Wetin de apin to yu mɛmori? Lɛ wi lan bɔt Creutzfeldt-Jakob Disease (CJD)?

Yu kin tink sɔm tɛm se, "O, a fɔgɛt dis bak!"? Fɔ fɔgɛt smɔl smɔl tin dɛn ɛn sɔntɛnde fɔ kɔnfyus kin bi nɔmal tin. Bɔt tin dɛm lɛk fɔ mɛmba smɔl smɔl ɛn fɔ chenj in bihayvya kin bi sayn dɛm bak fɔ siriɔs sik. Tide wi go tɔk bɔt wan sik we nɔ kin bɔku, bɔt we rili siriɔs, we kin afɛkt di bren. Dat na Creutzfeldt-Jakob sik, ɔ CJD as wi kin kɔl am fɔ shɔt.

Wetin na dis CJD? Fɔ tɔk am simpul wan...

Tink bɔt am, wi bren na mashin we rili kɔmpleks. Fɔ mek dis mashin wok fayn, in smɔl smɔl pat dɛn we dɛn kɔl sɛl, nid fɔ gɛt wɛlbɔdi. CJD na wan sik we nɔ kin apin so ɔltɛm, we kin pwɛl wi bren sɛl dɛn smɔl smɔl. di men tin we kin mek dis apin na wan abnכmal kayn protin we dεn kכl ``prions`` .

Naw yu kin de wɔnda wetin na dɛn ‘prion’ ya. Insay wi bɔdi, mɔ na di bren, tin dɛn de we dɛn kɔl prɔtin. Dɛn tin ya tan lɛk smɔl mashin dɛn, dɛn gɛt wan patikyula shep, ɛn na if dɛn de insay da shep de nɔmɔ dɛn go ebul fɔ du dɛn wok fayn fayn wan. Tink bɔt am lɛk origami. If yu fold am kɔrɛkt wan, yu kin mek fayn animal ɔ flawa. Bɔt if yu fold am di rɔŋ we? I nɔ de wok. Na so dɛn prɔtin ya de. Sɔntɛnde, dɛn prɔtin ya nɔ kin fold di rayt we. wi kכl dεn kayn misfold protin dεm ya 'prions'.

dis ‘prion’ dεm we dεn nכ fכl fayn kin bigin fכ kכmכt insay di bren sεl dεm. Dɛn kin gɛda dɛn sɛl dɛn de ɛn pwɛl dɛn. I tan lɛk bɔku bɔku dɔti we de gɛda ɛvride. Dis na wae mek pipul dɛm wae gɛt CJD kin gɛt sɔm kayn sik wae dɛn kin gɛt dis maynia sik , lɛk wae dɛn nɔr kin mɛmba ɔltɛm ɛn dɛn kin kɔnfyus. Dɛn kin gɛt chenj bak pan dɛn bihayvya ɛn i nɔ kin izi fɔ waka.

Di tin we impɔtant pas ɔl na dat CJD kin kil pɔsin ɔltɛm. Nɔr mɛrɛsin nɔr de yet, ɛn no we nɔr de fɔ slo di sik fɔ go bifo. Bɔt, tritmɛnt ɛn kia de we go ɛp di pɔsin fɔ liv fayn ɛn fɔ mek i nɔ fil pen.

Dis na sik we nɔ kin apin so ɔltɛm. Ɔlsay na di wɔl, dis sik kin kam pan lɛk wan to tu pipul dɛn pan wan milyɔn ɛvri ia. Ivin na kɔntri lɛk Amɛrika, na lɛk 350 pipul dɛn nɔmɔ kin gɛt CJD ɛvri ia.

Wan vεryכnt de fכ dis we dεn kכl ``vεryכnt CJD`` (כ ``vCJD``) . I nɔ kin bɔku bak. I kin kam we yu it bif we gɛt di sik ``bovine spongiform encephalopathy`` (BSE), we na sik we kin afɛkt kaw.

Wetin na di sayn dɛm fɔ CJD? Lɛ wi luk am frɔm di biginin.

