Yu dɔn ɛva wɔnda wetin go apin if di "ami" we de insay wi bɔdi, we dɛn se de protɛkt wi frɔm sik, sɔm tɛm dɛn go rɔng ɛn bigin fɔ atak wi yon ɔgan dɛn we gɛt wɛlbɔdi? Dat na di unfortunate, bot akchuali difren tin we wi go tok abaut tide. If na so i bi, wi imyun sistɛm, we na di difɛns ami, kin bigin fɔ atak wi liva fɔ natin. Dis na wetin wi kin kɔl Autoimmune Hepatitis na mɛrɛsin.
Fɔ tɔk am simpul wan, wetin na Autoimmune Hepatitis?
Imajin se ami de we de protɛkt wi kɔntri. Di wangren wok we da ami de du na fɔ protɛkt di kɔntri frɔm ɛnimi dɛn we de na do (i.e. jem dɛn lɛk vayrɔs ɛn baktri dɛm). Wi bɔdi in imyun sistɛm tan lɛk dat. I de wach ɔltɛm, de luk fɔ ɛn pwɛl di jem dɛn we de kam insay di bɔdi.
Bɔt, insay Autoimmune Hepatitis, sɔntin we rili strenj kin apin. sכmtin de go rכng wit dis imyun sistεm εn i de rεkכgnεz wi כwn liva sεl dεm as "εnεmi." Dɔn dis ami ɔ antibodi dɛn kin bigin fɔ atak wi inosɛnt liva sɛl dɛn jɔs lɛk aw dɛn kin atak fɔrina ɛnimi dɛn.
We dɛn kɔntinyu fɔ atak di liva dis kayn we, i kin swel ɛn inflam. Wi kin kɔl dis epataytis. As tɛm de go, dis damej kin bɔku ɛn mek di liva pwɛl bad bad wan.
Di impɔtant tin na dat, pan ɔl we dɛn nɔ gɛt kɔmplit mɛrɛsin fɔ dis, if dɛn tek di rayt tritmɛnt, dɛn kin kɔntrol dis sik fayn fayn wan, we kin mek di liva nɔ pwɛl ɛn liv wɛlbɔdi layf. Na if dɛn nɔ trit am, na in i kin bi denja.
Dis nɔto sik we bɔku pipul dɛn kin gɛt. Stɔdi dɔn sho se pan ɛvri 100,000 pipul dɛn, bitwin 10 ɛn 50 pipul dɛn kin gɛt dis sik.
Yu tink se men kayn ɔtoimyun ɛpatitis de?
Yɛs, tu men kayn dɛn de. Dɛn tu kayn ya difrɛn bay di kayn antibodi dɛm we wi imyun sistɛm de mek. Dis kin kɔmplikt smɔl, bɔt i fayn fɔ no if yu dɔktɔ tɔk bɔt am.
| Kayn | Udat dɛn kin afɛkt mɔ? | Spɛsifi k antibodi dɛn we rili impɔtant |
|---|---|---|
| Tayp 1 | Dis na di kayn we we pipul dɛn kin gɛt mɔ. I kin kam pan ɛnibɔdi, bɔt i kin bɔku pan uman dɛn we nɔ rich 40 ia yet. | Anti-smooth muscle antibodies (anti-SMA) ɛn sɔm ɔda wan dɛn. |
| Tayp 2 we de na di wɔl | Dis nɔ kin apin so ɔltɛm, bɔt i kin tranga smɔl pas tayp 1. Dɛn kin no am we dɛn smɔl. | Anti-liva-kidni maykrosɔm-1 (anti-LKM-1) antibodi dɛn. |
Wetin na di sayn dɛm fɔ dis sik?
Wan tin bɔt dis na dat nɔto ɔlman kin gɛt di sik. Sɔntɛm yu nɔ go ivin no se yu gɛt am. Yu dɔktɔ kin si am bay chans we yu de du blɔd tɛst fɔ ɔda sik. Fɔ sɔm pipul dɛm, di sayn dɛm kin apia afta di liva wok bigin fɔ afɛkt.
If yu gɛt sɔm sayn dɛn, di fɔs tin we yu go notis na we yu taya we yu nɔ ebul fɔ ɛksplen. Yu kin fil taya ivin afta yu dɔn slip ɔl di de.
Apat frɔm dat, yu kin si dɛn sayn ya bak:
- Di skin ɛn yay we de yɔlɔ (Jaundice) .
