Imajin se sɔmbɔdi we yu sabi, sɔntɛm na yu fambul, de gɛt tritmɛnt fɔ kansa. Ɛspɛshali wit wan pan di bɛst tritmɛnt dɛn we de tide. Afta sɔm dez we dɛn bigin fɔ tek tritmɛnt, dɛn kin gɛt ay fiva wantɛm wantɛm, dɛn bɔdi kin at, ɛn dɛn kin fil lɛk se dɛn gɛt bad kol. Bɔku tɛm wi kin tink se dis na jɔs nɔmal sayd ɛfɛkt we di tritmɛnt kin gɛt. Bɔt dis kin bi sayn fɔ sɔntin we rili siriɔs. Dis na wan mεdikal kכndyushכn wae wi kin kכl Cytokine Release Syndrome (CRS) .
Fɔ tɔk am simpul wan, wetin na CRS?
Fɔ ɔndastand dis, lɛ wi tink fɔs bɔt di we aw wi bɔdi de fɛt di sik. I tan lɛk ami we de protɛkt wi kɔntri. Dis ami gɛt mɛsenja dɛn we de kɔmyuniket mɛsej bitwin in sojaman dɛn (immune cells). Semweso, spɛshal prɔtin dɛn de we de ɛp wi imyun sɛl dɛn fɔ tɔk to dɛnsɛf ɛn kɔntrol di wok we dɛn de du, we dɛn kɔl saytokɛn . Dɛn tin ya impɔtant fɔ mek di bɔdi gɛt wɛlbɔdi.
Bɔt sɔntɛnde, mɔ wit sɔm tritmɛnt dɛn fɔ kansa, lɛk immunotherapy , wi imyun sistɛm kin wok pasmak. Dis kin mek dɛn mɛsenja dɛn ya we dɛn kɔl saytokin dɛn kɔmɔt wantɛm wantɛm na di blɔd. I tan lɛk se ami de go fɛt-fɛt ɛn sɛn bɔku bɔku mɛsej dɛn wan tɛm. sכmtεm dεn kin kכl dis "saytokin stכm." we bכku saytokכn dεm kכmכt wan tεm, i de mek di bכdi inflameshn. Na dat wi de kɔl CRS.
Wetin na di men tin dɛn we kin mek pɔsin gɛt CRS?
Di men ɛn kɔmɔn tin we kin mek pɔsin gɛt CRS na sɔm pan di mɔdan tritmɛnt dɛn we dɛn kin yuz fɔ kansa.
- Immunotherapy: Dis na di tin we kin mek pɔsin gɛt dis sik. Tritmεnt dεm lεk CAR-T sεl tεrapi εn bispεsifi k antibodi dεm de patikyular pan risk fכ CRS. Dɛn tritmɛnt ya kin mek wi yon imyun sistɛm ebul fɔ fɛt di kansa sɛl dɛn. pan dis prכsεs, di imyun sistεm kin bi ova aktif sכmtεm.
- Ɔda tin dɛn we kin mek dɛn gɛt dis sik: Pipul dɛn we gɛt sɔm kayn jɛnɛtik kɔndishɔn ɔ ɔtoimyun sik kin gɛt mɔ risk bak. fכ egzampl, wan jεnεtik kכndyushכn we dεn kכl Hεmophagocytic lymphohistiocytosis (HLH) .
Wetin na di poshubul simptom dɛm fɔ CRS?
Di sayn dɛm fɔ CRS kin tan lɛk di wan dɛm wae de kam wit kɔmɔn kol, so sɔmtɛm i kin at fɔ no. Bɔt dɛn sik ya kin tranga bak kwik kwik wan.
| Di sayn we de sho se di sik de | Tɔk bɔt |
|---|---|
| Ay fiva ɛn kol | Dis na di fɔs sayn wae dɛn kin si bɔrku tɛm. |
| Kɔnfyushɔn ɛn diziz | Di tin dɛn we kin apin to di bren kin mek pɔsin kɔnfyus ɛn nɔ kin mɛmba tin igen. |
| Nɔs ɛn vɔmit | dis simptom dεm kin apin bikoz fכ di ifekt dεm pan di dijestiv sistεm. |
| Bɛlɛ de at/dayarɛa | Flatulence na ɔda sayn we kin apin. |
| Ɛd we de at ɛn bɔdi we de at | Pen kin apin na di jɔyn ɛn mɔsul dɛn, we tan lɛk dengue fiva. |
| Skin rash we de kɔmɔt na di skin | Sɔm pipul dɛn kin gɛt rɛd spat na dɛn skin. |
| I nɔ izi fɔ swɛla | Trot we de at kin mek i nɔ izi fɔ swɛla. |
| Wok tranga wan | Fɔ fil se yu taya pasmak fɔ du ɛnitin. |
Aw siriɔs dis tin kin bi?
CRS na wan sik wae kin de frɔm wae nɔr kin pasmak to wae kin mek pɔrsin in layf de pan denja. Di inflamɛns we pasmak ɔlsay na di bɔdi kin pwɛl di men ɔgan dɛm lɛk di kidni, liva, lɔng, ɛn at.
Di tin we impɔtant pas ɔl na fɔ no dis sik kwik ɛn bigin fɔ trit am, ɔdasay siriɔs kɔmplikeshɔn kin apin.
