Sɔntɛnde yu kin fil se yu bɛlɛ asid kin bɔku, yu at kin bɔn, ɔ yu bɛlɛ nɔ kin fil fayn afta yu dɔn it? Ɔ yu gɛt wan sik lɛk gastritis? Dɔn yu go dɔn yɛri bɔt wan kayn mɛrɛsin we dɛn kɔl H2 blɔk. Tide, lɛ wi tɔk bɔt wetin na dɛn H2 blɔk ya, aw dɛn de wok, ɛn insay us sityueshɔn dɛn de yuz dɛn.
Wetin na H2 blɔk (H2 antagonist)?
Fɔ tɔk am simpul wan, H2 blɔk na wan kayn mɛrɛsin we de ridyus di asid we de kɔmɔt na yu bɛlɛ. Naw yu kin de wɔnda wetin na fɔ di bɛlɛ asid. Asid na di bɛlɛ impɔtant fɔ mek wi ebul fɔ digest di it we wi de it. Bɔt prɔblɛm kin bigin we dis asid kin bɔku. afta dat di dilik tisu dεm na wi dijestiv sistεm (GI - gastrointestinal tract) kin pwεl. Dis na di rizin we mek sɔm kayn sik lɛk bɛlɛ pen ɛn at bɔn kin apin. Sɔntɛnde, fɔ it spays it kin so tranga dat yu kin tink se, "O, wetin mek a it dat?"
So, if yu na pɔrsin wae gɛt sɔm kayn sik wae de kam wae yu bɛlɛ asid bɔrku, yu kin tink bɔt fɔ yuz H2 blɔk.
Us kɔndishɔn dɛn kin trit wit H2 blɔk?
H2 blכk dεm dεn kin yus mεntal fכ trit kכndishכn dεm we riliyt to εksyכs bεlε asid prodakshכn. Bɔt wan tin we yu fɔ mɛmba: If yu kɔntinyu fɔ yuz dɛn mɛrɛsin ya, di we aw dɛn de wok kin go dɔŋ smɔl smɔl as tɛm de go.
If yu gɛt wan sik we nɔ de mɛn ɛn we de te we gɛt bɔku bɔku asid na yu bɛlɛ, yu kin tink bɔt wan kayn mɛrɛsin we dɛn kɔl proton pump inhibitor (PPI) . pan ɔl we PPI dɛn nɔ de wok kwik lɛk H2 blɔk, dɛn kin ridyus di bɛlɛ asid prodakshɔn bak ɛn dɛn kin yuz dɛn fɔ lɔng tɛm pas H2 blɔk. PPI na wan kayn mɛrɛsin we gɛt mɔ pawa fɔ kɔntrol asid pas H2 blɔk.
Lɛ wi tek wan luk pan sɔm pan di men kɔndishɔn dɛm we dɛn kin trit wit H2 blɔk dɛm:
Ɔlsa na di bɛlɛ ɛn ɔlsa na di duodenal
We di bɛlɛ asid tu bɔku, i kin pwɛl di bɛlɛ layn ɛn mek yu gɛt ɔlsa. di H2 blכk dεm de ridyus di bεlε asid prodakshכn, we de gi dεn כlsa dεm ya tεm fכ hεl.
כlso, sכmtεm di bεlε asid kin travul go כp to di fכs pat pan wi sכmכl intestin (duodenum) εn mek כlsa de. Wi kin kɔl dɛn ɔlsa ya na di duodenal . Pan ɔl we PPI na rili di tritmɛnt we go wok pas ɔl fɔ dis, di H2 blɔk dɛn kin trit dis kɔndishɔn bak. Di US Food and Drug Administration (FDA) dɔn gri fɔ H2 blɔk fɔ shɔt tɛm mentenɛns tritmɛnt fɔ mek nyu ɔlsa nɔ fɔm. Yu dɔktɔ kin tɔk to yu bɔt di rayt tritmɛnt ɛn mentenɛns rijim fɔ yu.
Asid riflɔks ɛn GERD
Dis na prɔblɛm we bɔku pipul dɛn gɛt. Asid riflɔksi min se di asid we de na di bεlε de kam bak כp, dat min se i de kam כp, εn go insay di trot tru wi εsophagus (fud paip). Dis na wetin kin mek yu at bɔn. if dis kכndyushכn kכntinyu, inflameshn na di εsophagus (εsophagitis) kin apin bak. wan H2 blכk kin gi rilif fכ wan wan asid rεfluks. Bɔt if yu gɛt lɔng tɛm asid riflɔks kɔndishɔn, dat na GERD (Gastroesophageal Reflux Disease) , i go bɛtɛ fɔ yuz PPI.
