Yu dɔktɔ dɔn gi yu mɛrɛsin fɔ pwɛl hat? Ɔ ɛnibɔdi we yu sabi de yuz dis mɛrɛsin? Pan ɔl we bɔku stori dɛn de na sosayti bɔt dis mɛrɛsin, ɔmɔs pipul dɛn rili no aw i kin afɛkt di bren ɛn wetin kin apin bikɔs ɔf dat? Bɔku pipul dɛn kin fred dis mɛrɛsin, bɔt di rizin fɔ da fred de na bikɔs dɛn nɔ no natin. So, lɛ wi ɔndastand dis simpul ɛn klia wan tide, lɛk se wi de tɔk to wi padi.
Wetin na dɛn mɛrɛsin ya we de mek pɔsin fil bad?
Pan ɔl we dɛn kɔl dɛn mɛrɛsin ya ‘antidipreshan’, dɛn nɔr kin jɔs yuse dɛn fɔ trit pwɛl hat, na wan kayn maynd sik wae kin mek pɔrsin fil bad bad wan ɛn nɔr gɛt op. Dɛn bin fɔs bigin fɔ yuz dɛn mɛrɛsin ya insay di ia 1950. Tide, apat frɔm pwɛl hat, dɛn dɔn gri fɔ tek dɛn mɛrɛsin ya bak fɔ sik dɛn lɛk OCD (Obsessive-Compulsive Disorder), Sɔshial Fɔbia, Panik Disɔda, GAD (Jɛnɛralized Anxiety Disorder), ɛn PTSD (Posttraumatic Stress Disorder).
Apat frɔm dat, sɔntɛnde dɔktɔ dɛn kin gi dis mɛrɛsin fɔ sik dɛn lɛk pen we nɔ de dɔn, we pɔsin nɔ kin ebul fɔ slip, ɛn maygren. Dɛn kɔl dis ‘ɔf-lɛbul’ yus. Dis min se dɛn nɔ dɔn ɔfishal wan gri fɔ di mɛrɛsin yet fɔ da sik de, bɔt di dɔktɔ biliv se di pɔsin we sik go bɛnifit frɔm am.
Aw dis mɛrɛsin kin afɛkt wi bren?
Fɔ tɔk am simpul wan, dɛn mɛrɛsin ya kin wok bay we dɛn kin chenj di lɛvɛl we sɔm kemikal dɛn de na wi bren. Wi kin kɔl dɛn kemikal ya nyurotransmitta . Dɛn wan ya kin kɔntrol bɔku tin dɛn lɛk aw wi de fil, aw wi de fil, aw wi de slip, ɛn aw wi want fɔ it.
Tink bɔt am dis we. di nεv sεl dεm na wi bren de yuz dεn ‘mεsenja dεm’ we dεn kכl nyurotransmitta fכ kכmכnik wit dεn wan dεm. Wan nɛv sɛl de fri dis mɛsenja, ɛn pas di mɛsej to di nɛks sɛl. Afta dɛn dɔn sɛn di mɛsej, dɛn kin kɛr di mɛsenja bak kwik kwik wan insay di ɔrijinal sɛl (dɛn kɔl dis riuptek ).
Wetin antidipreshan kin du men wan na fɔ delay dat riuptek prɔses smɔl. afta dat, da mεsenja de (fכ egzampl, sεrotonin) de de na di gap bitwin di tu nεv sεl dεm (di sinaps) fכ lכng tεm. Dɔn i kin wok fɔ lɔng tɛm ɛn mek wi fil fayn.
Di trut na dat, ivin masta sabi pipul dɛn nɔ shɔ 100% aw dɛn drɔgs ya de wok, bikɔs mɔtalman bren na tin we rili kɔmpleks. Bɔt risach dɔn sho se dɛn kin ɛp fɔ kɔntrol di sayn dɛm.
di kayn tin dεm we dεn kin yus fכ riuptek inhibito dεm
Di mɛrɛsin wae dɛn kin gi pasmak fɔ mɛn pwɛl hat naw na dis grup. Dɛn sheb dɛn to bɔku men kayn dɛn.
1. SSRI dɛn (Sɛlektiv Sɛrotonin Riuptek Inhibitɔ dɛn) .
Dis na di fɔs mɛrɛsin dɛn we dɔktɔ dɛn kin gi dɛn bɔku tɛm. As di nem sho, dεn tin ya de spεshal tכk to di nyurotransmitta sεrotonin . Serotonin impɔtant fɔ tin dɛn lɛk aw wi de fil, aw wi de biev, ɛn aw wi de mɛmba.
