Yu wan no bak boht di ANCA Test? Lɛ wi tɔk bɔt am ditayli!

Yu don eva yehri boht `(ANCA tehst)`? Sɔntɛm yu dɔktɔ tɛl yu fɔ du dis tɛst, ɔ sɔntɛm yu jɔs si di nem sɔnsay ɛn yu want fɔ no mɔ. So, wetin na dis `(ANCA test)`? Wetin rili i de luk fɔ? Insay dis atikul, wi go fɛn ansa to dɛn kayn kwɛstyɔn dɛn ya we yu go gɛt na yu maynd.

Wetin na ANCA tɛst? Lɛ wi ɔndastand am simpul wan!

Fɔ tɔk am simpul wan, ANCA tɛst na blɔd tɛst we de tek wan sɛmpul pan yu blɔd ɛn luk fɔ patikyula tin dɛn we dɛn kɔl Antineutrophil Cytoplasmic Antibodies, ɔ ANCAs fɔ shɔt.

Naw yu kin de wɔnda, wetin na dɛn `(ANCA)` ya? `(ANCAs)` na wan kayn `(ɔtoantibodi dɛm)` . `(Autoantibodies)` na wan kayn protin we wi yon bכdi in imyun sistεm (dat na di sistεm we de protεkt wi frכm sik dεm). כltu, di prכblεm wit dεn `(autoantibodies)` dεm na dat dεn de mistek atak hεlty sεl dεm εn tisu dεm na wi bכdi. I tan lɛk se wi yon ami de atak wi yon kɔntri.

dis `(ANCA)` spεshal tכk di protin dεm we de insay wayt bכdi sεl dεm we dεn kכl `(nyutrofil) . `(Nyutrofil)` tan lɛk smɔl sojaman dɛn na wi bɔdi. Na dεn wan dεm de fεt jεm εn εp wi fכ protεkt wi sεf frכm sik. So, dis `(ANCA test)` kin no if yu gɛt dɛn `(autoantibodies)` ya na yu blɔd, ɛn if na so, ɔmɔs.

Us kayn sik dɛn kin yuz di ANCA tɛst fɔ no?

Dɔktɔ dɛn kin yuz di ANCA tɛst mɔ fɔ ɛp fɔ no sɔm sik dɛn we de mek pɔsin ebul fɔ fɛt insɛf, we de pan wan grup we gɛt sik dɛn we dɛn kɔl vasculitis .

Wetin na dis `(vasculitis)`?

Imajin, ɔlsay na wi bɔdi, smɔl smɔl tin dɛn de we tan lɛk tiub we de kɛr blɔd? Na dat wi de kɔl blɔd vesel. insay dis kכndyushכn we dεn kכl ``vasculitis,'' wetin kin apin na we wi כwn imyun sistεm de atak dεn blכd vεsul dεm ya εn mek dεn inflam, dat na fכ swel . I tan lɛk wund we de insay pɔsin in bɔdi.

Bɔku kayn vaskulaytis de we gɛt fɔ du wit ANCA:

• `(Granulomatosis wit polyangiitis)` (dεn bin kכl am fכs `(Wegener granulomatosis)`).
• `(Maykroskɔpik polyangiitis)` .
• Eosinophilic granulomatosis wit polyangiitis (dεn bin kכl am fכs Churg-Strauss sεndrכm).

Blɔd vesel na di wan dɛn we de kɛr blɔd kɔmɔt na wi at to ɔl di ɔda ɔgan ɛn tisu dɛn. So, we dɛn blɔd vesel ya inflam, blɔd nɔ de flɔ fayn. Dis kin pwɛl wi impɔtant pat dɛn, ɛn sɔntɛnde i kin ivin mek wi gɛt prɔblɛm dɛn lɛk we blɔd vesel kin bɔs (aneurysm) . Na dat mek i impɔtant fɔ no dɛn kayn tin ya kwik kwik wan.

Yu tink se men kayn (ANCA) de?

Yes, tu men kayn ANCA de. Dis ANCA tɛst kin no if yu gɛt wan ɔ ɔl tu.