Zollinger-Ellison sindrom we gɛt di sik
Dis na tin we nɔ kin apin so ɔltɛm. I kin apin we sɔm tɔŋ dɛn na wi bɔdi kin mek wi bɛlɛ mek tumɔs asid. di H2 blכk dεm kin εp bay we dεn de blכk di prodakshכn fכ di bεlε asid. Bɔt if na so i bi, i go mɔs bi se yu dɔktɔ go gi yu PPI.
Di simptom dɛm we H2 blɔk dɛn kin rilivu
Dɛn mɛrɛsin ya kin mek yu fil fri frɔm dɛn sik ya:
- Bloating, indigestion we yu nɔ de it fayn
- Bɛlɛ de pen
- At bɔn ɛn riflɔks
- Nɔs ɛn vɔmit
- Sɔl bɛlɛ, sɔl teys na di trot
Aw H2 blɔk dɛn de wok?
כda nem fכ H2 blכk dεm na histamin-2 (H2) antagonist dεm . Dis nem de gi wi smɔl aidia bɔt aw dɛn drɔgs ya de wok. Yu go dɔn lan bɔt di wok we ‘antagonist’ de du na Inglish klas we yu bin de na skul. Insay sɛntɛns, antagonist na sɔntin we de mek pɔsin nɔ ebul fɔ du am. di sem we, di H2 antagonist dεm de blכk di prodakshכn fכ di bεlε asid.
Tink bɔt am dis we. Afta yu it it, yu bɔdi de pul wan kemikal we dɛn kɔl H2. dis H2 de go εn atak to spεsifi k sayt dεm (H2 rεsεpכta dεm) na di sεl dεm na di wכl dεm na yu bεlε. dis atachmεnt na in de mek yu bεlε kכl asid.
we yu tek wan H2 antagonist, כ H2 blכk, di dכg de go to dεn H2 rεsεpכta dεm bifo H2 kin biεn dεm. sכm kayn we, di H2 blכk dεm de "bכk" H2 fכ biεn dεn rεsεpכta dεm de. dis de ridyus di prodakshכn fכ asid na di bεlε.
Dis nɔ go ambɔg yu dijestiv prɔses. Bɔt i go ridyus di ɛkstra asid we de mek dɛn gɛt dɛn pen. Dɔn gɛt am?
Wetin na di kayn H2 blɔk? (Mɛrɛsin dɛn we de na makit)
Difrɛn kayn H2 blɔk dɛn de. Sɔm yu kin bay ova-di-kɔnta (OTC) na famasi we yu nɔ gɛt prɛskrishɔn (Rx). Sɔm dɛn kin nid fɔ gɛt prɛskrishɔn frɔm dɔktɔ. Dis kin difrɛn difrɛn wan bay di kayn mɛrɛsin ɛn di doz.
Di kayn H2 blɔk dɛn we de naw na:
- Cimetidine ( brand nem, fɔ ɛgzampul, Tagamet®) - Dis de ɔl tu OTC ɛn Rx.
- Famotidin we dɛn kɔl famotidin(Brand nem, fɔ ɛgzampul, Pepcid®) - Dis de bak ɔl tu di OTC ɛn Rx.
- Nizatidine (brand nem Axid®, fכ egzampl) - Dis kin כnli fכ gεt wit Rx.
Yu go dɔn yɛri bɔt Ranitidine ( we dɛn kɔl di brand nem Zantac®). Na bin di fɔs H2 blɔk we di FDA bin gri fɔ insay 1983. Bɔt insay Epril 2020, di FDA bin ɔda di wan dɛn we de mek am fɔ pul Ranitidine na di makit. Di rizin fɔ dis na bikɔs FDA tɛst dɛn sho se we dɛn kip Ranitidine fɔ lɔng tɛm, di lɛvɛl dɛn we pɔsin kin gɛt kansa (nitrosodimethylamine, ɔ NDMA) kin go ɔp to di lɛvɛl dɛn we nɔ sef. Risach pipul dεm fכnshכn bak se di NDMA lεvεl dεm de inkrεs we dεn stכr Ranitidine na ay tεmprachכ.
Aw fɔ yuz dis mɛrɛsin?