Wae yu bigin fɔ tek dis mɛrɛsin, i kin tek sɔm wik, sɔmtɛm te to 2-3 mɔnt, fɔ si ful rizɔlt. So i impɔtant fɔ peshɛnt. Dɔn bak, nɔ ɛva stɔp fɔ tek dis mɛrɛsin wantɛm wantɛm if yu dɔktɔ nɔ advays yu. If yu du dat, i kin mek yu gɛt sayn dɛn we nɔ fayn (antidipreshan diskɔntinyueshɔn sindrom).
Serotonin Syndrome - Na sɔntin we yu fɔ wɔri bɔt!
Sɔntɛnde, we yu tek ɔda mɛrɛsin dɛn we de mek di sɛrotonin lɛvɛl go ɔp, lɛk SSRI, di sɛrotonin we de na di bren kin go ɔp we yu nɔ nid. Dis kin mek pɔsin denja.
| Di kɔmɔn simptom dɛm fɔ Serotonin Syndrome | |
|---|---|
| - Wɔri, nɔr de rɛst | - Dilayt pupil dɛn |
| - Nɔs, vɔmit, bɛlɛ at pwɛl | - Mɔsul dɛn de twitch, stiffness |
| - Fɔ swet pasmak, fɔ shek shek | - Rapid ay muvmεnt frכm sayd to sayd |
| Siriɔs sayn dɛm wae nid fɔ admit na ɔspitul kwik kwik wan: | |
| - Siriɔs kɔnfyushɔn ɔ delirium | - Ay fiva |
| - At rit de rili fast | - Di sik dɛn we de mek pɔsin sik |
| - Ay blɔd prɛshɔn | - Lɔs pan kɔnshɛns |
If yu gɛt ɛni wan pan dɛn siriɔs sayn ya, go na di ɔspitul we de nia yu in Imejɛnsi Tritmɛnt Yunit (ETU) wantɛm wantɛm .
2. SNRI dɛn (Serotonin-Norepinephrine Riuptek Inhibitɔ dɛn) .
Dis na smɔl mɔ advans klas ɔf mɛrɛsin dɛm we kam afta di SSRI dɛm. Dɛn kin afɛkt ɔl tu di nyurotransmitta dɛn we dɛn kɔl sɛrotonin ɛn norepinephrine . Norepinephrine impɔtant fɔ mek wi pe atɛnshɔn ɛn fɔ wach. Na dat mek sɔmtɛm dɛn kin yuse dɛn mɛrɛsin ya fɔ trit pen we nɔ de dɔn (e.g., dayabitik nyuropathy, fibromyalgia).
- Sɔm ɛgzampul dɛn we dɛn kin yuz: Duloxetine (Cymbalta), Venlafaxine (Effexor) .
- Di sayd ɛfɛkt dɛm we kin apin: nɔs, yu mɔt kin dray, yu kin taya, yu kin slip, yu kin gɛt diziz, yu kin swet.
3. NDRI dεm (Norepinephrine εn Dopamin Riuptek Inhibitors) .
dis mεdikeshכn de inkrεs di lεvεl dεm fכ di nyurotransmitta dεm we dεn k כl norepinephrine εn dopamine . Dopamine impɔtant fɔ mek wi gladi, fɔ mek wi want fɔ du sɔntin, ɛn fɔ pe atɛnshɔn to wi.
- Praymɛnt ɛgzampul: Bupropion (Wɛlbutrin). Dis na mɛrɛsin we kin ɛp yu bak fɔ lɛf fɔ smok.
- Speshal not: I nɔ gɛt bɛtɛ sayd ɛfɛkt pan mami ɛn dadi biznɛs pas ɔda mɛrɛsin dɛn we de mek pɔsin fil bad. Bɔt i nɔ fayn fɔ pipul dɛn we de pan denja fɔ gɛt sik.
Ɔda kayn dɛn, ol bɔt stil impɔtant
Pan ɔl we dɛn nɔ de yuz dɛn mɛrɛsin ya bɔku bɔku wan naw, dɛn kin rili yus fɔ sɔm pipul dɛn we nɔ de tek nyu mɛrɛsin. Bɔt dɛn kin gɛt bɔku bad bad tin dɛn we kin apin to dɛn.
