Wetin na G6PD Dɛfisiɛns? Lɛ wi lan witout fred!

Yu don eva yehri boht G6PD Deficiency? Sɔntɛm di nem de sawnd smɔl strenj. Bɔt fɔ tru, na wan sik we bɔku pipul dɛn na di wɔl gɛt, bɔt bɔku tɛm i nɔ kin mek ɛni big prɔblɛm. So, tide wi go tɔk bɔt wetin na dis G6PD dɛfisiɛns, wetin mek i kin apin, ɛn wetin wi nid fɔ no. No nid fɔ fred, lɛ wi ɛksplen ɔltin simpul wan.

Wetin na di ɛksaktɔli G6PD Dɛfisiɛns?

Fɔ tɔk am simpul wan, G6PD dɛfisiɛns na jɛnɛtik kɔndishɔn we yu bɔdi gɛt rili lɔw lɛvɛl fɔ G6PD. Okay, naw yu de aks wetin G6PD bi. G6PD (Glucose-6-Phosphate Dehydrogenase) na wan rili imכtant εnzym na wi bכdi. Di men wok we dis ɛnzaym de du na fɔ protɛkt wi rɛd blɔd sɛl dɛn frɔm difrɛn difrɛn tin dɛn we de pwɛl.

dis dεfisit de apin we dεn bכn pכsin wit chenj, כ m כtεshכn, na di jin we de mek di G6PD εnzym. dis de mek yu rεd bכdi sεl dεm nכ de prodyuz inof fכ di G6PD εnzym.

Bɔt na di tin ya. Bɔrku pipul dɛm wae gɛt G6PD dɛfisiɛns nɔr kin gɛt ɛni simptom . Dɛn de liv nɔmal layf. Bɔt sɔmtɛm, prɔblɛm kin kam frɔm "trig" lɛk sɔm mɛrɛsin, infɛkshɔn, ɔ sɔm it dɛm (wi go tɔk bɔt dɛn tin ya leta). If dɛn kayn tin ya apin, wan sik we dɛn kɔl ɛmolaytik anemia kin kam. Dis min se di rɛd blɔd sɛl dɛn kin brok kwik kwik wan ɛn pwɛl. sכmtεm, nyu bכbi pikin dεm kin gεt siri כs janda bikoz fכ G6PD dεfisiεns.

G6PD dɛfisiɛns na wan sik wae kin pasmak pas aw yu kin tink. Dɛn se bitwin 400 ɛn 500 milyɔn pipul dɛm ɔlsay na di wɔl gɛt dis sik. So if yu gɛt am, yu dɔktɔ kin ɛp yu fɔ mek yu rɛd blɔd sɛl dɛn nɔ gɛt wan prɔblɛm.

Wetin na di sayn dɛm fɔ G6PD dɛfisiɛns?

As wi bin dɔn tɔk, bɔrku pipul dɛm wae gɛt G6PD dɛfisiɛns nɔr kin gɛt sɔm kayn sik. Bɔt di sayn dɛn kin jɔs apin we sɔntin we de mek yu gɛt strɛs pan yu rɛd blɔd sɛl dɛn ɛn mek dɛn brok (hɛmolaysis). We dat apin, tin dɛn lɛk dis kin apin:

• Fɔ fil se yu taya pasmak
• At bit kwik kwik wan ( takikadia ) .
• I nɔ izi fɔ blo ( Dyspnea ) .
• Di skin we de yɔlɔ ɔ di wayt na di yay (dɛn tin ya na sayn dɛn we de sho se yu gɛt janda ) .
• Pale skin (lip ɛn tong kin ivin pale) .
• Dak yɔlɔ, ɔrɛnj, ɔ ti kɔlɔ urine
• Spleen we dɔn big

If dɛn sik ya apin wantɛm wantɛm ɛn bad bad wan, dɛn kin kɔl am ɛmolaytik kraysis . If yu gɛt dis , i rili impɔtant fɔ go to dɔktɔ wantɛm wantɛm.