Mɔs pan di H2 blɔk dɛn kin kam insay di fɔm fɔ pils ɔ kapsul we yu kin tek wit yu mɔt. Sɔntɛnde dɛn kin kam bak wit paoda we yu kin miks wit wata ɛn drink fɔ pipul dɛn we gɛt prɔblɛm fɔ swɛla pils.
Sɔm H2 blɔk dɛn kin gi yu bak insay yu bɛlɛ (IV) , mɔ if yu de na ɔspitul ɛn yu nɔ ebul fɔ tek di mɛrɛsin bay mɔt.
Wetin na di bes taim fo tek H2 bloka?
If yu no se yu go it sɔntin we yu nɔ lɛk, lɛk spaysi it, i fayn fɔ tek H2 blɔk lɛk 30 to 60 minit bifo yu it am. Da we de, di mɛrɛsin kin gɛt tɛm fɔ bigin fɔ wok. I nɔ bad fɔ tek am afta yu dɔn it, bɔt i kin tek wan awa fɔ mek yu sik nɔ kam.
As shɔt tɛm tritmɛnt fɔ wan sik lɛk bɛlɛ ɔlsa, yu dɔktɔ kin tɛl yu fɔ tek dis mɛrɛsin lɛk dis:
- Wan tɛm insay di de, bifo yu go slip na nɛt.
- Ɔ wan tɛm na mɔnin ɛn wan tɛm na nɛt.
Di tin we impɔtant pas ɔl na dat if yu nid fɔ yuz H2 blɔk fɔ pas tu wiks fɔ kɔntrol yu sik dɛn, yu fɔ rili go to dɔktɔ. I nɔ fayn fɔ abop pan H2 blɔk fɔ lɔng tɛm we yu nɔ tɔk to dɔktɔ.
Aw lɔŋ i kin tek fɔ mek H2 blɔk dɛn wok? Aw i difrɛn frɔm ɔda mɛrɛsin dɛn?
I kin tek lɛk wan awa fɔ fil fri frɔm di sayn dɛm afta yu tek wan H2 blɔk. Di tin dɛn we kin apin kin las frɔm 4 to tɛn awa . Dis akshɔn we de du tin kwik kwik wan de mek i fayn fɔ disayd if yu nid fɔ gɛt rilif wantɛm wantɛm ɔ if yu at kin bɔn wan wan tɛm nɔmɔ.
If yu nid fɔ gɛt wɛlbɔdi kwik kwik wan, yu kin tray fɔ tek wan mɛrɛsin we de mek yu nɔ gɛt asid . Antasid dεm de neutralize di asid we de na yu bεlε. Dɛn go bigin fɔ wok fast pas H2 blɔk, bɔt dɛn ifɛkt nɔ go las lɛk H2 blɔk.
If yu simptom dɛn de fɔ lɔng tɛm, mɔ if H2 blɔk nɔ de gi yu inof rilif, yu kin nid fɔ tek PPI. PPI kin tek wan to 4 dez fɔ tek ful ɛfɛkt, bɔt i kin las fɔ lɔng tɛm pas H2 blɔk.
Yu tink se H2 blɔk dɛn gɛt sayd ɛfɛkt?
H2 blכk dεm de gi rilif wit lכw risk fכ sayd ifekt dεm. Bɔt lɛk ɛni mɛrɛsin, smɔl smɔl sayd ɛfɛkt dɛn kin apin.
Kɔmɔn sayd ɛfɛkt dɛn
- Bɛlɛ de pen
- Mɔsul dɛn kin pen
- Banbɛlɛ
- Dayarɛa (we pɔsin kin blo) .
- Dray mɔt
- We pɔsin taya
- Ed de at
Tin dɛn we yu fɔ pe spɛshal atɛnshɔn to
pan ɔl we i nɔ kin apin so ɔltɛm, di H2 blɔk dɛn kin mek nyurolɔjik simptom (e.g., kɔnfyushɔn, slɔr tɔk) na sɔm grup dɛn we gɛt ay risk. Yu kin gɛt dɛn sik ya if yu pas 50 ia ɛn yu kidni ɔ liva nɔ de wok fayn . Bɔt dɛn sik ya kin dɔn insay sɔm dez afta dɛn dɔn stɔp di mɛrɛsin.
Prɔblɛm kin de wit ɔda mɛrɛsin dɛn?
