Yu no bɔt BRCA tɛst? (BRCA Testing) Na we fɔ no di risk fɔ gɛt kansa kwik kwik wan!

Yu go mɔs dɔn yɛri di wɔd `BRCA` (BRCA) we yu de tɔk bɔt tin dɛn lɛk bɔdi kansa, ovarian kansa. Sɔntɛm yu dɔktɔ sɛf dɔn tɔk bɔt am. Wetin na dis `BRCA` jin rili? Wetin wi kin lan bay we wi du dis `(BRCA testing)`? Tide wi go tɔk bɔt ɔl dis rili simpul wan, insay wan we we yu go ɔndastand. Jɔs lɛk we yu de tɔk to yu padi.

Wetin na BRCA? Wetin mek i impɔtant to wi?

Fɔ tɔk am simpul wan, `BRCA1` ɛn `BRCA2` na tu spɛshal jin dɛn na wi bɔdi. Dɛn tan lɛk di gad dɛn we de insay wi sɛl dɛn. di men wok we dεn de du na fכ mek di damej we wi `DNA` du εn fכ stכp di sεl dεm fכ gro tu kwik εn fכ kכntrכl na ples dεm lεk di brεst εn ovaria. Tink bɔt dɛn jin ya as smɔl "brɛk" sistɛm na wi bɔdi we de stɔp di kansa sɛl dɛm fɔ fɔm. na dat mek wi kכl dεm `(tumor suppressor genes)`.

כltu, sכmtεm dεn imכtant `BRCA` jin dεm kin gεt sכm chenj dεm, כ `mכtayshכn` . Na da tɛm de di prɔblɛm kin bigin. We dɛn jin ya nɔ de wok fayn, di sɛl dɛn we a bin tɔk bɔt kin gro pasmak. Dɔn di risk fɔ gɛt nɔto jɔs bɔdi kansa, ovarian kansa, bɔt sɔm ɔda kayn kansa dɛn kin go ɔp.

di imכtant tin na dat dεn `BRCA` jin mכ tayshכn dεm de pas dכn frכm jεnereshכn to jεnereshכn. Dat min se yu kin gɛt dis muteshon frɔm yu mama ɔ papa. I tan lɛk se na famili ɛri. wi de du wan jεnεtik tεst we dεn kכl `(BRCA testing)` fכ no if yu gεt dεn `BRCA` mכtayshכn dεm ya. Fɔ dis, dɛn kin tek smɔl blɔd sɛmpul frɔm yu ɛn tɛst am.

Udat fɔ gɛt di BRCA tɛst? Yu tink se ɔlman nid am?

fכ tru, dεn `BRCA` jin mכtayshכn dεm ya nכ de kכmכn so. Fɔ ɛgzampul, lɛk 0.2% pan di pipul dɛm na Amɛrika gɛt dis sik. Dat na rili smɔl pasɛnt. So, bɔku dɔktɔ dɛn nɔ kin se ɔlman fɔ gɛt dis `BRCA` tɛst. Bɔt if yu gɛt sɔm tin dɛn we kin mek yu gɛt dis sik, yu dɔktɔ go advays yu fɔ du dis tɛst.

Naw lɛ wi si wetin na dɛn tin dɛn de we kin mek wi gɛt prɔblɛm:

• If yu dɔn gɛt bɔdi kansa , mɔ if i bin kam bifo yu ol 50 ia.
• If dɛn dɔn ɔlrɛdi no se yu fambul we de nia yu na yu famili (mama, papa, brɔda ɛn sista, pikin dɛn) gɛt `BRCA` muteshon.
• If wan ɔ mɔ pipul dɛn na yu famili dɔn gɛt bɔdi kansa (especially if man dɛn dɔn gɛt bɔdi kansa, dat bak impɔtant).
• If yu gɛt ɔl tu di bɔdi kansa ɛn ovarian kansa.
• If yu na di Ashkenazi Ju etnik grup (pipul dɛn na dis etnik grup kin gɛt BRCA muteshon).
• If yu ɔ sɔmbɔdi na yu famili gɛt histri fɔ gɛt bɔku kayn kansa.
• If pɔsin na yu famili gɛt wan jenɛtik risk factor fɔ gɛt kansa, fɔ ɛgzampul, Cowden syndrome, Fanconi anemia, Li-Fraumeni syndrome, ɔ Peutz-Jeghers syndrome.

If wan ɔ mɔ pan dɛn tin ya apin to yu, i go fayn fɔ tɔk to dɔktɔ ɛn tink bɔt fɔ du BRCA tɛst.

Wetin wi kin lan frɔm BRCA tɛst?

Imajin se yu gɛt dis tɛst. if i sho se yu gεt mכtεshכn na di `BRCA1` כ `BRCA2` jin dεm, i min se yu gεt bכku bכku risk fכ gεt brεst kεnsar pas di avεrej pכsin . sכm stכdi dεn sho se pכsin we gεt `BRCA` mכtεshכn kin gεt brεst kεnsar we i ol 80 ia pas di avεrej pכsin. Dɔn bak, di kansa kin gɛt mɔ we i yɔŋ ɛn i kin afɛkt di tu bɔdi dɛn .

