Ɛnibɔdi na yu famili gɛt tayp 1 dayabitis? Ɔ dɔktɔ dɔn tɛl yu se yu de pan denja fɔ gɛt dis sik? If na so, tide wi de tɔk bɔt wan nyu mɛrɛsin wae kin delay fɔ bigin fɔ gɛt shuga sik fɔ sɔm ia. Dis na sɔntin we dɔn rili mek bɔku pipul dɛn gɛt big op. Lɛ wi si wetin na dis drɔg ɛn aw i de wok.
Tayp 1 dayabitis ɛn di wok we Tzield in drɔg de du
Fɔs, lɛ wi jɔs ɔndastand wetin na tayp 1 dayabitis. Na tru tru wan sik we pɔsin kin gɛt we i de fɛt insɛf . Fɔ tɔk am simpul wan, di imyun sistɛm we tan lɛk ‘ami’ we de protɛkt wi bɔdi frɔm sik, kin mistek bigin fɔ atak wi yon gud sɛl dɛn. pan tayp 1 dayabεtis, dis ‘atכk’ de apin pan di beta sεl dεm na wi pankrias.
Tink bɔt dɛn beta sɛl ya as smɔl smɔl faktri dɛn we de mek wan ɔmon we dɛn kɔl insulin, we rili impɔtant fɔ wi bɔdi. Insulin de ɛp di sɛl dɛn fɔ chenj di shuga (glukɔs) we de insay di it we wi de it to ɛnaji. So, we di imyun sistεm de pwεl dεn beta sεl dεm ya, insulin prodakshכn de dכn sכmtεm.
Dis pwɛl pwɛl nɔ go apin wan tɛm. I go apin insay tri stej.
- Stej 1: di imyun sistεm de bigin fכ atak di beta sεl dεm, bכt dεn stil de prodyuz inof insulin.
- Stej 2: di beta sel dεm we de damej de inkrεs, di bכdi shuga lεvεl de bigin fכ bi sכmtεm abnכmal, bכt stil nכ simptom dεm de na do.
- Stej 3: Bɔku pan di beta sɛl dɛn kin pwɛl, ɛn di bɔdi nɔ kin ebul fɔ mek insulin. Di blɔd shuga lɛvɛl kin go ɔp bad bad wan. Dis na we di sayn dɛm fɔ dayabitis, lɛk fɔ tɔsti pasmak ɛn fɔ pis ɔltɛm, de sho.
Dis na di say we wan mɛrɛsin we dɛn kɔl Tzield (teplizumab-mzwv) kin kam insay Tzield na bayolojikal mɛrɛsin. I kin slo di rεt we di imyun sistεm de atak di beta sεl dεm fכ pipul dεm we gεt stej 2 tayp 1 dayabεtis. Dis min se i kin delay fɔ mek di sik go bifo te i rich stej 3, we di sayn dɛn de sho ɛn dɛn nid fɔ tek insulin shot ɛvride.
Dis na mɛrɛsin we dɛn kin gi tru wan vein (intravenous infusion, ɔ IV) . Dɛn kin gi dis tritmɛnt kɔs wan tɛm insay di de fɔ 14 dez kɔnsɛkutiv wan.
Dis Tzield tritmɛnt fit fɔ mi?
Tayp 1 dayabitis kin afɛkt ɛnibɔdi pan ɛni ej ɛn wit ɛni layf. Tzield tritmɛnt kin fayn fɔ yu if yu mit dɛn krayteria ya:
- If yu gɛt stej 2 tayp 1 dayabitis .
- To yuIf yu nɔ gɛt tayp 2 dayabitis .
- If yu ol 8 ia ɔ pas dat .
Fɔ no if yu gɛt tayp 1 dayabitis na di sɛkɔn stej, yu dɔktɔ go du sɔm spɛshal blɔd tɛst. di mכst imכtant pan dεm na wan tεst fכ chεk fכ כtoantibodi dεm agens beta sεl dεm εn wan כral shuga tכlerans tεst . Dɛn go chɛk yu blɔd sɛl dɛn bak ɛn di liva ɛnzaym dɛn fɔ si if dis mɛrɛsin nɔ bad fɔ yu.
Pan ɔl we i kin mek yu gɛt pɔsin na yu famili we gɛt tayp 1 dayabitis, mɛmba se bɔku pan di pipul dɛn we gɛt dis sik nɔ gɛt famili histri.
Aw dɛn bin stɔdi di ifɛkt dɛn we di Tzield drɔg bin gɛt?
Dɛn bin du wan spɛshal klinik stɔdi we dɛn kɔl TN-10 fɔ chɛk di bɛnifit ɛn risk dɛn we dis mɛrɛsin gɛt. Di men kwɛstyɔn we i aks na, "Tzield kin stɔp ɔ delay di prɔgrɛs fɔ tayp 1 dayabitis to stej 3 pan pipul dɛm we gɛt ay risk?"
Dɛn bin sheb di wan dɛn we tek pat to tu grup dɛn. Dɛn bin gi wan grup di Tzield drɔg. Dɛn bin gi di ɔda grup wan plesibo . Dat min se, salin sɔlvushɔn we tan lɛk di drɔg bɔt nɔ gɛt ɛni mɛrɛsin. Di sik pipul dɛn ɔ di dɔktɔ dɛn nɔ bin no udat de gɛt wetin.
