Lɛ wi tɔk bɔt Ɔtofaji: Di ​​Bɔdi in Nɛchɔral ‘Rɛsaykul’ Prɔses!

Yu dɔn ɛva wɔnda aw di trilyɔn sɛl dɛn we de insay wi bɔdi kin kɔntinyu fɔ wok fayn fɔ lɔng lɔng tɛm? Jɔs lɛk motoka, as tɛm de go, sɔm pat dɛn na wi sɛl dɛn kin ol, pwɛl, ɛn nɔ gɛt wan yus. So wetin de apin to dis ‘garbage’ we dɔn gɛda? Aw wi bɔdi kin klin insɛf pan dis? na de wi spika, di fayn fayn tin we dεn kכl Autophagy (dεn kin pronounce auto-phagy), de kam in. Dis impɔtant fכ di hεlth fכ wi bכdi. Tide, wi go tɔk bɔt dis simpul wan, di we we yu go ɔndastand.

Wetin na ɔtofaji simpul wan?

Fɔ tɔk am simpul wan, ɔtofagi na wan we we di sɛl dɛn na wi bɔdi kin klin ɛn mek dɛnsɛf fayn. I tan lɛk se wi de pul di dɔti we kin gɛda na wi os ɛvride ɛn risaykul di tin dɛn we wi kin yuz.

Tink bɔt yu os. Wetin wi kin du we wi gɛda ol tin dɛn, chia dɛn we dɔn brok, ɛn pepa dɛn we nɔ gɛt yus? Sɔm pan dɛn wi kin trowe, sɔm wi kin tek di gud pat dɛn ɛn mek nyu tin. כtofagi na wan kayn ‘dip klin’ εn ‘risaykul’ we de apin insay wi sεl dεm.

כl di tisu εn כgan dεm na wi bכdi na di bεs bildin blכk dεm we dεn kכl sεl dεm. Insay ɛni sɛl, bɔku smɔl smɔl pat dɛn de we de ɛp am fɔ du in wok. As tɛm de go, sɔm pan dɛn pat ya nɔ de wok fayn, dɛn kin pwɛl, ɔ dɛn kin bi ‘dɔti’ we nɔ gɛt yus. di prכsεs fכ כtofagi de sכk dεn yusles pies dεm ya, brok dεm dכn, εn tek di tin dεm we yu kin yuz frכm dεm fכ bil nyu pat dεm fכ di sεl. I de pul di pat dɛn we nɔ gɛt yus.

Wetin mek ɔtophagy impɔtant to wi bɔdi?

Ɔtofaji nɔto jɔs fɔ klin. I impɔtant fɔ mek wi sɛl dɛn kɔntinyu fɔ liv ɛn gɛt wɛlbɔdi. Bɔku men rizin dɛn de fɔ dis:

• Risaykul pat dɛn we dɔn pwɛl: Dɛn kin tɔn ol pat dɛn na di sɛl we nɔ de wok fayn to nyu pat dɛn we de wok. I tan lɛk se yu de mɛlt ol mɛtal fɔ mek nyu tin. dis min se di sεl nכ nid fכ tek di raw mεtirial dεm we i nid fכ mek nyu pat dεm.
• Fɔ pul di pat dɛn we nɔ nid: Di sɛl de pul di pat dɛn we nɔ gɛt yus we de tek ples ɛn we de ambɔg in wok. dis de mek di sεl de wok bכku bכku wan.
• Protεkshכn frכm infεkshכn: כtofagi de εp bak fכ fכn εn pwεl di patogen dεm lεk vayrus εn baktri dεm we de kam insay wi sεl dεm. Na impɔtant pat pan wi imyun sistɛm.
• Fɔ kɔntrol di ol we pɔsin de ol:As wi de ol, dis Autophagy prכsεs de slo dכn. Dɔn, ‘dɔti’ kin bigin fɔ gɛda insay di sɛl dɛn. Dis kin mek di sɛl dɛn kin stɔp fɔ wok fayn fayn wan. Dat na wan rizin we mek di risk fɔ gɛt sik dɛn kin bɔku as wi de ol. dεn biliv se fכ mεnten di כtofagi prכsεs fayn fayn wan de εp wi fכ hεlth εn yכng.

Aw dis prɔses we dɛn kɔl Ɔtofagi kin apin?

Di nem kin tan lɛk se i kɔmplikt smɔl. Di wɔd ɔtofagi na tu Grik wɔd dɛn.

• "Autos" min 'sɛf'.
• "Phagomai" min 'fɔ it'.

Dat min se ‘fɔ it insɛf.’ wetin di sεl de rili du na fכ ‘it’ in yon pat dεm we i nכ want εn klin insεf.

Dis prɔses kin apin lɛk dis:

1. Fɔs, di sɛl de no di pat dɛn we dɔn pwɛl ɔ we i nɔ want insay insɛf.

2. afta dat, wan spεshal 'bag' we dεn kכl ``Autophagosome'' de fכm rawnd dεn pies dεm fכ doti. Dis kin tan lɛk we wi gɛda di dɔti ɛn put am na dɔti bag.

3. nεks, dis ‘garbage bag’ de go na wan pat pan di sεl we dεn kכl `(Lysosome)`. `(Lysosome)` na lεk di `(Recycling Centre)` na di sεl.

4. pawaful εnzym dεm we de insay dis sεntrכm de daygεst di west, כ brok am dכn to sכm sכm pat dεm.

