Imajin se ilɛk ɔmɔs wata yu drink, yu kin fil lɛk se yu tɔsti. Na di sem tɛm, yu nid fɔ go na di bafa ɔltɛm. Yu nɔ kin ebul fɔ slip fayn na nɛt, ɛn yu fɔ grap bɔku tɛm. Yu nɔ tink se dis na tin we de mɔna wi smɔl? Pan ɔl we bɔku pipul dɛn kin tink se dis na nɔmal tin, sɔntɛnde i kin bi sayn fɔ sɔm ɔda prɔblɛm we de insay wi bɔdi. Tide wi go tɔk bɔt dis kayn sik we nɔ kin apin so ɔltɛm, bɔt we pɔsin kin trit. Dat na Arginine Vasopressin Disorders, ɔr Dayabitis Insipidus as bɔku pipul dɛn sabi am wit in ol nem.
Fɔ tɔk am simpul wan, wetin na Arginine Vasopressin Disorders?
Pan ɔl we di nem kɔmplikt smɔl, i rili izi fɔ ɔndastand wetin de apin. Fɔ tɔk am simpul wan, dis na tin we wi bɔdi nɔ kin ebul fɔ kip di wata we wi nid. fכ dat, di wata we dεn nid de kכmכt bak na di urine.
Di men rizin fɔ dis na wan ɔmon we de na wi bɔdi. Dɛn kɔl am Arginine Vasopressin (AVP) . Sɔm dɔktɔ dɛn kin kɔl am bak Antidiuretic Hormone (ADH) . Dis AVP ɔmon tan lɛk manija we de gi instrɔkshɔn to wi kidni dɛn. Na di wan we de tɛl di kidni dɛm se, "Okay, di bɔdi nid wata naw, so sev sɔm wata ɛn ridyus di wata we de kɔmɔt as urine."
Insay dis sik, dis prɔses kin ambɔg tu men we dɛn:
1. AVP Deficiency (AVP-D): Dis na we wi bren nɔ de prodyuz di AVP ɔmon di kayn we we i nid. Dis min se nɔbɔdi nɔ de fɔ tɛl di kidni dɛn.
2. AVP Resistance (AVP-R): Insay dis, pan ɔl we di bren de mek inof AVP ɔmon, di kidni dɛn nɔ de aksept di advays. Jɔs lɛk aw di manija de gi advays bɔt di wokman dɛn nɔ de pe atɛnshɔn to am.
εni we, di εnd rizulyt na di sem: di kidni dεm de filta di wata lεk aw dεn nid εn kכl am kכl urine. Dis kin mek di bɔdi lɔs di wata we i nid.
| Tayp fɔ di mɛdikal kɔndishɔn | Fɔ tɔk am simpul wan, wetin de apin? |
|---|---|
| AVP Dɛfisiɛns (AVP-D) . | di AVP כmon we de sεnd mεsej frכm di bren to di kidni dεm, nכ de prodyuz insay inof kwantiti. |
| AVP Resistans (AVP-R) ɛn di ɔda wan dɛn. | pan ɔl we di bren de mek di AVP ɔmon, di kidni dɛn nɔ kin ebul fɔ ɔndastand (gɛt) da mɛsej de fayn fayn wan. |
Wetin na di sayn dɛm fɔ dis sik?
De men ɛn klia sayn dɛm fɔ dis sik na:
- Tɔsti pasmak (polydipsia): Fɔ fil lɛk se yu nɔ tɔsti ilɛksɛf yu drink bɔku wata.
- Fɔ pis bɔku tɛm: Na fɔ grap bɔku tɛm fɔ pis, nɔto jɔs na de, bɔt na nɛt bak (nocturia).
- Fɔ pis pasmak: Di urine we dɛn kin mek kin rili bɔku. Di urine nɔ gɛt kɔlɔ ɛn i gɛt wata.
Nɔmal wan, pɔsin kin pul bitwin 1 ɛn 3 lita urine ɛvride. Bɔt pɔsin we gɛt dis sik kin pul te to 20 lita urine ɛvride! Imajin aw dat na bɔku tin!