Di simptom dɛm fɔ G6PD dɛfisiɛns na nyu bɔn pikin dɛm

Nyu bכn pikin dεm nכ kin gεt klia simptom dεm fכ G6PD dεfisiεns. Di tin we kin apin mɔ na di sik we dɛn kɔl janda . Dis kin apin insay sɔm dez afta dɛn bɔn am. If dɛn nɔ trit am fayn, siriɔs janda kin mek di pikin in bren pwɛl. Dɛn kɔl dis kenicterus . Dis na di rizin we mek dɔktɔ dɛn kin tɛst nyu bɔbɔ fɔ si if dɛn nɔ gɛt G6PD if dɛn sɔspɛkt am.

Wetin kin mek di G6PD nɔ de?

G6PD dεfisiεns de kכz bay wan vεryushכn (vεryכnt) na yu G6PD jin. dis vεryushכn de mek yu bכdi nכ de instכkt yu fayn fayn wan fכ mek di G6PD εnzym. Yu kin gɛt dis jɛnɛtik chenj frɔm yu mama ɛn papa, tru di X kromozom .

we yu gεt dis jεnεtik vεryushכn min se yu rεd bכdi sεl dεm gεt lכw lεvεl fכ G6PD. di G6PD εnzym rili imכtant biכs i de mek di rεd bכdi sεl dεm nכ de kכmכt tu mכch "fri radikal dεm ." Bɔku tɛm, fri radikal dɛn na tin dɛn we nɔ de ambɔg pɔsin. Dɛn kin de na di say we dɛn de, na sɔm it dɛn (fava bins, fɔ ɛgzampul), ɛn na mɛrɛsin dɛn.

כltu, if yu nכ gεt inof G6PD, sכm trigεr dεm (e.g. fכ it fava bins) kin mek tu mכch pan dεn fri radikal dεm ya fכ bil insay yu sεl dεm. Dis kin mek yu gɛt wan sik we dɛn kɔl ɔksidativ strɛs , we kin mek yu rɛd blɔd sɛl dɛn strɛs. Afta sɔm tɛm, dɛn sɛl dɛn ya kin brok ɛn pwɛl. Dis kin mek di rɛd blɔd sɛl dɛn nɔ bɔku, ɛn dis kin mek di blɔd nɔ gɛt bɛtɛ blɔd .

Wetin na di tin dɛm wae kin mek pɔrsin nɔr gɛt bɛtɛ blɔd we gɛt fɔ du wit dis sik?

Sɔm pipul dɛn we de stɔdi bɔt dis bin tɔk se fɔ it fava bins na di tin we kin mek pɔsin want fɔ du sɔntin . If pɔsin we nɔ gɛt G6PD gɛt anemia afta i it fava bins, dɛn kin kɔl am favism . Ɔda tin dɛn we kin mek pɔsin gɛt dis sik na:

• Infεkshכn: Infεkshכn dεm lεk Epataytis A εn Epataytis B , Tayfoyd Fiva , εn Nyumonia .
• Sɔm mɛrɛsin dɛn we dɛn kin yuz fɔ malaria: Fɔ ɛgzampul , Primaquine .
• Sɔm antibayɔtiks : lɛk nitrofurantoin , dapsone, ɛn sɔlfa drɔgs .
• NSAID (di tin dɛn we de mek pɔsin fil pen): Lɛk aspirin ɛn ibuprofen .
• Smok ɛn drink pasmak.
• Siriɔs strɛs na yu maynd.
• Intɛns fyzikal ɛksesaiz.

Wetin na di tin dɛn we kin mek pɔsin gɛt dis sik?

difrεn tin dεm de we de mek di risk fכ inhεrit G6PD dεfisiεns de inkrεs:

• Bɔy ɔ gal:Man dɛn kin gɛt mɔ chans fɔ gɛt G6PD dɛfisiɛns. dis na biכs man dεn nכ gεt wan X kromozom we de kכri dis jεnεtik mכtεshכn. (Bikɔs uman dɛn gɛt tu X kromozom, tɛm kin de we di ɔda wan kin kɔmpɛns di prɔblɛm wit wan.)
• Di say we dɛn de: Dis sik kin apin to pipul dɛn we de na di sab-Sahara Afrika, di Mɛditarenian rijɔn, ɛn Sawt Is Eshia.
• Ras: Risach pipul dɛm se pas 10% pan di man dɛm we kɔmɔt na Afrika na Amɛrika gɛt G6PD dɛfisiɛns.