- Fɔ skrach di skin
- Di we aw difrɛn skin rash dɛn kin apia
- Pen na di jɔyn dɛn
- Bɛlɛ de at
- Nɔs ɛn vɔmit
- Fil fɔ it
- Dak urine (lɛk di kɔlɔ fɔ ti wata) .
- Pale ɔ grey stɔl dɛn
Wetin mek dis kayn sik kin apin?
Di wan dɛn we de stɔdi bɔt dis stil nɔ no di rayt tin we kin mek i apin. Bɔt wi no se na sik we pɔsin kin gɛt we i de fɛt insɛf. Dat min se na sɔntin we nɔ rayt na wi imyun sistɛm de mek am. Bɔku tin dɛn de we dɛn tink se kin mek i apin:
- Jɛnɛtik prɛdispɔzishɔn: Sɔm pipul dɛn gɛt jɛnɛtik prɛdispɔzishɔn fɔ gɛt ɔtoimyun sik dɛn. Dis min se if pɔsin na yu famili gɛt am, yu kin gɛt smɔl chans bak fɔ gɛt am.
- Vayral infεkshכn: If yu bin dכn gεt vayral infεkshכn lεk Epstein-Barr, hεpi, parvovirus B19, כ epataytis A, B, כ C, i kin "aktivet" di imyun sistεm εn mek i nכ wok fayn dis we.
- Di tin dɛn we de apin na di envayrɔmɛnt: Sɔm pɔyzin ɔ ɔda tin dɛn we kin apin na di envayrɔmɛnt kin mek di imyun sistɛm wok pasmak.
- Sɔm mɛrɛsin dɛn:Na smɔl tɛm nɔmɔ, sɔm mɛrɛsin dɛn (fɔ ɛgzampul, nitrofurantoin, minocycline, ɛn atorvastatin) kin mek dis sik apin.
I rili impɔtant: Nɔ stɔp fɔ tek ɛni mɛrɛsin we yu dɔn ɔlrɛdi de tek wantɛm wantɛm jɔs bikɔs yu si dis mɛrɛsin. I kin denja. If yu gɛt ɛni dawt, tɔk to yu dɔktɔ fɔs ɛn fala in advays.
Yu tink se ɔtoimyun Ɛpataytis kin pas?
Nɔ, nɔto so atɔl. Dis nɔto sik we pɔsin kin pas. Di kayn epataytis we vayrɔs lɛk Epataytis A, B, ɛn C kin kam wit kin kɔmɔt frɔm wan pɔsin to ɔda pɔsin. Bɔt Ɔtoimyun Ɛpataytis na wan tin we kin apin insay wi bɔdi. So, if yu tɔch pɔsin we gɛt dis sik, ɔ sheb it ɔ drink wit am, yu nɔ go gɛt dis sik pan ɛni we.
Udat de pan denja fɔ gɛt dis sik?
Stɔdi dɔn sho se dis sik kin bɔku pan uman dɛn. Frɔm 10 pasɛnt dɛn, 7 na uman dɛn. Dɔn bak, dis sik kin apin mɔs pan di ej grup bitwin 15 ɛn 40 ia.
Apat frɔm dat, pɔsin we dɔn ɔlrɛdi gɛt ɔda ɔtoimyun sik kin gɛt bɔku risk fɔ gɛt Ɔtoimyun Ɛpataytis.
| Ɔda Ɔtoimyun Sik dɛn we gɛt fɔ du wit Ɔtoimyun Ɛpataytis |
|---|
| Tayp 1 dayabitis |
| Ulcerative colitis (ɔlsa na di big intestinal) . |
| Siliak sik (wan alɛji fɔ gluten) . |
| Vitiligo (wayt pat na di skin) . |
| Sjögren’s syndrome (na sik wae de mek yu yay ɛn yu mɔt dray) . |
| Graves’ disease (wan tayroyd gland we de wok pasmak) . |
| Rimatɔyd at at sik |
Wetin na di prɔblɛm dɛn we kin apin if dɛn nɔ trit dɛn?
Dis na di say we wi ɔl nid fɔ pe atɛnshɔn. If dɛn nɔ trit di Autoimmune Hepatitis fayn, di damej we de na di liva kin go ɔp smɔl smɔl ɛn i kin mek i gɛt siriɔs prɔblɛm dɛn.
