Yu want fɔ no bak bɔt dis sik we nɔ kin bɔku? Lɛ wi tɔk bɔt EGPA (Eosinophilic Granulomatosis With Polyangiitis) insay simpul wɔd dɛn!

Yu kin gɛt asma ɔltɛm? Ɔ yu na pɔsin we gɛt siriɔs alɛji? Dɔn wetin a go tɔk kin rili impɔtant to yu. Bikɔs tide wi go tɔk bɔt wan sik we rili strenj ɛn we nɔ kin bɔku we sɔm tɛm dɛn kin gɛt fɔ du wit dɛn kayn tin ya. Dɛn kɔl dis sik EGPA . Fɔs, dɛn bin de kɔl am Churg-Strauss syndrome . If i tan lɛk se di nem lɔng smɔl, nɔ wɔri, lɛ wi ɔndastand am simpul wan.

Wetin na EGPA (Eosinophilic Granulomatosis Wit Polyangiitis)?

Dis lɔng nem kin kɔnfyus smɔl, bɔt lɛ wi brok am to pat ɛn ɔndastand am. Dɔn i kin izi fɔ am fa fawe.

1. Eosinophilic we de mek pɔsin gɛt di sik

Fɔ tɔk am simpul wan, eosinophilic min se yu gɛt ay pas di nɔmal nɔmba fɔ wan kayn wayt blɔd sɛl we dɛn kɔl eosinophils na yu blɔd. Tink bɔt am dis we, di eosinophils tan lɛk smɔl smɔl gad dɛn na wi bɔdi, dɛn de ɛp wi imyun sistɛm . Bɔt pan pɔsin we gɛt EGPA, sɔntɛnde di nɔmba fɔ di eosinophils kin dubl, ɔ ivin pas di nɔmal nɔmba. Dis min se di imyun sistɛm de wok ova tɛm.

2. Granulomatosis we de mek pɔsin gɛt sik

Granulomatosis na wan kכndyushכn we di imyun sεl dεm de fכm sכm sכm sכm bכdi dεm na di bכdi in tisu dεm we inflameshn de, כ swεla. Wi kin kɔl dɛn lumps ya granulomas . Dis na di wok bak we di imyun sistɛm de du. I tan lɛk se yu de rawnd say we yu gɛt prɔblɛm ɛn tray fɔ stɔp am fɔ mek i nɔ skata.

3. Pɔlyangiitis we pɔsin kin gɛt

Polyangiitis na wan inflamɛns we kin de fɔ lɔng tɛm pan bɔku pan di blɔd vesel dɛm na yu bɔdi, mɔ di smɔl ɛn midul saiz wan dɛm (poly min bɔku). Na wan sik wae de pan wan big grup fɔ sik dɛm wae dɛn kɔl vasculitis . Angiitis na ɔda nem fɔ vaskulaytis.

So, ɔl dis we dɛn put togɛda, EGPA na wan kayn tin we nɔ kin apin so ɔltɛm we di imyun sistɛm nɔ de wok fayn we kin bigin wit asma ɔ alɛji, we kin mek di eosinofil dɛn bɔku, we kin mek granulomas, ɛn te go mek di blɔd vesel dɛn inflamɛns.

Aw dis EGPA kɔndishɔn kin afɛkt mi bɔdi?

We di blɔd vesel dɛn de kɔntinyu fɔ inflamɛns, we dɛn kɔl vasculitis , di wɔl dɛn na di blɔd vesel dɛn kin wik. dis kin mek dεn strεch εn bulge lεk balכn – we wi kכl aneurysm . Ɔ, dɛn blɔd vesel ya we wik kin bɔs ɛn blɔd go insay di bɔdi.

Wan ɔda tin na dat, if pɔsin inflamɛns, i kin mek di blɔd vesel dɛn swel, gɛt skata, ɛn smɔl insay. Wetin kin apin da tɛm de? Blɔd nɔ kin flɔ fayn, sɔntɛnde i kin ivin blok ɔl. Dis kin mek di bɔdi nɔ gɛt ɔksijɛn ɛn di tin dɛn we i nid fɔ mek i wok fayn fayn wan.

Bikɔs polyangiitis kin afɛkt di smɔl smɔl blɔd vesel dɛm ɔlsay na wi bɔdi, di sayn dɛm kin apin ɛnisay na di bɔdi. Bɔt i kin afɛkt di we aw pɔsin de blo , we min di lɔng dɛn. I kin afɛkt bak di kidni dɛm, di intestinal dɛm, di at, ɛn di nerv dɛm.

Wetin na di sayn dɛm fɔ EGPA?