Aw dɛn kin no if pɔsin gɛt G6PD?

Bɔku tɛm, dɔktɔ dɛn go aks yu fɔs bɔt yu kɔmplit mɛdikal istri ɛn du ɛgzam fɔ yu bɔdi. Dɛn kin aks bak if yu jɔs dɔn chenj di mɛrɛsin ɔ yu dɔn gɛt ɛni infɛkshɔn. Dɛn go chɛk bak fɔ si if ɛnibɔdi na yu famili gɛt G6PD dɛfisiɛns.

di tεst dεm we dεn kin yuz fכ no if yu gεt G6PD na:

• Kɔmplit Blɔd Kɔnt (CBC): I de chɛk yu rɛd blɔd sɛl kɔnt.
• Peripheral Blood Smear: I de chɛk fɔ si if sayn dɛn de we de sho se pɔsin nɔ gɛt bɛtɛ blɔd na di blɔd smyuɛl, dat na fɔ si if di rɛd blɔd sɛl dɛn we shep ɔ saiz nɔmal.
• Bilirubin Test: Chɛk di lɛvɛl we bilirubin de, we na wan dɔti tin we dɛn kin mek frɔm di rɛd blɔd sɛl dɛn we dɔn brok.
• G6PD Tεst: Chεk yu G6PD εnzym lεvεl dεm.

Aw dɛn kin trit G6PD dɛfisiɛns?

Dɔktɔ dɛn kin trit di sik bay di sik. Fɔ ɛgzampul, if yu gɛt mild janda ɛn yu no se yu nɔ gɛt G6PD, dɛn go fɔs trit di sayn dɛm fɔ janda. Dɔn, dɛn go tɛl yu us trig dɛn yu nid fɔ avɔyd.

Bɔt if de sik tranga, di tritmɛnt kin difrɛn. If yu gɛt siriɔs ɛmolaytik anemia, yu kin nid fɔ transfyushɔn blɔd .

If yu pikin we dɛn jɔs bɔn gɛt janda, yu dɔktɔ kin trit am wit fototɛrapi (trit we dɛn kin yuz natura ɔ atifishal layt). If i rili bad, yu pikin go nid fɔ gɛt ɛkshɛnj transfyushɔn . Dis min se dɛn fɔ pul di pikin in blɔd we nɔ fayn ɛn put blɔd we gɛt wɛlbɔdi ɛn we dɛn gi am.

Yu tink se dɛn kin ebul fɔ protɛkt di G6PD dɛfisiɛns?

Bikɔs dis na tin we pɔsin kin gɛt frɔm in jɛnɛtiks, i nɔ pɔsibul fɔ mek i nɔ apin. Bɔt we dɛn de fɔ no am bifo i kam wit big big wɛlbɔdi prɔblɛm. Dɛn tin ya na:

• Skrin pikin dεm we dεn bכn pikin dεm: Insay bכku kכntri dεm usay dis kכndyushכn kin kכmכn, dεn dכn mek program dεm fכ skrεn fכ no if G6PD dεn nכ de pan nyu bכbi dεm.
• Jɛnɛtik tɛst: If pɔsin na yu famili gɛt G6PD dɛfisiɛns, yu kin nid bak fɔ du DNA tɛst.Yu dɔktɔ go advays yu fɔ du dat.

Wetin a go ɛkspɛkt if a gɛt dis sik?

No pɔrmɛnt mɛrɛsin nɔ de fɔ G6PD dɛfisiɛns. Bɔt bɔku pipul dɛn kin liv witout ɛni prɔblɛm if dɛn avɔyd tin dɛn we kin mek dɛn nɔ gɛt prɔblɛm. Ɛn i nɔ de afɛkt di layf we pɔsin de liv.