Di sayn dɛm fɔ CJD kin apin smɔl smɔl. Bɔt as di sik de go bifo, dɛn sayn ya kin bɔku kwik kwik wan. Lɛ wi tek wan luk pan di men sayn dɛm, frɔm di fɔs stej dɛm fɔ di sik to di let stej dɛm:

• Fɔgɛt ɛn mɛmba prɔblɛm:I kin bigin wit fɔgɛt smɔl smɔl tin dɛn. Tin dɛn lɛk yu padi in nem, wan strit, ɔ di wok we yu bin de du. Smɔl smɔl, dis kin wɔs.
• Kɔnfyushɔn ɛn disorientation: Yu nɔr kin mɛmba usai yu de, ustɛm na, ɔr udat de arawnd.
• Di chenj we yu de biev ɛn di kayn pɔsin we yu bi: Sɔntɛm yu nɔ go bi di sem pɔsin we yu bin de du trade. Yu kin vɛks izi wan, fil bad, ɔ yu nɔ kin fil fayn igen.
• Prɔblɛm fɔ si, i nɔ kin izi fɔ ɔndastand wetin yu de si: Yu yay kin wik, ɛn yu nɔ kin ebul fɔ no wetin yu de si.
• Hallucinations or delusions: Fɔ si ɔ yɛri tin wae nɔr de, ɔr gɛt lay lay biliv se sɔmbɔdi de tray fɔ du yu bad.
• Prɔblɛm wit kɔdineshɔn (ataxia): Yu nɔ kin ebul fɔ waka fayn, i nɔ kin izi fɔ kɔntrol yu an ɛn fut, ɛn yu kin swɛla lɛk pɔsin we dɔn chak.
• Prɔblɛm dɛn we de wit bɔdi balans: Fɔ fɔdɔm we yu tinap ɔ waka.
• di mכsul dεm we dεn nכ de kכntro (`myoclonus`) εn di mכsul dεm we de stiff (`dystonia`): di an כ leg de jכk wan wan, כ i de fil se di mכsul dεm na di bכdi tayt.
• Seizures: I kin kam pan lɛk fit.
• Paralayz: Sɔm pat dɛn na di bɔdi kin paralayz.
• Muscle atrophy: Di bɔdi in mɔsul dɛn kin lɔs.

Dɛn sayn ya kin apin wan bay wan, ɔr sɔm kin apin togɛda. De tin wae impɔtant pas ɔl na fɔ go to dɔktɔ kwik kwik wan if yu gɛt ɛni wan pan dɛn sik ya.

Wetin kin mek pɔsin gɛt CJD? Mek wi memba dem ‘prions’ bak

as wi bin dכn tכk bכt, di men kכz fכ CJD na di misfold protin dεm we dεn kכl ``prions.'' di mכst denja fכ dεn ``prion'' ya na dat dεn kin misfold ivin nכmal, hεlty protin dεm. Jɔs lɛk aw wan bad apul kin mek ɔl di ɔda apul dɛn go bad.

di bren sεl dεm nכ kin ebul fכ pul dεn misfold ‘prions’ dεm ya. So dɛn kin gɛda, ɛn leta dɛn kin pwɛl di bren sɛl dɛn. as dεn ‘prion’ dεm ya de spre כlsay na di bren, di sik de go bifo kwik kwik wan.

Difrɛn kayn CJD de?

Yɛs, sɔm men kayn CJD dɛn de:

• Sporadic CJD: Dis na di kayn CJD wae kin pasmak. Wi nɔ stil no di rayt tin we mek i apin. I kin apin wantɛm wantɛm, ɛn i nɔ kin gɛt ɛni klia rizin.
• Jɛnɛtik CJD: Dis na tin we pɔsin kin gɛt frɔm dɛn mama ɛn papa. Na wan jin we nɔ fayn we dɛn gɛt frɔm wan ɔ dɛn ɔl tu mama ɛn papa kin mek am. Tu sɔbtayp dɛn de fɔ dis: Gerstmann-Sträussler-Scheinker (GSS) syndrome ɛn famili inshɔmnia we kin kil pɔsin . Dis kin triki smɔl, bɔt dɛn na rili spɛshal kɔndishɔn.
• CJD we dɛn dɔn gɛt (`CJD we dɛn dɔn gɛt`):Dis kin apin bikɔs ɔf tin dɛn we kin apin na do. Fɔ ɛgzampul, i kin apin tru wan ɔgan transplant frɔm pɔsin we gɛt CJD, we dɛn transplant tisu, ɔ yuz ɔspitul inschrumɛnt dɛn we gɛt dɔti. Bɔt dis nɔ kin apin so ɔltɛm. Naw, bɔku pipul dɛn de wɔri bɔt dis.
• Variant CJD (vCJD): Wi don tok boht dis bifo. Na wae yu de it bif wae dɔn gɛt mad kaw sik (BSE). Di priɔn dɛm we de mek BSE kin ambɔg mɔtalman ɛn ɔda animal dɛm bak.