Dɛn sayn ya na strɔng sayn fɔ sho se sɔntin nɔ de wok fayn insay yu bɔdi. So, if yu gɛt dɛn sik ya, i rili impɔtant fɔ go to dɔktɔ kwik kwik wan.
Aw dɛn sik ya kin apia pan yɔŋ pikin dɛn?
Yɔŋ pikin dɛn nɔ kin ebul fɔ tɔk kɔrɛkt wan se "A tɔsti." So if dɛn gɛt dis sik, de sik kin luk difrɛn smɔl.
- Di wata we de kɔmɔt na di bɔdi bad bad wan
- Banbɛlɛ
- Fɔ vɔmit
- Fiva we kin kam ɔltɛm
- Nɔ de rɛst ɔltɛm ɛn kray
- Failure to thrive (nɔto fɔ gɛt wet) .
Wetin mek dis tin kin apin?
Bɔku tin dɛn de we kin mek pɔsin gɛt dis, i kin dipen pan di kayn sik we i gɛt.
Di tin dɛn we kin mek pɔsin nɔ gɛt arginine vasopressin (AVP-D) .
Dis na di kayn we we pipul dɛn kin gɛt mɔ. i kin kam we di pat dεm na di bren we de mek di AVP כmon (di haypothalamus כ pituitary gland) dכn pwεl.
- Injury na di ed ɔ ɔpreshɔn: Dɛn pat ya kin pwɛl if dɛn du ɔpreshɔn ɔ aksidɛnt na di bren.
- Tכmכro: Na fכ sכm tכmכro dεm we de fכm na di bren.
- Inflameshɔn: Na inflammatory conditions wae kin kam wit sik dɛm lɛk sarcoidosis ɔ tuberculosis.
- Jɛnɛtik kɔz: Jɛnɛtik chenj dɛn we dɛn kin gɛt frɔm dɛn mama ɛn papa.
- Idiopathic: Sɔm tɛm, lɛk af pan ɔl di kes dɛm, dɛn nɔ kin fɛn ɛni patikyula kɔz .
Di tin dɛn we kin mek di arginine vasopresin rɛsistɛns (AVP-R) .
no prכblεm de wit di bren we de prodyuz di כmon, di prכblεm de na di kidni dεm.
- Jɛnɛtik kɔz: Jɛnɛtik prɔblɛm we kin pas to jɛnɛreshɔn.
- Sɔm mɛrɛsin dɛm: Ɛspɛshali sɔm mɛrɛsin dɛm fɔ mental sik, lɛk lithium.
- Urinary tract we nɔ de wok fayn.
- di kalsiכm lεvεl dεm we de na di bכdi de inkrεs (Hypercalcemia).
- Di blɔd potashɔm lɛvɛl smɔl (Hypokalemia).
Spɛshal kɔndishɔn dɛn we kin apin we uman gɛt bɛlɛ
Na smɔl tɛm nɔmɔ uman dɛn kin gɛt dis sik fɔ sɔm tɛm we dɛn gɛt bɛlɛ. dis na biכs wan εnzym we di plasεnta de mek de brok di mama in AVP כmon we i bεlε. dis risk kin bכku fכ mama dεm we de kכri twin εn fכ mama dεm we gεt kכndyushכn lεk prεeklampsia, we de afekt di liva fכ wok. Bɔt di gud nyus na dat, dis sik kin dɔn kpatakpata insay tu to tri wiks afta yu bɔn pikin.
Us prɔblɛm dɛn dis kin mek?
Di mɔs denja ɛn big kɔmplikeshɔn fɔ dis kɔndishɔn na di wata we de kɔmɔt na di bɔdi , we min se di wata ɛn ilɛktrɔlayt dɛn go lɔs fɔ di bɔdi fɔ wok.