Dis sik we dɛn kɔl EGPA nɔ kin apin wantɛm wantɛm. De sik kin kam smɔl smɔl, fɔ lɔng tɛm, insay sɔm stej dɛm. Lɛ wi si wetin na dɛn stej dɛn de.

Stej 1: Kɔmɔn sayn dɛm wae dɛn kin si na di fɔs stej dɛm

Insay dis tɛm yu kin fil tin lɛk:

• Asma we kin bigin fɔ big pipul dɛn: Ivin pɔsin we nɔ ɛva gɛt asma bifo kin gɛt nyu asma wit sɔm sayn dɛn lɛk fɔ kɔf, swɛt, ɛn i nɔ kin izi fɔ blo.
• Hay fiva: I kin kɔntinyu fɔ sniz, i kin it yu nos, ɛn yu nos kin rɔtin.
• Kronik Saynsaytis: Na filin fɔ ebi ɛn prɛshɔn na di ed bikɔs ɔf inflamɛns na di sayn dɛn we de na di sayn.
• Nasal polyps: Smɔl smɔl tin dɛn we nɔ gɛt kansa we de mek insay di nos.
• Jɛnɛral bɔdi pen: Fɔ fil lɛk se yu jɔyn dɛn de at, yu mɔsul dɛn de pen.
• Fiva, malaise, ɛn taya: Jɔs fil pen ɛn taya.

Stej Tu: Di simptom dɛm fɔ di Eosinophils we de go ɔp

As di sik de go bifo, dɛn eosinophils we wi bin tɔk bɔt kin bigin fɔ gɛda na difrɛn tisu dɛn na di bɔdi, mɔ di lɔng dɛn. Dɛn kɔl dis eosinophilic infiltrates . Dis kin mek yu gɛt nyu sayn dɛn:

• Chɛst pen ɛn i kin at fɔ blo mɔ ɛn mɔ.
• Di at we de blo.
• Skin rash ɔ spat.
• Di dijestiv sistɛm simptom dɛm: tin dɛm lɛk bɛlɛ at, dayarɛa.

Stej Tri: Di ​​sayn dɛm fɔ Vaskulaytis

Vasculitis , we na inflamɛns na di blɔd vesel, na di las stej fɔ di sik. Dis kin mek yu gɛt siriɔs sik lɛk:

• Sayn dɛn we de sho se pɔsin de blɔd insay yu bɔdi: Blɔd de na di stɔl, blɔd de na di kɔf, ɛn di say dɛn we de ɔnda di skin we nɔ gɛt kɔlɔ.
• Di sayn dɛm we kin kam bikɔs ɔf inflamɛns ɔ damej pan di nerv dɛm: di limb dɛm kin swɛt, tingling, wik, nerve pen.
• Di sayn dɛm fɔ at sik: at nɔ de bit ɔltɛm, yu de fɔdɔm, yu nɔ de blo shɔt, yu de swel (ɛdima) .

Dis na polyangiitis.Dis sik kin afɛkt di kidni dɛm bak, bɔt bɔrku tɛm i kin apun witout sɔm sayn dɛm.

Wetin mek dis EGPA de kam? Wetin na di rizin?

Infakt, dis EGPA kin kam bikɔs wi yon imyun sistɛm nɔ de wok fayn . Imajin, wetin de apin ya tan lɛk di sojaman dɛn we fɔ protɛkt wi bɔdi, we de atak dɛn yon. di inflameshn na yu bכdi vεsul dεm, di fכmeshכn fכ dεn granulomas dεm we wi bin tכk bכt, di inkrεs pan di eosinophils – כl dis de apin biכs di imyun sistεm de ova aktif εn i de riak kכrekt.

Bɔt di wan dɛn we de stɔdi bɔt dis stil nɔ ebul fɔ no di rayt tin we mek dis kin apin.

Sɔntɛnde dɛn kin kɔl sik dɛn we kin mek di imyun sistɛm wam fɔ lɔng tɛm, ɔtoimyun sik dɛn . Wan tin we kin apin to dɛn kayn sik ya na we dɛn kin mek antibodi dɛn agens ɛn atak sɔm sɛl dɛn na di bɔdi. Dis kin bi wan tin we kin mek pɔsin gɛt EGPA.