Dis na sɔm pan di siriɔs prɔblɛm dɛn we kin apin:
- Efεkt dεm pan di at: Cardiomyopathy εn hat fεil kin kam.
- di ifekt dεm pan di lכng dεm: di lכng fεil εn di bכdi כksijεn lεvεl dεm kin rili lכw.
- Kidni ɛn Liva we nɔ de wok fayn: If dɛn ɔgan ya pwɛl, dat kin mek dɛn nɔ de wok igen.
- Capillary leak syndrome: Fluid we de lik kɔmɔt na smɔl smɔl blɔd vesel dɛn kin mek blɔd prɛshɔn go dɔŋ bad bad wan.
Aw dɔktɔ dɛn kin fɛn dis?
Di mɛdikal tim we de trit yu rili no bɔt CRS, so if yu de gɛt tritmɛnt lɛk imyunotɛrapi, dɛn go de wach yu sik dɛn gud gud wan.
If di sik sho, di dɔktɔ go ɔda fɔ du bɔku tɛst fɔ no if pɔsin gɛt di sik.
- Kɔmplit Blɔd Kɔnt (CBC): I de wach di chenj dɛn we de apin na di blɔd sɛl dɛn.
- di saytokin lεvεl dεm: Mek yu mכsu di כmכnt כf saytokכn dεm na di bכdi.
- C-reactive protein test (CRP): Dis tεst de εp fכ mכsu di lεvεl fכ inflameshn na di bכdi.
- Fɔ chɛk aw di kidni ɛn di liva de wok: Fɔ no if dɛn ɔgan ya dɔn pwɛl.
Dipen pan aw di sik bad, dɔktɔ dɛn kin put am na Gret 1 to 4. Di mɔ di nɔmba bɔku, na di mɔ di sik siriɔs. Dɛn kin no dis stej bay we dɛn tink bɔt tin dɛn lɛk fiva, blɔd prɛshɔn, ɔksijɛn lɛvɛl, ɛn di ɔgan dɛn we de wok.
Wetin na di tritmɛnt dɛm fɔ CRS?
Di tritmɛnt de dipen pan aw yu sik bad bad wan. Fɔ di kes dɛm wae nɔr kin pasmak, simpul tin dɛm lɛk mɛrɛsin wae de ridyus fiva kin inof. Bɔt if di sik rili bad, dɛn kin nid fɔ gɛt mɔ spɛshal tritmɛnt.
| Di we aw dɛn kin trit am | Wetin kin apin? |
|---|---|
| Kɔtikosterɔyd dɛn | I de kɔntrol di inflamɛns we pasmak na di bɔdi ɛn di wok we di imyun sistɛm de du. |
| Drug dεm we de tכk bכt spεsifi k saytokεn dεm | tכgεt εn blכk כva prodyuz saytokεn dεm. Fɔ ɛgzampul: tosilizumab, siltuximab, anakinra. |
| Sɔpɔtiv Keya | Gi mɛrɛsin fɔ mek yu blɔd prɛshɔn go dɔŋ, gi am ɔksijɛn, ɛn yuz mashin we de mek yu blo if nid de. |
Ustɛm a fɔ go to dɔktɔ?
Dis na di pat we impɔtant pas ɔl.
If yu de tek imyunotɛrapi fɔ kansa, ɛn yu gɛt fiva ɔ ɔda CRS simptom (lɛk joyn pen, kɔnfyushɔn) afta yu dɔn trit yu, i nɔ fayn fɔ delay am ivin smɔl.
Dis sik kin kam siriɔs kwik kwik wan. So, tɛl yu dɔktɔ ɔ ɔspitul wantɛm wantɛm. Di kwik we yu bigin fɔ tek tritmɛnt, na di mɔ yu go gɛt siriɔs prɔblɛm dɛn.
E fayn fɔ ɔndastand fɔ fil frayd ɛn pwɛl hat fɔ yɛri bɔt sɔmtin lɛk dis wae yu de fɛt kansa. Bɔt mɛmba se di mɛdikal tim we de trit yu rili sabi CRS. Dɛn de wach yu gud gud wan. Nɔ fred fɔ tɛl dɛn bɔt ɛni chenj na yu bɔdi, ivin di smɔl smɔl wan dɛn. Wit yu sɔpɔt, dɛn kin mɛn dis kɔndishɔn bifo i siriɔs.
Mɛsej we dɛn kin kɛr go na os
- CRS na siriɔs sik we di imyun sistɛm we de wok pasmak kin kam wit. I kin apin, mɔ afta dɛn dɔn gɛt imyunotɛrapi tritmɛnt fɔ kansa.
- Di sayn dɛm kin bigin lɛk kɔmɔn kol, bɔt kin kam tranga kwik kwik wan. Di men sayn dɛm na wae yu kin gɛt ay fiva, yu kin kol, ɛn yu kin kɔnfyus.
- If yu de tek imyunotɛrapi, tɛl yu dɔktɔ wantɛm wantɛm if yu gɛt fiva ɔ ɔda tin dɛn we nɔ kɔmɔn.
- Dɛn gɛt fayn tritmɛnt dɛn fɔ CRS. If yu trit yu kwik kwik wan, dat kin mek yu nɔ gɛt siriɔs prɔblɛm dɛn.
- Mek yu mɛdikal tim no bɔt dis. Tɔk wit dɛn opin wan bɔt di tin dɛn we de mɔna yu ɛn di sayn dɛn we yu gɛt.
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