Yu ɔ pɔsin we yu sabi dɔn ɛva gɛt mɛrɛsin we dɛn kɔl ‘Givosiran’ frɔm dɔktɔ? We yu yɛri da nem de, yu go fil se yu nɔ no am smɔl, dat min se yu nɔ sabi am, ɛn sɔntɛm yu go ivin fred smɔl. Na nɔmal tin fɔ fil da we de. Bikɔs dɛn kayn mɛrɛsin ya nɔto di kayn mɛrɛsin we wi kin yɛri bɔt ɛvride. So tide, lɛ wi tɔk bɔt dis mɛrɛsin we dɛn kɔl Givosiran, wetin i de fɔ, aw fɔ yuz am, ɛn wetin fɔ tek tɛm wit yu, insay wan rili simpul we we yu go ɔndastand.
Wetin na dis Givosiran?
Fɔ tɔk am simpul wan, Givosiran na vaysin. Dɛn kin kɔl am di brand nem ``(GIVLAARI)``. Dɛn kin yuz dis mɛrɛsin mɔ fɔ trit wan sik we nɔ kin bɔku we dɛn kɔl ``Acute Hepatic Porphyria`` .
Naw yu kin de wɔnda wetin na ‘Acute Hepatic Porphyria’. Dis na wan sik we wi kin gɛt frɔm wi liva. Wi bɔdi nid wan kemikal we dɛn kɔl ‘porphyrin’ fɔ mek ɛmoglobin insay di blɔd. Bɔt pan pipul dɛn we gɛt dis sik, bikɔs ɔf wan prɔblɛm we de na da prɔses de, dis kemikal we dɛn kɔl pɔfyurin kin gɛda na di bɔdi we nɔ nid. Dis kin mek yu gɛt siriɔs sik lɛk fɔ gɛt siriɔs bɛlɛ pen, fɔ vɔmit, fɔ gɛt mɔsul dɛn we wik, ɛn fɔ gɛt prɔblɛm wit yu maynd.
Dis vaysin we dɛn kɔl Givosiran, rili spɛshal. dεn mek am yuz wan vεri advans tεknכlכji we dεn kכl 'small interfering RNA' (siRNA) . Dis min se dis drɔg de go dairekt insay wi sɛl dɛn ɛn stɔp di jɛnɛtik mɛsej we de mek di pɔfyrin we de ambɔg di bad bad tin dɛn we de apin. I tan lɛk se yu stɔp pɔsin we de gi yu di rɔng advays.
Dis nɔ tan lɛk mɛrɛsin we dɛn kin yuz fɔ mɛn pen ɔltɛm. Na mɛrɛsin we dɛn kin rili tɔch ɛn we kin go to di rut fɔ di sik ɛn trit am.
Tin dɛn we yu fɔ tɛl yu dɔktɔ bifo yu tek mɛrɛsin
Bifo yu bigin Givosiran, i rili impɔtant fɔ tɔk opin wan wit yu dɔktɔ bɔt yu kɔmplit wɛlbɔdi istri. Mek shɔ se yu tɛl dɛn bɔt dɛn tin ya:
- Kidni sik: If yu gɛt ɛni sik we gɛt fɔ du wit di kidni.
- Liva sik: If yu gɛt ɔda liva sik dɛn apat frɔm di pɔfyuria kɔndishɔn we yu gɛt naw.
- Alɛji: Tɛl yu dɔktɔ if yu gɛt ɛni alɛji, nɔto jɔs fɔ Givosiran, bɔt fɔ ɛni ɔda mɛrɛsin, it, day, ɔ tin we de mek yu nɔ gɛt am.
- Bɛlɛ: If yu gɛt bɛlɛ ɔ yu de op fɔ bɔn pikin jisnɔ.
- If yu na mama we de gi pikin in bɛlɛ: If yu de gi yu pikin in bɛlɛ.
Bay dis infɔmeshɔn, di dɔktɔ go disayd if dis tritmɛnt fayn fɔ yu ɔ nɔ fayn fɔ yu ɛn aw fɔ go bifo.
Aw fɔ gɛt di mɛrɛsin ɛn wetin fɔ wach fɔ
Dis nɔto mɛrɛsin we yu kin kɛr go na os ɛn yuz am.
- Aw fɔ gi am: Dis na injɛkshɔn we dɛn kin put ɔnda di bɔdi .
- Di say we dɛn de: Na pɔsin we tren fɔ kia fɔ wɛlbɔdi biznɛs nɔmɔ kin gi dis vaysin na say usay dɛn de mɛn pipul dɛn, lɛk ɔspitul ɔ klinik.
- Fɔ pikin dɛn: If dɛn yuz dis mɛrɛsin fɔ yɔŋ pikin dɛn, dɛn nid fɔ kia fɔ spɛshal kia ɔnda di advays we dɔktɔ we de mɛn pikin dɛn go gi.
- If yu mis wan doz: Yu dɔktɔ go gi yu de ɛn tɛm fɔ gɛt yu vaysin. I rili impɔtant fɔ gɛt yu tritmɛnt di rayt tɛm. If fɔ sɔm rizin yu nɔ ebul fɔ go da de de, kɔl yu dɔktɔ ɔ klinik wantɛm wantɛm ɛn mek dɛn no.