Bɔt dis sik nɔ kin afɛkt ɔlman di sem we. Bɔrku pipul dɛm wae gɛt G6PD dɛfisiɛns nɔr kin ivin no se dɛn gɛt am bikɔs dɛn nɔr gɛt ɛni sayn. Bɔrku pipul dɛm wae gɛt dis sik nɔr kin pasmak. Bɔt fɔ sɔm pipul dɛn, we dɛn gɛt sɔntin we de ambɔg dɛn, dɛn kin gɛt wan sik we dɛn kɔl hemolytic crisis, we kin mek dɛn layf de pan denja.

Yu dɔktɔ kin ɛksplen fayn fayn wan wetin yu kin ɛkspɛkt bay aw yu dɔn no bɔt yu sik.

Aw a go tek kia ɔf misɛf?

Aks yu dɔktɔ us it ɛn mɛrɛsin yu fɔ avɔyd. Na sɔm ɔda advays dɛn ya:

• Nɔ drink rɔm: If yu drink bɔku rɔm, dat kin mek yu rɛd blɔd sɛl dɛn prɛshɔ.
• Nɔ smok: If yu smok, dat kin mek fri radikal dɛn gɛda na yu rɛd blɔd sɛl dɛn.
• Ɛksesaiz we yu de du mɔdaret: If yu du ɛksɛsayz tumɔs, dat kin mek di ɔksidativ strɛs go ɔp.
• Tray fɔ rɛst fayn: Slip de mek yu imyun sistɛm strɔng, we de ɛp fɔ fɛt di infɛkshɔn dɛn we kin mek yu nɔ gɛt blɔd we yu de gi yu blɔd.
• Manej strɛs: If yu de fil bɔku strɛs, aks yu dɔktɔ fɔ ɛp yu fɔ kɔntrol yu strɛs.

Impɔtant: If yu nyu bɔbɔ gɛt G6PD dɛfisiɛns, yu fɔ avɔyd fɔ it fava bins we yu de gi in bɛlɛ . di kכmpawnd dεm we kin mek di pikin in bכdi bכku bכku wan kin pas to di pikin tru in mama in milk.

Ustɛm a fɔ go to mi dɔktɔ?

Si yu dɔktɔ ɛni tɛm if yu gɛt sɔm sayn dɛm fɔ G6PD dɛfisiɛns. If di sayn dɛn rili bad ɛn i kin bigin kwik (sayn fɔ se yu gɛt blɔd prɔblɛm), go to dɔktɔ wantɛm wantɛm .

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

Na sɔm kwɛstyɔn dɛn fɔ aks if yu gɛt G6PD dɛfisiɛns:

• Aw siriɔs mi sik de?
• Us it ɛn mɛrɛsin dɛn a fɔ avɔyd?
• Ɛni tin dɛn de we kin mek a nɔ du ɛnitin we go mek a nɔ gɛt prɔblɛm wit di envayrɔmɛnt?
• Wetin na di chans fɔ mek mi pikin gɛt G6PD dɛfisiɛns?

Fɔ dɔn, wetin fɔ mɛmba (Take-Home Message) .

Di diagnosis fɔ G6PD dɛfisiɛns kin afɛkt ɔlman difrɛn we. Pan ɔl we dɛn nɔ kin ebul fɔ mɛn am, bɔku tɛm na sik we pɔsin kin ebul fɔ kɔntrol. Di men tin na fɔ no ɛn avɔyd di tin dɛn we kin mek pɔsin gɛt prɔblɛm wit in anemia we kin mek pɔsin nɔ gɛt bɛtɛ blɔd.Dat kin min se yu fɔ avɔyd fava bins ɛn ɔda tin dɛn we kin mek yu nɔ it. I impɔtant bak fɔ praktis wɛl bɔdi abit, lɛk fɔ rɛst bɔku ɛn nɔ smok. Aks yu dɔktɔ fɔ infɔmeshɔn fɔ ɛp yu fɔ manej aw G6PD dɛfisiɛns de afɛkt yu layf. Nɔ panik, awareness na di bɛst difens!

` G6PD dεfisiεns, hεmolaytik anemia, janda, jεnεtik sik dεm, rεd blכd sεl dεm, fava bins, εnzym dεm