Risach pipul dɛm dɔn grup sɔm ɔda sik dɛm lɛk EGPA insay wan grup. Dɛn ɔl gɛt wan patikyula antibodi we dɛn kɔl ANCA . Dɛn kɔl dis grup ANCA-associated vasculitis (AAV) . כltu, na 40% pan di pipul dεm we gεt EGPA gεt dis ANCA antibodi. Dis min se nɔto in wangren de mek i sik.

i tan lεk se di inkrεs pan di eosinofil dεm na wan sεparat kכz fכ di simptom dεm we de bifo vaskulεt. we di eosinofil dεm de kכmכt na di tisu dεm, dεn de mek inflameshn εn de pwεl di tisu dεm. dis inkrεs pan di eosinofil dεm de strכng wan wit asma εn alerji. Pipul wae gɛt asma kin gɛt EGPA 34 tɛm pas ɔda pipul dɛm.

Wetin na di siriɔs prɔblɛm dɛn we kin apin bikɔs ɔf EGPA?

If dɛn nɔ trit dis sik fayn, i kin mek yu ɔgan ɛn tisu dɛn pwɛl bad bad wan. Na sɔm ɛgzampul dɛn ya:

• Pleural effusion: Fluid we de kכmכt rawnd di lכng dεm.
• Pɛrikardial efyushɔn: Fluid we de gɛda rawnd di at.
• Pεrifεral nyuropathy: Dεmεj to di pεrifεral nεv dεm.
• Kidni sik we nɔ de mɛn.
• Di we aw pɔsin de blo fayn fɔ lɔng tɛm.
• Kɔnjɛstiv at we nɔ de wok fayn.

De tin wae impɔtant pas ɔl na fɔ no ɛn trit di sik bifo kɔmplikeshɔn lɛk dis kin kam.

Aw dɛn kin no if pɔsin gɛt EGPA?

Fɔ no EGPA kin tranga smɔl, bikɔs yu kin gɛt difrɛn sayn dɛn difrɛn tɛm. I kin tek sɔm tɛm fɔ mek yu ɛn yu dɔktɔ put ɔltin togɛda. Dɔn bak, di sayn dɛm fɔ EGPA kin tan lɛk di sayn dɛm fɔ bɔku ɔda sik dɛm.

Bɔt, dɔktɔ kin sɔprayz se yu gɛt EGPA if yu gɛt sɔm pan dɛn tin ya:

• Wan histri bɔt asma ɔ hay fiva.
• we yu blɔd tɛst sho se di eosinophil kɔnt dɔn bɔku.
• imej tεst dεm sho pruf fכ eosinophilic infiltrates.
• di tisu bayopsi sho pruf fכ granulomas εn/כ vasculitis.

Wetin na di tritmɛnt fɔ dis EGPA sik? Natin nɔ de fɔ fred, nɔto so?

Yɛs, fɔ tru, wan tritmɛnt de fɔ dis sik we dɛn kɔl EGPA. Nɔ wɔri! Di men tin na fɔ no di sik kwik kwik wan ɛn bigin fɔ trit am.

Bɔku tɛm, di fɔs tin we yu fɔ du na fɔ gi bɔku kɔtikosterɔyd fɔ ridyus di inflamɛns ɛn di eosinophils . We dɛn mɛrɛsin ya de kɔntrol di sayn dɛm, wi kin se di sik de dɔn . Dat min se di sayn dɛm dɔn dɔn. Dɔn di dɔktɔ kin ridyus di doz fɔ di mɛrɛsin smɔl smɔl. Bɔrku pipul dɛn nid fɔ kɔntinyu fɔ tek kɔtikosterɔyd pan smɔl doz fɔ mek dɛn kɔntinyu fɔ gɛt dis rɛmishɔn.

Sɔntɛnde, kɔtikosterɔyd nɔmɔ nɔ kin du, ɔ yu kin nid fɔ kɔntinyu fɔ tek bɔku bɔku kɔtikosterɔyd fɔ avɔyd di sayd ɛfɛkt dɛn. If na so i bi, yu dɔktɔ kin gi yu ɔda mɛrɛsin dɛn.

Dɛn ɔda mɛrɛsin ya na di mɛrɛsin dɛn we de mek pɔsin nɔ ebul fɔ fɛt di sik ɛn di tin dɛn we dɛn kin yuz fɔ mɛn sik dɛn we gɛt layf . Mepolizumab na di fɔs bayolojikal we di US Food and Drug Administration (FDA) dɔn gri fɔ fɔ EGPA. Wan ɔda biologic , benralizumab, dɔn sho bak fayn fayn rizɔlt dɛn insay klinik trial dɛn we dɛn jɔs dɔn du. Dis nyu risach dɔn opin nyu tritmɛnt opshɔn fɔ pipul dɛm wae gɛt EGPA.

Aw layf go tan lɛk wit EGPA? (Prɔgnosis) .