Udat de pan ay risk fɔ gɛt CJD?

Enibodi kin geht CJD. Sɔmtɛm, di ‘prions’ na yu bɔdi kin de fɔ lɔng lɔng tɛm ɛn nɔr de sho ɛni sayn. Bɔt we di sik dɔn sho, di sik kin rili bad kwik kwik wan as di bren kin pwɛl.

Dis sik kin ambɔg pipul dɛm wae ol bitwin 50 ɛn 80. Bɔt di kayn CJD wae gɛt fɔ du wit jɛnɛtik kin ɔltɛm apia bitwin 30 ɛn 50 ia.

Yu tink se CJD na sik we pɔsin kin pas?

Dis na prɔblɛm fɔ bɔku pipul dɛn. CJD nɔr kin spre tru kɔzhɔl kɔntakt, lɛk fɔ shek an, tɔk, ɔr it togɛda. Di wangren we we CJD kin pas frɔm wan pɔsin to ɔda pɔsin na bay we dɛn transplant wan ɔgan ɔ tisu frɔm pɔsin we gɛt CJD, ɔ bay we dɛn yuz sɔm ɔmon dɛn frɔm pɔsin we dɔn gɛt am.

Dɛn se di kayn we dɛn kɔl `vCJD` kin pas tru blɔd transfyushɔn, bɔt dat kin rili, rili rare. Di sik we dɛn kɔl `vCJD` insɛf nɔ kin bɔku.

Aw dɔktɔ dɛn kin no se pɔsin gɛt CJD?

Dɔktɔ kin no se yu gɛt CJD bay we i tek tɛm luk yu sayn ɛn sayn dɛn. Apat frɔm di ɛgzam fɔ dɛn bɔdi, dɛn go du ɛgzam bak fɔ di nyurolɔjik. Dɛn go aks yu fɔ du sɔm simpul wok dɛn fɔ tray fɔ no di prɔblɛm dɛn we de wit yu bren we de wok.

Spɛshal pipul dɛn kin klas CJD as ‘transmissible spongiform encephalopathy’ . pan ɔl we dis nem kin tan lɛk se i kɔmplikt smɔl, i de tɔk bɔt di we aw di bren we ‘prion’ dɔn pwɛl de luk ɔnda maykroskɔp. Dat min se, i tan lɛk spɔnj we gɛt bɔmp.

fכ kכnfכm se dεn no se yu gεt CJD, dεn kin du tεst dεm lεk MRI skan כ spεnal tap (lumbar pancture).

Apat frɔm dat, dɔktɔ dɛn kin yuz tɛst dɛn lɛk dɛn wan ya fɔ pul ɔda tin dɛn we gɛt di sem kayn sayn to CJD ɛn fɔ mek dɛn no mɔ bɔt CJD:

• Blɔd tɛst dɛn
• jεnεtik tεst - spεshal fכ si if wan tכp na ɛritayt
• Wan ilɛktrɔ-ɛnsɛfalogram (EEG) .
• Urinalysis we dɛn kin du
• di bren bayopsi - dεn kin du dis bכku bכku wan, nכmכ if כl di כda tεst dεm nכ de gi difinitiv diagnosis.

Tritmɛnt de fɔ CJD?

Bɔt i sɔri fɔ no se, no mɛrɛsin nɔ de fɔ CJD, no tritmɛnt nɔ de fɔ kɔntrol aw di sik de skata, ɔ no tritmɛnt nɔ de fɔ mek i slo fɔ go bifo. Di wangren tin wae dɔktɔ kin du na fɔ ɛp fɔ ridyus de diskɔmfɔt wae de kam wit de sik. Dɛn kɔl dis palliative care .

Fɔ ɛgzampul, dɛn kin gi mɛrɛsin fɔ mɛn di sik we de mek pɔsin sik, we i de chenj di we aw i de biev, ɔ we di mɔsul dɛn de shek shek we i nɔ ebul fɔ kɔntrol. Bɔt di bɛnifit dɛn we dɛn tritmɛnt ya kin gi nɔ bɔku.