• `cANCA` : dis de tכk to wan protin we dεn kכl `(proteinase 3)` כ `(PR3)` .
• `pANCA` : dis de tכk to wan protin we dεn kכl `(myeloperoxidase)` כ `(MPO)` .

dεn tu kayn `(protein)` dεm de fכn insay di wayt bכdi sεl dεm we dεn kכl `(nyutrofil)` we wi bin dכn tכk bכt. We di dɔktɔ no us kayn `(ANCA)` de de, dat kin ɛp di dɔktɔ fɔ no di sik ɛn plan fɔ trit am.

Udat de du di ANCA tɛst? Aw dɛn kin tɛst am na di lab?

Bɔku tɛm, nɔs, dɔktɔ, ɔ lɛbɔtri tɛknishian kin tek yu blɔd sɛmpul, ɛn dɛn kin sɛn am na lɛbɔtri fɔ mek dɛn tɛst yu.

Wetin kin apin na di laboratori (`lab`)?

Dɛn kin tek wan sɛmpul pan yu blɔd ɛn miks am wit di nyutrofil dɛn we de na wan slayd. Naw, if ANCA dɛn de na yu blɔd, dɛn go stik to di nyutrofil dɛn. Dɔn dɛn kin ad spɛshal day (stain) to di slayd. Dɔn, we yu luk am ɔnda maykroskɔp, yu kin si klia wan di patɛn fɔ di ANCA dɛn we dɛn tay pan di slayd.

di lab de aydentify dεn sεl dεm ya as εither cANCA (saytoplasmik patεn) כ pANCA (perinuclear pattern) bays pan di spεsifi k fכrosεns patεn we dεn si insay dεn sεl dεm ya.

Labɔrɔtɔri kin yuz wan ɔ tu kayn ANCA tɛst:

• `(Indirect immunofluorescence) (IIF)` : Dis tεst de כnli tεl yu if yu gεt dεn `(autoantibodies)` dεm כ nכ. Dat min se di rizɔlt na `(positiv)` ɔ `(negativ)`.
• εnzym-linked immunosorbent assay (ELISA) : dεn de yuz dis tεst mεtכd fכ no εksakכt wetin di tכgεt protin (i.e. PR3 כ MPO) de insay di nyutrofil dεm.

Ɛni spɛshal pripiamɛnt de we dɛn nid bifo di ANCA tɛst?

Bɔrku tɛm , nɔr spɛshal pripiamɛnt nɔr de fɔ ANCA tɛst. Bɔt sɔntɛnde, dɛn kin tɛst bɔku tin dɛn wit di sem blɔd sɛmpul. If na so i bi, sɔm tɛst dɛn kin mek yu fɔ fast fɔ 8 to 12 awa, we min se yu nɔ fɔ it ɔ drink ɛnitin pas wata. Bɔt yu dɔktɔ go gi yu patikyula tin dɛn bɔt dis. So nɔ wɔri bɔt am.

Wetin yu fɔ ɛkspɛkt we yu de du di ANCA tɛst?

I jɔs tek sɔm minit fɔ mek dɛn pul yu blɔd. Dɛn kin du am na ɔfis, klinik, ɔ lɛbɔtri. Na dis na aw dɛn kin pul di blɔd:

• Fɔs, dɛn kin rap wan tɔnik ɔ band tayt tayt wan rawnd yu ɔp an (ɔp yu bɛlɛ).
• Dɔn, dɛn kin klin di skin usay dɛn go pul di blɔd wit wan antiseptik.
• Neks, dɛn kin put nidul insay wan vein nia di ɛlb. Dis tɛm ya yu kin fil lɛk se yu de swɛt ɔ yu kin fil lɛk se yu de tik smɔl . Dis na nɔmal tin.
• Dɛn kin tay wan smɔl tiub na di nidul ɛn dɛn kin gɛda di blɔd we dɛn nid.
• Dɔn, dɛn kin pul di tep ɛn di nidul, ɛn ol di say we dɛn put di nidul wit wan kɔtɔn fɔ mek di blɔd nɔ kɔmɔt.
• Fɔ dɔn, dɛn kin put smɔl bandej (plasta) pan di say we dɛn de.