5. afta dεn dכn brok dכn dis we, di yusful raw mεtirial dεm (fכ egzampl, amino asid dεm) de yuz di sεl bak. dεn kin yuz dεn tin ya fכ mek nyu protin dεm εn nyu pat dεm we di sεl nid.

Dis we ya, di sɛl de yuz in yon tin dɛn fɔ mek i klin ɛn gɛt wɛlbɔdi.

Ustɛm di ɔtofagi prɔses de bigin?

כtofagi na sכmtin we de apin כltεm na sכm lεvεl na wi sεl dεm. Bɔt insay sɔm spɛshal kes dɛn, dis kin apin kwik kwik wan.

Fɔ tɔk am simpul wan, dis kin apin kwik kwik wan we di sɛl dɛn gɛt strɛs. Sɔm pan de men we dɛn we dis strɛs kin apin na:

• Nutritional deficiency: We di sεl dεm nכ de gεt di nyutriεnt dεm we dεn nid.
• כksijεn we de kכmכt: We di כksijεn we de rich di sεl dεm de dכn.
• Sεl dεm we dεn dכn pwεl: We di sεl dεm dכn pwεl bikoz fכ infεkshכn, tכxin, כ כda tin.

Imajin se yu de na say we yu nɔ gɛt tin fɔ it ɔ drink. Wetin yu de du? Yu kin yuz di tin dɛn we yu gɛt fayn fayn wan, nɔto so? Sɛl dɛn tan lɛk dat. We it nɔ kɔmɔt na do, dɛn kin ‘it’ ol, pat dɛn we nɔ nid insay dɛnsɛf fɔ mek ɛnaji ɛn raw matirial fɔ mek dɛn liv. Dis na Ɔtofaji. in ɔda wɔd dɛn, dis na wan impɔtant tin we rili impɔtant fɔ mek wan sɛl kɔntinyu fɔ liv.

Wi kin stimulate Autophagy we wi want?

Yɛs, risach dɔn sho se we wi mek sɔm chenj dɛn na wi layf ɛn gi kɔntrol strɛs to di sɛl dɛn, wi kin mek di ɔtofagi prɔses go bifo. Bɔku men we dɛn de fɔ du dis.

Wan wɔnin we rili impɔtant!

Bɔt na wan tin we rili impɔtant. fכ fala dεn mεtכd ya fכ stimulate Autophagy nכto gud tin fכ כlman. Dɔn bak, dis nɔto fayn tin fɔ du if yu nɔ gɛt dɔktɔ advays.

Fɔ ɛgzampul,

• Mama dɛn we gɛt bɛlɛ
• Mama dɛn we de gi pikin in bɛlɛ
• Pipul wae gɛt krɛse sik lɛk dayabitis
• Di wan dɛn we de du tritmɛnt fɔ ɔda mɛrɛsin

Fast ɔr nɔr gɛt bɛtɛ kalori kin denja fɔ dɛn pipul ya, ɛn i nɔr fayn bak fɔ bigin fɔ ɛksesaiz tranga wan wantɛm wantɛm if yu nɔr gɛt dɔktɔ advays.

Wetin na di rilayshɔn bitwin ɔtofagi ɛn sik?

sayɛnsman dεm bin de tink se כtofagi na jכs wan prכsεs we de tek kia fכ di sεl dεm in ‘haus kipin’. Bɔt di risach we dɛn jɔs dɔn du dɔn sho se i de ple impɔtant pat bak fɔ mek dɛn nɔ gɛt sik ɛn fɛt am.

wan dεfisiεns כ abnכmaliti na di כtofagi prכsεs kin kכnεkt wit difrεn sik kכndishכn dεm. Fɔ ɛgzampul:

• Dis sik we dɛn kɔl Parkinson
• Wan sik we dɛn kɔl Huntington
• Shuga
• At sik
• Di sik we dɛn kɔl Crohn in sik
• Kidni ɛn Liva sik

Awtofagi gɛt tu tin dɛn we i kam pan kansa. sכm stכdi dεm sho se we dis prכsεs de go fayn, i de mek di ‘garbage’ nכ de kam insay di sεl dεm, we de pwεl DNA εn mek kεnsar nכ fכm. In ɔda wɔd, i de wok lɛk difens sistɛm we de mek kansa nɔ fɔm.

Bɔt, na di ɔda say, dɛn dɔn si se afta kansa dɔn bigin, ɔtofagi kin gi di kansa sɛl dɛn tin fɔ it, ɛn i kin ɛp dɛn fɔ liv ɛn gro bɛtɛ.

So, bɔku risach stil de go bifo pan dis eria. Bɔku pan di risach we dɛn de du naw, dɛn nɔ dɔn du am pan mɔtalman. Dɛn dɔn du am pan animal dɛn lɛk mays. So, i stil tu ali fɔ tɔk fɔ tru aw dɛn go yuz ɔtofagi as tritmɛnt fɔ sik dɛn.

Naw, sɔm pipul dɛn de si Ɔtofaji as ‘mɛjik’ fɔ de yɔŋ ɛn gɛt wɛlbɔdi. Bɔt di stori nɔ simpul so. na tru se כtofagi na imכtant prכsεs fכ hεlty sεl dεm. Na tru bak se we pɔsin nɔ gɛt bɛtɛ tin fɔ it na Ɔtofagi kin gɛt fɔ du wit sɔm sik dɛn. Bɔt nɔr inof sayɛns pruf de yet fɔ rεkomεnd fɔ stimulate Autophagy as strateji fɔ impɔtant wɛl bɔdi.