- Sirosis: We di liva dɔn pwɛl as tɛm de go, di liva sɛl dɛn we gɛt wɛlbɔdi kin tek ples fɔ di ska tisu. Di liva kin at lɛk rɔk. Dis kin mek i nɔ ebul fɔ du in wok fayn fayn wan.
- Liva nɔ de wok fayn: We sirosis kam tranga, di liva kin stɔp fɔ wok kpatakpata. Dis kin mek pɔsin in layf de pan denja.
- Liva kansa: Pipul dɛm wae gɛt sirosis kin gɛt bɔrku risk fɔ gɛt liva kansa.
- Varicose veins: We di blɔd nɔ de flɔ tru di liva, di prɛshɔn we de na di veins na di esophagus ɛn bɛlɛ kin go ɔp ɛn dɛn kin swel. If dɛn tin ya brok, dɛn kin mek yu blɔd bad bad wan.
- Asita: We di liva nɔ de wok fayn, wata kin bigin fɔ gɛda na di bɛlɛ.
Aw dɔktɔ dɛn kin no bɔt dis sik?
If yu gɛt dɛn sik ya ɔ if tɛst fɔ ɔda rizin sho se yu gɛt prɔblɛm wit yu liva, yu dɔktɔ kin tink se dis sik de. di diagnostik prכsεs involv sεvεra stεp dεm.
1. Aks yu fɔ di ditel: De dɔktɔ go aks yu bɔku kwɛstyɔn bɔt yu sik, if ɛnibɔdi na yu famili gɛt dis sik, di mɛrɛsin dɛn we yu de tek, ɛn if yu de drink rɔm.
2. Fɔ chɛk yu bɔdi: Dɛn go chɛk yu yay ɛn yu skin fɔ si if yu yɔlɔ (jaundice), dɛn go chɛk yu bɛlɛ fɔ si if di liva ɔ splin dɔn swel, wata we de na yu bɛlɛ, ɛn yu leg dɛn dɔn swel.
3. Spɛshal tɛst: Dɛn kin du bɔku tɛst fɔ no if pɔsin gɛt di sik.
| Tɛst | Wetin yu si pan dis? |
|---|---|
| Blɔd tɛst dɛn | Mek shɔ se nɔr ɔda sik nɔ de we de afɛkt di liva, lɛk vayral ɛpatitis. |
| Tɛst dɛn we di liva de wok | Chek di lɛvɛl dɛn na yu liva ɛnzaym. We di liva pwɛl, dɛn ɛnzaym dɛn ya kin gɛda na di blɔd. |
| Antibodi tɛst dɛn we dɛn kin du | chεk di bכdi fכ spεshal antibodi dεm (lεk anti-SMA, anti-LKM-1) we de atak wi כwn sεl dεm. |
| Skan dɛn | Ɔltra saund, CT skan, ɔ MRI skan kin chɛk di shep, saiz, ɛn if ɛnitin dɔn pwɛl di liva. |
| Liva bayɔpsi (we dɛn de chɛk wan smɔl pat pan di liva) . | Dis na de test wae de konfam de sik 100% of de taim. Dɛn kin tek wan rili smɔl pat pan di liva wit smɔl nidul ɛn chɛk am ɔnda maykroskɔp. Dis kin mek wi no gud gud wan aw di sik kin tranga. |
Wetin na di tritmɛnt dɛm fɔ dis?
di men gol fכ tritmεnt na fכ kכntrכl di ova aktiv imyun sistεm εn stכp di damej pan di liva. Dɛn kin yuz tu men kayn drɔgs fɔ dis.
1. Kɔtikosterɔyd dɛn
Dis na sterɔyd mɛrɛsin dɛn. Dɛn kin wok bay we dɛn kin ridyus di inflamɛns na di bɔdi kwik kwik wan. Yu dɔktɔ go stat yu pan ay doz ɛn smɔl smɔl i go ridyus di doz as yu kɔndishɔn de bɛtɛ. Di mɛrɛsin we dɛn kin yuz mɔ na prɛdnison . Pan ɔl we dis kin wok fayn fɔ bɔku pipul dɛn, i kin mek sɔm bad bad tin dɛn apin. Ɔda tin dɛn de we yu kin du, lɛk budesonide , bɔt dɛn nɔ fayn fɔ pipul dɛn we gɛt sirosis.