Nɔto dat nɔmɔ, di BRCA muteshon kin mek di risk fɔ gɛt sɔm ɔda kayn kansa bɔku. Di men wan dɛn na:

• Ovarian kansa ɛn tu kansa dɛn we gɛt fɔ du wit am, fallopian tube kansa ɛn peritoneal kansa.
• Prɔstat kansa - Dis impɔtant fɔ man dɛn.
• ` (Pankrias kansa)` (pankrias kansa).
• ` (Fanconi anemia)` (Fanconi anemia) - Dis na kansa we nɔ kin bɔku, we kin apin bɔku tɛm we dɛn smɔl.

Impɔtant: Fɔ gɛt BRCA muteshon nɔ min se yu go rili gɛt kansa. I min se yu de pan risk mɔ. We yu no dis, dat kin ɛp yu fɔ du tin fɔ ridyus di prɔblɛm we yu gɛt.

Wetin kin apin bifo di BRCA tɛst?

Bifo yu du BRCA tɛst, yu go nid fɔ go to pɔsin we de advays yu bɔt yu jɛnɛtiks . Dis na tin we rili impɔtant. Dis jenɛtik advaysa go ɛksplen to yu aw di jin dɛm we yu gɛt frɔm yu famili kin afɛkt yu risk fɔ gɛt kansa. Dɛn go ɛksplen to yu se:

• Wetin i min if BRCA tɛst rizɔlt na pɔsitiv ɔ negatif?
• Aw yu tɛst rizɔlt kin afɛkt yu kansa risk?
• Aw yu rizɔlt kin afɛkt di risk fɔ ɔda pipul dɛn na yu famili?

I bɛtɛ fɔ tek di tɛst nɔmɔ afta yu dɔn ɔndastand ɔl dis gud gud wan.

Wetin kin apin we yu gɛt BRCA tɛst?

I rili simpul. Di BRCA tɛst jɔs nid fɔ tek smɔl blɔd frɔm yu.I jɔs tan lɛk we yu de du blɔd tɛst ɔltɛm ɔ we yu de gi blɔd. Di dɔktɔ ɔ nɔs kin put smɔl nidul insay wan vein na yu an ɛn pul smɔl blɔd insay wan smɔl bɔtul.

Yu kin fil smɔl pen we dɛn put di nidul ɛn pul am. Bɔt dis go dɔn insay lɛs pas fayv minit. If blɔd de kɔmɔt smɔl, dɛn kin put smɔl plasta na di say. Sɔntɛnde dɛn kin du dis tɛst bak wit saliva sɛmpul.

Wetin kin apin afta di BRCA tɛst?

Yu dɔktɔ go tɛl yu aw lɔng i go tek fɔ gɛt yu rizɔlt. Afta yu rizɔlt kam bak, i impɔtant fɔ si yu jenɛtik kɔlnɔ bak. Dɛn kin ɛksplen to yu di tin dɛn we go apin ɛn ɛksplen di tin dɛn we yu go ebul fɔ du.

Wetin na di pɔsibul rizɔlt fɔ BRCA tɛst?

Tri kayn rizulyt kin de.

1. Wetin wi go du if di tin we apin na gud tin?

If yu gɛt BRCA muteshon, dat min se yu gɛt bɔku bɔku risk fɔ gɛt kansa. Bɔt, nɔ wɔri. I nɔ min se yu go mɔs gɛt kansa. If yu no dis, dat kin ɛp yu fɔ du fayn tin dɛn fɔ mek yu nɔ gɛt kansa, fɔ no am kwik, ɔ ivin fɔ mek yu nɔ gɛt am. I kin ɛp ɔda pipul dɛn bak na yu famili fɔ ɔndastand di prɔblɛm we dɛn kin gɛt.

Tɔk to yu dɔktɔ ɛn di pɔsin we de advays yu bɔt yu jɛnɛtiks fɔ disayd if dɛn fɔ tɛst ɔda pipul dɛn na yu famili. Dɛn go tɛl yu bak bɔt di tin dɛn we yu kin du fɔ mek yu nɔ gɛt dis sik. Fɔ ɛgzampul:

• Fɔ gɛt mɔr fɔ gɛt kansa skrinin: Fɔ ɛgzampul, fɔ gɛt mammogram bɔku tɛm.
• Ɔda we dɛn fɔ tɛst: Tin dɛn lɛk MRI skan na di bɔdi.
• Fɔ stɔp fɔ yuz sɔm bɔn kɔntrol pils: Pan ɔl we sɔm bɔn kɔntrol pils kin ridyus di risk fɔ gɛt ovarian kansa, dɛn kin mek sɔm pipul dɛn gɛt mɔ kansa na dɛn bɔdi. Yu fɔ tɔk to yu dɔktɔ bɔt dis.
• Yuz mɛrɛsin fɔ mɛn kansa: Fɔ ɛgzampul, drɔgs lɛk tamoxifen.
• Prɛvɛntiv ɔpreshɔn: Fɔ pul di wɛlbɔdi tisu na di bɔdi bifo kansa kam (prophylactic mastectomy) ɔ fɔ pul di ovaries ɛn fallopian tubes (prophylactic removal of ovaries and fallopian tubes). Dis na big tin fɔ disayd, so yu fɔ disayd fɔ du dɛn afta yu dɔn tek tɛm tink bɔt am ɛn tɔk to yu dɔktɔ.