Sɔm H2 blɔk dɛm (fɔ ɛgzampul, cimetidine) kin mek sɔm ɔda mɛrɛsin dɛm we yu de tek nɔ wok fayn. Fɔ ɛgzampul, simetidin kin ridyus di wok we sɔm SSRI (wan kayn mɛrɛsin we dɛn kin yuz fɔ mɛn maynd sik lɛk pwɛl hat) ɛn warfarin (wan mɛrɛsin we de mek blɔd nɔ klɔt) nɔ wok fayn.
So, bifo yu bigin fɔ tek nyu mɛrɛsin, i rili impɔtant fɔ tɔk to yu dɔktɔ fɔ no if ɛni bad tin de apin to di mɛrɛsin dɛn we yu dɔn ɔlrɛdi de tek.
I sef fɔ yuz H2 blɔk we yu gɛt bɛlɛ ɛn we yu de gi pikin in bɛlɛ?
Dɛn nid fɔ du mɔ risach fɔ no if i sef fɔ yuz H2 blɔk we uman gɛt bɛlɛ, bɔt di wan dɛn we de du risach no se di mɛrɛsin kin pas insay di mama in milk .
If yu de tek wan H2 blɔk ɛn yu gɛt bɛlɛ, mek shɔ se yu tɔk to yu dɔktɔ. Aks am if i sef fɔ tek dis mɛrɛsin we yu gɛt bɛlɛ ɔ we yu de gi pikin in bɛlɛ.
Ustɛm yu nid fɔ go to dɔktɔ?
As wi bin dɔn tɔk, if yu fɔ yuz H2 blɔk fɔ pas tu wiks fɔ kɔntrol yu sik dɛn, yu fɔ rili go to dɔktɔ. E fayn fɔ no wetin de mek yu gɛt dis sik. Yu kin nid fɔ gɛt sɔlv fɔ lɔng tɛm, lɛk PPI.
Dɔn bak, tɛl yu dɔktɔ if yu gɛt ɛni bad tin fɔ du wit di mɛrɛsin ɔ yu notis ɛni bad bad tin we de apin to yu. Yu kin nid fɔ chenj di mɛrɛsin we yu de tek ɔ yu kin nid fɔ chenj to ɔda mɛrɛsin.
Wetin na di H2 blɔk we sef pas ɔl? Wetin na di bɛst fɔ GERD?
FDA-apruv H2 blɔk dɛn bɔku pan dɛn fiba pan dɛn sef ɛn ɛfɛktiv.
Bɔt if yu de tek ɔda mɛrɛsin ɛn yu de tink bɔt fɔ yuz H2 blɔk, i bɛtɛ fɔ tɔk to yu dɔktɔ. I impɔtant fɔ pik wan mɛrɛsin we nɔ go ambɔg di we aw di mɛrɛsin dɛn we yu dɔn ɔlrɛdi de tek go wok fayn.
Fɔ GERD, ɛni H2 blɔk kin ɛp fɔ pul di asid riflɔks simptom dɛm. Bɔt if yu asid riflɔks de te (lɛk na GERD), i kin bɛtɛ fɔ skip H2 blɔk dɛn ɔltogɛda ɛn pik PPI. Tɔk to yu dɔktɔ bɔt dis bak.
Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .
Okay, so wi tok plenti boht H2 bloka tide, no?
H2 blכk dεm, antisid dεm, εn PPI dεm כl dεn de yuz fכ trit kכndishכn dεm we kכz fכ εksyכs bεlε asid. Sɔntɛnde, we yu gɛt bɔku tin dɛn fɔ du, i kin mek yu kɔnfyus fɔ no uswan fɔ pik.
Tink bɔt am dis we: If yu de luk fɔ shɔt tɛm rilif we go las fɔ sɔm awa, H2 blɔk kin bi di bɛst opshɔn fɔ yu. Ɛspɛshali if yu no se yu go gɛt at bɔn afta yu it sɔntin we gɛt spays, i fayn fɔ tek H2 blɔk bifo tɛm.
Mɛmba se if yu gɛt ɛni ɔda kwɛstyɔn bɔt dis mɛrɛsin, nɔ fred fɔ aks yu dɔktɔ. I rili impɔtant fɔ mek dɛn no bɔt yu wɛlbɔdi biznɛs!
` H2 blɔk, gastritis, bɛlɛ inflamɛns, bɛlɛ asid, chɛst inflamɛns, bɛlɛ ɔlsa, Sinhala mɛdikal atikul dɛn
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