Nɔmal wan, yu kin kɔmpɛns di lɔs bay we yu drink inof wata fɔ mach di amount of urine we yu de mek. Bɔt if fɔ sɔm rizin yu nɔ ebul fɔ drink bɛtɛ wata, yu kin gɛt bɔku bɔku wata we yu nɔ gɛt na yu bɔdi kwik kwik wan.
Dis kin mek pɔsin in layf de pan denja . If yu fil se yu de tɔn diziz, yu de nɔs, yu taya pasmak, ɔ yu de fɔdɔm, we na sayn fɔ se yu nɔ gɛt wata na yu bɔdi, go na di ɔspitul imejensi rum (ETU) we de nia yu wantɛm wantɛm.
Aw dɔktɔ kin fɛn dis?
Ɔda kɔmɔn sik dɛn de we kin mek pɔsin tɔsti ɛn pis ɔltɛm. Fɔ ɛgzampul, sik we dɛn kɔl dayabitis. So, di fɔs tin we dɔktɔ kin du na fɔ chɛk fɔ ɔda sik dɛn we tan lɛk dis.
Dɛn kin du bɔku tɛst fɔ no if pɔsin gɛt dis sik kɔrɛkt wan.
- Wata Deprivation Test: Dis na di we we pɔsin kin abop pan fɔ no dis sik. Insay dis tɛst, yu fɔ go we yu nɔ drink ɛni wata fɔ sɔm awa. Dɛn kin du dis na ɔspitul we dɔktɔ ɔ nɔs de kia fɔ dɛn dairekt wan . Dis na bikɔs dis kin mek yu nɔ gɛt wata na yu bɔdi. If yu gɛt dis sik, yu bɔdi go kɔntinyu fɔ mek bɔku bɔku urine pan ɔl we yu nɔ drink ɛni wata. pan pɔsin we gɛt wɛlbɔdi, yu urine go ridyus, ɛn yu go jɔs mek smɔl dak yɔlɔ, kɔnsɛntret urine.
- Ɔda tɛst dɛn:
- Fɔ chɛk di blɔd shuga lɛvɛl (fɔ mek shɔ se yu nɔ gɛt dayabitis).
- Urinalysis - Chεk di kכnsantreshכn (osmolality) fכ di urine.
- bכdi tεst - mכsu sכmtin we dεn kכl Copeptin, we riliyt to di כmon AVP.
- MRI skan - fכ si if damej de pan di pituitary gland כ haypothalamus na di bren.
Wetin na di tritmɛnt dɛm fɔ dis?
Di tritmɛnt opshɔn dɛn dipen pan if yu gɛt AVP-D ɔ AVP-R, bɔt ilɛksɛf na di tritmɛnt, fɔ drink inof wata na sɔntin we yu fɔ drink.
Tritmɛnt fɔ di AVP-D stetɔs
Di men mɛrɛsin we dɛn kin yuz fɔ dis na Desmopressin . dis na sεntetik כmon we de wok fכ tek di ples fכ di AVP כmon we de mis. Yu kin tek am as pil, sprɛy na yu nos, ɔ injɛkshɔn. Sɔntɛnde dɛn kin gi am bak fɔ sɔm tɛmporari kɔndishɔn dɛn we kin apin we uman gɛt bɛlɛ.
Tritmɛnt fɔ AVP-R stetɔs
Fɔ trit dis kin kɔmplikt smɔl. Bikɔs di prɔblɛm we de ya nɔto we di ɔmon dɛn nɔ de, bɔt na di kidni dɛn we nɔ de ansa dɛn. So, dɛn gɛt fɔ yuz difrɛn tritmɛnt dɛn togɛda.
- Thiazide diuretics: Pan ɔl we dɛn wan ya na wan kayn mɛrɛsin we de mek di urine kɔmɔt, dɛn kin wok difrɛn we pan dis kɔndishɔn ɛn dɛn kin ridyus di urine.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Sɔm drɔgs dɛn we de na di kategori we de mek pɔsin fil pen.
- If dis sik na ɔda mɛrɛsin we yu de tek, yu dɔktɔ go chenj da mɛrɛsin de ɛn gi yu ɔda mɛrɛsin.
