum nug kuv tus kws kho mob li cas?

Yog tias koj muaj tus mob Stiff Person Syndrome, nws yuav pab tau yog tias koj nug koj tus kws kho mob cov lus nug no:

• Koj pom zoo kom muaj kev kho mob dab tsi rau kuv cov tsos mob?
• Kuv ua tau dab tsi hauv tsev los pab kho kuv cov tsos mob?
• Kuv yuav tsum saib xyuas cov cim qhia txog teeb meem twg?
• Kuv yuav cia siab tias kuv txoj kev noj qab haus huv yuav zoo li cas yav tom ntej?
• Puas muaj kev sim tshuaj rau tus mob Stiff Person Syndrome?

Thaum kawg, tej yam yuav tsum nco ntsoov (Cov Lus Coj Mus Tsev)

Nrhiav kom paub tias koj muaj ib yam mob tsis tshua muaj xws li Stiff Person Syndrome tsis yooj yim. Tej zaum koj yuav xav tias ntxhov siab, ntxhov siab, thiab tsis paub meej txog yav tom ntej. Tab sis koj tsis tas yuav ntsib qhov no ib leeg. Koj pab neeg kho mob nyob ntawm no los teb cov lus nug uas koj muaj thiab pab koj tswj koj cov tsos mob.

Txawm hais tias koj txoj kev kho mob tsom mus rau koj txoj kev noj qab haus huv lub cev, nco ntsoov txog koj txoj kev noj qab haus huv ntawm lub hlwb thiab . Cov tsos mob sib txawv ntawm ib tus neeg mus rau ib tus neeg. Tab sis kev nyob nrog qhov mob, kev tsis xis nyob, thiab cov leeg nqaij ntswj uas tsis paub tseeb tias yuav ua rau koj lub hlwb puas tsuaj. Qhov mob no tuaj yeem ua rau nws nyuaj rau tawm mus ua tej yam txhua hnub. Yog li, yog tias koj xav tau kev pab, tsis txhob yig mus cuag kws kho mob ntxiv rau koj cov neeg hlub. Nco ntsoov, koj tsis nyob ib leeg.

Kab Mob Ntsws Nqaij, cov leeg nqaij tawv, cov kab mob ntawm lub paj hlwb, cov kab mob autoimmune, cov tshuaj tiv thaiv GAD, GABA, cov leeg nqaij ntswj, cov tsos mob ntawm SPS