Dis sik kin wɔs kwik kwik wan. So, di opshɔn fɔ sɔpɔt kia fɔ yu ɛn di wan dɛn we yu lɛk rili impɔtant. Na di las stej dɛm fɔ di sik, hospice savis kin rili ɛp.

Sɔntɛnde, if yu kwalifay, yu mɛdikal tim kin tɛl yu fɔ tek pat pan klinik trial we de du risach bɔt nyu tritmɛnt dɛn.

Us kayn fiuja pɔsin we gɛt CJD kin ɛkspɛkt?

Bikɔs CJD nɔ de mɛn ɛn i nɔ gɛt ɛni mɛrɛsin, di we aw pɔsin we gɛt dis sik de si am rili dak. Wae di sik bigin, i nɔr kin te bifo di ebul fɔ woke fɔ insɛf, muv rawnd, ɛn tɔk nɔr de igen.

Bikɔs chenj kin apin kwik kwik wan, i impɔtant fɔ wok wit yu mɛdikal tim fɔ plan bifo tɛm fɔ mek shɔ se dɛn mit wetin yu want ɛn nid. Infakt, ilɛksɛf yu gɛt mɛdikal kɔndishɔn ɔ nɔ gɛt am, i fayn fɔ mek ɔlman gɛt `advance directive` . Dis min se yu dɔn rayt bifo tɛm us mɛrɛsin yu want if yu nɔ ebul fɔ tɔk wetin yu want. I impɔtant mɔ fɔ gɛt dis plan in ples kwik kwik wan pan sik we de prɛd kwik kwik wan lɛk CJD.

We yu tink bɔt aw dis sik siriɔs, i go fayn fɔ mek yu aks fɔ advays frɔm pɔsin we sabi bɔt mɛntɛl hεlth fɔ ɛp yu ɛn yu famili fɔ bia wit dɛn chenj ya ɛn kɔntinyu fɔ gɛt strɔng maynd.

Wetin na di layf we pɔsin we gɛt CJD kin liv?

Bɔku pan di wan dɛn we gɛt CJD kin day insay sɔm mɔnt ɔ wan ia afta dɛn dɔn no se dɛn gɛt di sik. Di wangren tin we nɔ de insay di jenɛtik we fɔ CJD, we pipul dɛn kin liv frɔm wan to tɛn ia afta di sik bigin.

Yu dɔktɔ kin gi yu patikyula, ɔp-to-dɛt infɔmeshɔn bɔt yu sik. Mɛmba se, statystik nɔ de afɛkt ɔlman di sem we.

Yu tink se dɛn kin ebul fɔ stɔp CJD?

Bɔrku kayn CJD nɔr kin ebul fɔ stɔp. Di onli eksepshɔn na di kayn we dɛn kɔl `vCJD`. I kɔmɔt frɔm it bif we gɛt `BSE` (mad kaw sik).

Animal tɛst de ɛp fɔ mek kaw dɛn we gɛt BSE nɔ go insay di it sapɔt chen. Bɔt mit we dɛn nɔ tɛst ɛn we dɛn nɔ pripia fayn kin stil mek yu gɛt prɔblɛm. Fɔ mek yu sef, nɔ it mit we yu nɔ tɛst ɛn we nɔ gɛt rayt fɔ it, mɔ di pat dɛn na yu bren ɔ di bon mɛro.

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

Wae yu no se yu gɛt CJD na tin wae kin chenj yu layf. I kin fil lɛk se yu ɛn di wɔl we de rawnd yu dɔn go insay wan blink ɔf wan yay. Dis kayn chenj kin rili at fɔ yu ɛn di wan dɛn we yu lɛk fɔ bia wit.

If yu nɔr shɔ bɔt wetin fɔ ɛkspɛkt ɔr aw fɔ bia, yu mɛdikal tim de ya fɔ ɛp yu. Dɛn kin ɛp yu fɔ plan bifo tɛm ɛn rɛdi fɔ wetin gɛt fɔ apin. Mɛmba se nɔto yu wangren de.

` CJD, Creutzfeldt-Jakob Sik, prion, bren sik, nyurolɔjik sik, mɛmori lɔs, dimɛnshɔn, mad kaw sik