2. Di tin dɛn we de mek di bɔdi nɔ ebul fɔ fɛt di sik
As di nem sho, dɛn mɛrɛsin ya de wok bay we dɛn de stɔp di imyun sistɛm, we min se dɛn de slo am. Dɛn kin bigin dɛn di sem tɛm wit stɛroyd, ɔ gi dɛn afta dɛn dɔn ridyus di stɛroyd doz. Azathioprine ɛn CellCept® na tu pan di mɛrɛsin dɛn we dɛn kin yuz mɔ.
Bikɔs dɛn nɔ gɛt bɛtɛ sayd ɛfɛkt pas stɛroyd, dɛn kin yuz dɛn as tritmɛnt fɔ lɔng tɛm. Yu kin nid fɔ tek dɛn mɛrɛsin ya wan wan tɛm insay yu layf.
Aw lɔng i kin tek fɔ si di rizɔlt frɔm di tritmɛnt?
Di ɔltimat gol fɔ tritmɛnt na fɔ gɛt rɛmishɔn, we min se ɔl di simptom ɛn di tɛst rizɔlt go kam bak to nɔmal. Dis kin tek mɔnt ɔ ivin ia fɔ mek dɛn ebul fɔ du am.
If di sik dɔn de fɔ at le tu ia, di dɔktɔ kin disayd fɔ stɔp di mɛrɛsin. Bɔt afta dɛn dɔn stɔp di tritmɛnt, chans de fɔ mek di sik kam bak (relaps). Na lɛk 50% pan di pipul dɛm wae kin go na remission go gɛt de sik kam bak ɛn gɛt fɔ stat di mɛrɛsin bak.
Fɔ sɔm pipul dɛn, di sik nɔ kin dɔn ɔltogɛda wit mɛrɛsin. If na so i bi, di dɔktɔ go tray fɔ tek ɔda kayn mɛrɛsin. Na smɔl tɛm nɔmɔ, sɔm sik pipul dɛn nɔ kin ansa di tritmɛnt atɔl. If di sik kam tranga ɔ bad bad tin kin apin, di las tin we dɛn kin du na fɔ transplant di liva .
Aw di tumara bambay go tan lɛk fɔ pɔrsin wae gɛt dis sik?
Dis na prɔblɛm we bɔku pipul dɛn gɛt. Di tru tin na dat, if dɛn nɔ trit dis sik, i denja. If dɛn nɔ trit am, lɛk 50% pan di sik pipul dɛn kin day insay 5 ia.
Bɔt, wit di rayt tritmɛnt, di tin kin difrɛn atɔl. 91% pan di wan dɛm wae de gɛt tritmɛnt stil de alayv afta 10 ia. 70% stil de alayv afta 20 ia. Dat min se wit tritmɛnt, yu kin liv fayn fayn layf, fɔ lɔng tɛm.
Fɔ liv wit wan sik wae nɔr de dɔn lɛk dis kin tranga pan aw pɔrsin de fil. Bɔt if yu no di tritmɛnt dɛn we yu go gɛt ɛn wok togɛda wit yu dɔktɔ, yu go ebul fɔ kɔntrol yu wɛlbɔdi. Tritmɛnt we yu no bɔt, we yu dɔn mekɔp yu maynd fɔ du na di bɛst we fɔ mek yu gɛt bɛtɛ tin fɔ du tumara bambay.
Mɛsej we dɛn kin kɛr go na os
- Awtoimyun Epataytis na sik wae yu yone imyun sistεm de atak yu liva. Nɔto vayrɔs de kam wit am ɛn i nɔ de pas frɔm pɔsin to ɔda pɔsin.
- Taya we yu nɔr ɛksplen ɛn jaundice na kɔmɔn sayn dɛm, bɔt sɔm pipul dɛm nɔr kin gɛt ɛni sayn atɔl.
- Pan ɔl we no kɔmplit mɛrɛsin nɔ de fɔ dis, mɛrɛsin kin kɔntrol di sik fayn fayn wan ɛn mek di liva nɔ pwɛl mɔ.
- Tritmɛnt na tin we kin tek lɔng tɛm. Nɔ ɛva stɔp fɔ tek yu mɛrɛsin ɔ chenj di doz if yu dɔktɔ nɔ advays yu.
- If yu trit yu fayn ɛn ɔltɛm, yu kin liv lɔng, wɛl bɔdi, ɛn gladi at wit dis sik.
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