Wetin kin apin afta di ANCA tɛst?

Yu dɔktɔ go mɔs tɛl yu fɔ kip di bandej fɔ sɔm awa. Dɛn kin tɛl yu bak fɔ avɔyd fɔ du ɛksɛsayz fɔ sɔm awa afta yu dɔn gi yu blɔd. Ɔda pas dat, natin nɔ de we spɛshal.

Ɛni risk de wit dis (ANCA tɛst)?

Blɔd tɛst rili sef ɛn di risk dɛn rili smɔl .

Yu kin gɛt smɔl brus usay dɛn put di nidul. Dis go ɔltɛm go fɔ insɛf insay tu-tri dez. Na smɔl tɛm nɔmɔ, di vein kin swel smɔl. If dis apin, kɔmprɛs we wam kin ɛp. Dis nɔto natin fɔ wɔri bɔt.

Aw lɔŋ i kin tek fɔ gɛt di rizɔlt fɔ di ANCA tɛst?

Di ANCA tɛst na spɛshal tɛst, so dɛn kin du am na spɛshal lɛbɔraytri. So, i kin tek ɛnisay frɔm sɔm dez to wan wik fɔ mek di rizɔlt kam bak. Yu dɔktɔ go mek yu no.

Wetin di ANCA tɛst rizɔlt min? Aw a go ɔndastand?

Dis na di pat we impɔtant pas ɔl. Yu dɔktɔ na di wan we go tɔk to yu bɔt di rizɔlt fɔ di ANCA tɛst ɛn aw dɛn kin afɛkt yu wɛlbɔdi.

• if di rizulεt dεm na ``nεgεtiv``: Dis kin min se yu nכ gεt di ``autoimmune vasculitis`` kכndishכn we wi bin dכn tכk bכt.
• If di rizulεt na ``positiv``: I kin min se yu gεt ``autoimmune vasculitis``.

Bɔt, sɔntin de we impɔtant fɔ ɔndastand na ya. If yu gɛt di ANCA tɛst fɔ no if yu gɛt di sik, dat nɔ min se yu gɛt di sik. Yu dɔktɔ kin tɛl yu fɔ du ɔda tɛst , lɛk fɔ tek bayɔpsi (we dɛn tek wan sɛmpul pan tisu fɔ tɛst), ɔ ɔda blɔd tɛst. Apat frɔm dat, dɛn kin no bɔt di sik bay bɔku tin dɛn, lɛk di sayn dɛn we yu gɛt ɛn di tin dɛn we kin kɔmɔt frɔm ɔda tɛst dɛn.

Impɔtant: Di rizɔlt fɔ di ANCA tɛst na jɔs wan pat pan di diagnostik prɔses. I nɔ de sho if sik de fɔ insɛf. Yu dɔktɔ go tink bɔt dis wit bɔku ɔda tin dɛn, lɛk di sayn dɛm we yu gɛt, di rizɔlt fɔ ɔda tɛst dɛm, ɛn yu mɛdikal histri.

So, wetin na di impɔtant tin we wi fɔ mɛmba frɔm dis?

di ``Antineutrophil Cytoplasmic Antibodies'', כ ``ANCA'' tεst, na imכtant blכd tεst we de εp dכkta fכ no sכm kayn ``autoimmune vasculitis'', kכndyushכn dεm we wi כwn imyun sistεm de atak wi bכdi vεsul dεm.

Yu dɔktɔ go ɛksplen to yu wetin mek yu nid fɔ du dis tɛst ɛn wetin di rizɔlt go min fɔ yu. So, nɔ fred ɔ dawt. If yu gɛt ɛni kwɛstyɔn ɔ yu nɔ ɔndastand sɔntin, aks yu dɔktɔ wantɛm wantɛm. I bɛtɛ fɔ mek dɛn tɛl yu we yu de disayd fɔ du sɔntin bɔt yu wɛlbɔdi biznɛs.

` (ANCA tεst), ANCA tεst, bכdi tεst, vaskulεt, כtoimyun sik dεm, antibodi dεm, nyutrofil dεm, blכd vεsεl inflameshn