- If yu tek di mɛrɛsin pasmak: Bikɔs na dɔktɔ we sabi du dis, di chans fɔ mek yu tek am pasmak nɔ bɔku. Bɔt if yu tink se sɔntin dɔn apin, yu fɔ kɔl di Nashɔnal Pɔyzin Infɔmeshɔn Sɛnta wantɛm wantɛm na di Kolombo Nashɔnal Ospital , ɔ go na di Imejɛnsi Tritmɛnt Yunit (ETU) na di ɔspitul we de nia yu.
Di sayd ɛfɛkt dɛn we di mɛrɛsin kin gɛt
Lɛk ɛni mɛrɛsin, Givosiran kin mek sɔm pipul dɛn gɛt sayd ɛfɛkt. I impɔtant fɔ no bɔt dɛn tin ya. Lɛ wi sheb dɛn tin ya to tu pat.
| Di sayd ɛfɛkt ɛn di sayn dɛn we pɔsin kin gɛt | Tɔk bɔt |
|---|---|
| Siriɔs sayd ɛfɛkt dɛn we nid fɔ go to dɔktɔ wantɛm wantɛm | |
| Alɛji Riakshɔn dɛn | Skin rash, kɔndishɔn we tan lɛk ɛkzema, it, swel na yu fes, lip ɔ yu tɔŋ, i nɔ izi fɔ blo. If ɛni wan pan dɛn tin ya apin, na imejensi. |
| Simptom dɛm fɔ Liva Injury | Dak yɔlɔ ɔ brawn urine, yu yay ɔ yu skin kin yɔlɔ (jaundice), pen na di ɔp rayt say na yu bɛlɛ, yu kin nɔs, yu nɔ kin want fɔ it, yu kin fil lɛk yu taya, ɛn yu kin gɛt fiva. |
| Di Simptom dɛm fɔ Kidni Injuri | I at fɔ pis ɔ big chenj na di amount of urine we yu de pas (we yu de pas smɔl ɔ nɔ urine atɔl). |
| Tin dɛm wae nɔr kin siriɔs, bɔt dɛn fɔ ripɔt to di dɔktɔ if dɛn kɔntinyu fɔ de | |
| Vɔmit | Fɔ fil lɛk se yu bɛlɛ de rɔn ɔ yu fil lɛk fɔ vɔmit. |
| Pen na di say we dɛn injɛkshɔn | Rɛd, swel smɔl, ɔ pen na di say we dɛn injekt am. |
| We pɔsin taya | Fɔ fil taya pas aw i kin fil. |
Prɔblɛm kin de wit ɔda mɛrɛsin dɛn?
Yɛs, i rili ebul fɔ du am. Wi de kɔl dat ‘Drug Interactions’. Di Givosiran vaysin kin intarakt wit sɔm ɔda mɛrɛsin dɛn.
So, tɛl yu dɔktɔ bɔt ɔl wetin yu de yuz . Dat min se:
- Mɛrɛsin dɛn we dɔktɔ dɛn kin gi fɔ ɔda sik dɛn.
- Mεdisin dεm we yu kin bay na di famasi we yu nכ gεt prεskrishכn (e.g. pen kil, kol mεdisin).
- Vitamin, minral ɔ ɔda sɔpɔtmɛnt dɛn.
- Ayurvedic, lokal ɔ tradishɔnal ɛvbɔdi.
- If yu smok ɔ drink rɔm, tɛl mi.
Na mɔtalman, dɛn nɔ fɔ yuz di saykayatrik drɔg we dɛn kɔl thioridazine wit dis vaysin atɔl. Dɔn bak, tin dɛn we gɛt kafin ɛn mɛrɛsin fɔ kɔf lɛk dɛkstromɛtɔrfan kin mek yu gɛt prɔblɛm wit dis.
Dis list nɔ kɔmplit, so i bɛtɛ fɔ mek yu tɛl yu dɔktɔ klia wan bɔt ɔltin we yu de tek.
Mɛsej we dɛn kin kɛr go na os
- Givosiran na spɛshal injɛkshɔn we dɛn kin gi ɔnda di skin fɔ wan sik we nɔ kin bɔku na di liva we dɛn kɔl ‘Acute Hepatic Porphyria’.
- Na ɔspitul ɔ klinik nɔmɔ pɔsin we tren fɔ mɛn pipul dɛn kin gi dis mɛrɛsin. I nɔ de fɔ yuz na os.
- Bifo yu bigin fɔ trit yu, i impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl yu mɛrɛsin, alɛji, ɛn ɔl ɔda mɛrɛsin ɛn sɔpɔtmɛnt dɛn we yu de tek.
- Ɔltɛm de wach fɔ siriɔs sayd ɛfɛkt, lɛk alɛji ɔ sayn dɛm fɔ se yu liva ɔ kidni dɔn pwɛl. If yu notis ɛni wan pan dɛn tin ya, tɛl yu dɔktɔ wantɛm wantɛm.
- Nɔ ɛva mis blɔd tɛst ɛn tritmɛnt apɔntinmɛnt we yu dɔktɔ tɛl yu fɔ du.
- If yu gɛt ɛni kwɛstyɔn ɔ wɔri bɔt dis mɛrɛsin, di bɛst pɔsin fɔ aks bɔt am na di dɔktɔ we de trit yu.
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