Trisayklik ɛn tetrasayklik antidipreshɔn (TCA) .
Dis na ol mɛrɛsin wae dɛn dɔn de yuse frɔm di 1950 dɛm. Pan ɔl we dɛn kin wok lɛk nyu mɛrɛsin dɛn, dɛn kin gɛt mɔ bad bad tin dɛn. Fɔ ɛgzampul, dɛn kin mek yu slip, yu mɔt kin dray, yu bɔdi kin gɛt bɔku bɔku bɔdi, ɛn yu at kin chenj.
- Kɔmɔn ɛgzampul dɛn: Amitriptyline, Nortriptyline, Clomipramine.
Monoamin oksidaz inhibito dεm (MAOIs) .
Dɛn mɛrɛsin ya bak na mɛrɛsin dɛn we rili ol ɛn we dɛn nɔ kin yuz bɔku tɛm. We yu de yuz dɛn tin ya , yu nid fɔ rili tek tɛm wit wetin yu de it. Bikɔs if yu it it dɛn we gɛt di amino asid ‘Tyramine’ (e.g., chiz we dɔn ol, soya sos, sɔm mit, sɔm frut), yu blɔd prɛshɔn kin go ɔp bad bad wan. Dɔn bak, fɔ tek dɛn tin ya wit ɔda mɛrɛsin dɛn we de mek pɔsin fil bad, dat kin rili denja.
I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɛni mɛrɛsin, vaytamɛn, ɔ ɛbul prɔdak we yu de tek, bikɔs dɛn mɛrɛsin ya kin wok togɛda.
Nutraceuticals wae yu kin tek fɔ ɛp wit mɛrɛsin
Dɛn tin ya nɔto mɛrɛsin, bɔt na tin dɛn we pɔsin kin it ɔ it tin dɛn we kin ɛp wit sɔm mɛrɛsin dɛn. Nɔr kin fayn fɔ yuse dɛn wan fɔ pwɛl hat. Bɔt yu kin yuz dɛn togɛda wit di men tritmɛnt, lɛk aw yu dɔktɔ advays yu.
- SAMe (S-adenosyl-methionine): na kεmikכl we di bכdi de mek we de εp fכ mek nyurotransmitta dεm.
- Omega-3 Fatty Acids: Dɛn wan ya, mɔ we de insay fish ɔyl, kin ɛp fɔ ridyus sɔm inflamɛns na di bren.
- Vitamin D: Risach dɔn sho se sɔntin de bitwin we pɔsin nɔ gɛt dis vaytamɛn, we dɛn kin gɛt frɔm di san, ɛn we pɔsin kin fil bad.
Bɔt mɛmba se i nɔ fayn fɔ tek dɛn tin ya bay yu yon sɛns. Tɔk to yu dɔktɔ ɛn yuz dɛn nɔmɔ if i gri fɔ yu. Bikɔs sɔm tɛm dɛn tin ya kin miks wit ɔda mɛrɛsin dɛn we yu de tek.
Mɛsej we dɛn kin kɛr go na os
- Antidipreshan na wan kayn mɛrɛsin wae de chenj di wok wae di bren kεmεkal dεm (nyurotransmitta dεm) de du.
- I kin tek sɔm wik ɔ mɔnt fɔ mek dɛn mɛrɛsin ya bigin fɔ wok, so i impɔtant fɔ peshɛnt .
- Nɔ ɛva bigin, chenj di doz, ɔ stɔp fɔ tek ɛni mɛrɛsin wantɛm wantɛm if yu dɔktɔ nɔ advays yu. If yu du dat, dat kin mek yu denja.
- Tɛl yu dɔktɔ bɔt ɛni ɔda mɛrɛsin, vaytamɛn, ɔ ɛbul prɔdak we yu de tek.
- If siriɔs sayn dɛn lɛk bad bad kɔnfyushɔn, ay fiva, ɛn sik we de mek pɔsin sik, go wantɛm wantɛm na ɔspitul in Imejɛnsi Dipatmɛnt (ETU), bikɔs i kin bi serotonin sindrom.
- If yu gɛt ɛnitin fɔ wɔri bɔt ɔr de fred bɔt dis mɛrɛsin, tɔk to yu dɔktɔ bɔt am opin wan.
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