2. Wetin wi go du if di tin we apin nɔ fayn?

wan negatif risכlt min se yu nכ gεt `BRCA` mכtεshכn. Dɔn bak, yu nɔ go pas `BRCA` muteshon to yu pikin dɛm. Bɔt if yu gɛt negatif `BRCA` tɛst nɔ de gi garanti se yu nɔ go ɛva gɛt kansa. E min se yu risk tan lɛk pɔrsin na di jenɛral pɔpuleshɔn.

Bɔt if yu tɛst nɔ no, bɔt wan ɔ mɔ pipul dɛn na yu famili dɔn gɛt bɔdi kansa bifo dɛn ol 50 ia, di tin kin tranga smɔl. Dis kin min se yu famili gɛt ɔda tin we de chenj na yu jɛnɛtiks we de mek yu gɛt kansa mɔ ɛn mɔ. Yu jenɛtik kɔstɔma kin ɛp yu fɔ ɔndastand dɛn rizɔlt ya ɛn disayd if dɛn nid fɔ du mɔ tɛst.

3. Wetin wi go du if wi nɔ shɔ bɔt wetin go apin?

Sɔntɛnde di rizɔlt kin bi "indeterminate." dis min se yu gεt chenj na wan pan yu BRCA1 כ BRCA2 jin dεm, bכt dεn nכ dכn no yet se dat chenj na mכtεshכn we de mek yu risk fכ gεt brεst kεnsar. Dɛn kɔl dis "Variant of unknown significance" (VUS) . If dis apin, yu jenɛtik kɔlnɔ go ɛksplen to yu di rizɔlt ɛn ɛp yu fɔ disayd if yu ɔ ɔda pipul dɛn na yu famili nid fɔ du mɔ jenɛtik tɛst.

Wetin na di bɛnifit dɛn we pɔsin kin gɛt we i du BRCA tɛst? Ɛni risk dɛn de we kin apin?

di big advantej fכ dis tεst na dat i de tεl yu if yu gεt `BRCA` jin mכtεshכn. Dis kin mek yu ɔndastand mɔ bɔt yu kansa risk. Dɔn bak, dis infɔmeshɔn kin ɛp yu famili fɔ disayd bɔt dɛn wɛlbɔdi biznɛs. naw ``kכmprεhεnsiv jεnεtik tεst panεl dεm`` de we de tεst fכ sεvεra כda jin dεm apat frכm ``BRCA1/BRCA2``. Yu jenɛtik kɔstɔma kin gayd yu fɔ no us tɛst we go fayn fɔ yu.

As fɔ di risk dɛm, nɔr big risk nɔr de wit dis tɛst. Na jɔs wan rili simpul blɔd drɔ.

Wetin a fɔ aks mi dɔktɔ/nɔs?

If yu de tink bɔt dis tɛst, ɔr yu dɔn ɔlrɛdi gɛt am, i fayn fɔ aks yu dɔktɔ ɔ yu jenɛtik kɔlnɔ dɛn kwɛstyɔn ya:

• I fayn fɔ mek ɛni ɔda pɔsin na mi famili gɛt dis `BRCA` tɛst?
• If mi tɛst sho se dɛn gɛt di sik, dat min se mi pikin dɛnsɛf go gɛt da jɛnɛtik muteshɔn de?
• Aw mi tɛst rizɔlt go afɛkt di we aw dɛn de chɛk mi bɔdi kansa, ɛn di we aw dɛn de chɛk ɔda kayn kansa?
• If mi tɛst sho se a gɛt di sik, wetin a fɔ du fɔ mek a nɔ gɛt sɔm kayn kansa?
• Di kayn tɛst we a du kin no ɔda jɛnɛtik muteshon?

I rili impɔtant fɔ mek yu no di ansa to dɛn kwɛstyɔn dɛn ya.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

di `BRCA` tεst na tεst we de luk fכ abnכmal chenj dεm, כ mכtεshכn dεm, na di jin dεm `BRCA1` εn `BRCA2`. If di rizɔlt fayn, dat min se yu gɛt ay risk pas di avɛrej pɔsin fɔ gɛt bɔdi, ovarian, ɛn sɔm ɔda kayn kansa.

Bɔt, di impɔtant tin, fɔ no se yu gɛt BRCA jin muteshɔn de alaw yu fɔ tek stɛp fɔ ridyus yu risk ɛn fɔ mek yu nɔ gɛt kansa.Dɔn bak, dis infɔmeshɔn kin rili impɔtant to yu famili. So, nɔr frayd fɔ tɔk to yu dɔktɔ ɔr jenɛtik kɔlnɔ bɔt dis, ɛn ɔndastand gud gud wan if yu nid dis tɛst ɛn if na so, aw fɔ go bifo wit di rizɔlt.

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