EGPA na sik we pɔsin kin mɛn, bɔt i nɔ kin mɛn . Bɔrku pipul kin kɔntrol dɛn sik wit mɛrɛsin ɛn go na rɛmishɔn. Dis min se di sayn dɛm kin go. Bɔt if yu stɔp fɔ trit yu, de sik kin kam bak (relaps) . So yu dɔktɔ go de wach yu sik fɔ di res ɔf yu layf.

I pɔsibul fɔ liv lɔng tɛm wit EGPA?

If yu gɛt fayn tritmɛnt, yu kin liv nɔmal layf wit EGPA. We di sik dɔn go bifo, prɔblɛm dɛn lɛk we yu ɔgan dɛn nɔ de wok fayn kin afɛkt yu layf. Bɔt bɔku tɛm, tritmɛnt kin stɔp ɔ rivɛns di ɔgan dɛn we nɔ de wok fayn. Wit tritmɛnt, di fayv ia sɔvayv rɛt fɔ EGPA pas 80%.

Wan we de fɔ mek EGPA nɔ de divɛlɔp?

Bikɔs wi stil nɔ no bɛtɛ bɛtɛ wan wetin mek EGPA de divɛlɔp, wi nɔ no aw fɔ mek i nɔ apin. Bɔt if dɛn no di sik kwik kwik wan ɛn trit am, dat kin ɛp fɔ mek i nɔ wɔs . If yu pe atɛnshɔn gud wan to yu sik dɛn ɛn ripɔt am to yu dɔktɔ, yu kin ɛp fɔ mek yu nɔ gɛt siriɔs prɔblɛm dɛn we EGPA gɛt.

Aw a fɔ tek kia ɔf misɛf we a de liv wit EGPA?

Dis na kwɛstyɔn we rili impɔtant. Di mɛrɛsin dɛn we dɛn kin gi fɔ EGPA, mɔ di kɔtikosterɔyd ɛn di imyun supreshɔn , kin mek yu nɔ ebul fɔ fɛt di sik . Dis min se yu kin sik mɔ, ɛn if yu sik, i kin tek lɔng tɛm fɔ mek yu wɛl.

• So, yu nid fɔ tek tɛm pas aw yu kin tek tɛm fɔ avɔyd sik dɛn we yu kin gɛt . Tek tɛm mɔ we yu de go na say dɛn we pipul dɛn kin bɔku ɛn usay sik pipul dɛn de.
• Wash yu an dɛn fayn fayn wan ɔltɛm.
• It tin dɛn we go mek yu gɛt wɛlbɔdi.
• Tek bɔku tɛm we yu nid fɔ slip.
• We dɛn tek kɔtikosterɔyd fɔ lɔng tɛm, sɔm bad tin dɛn lɛk we yu gɛt bɔku blɔd shuga (lɛk dayabitis), we yu gɛt bɔku bɔku wet, we yu bon dɛn kin tan (lɛk ɔstioporosis), ɛn we yu de fil kin chenj . Tɔk to yu dɔktɔ bɔt dɛn tin ya ɛn lan aw fɔ mɛn dɛn. Tɛl yu dɔktɔ wantɛm wantɛm if yu gɛt ɛni nyu sayn.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Eosinophilic granulomatosis wit polyangiitis (EGPA) na wan kayn vaskulaytis, ɛn i kin rili shɔt bak ɛn i nɔ kin izi fɔ no. Yu kin gɛt difrɛn kayn sayn dɛm wae kin tan lɛk se yu nɔr gɛt ɛnitin fɔ du wit dɛnsɛf. I kin tek sɔm tɛm fɔ mek yu dɔktɔ no wetin dɛn min ɛn disayd us tritmɛnt yu nid.

Di gud nyus na dat dɛn kin manej EGPA fayn fayn wan wit tritmɛnt . Bɔt, yu go nid fɔ mek sɔm chenj dɛn na yu layf ɛvride. Fɔ liv wit wan sik wae nɔr de mɛn wae bɔrku pipul nɔr dɔn ɛva yɛri bɔt, sɔmtɛm kin fil lɛk yu wangren. Na tɛm lɛk dis, i kin ɛp fɔ kɔnɛkt wit sɔpɔt nɛtwɔk fɔ ɔda pipul dɛn we de liv wit EGPA. Nɔ ɛva giv ɔp op, fala di rayt advays we dɔktɔ gi yu, ɛn yusɛf go ebul fɔ liv gud layf.

` EGPA, Churg-Strauss sindrom, eosinophilic granulomatosis polyangiitis, asma, alɛji, vaskulaytis, eosinofil