Wetin mek dɛn chenj di nem frɔm ‘Diabetes Insipidus’ to ‘Diabetes Insipidus’?
Dis na prɔblɛm we bɔku pipul dɛn gɛt. Fɔ lɔng tɛm, dɛn bin de kɔl dis sik Dayabitis Insipidus. Bɔt insay 2022, sɔm big big ɔganayzeshɔn dɛn we de mɛn pipul dɛn bin kam togɛda ɛn disayd fɔ chenj dis nem.
Di men rizin na di kɔnfyushɔn we di wɔd "Dayabetes" kin mek. Wi kin yuz "Dayabetes" fɔ min Dayabitis Mɛlitus . Na wan sik we rili kɔmɔn na wi kɔntri. I kin bi se di shuga na di blɔd kin go ɔp. Pan ɔl we dɛn tu sik ya gɛt kɔmɔn sayn dɛn we na fɔ tɔsti ɔltɛm ɛn fɔ pis, dɛn sik ya na tu sik dɛn we rili difrɛn . Di tritmɛnt dɛn bak rili difrɛn.
Di nem "Diabetes Insipidus" dɔn mek dɛn nɔ no sɔm sik pipul dɛn di rɔŋ we se dɛn gɛt dayabitis, ɛn ivin di tritmɛnt mistek. Fɔ pul dis kɔnfyushɔn, dɛn de yuz di nem "Arginine Vasopressin Disorder" naw fɔ tɔk bɔt di sik.
Yu tink se i pɔsibul fɔ liv fayn fayn wan wit dis sik?
Yɛs, i rili pɔsibul. If yu gɛt di rayt tritmɛnt fɔ dis sik ɛn drink inof wata lɛk aw yu dɔktɔ tɛl yu, bɔku tɛm yu nɔ go gɛt ɛni siriɔs prɔblɛm.
Bɔt sɔm grup dɛn kin gɛt smɔl prɔblɛm:
- Smɔl bebi dɛn
- Pipul dɛn we dɔn pas 65 ia
- Pipul dɛm wae gɛt sɔm kayn mɛntɛl hεlth prɔblɛm ɔr divɛlɔpmɛnt disabiliti
Dɛn pipul ya kin gɛt prɔblɛm fɔ no we dɛn tɔsti ɔ we dɛn de aks fɔ wata da tɛm de, we kin mek dɛn nɔ gɛt wata na dɛn bɔdi.
If yu fil lɛk se yu de liv na di bafa ɔltɛm, ɛn ilɛksɛf yu drink bɔku, yu nɔ go ebul fɔ stɔp yu tɔsti, mɛmba se dis na tin we pɔsin kin ebul fɔ kɔntrol. Yu dɔktɔ go mek wan tritmɛnt plan we go fayn fɔ yu. I go tɛl yu bak ɔmɔs wata yu fɔ drink fɔ wan de fɔ mek yu nɔ gɛt wata na yu bɔdi. So nɔ fred fɔ go to dɔktɔ.
Mɛsej we dɛn kin kɛr go na os
- I nɔmal fɔ de tɔsti ɔltɛm ɛn fɔ pis bɔku bɔku wan. If yu gɛt dɛn sayn ya, go to dɔktɔ.
- Dis sik (Arginine Vasopressin Disorder) nɔr de di sem wit Dayabitis Mɛlitus lɛk aw wi no am. Dis na tu sik dɛn we rili difrɛn.
- Dis na bikɔs ɔf wan prɔblɛm wit wan ɔmon we dɛn kɔl AVP we wi bren de mek. Either i nɔ de prodyuz inof, ɔ di kidni dɛn nɔ de ansa am.
- Di men ɛn denja kɔmplikeshɔn fɔ dis sik na we yu nɔ gɛt wata na yu bɔdi, so fɔ drink bɔku wata rili impɔtant.
- Nɔr wɔri, fayn fayn tritmɛnt dɛn de wae kin ɛp fɔ mɛn dis sik.
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