Yu kin si izi wan wetin na di eligibiliti ɛn diskwalifayeshɔn fɔ tek pat pan di stɔdi frɔm di tebul we de dɔŋ ya.
| Krayteria fɔ Inklushɔn | Di Krayteria we dɛn fɔ nɔ fɔ tek pat pan di wok |
|---|---|
| Bikɔs i ol bitwin 8 ɛn 45 ia. | Fɔ gɛt stej 3 dayabitis. |
| Fɔ gɛt pɔsin we de nia yu fambul we gɛt tayp 1 dayabitis. | Di blɔd sɛl ɔ liva ɛnzaym lɛvɛl we nɔmal. |
| di prεsεns fכ at le tu spεsifi k tכp dεm fכ כtoantibodi dεm. | Fɔ gɛt histri bɔt infɛkshɔn lɛk HIV, ɛpatitis B ɔ C. |
| Abnɔmal rizɔlt frɔm wan shuga tolɛreshɔn tɛst. | Fɔ bi mama we gɛt bɛlɛ ɔ we de gi pikin in bɛlɛ. |
Wetin na di tin dɛn we di stɔdi dɔn du?
Afta 14 dez we dɛn dɔn trit dɛn pipul ya, dɛn bin de fala dɛn pipul ya fɔ lɛk 5 ia so. Di tin dɛn we kin apin kin rili ɛnkɔrej wi.
Di men bɛnifit na dat di wan dɛn we bin tek di Tzield drɔg bin go bifo to stej 3 dayabitis bay wan avɛj lɛk tu ia afta dat pas di wan dɛn we nɔ bin tek di drɔg (plasɛbo).
Fɔ tɔk am simpul wan, i tek lɛk 4 ia fɔ mek di wan dɛn we de tek Tzield gɛt di sik, we di wan dɛn we de tek plasɛbo gɛt di sik insay lɛk 2 ia. Ɛspɛshali insay di fɔs ia we dɛn bin de trit dɛn, na smɔl nɔmba pan di wan dɛn we bin de tek Tzield bin gɛt di sik we bin de wɔs. We di stɔdi dɔn, 57% pan di wan dɛn we tek Tzield bin stil gɛt wɛlbɔdi ɛn dɛn nɔ bin gɛt ɛni dayabitis simptom. Bɔt na 28% nɔmɔ pan di wan dɛn we bin de tek plasɛbo bin du am.
Wetin na di sayd ɛfɛkt dɛm we Tzield gɛt?
Lɛk ɛni mɛrɛsin, Tzield kin gɛt sayd ɛfɛkt. Bɔt nɔ wɔri, yu kin ebul fɔ kɔntrol bɔku pan dɛn tin ya.
Di kɔmɔn sayd ɛfɛkt dɛn:
- Skin rash: Dis kin bi sayn fɔ se yu gɛt alɛji. Bɔrku tɛm, i nɔr kin siriɔs ɛn i go go fɔ insɛf. Kip di skin wet ɛn nɔ skrach. Tin dɛn lɛk fɔ was wit kol wata ɔ fɔ was wit ɔtmil kin ɛp. Tɔk to yu dɔktɔ bɔt dis. I go gi am mɛrɛsin if nid de. Bɔt , if di rash de wit yu tɔŋ ɔ yu trot we de swel, ɔ if yu gɛt prɔblɛm fɔ blo, go na di imejensi rum (ETU) na ɔspitul wantɛm wantɛm.
- Lɔw wayt blɔd sɛl (Lymphopenia): Yu wayt blɔd sɛl kin go dɔŋ fɔ sɔm tɛm insay di fɔs de dɛn we yu de trit yu. Dis nɔ kin afɛkt yu, bɔt i kin mek yu gɛt infɛkshɔn mɔ ɛn mɔ. Dis go kam bak to nɔmal insay sɔm wiks. Yu dɔktɔ go de wach yu ɔltɛm fɔ dis.
- Ɛd we de at: I kin gɛt smɔl ed pen. Bɔku tɛm, i kin go fɔ insɛf. If di ed de at ɔltɛm ɔ i de kam bad bad wan, mek yu dɔktɔ no.
Siriɔs sayd ɛfɛkt dɛn we yu fɔ wach bɔt:
- Saytokin Rilis Sindrom: .Bikɔs mɛrɛsin dɛn we de afɛkt di imyun sistɛm, lɛk Tzield, kin mek sɔntɛnde bɔku bɔku tin dɛn we dɛn kɔl saytokin kɔmɔt na di blɔd wan tɛm. Dis kin apin di fɔs tɛm we dɛn de trit am. Sɔm kayn sik lɛk fiva, nɔs, bɔdi pen, ɛn taya pasmak kin apin. Yu dɔktɔ go gi yu ɔda mɛrɛsin (e.g. paracetamol) bifo yu trit yu fɔ ridyus dɛn mɛrɛsin ya. If yu gɛt ɛni wan pan dɛn sayn ya, tɛl yu dɔktɔ wantɛm wantɛm.
- Sivεr wayt blɔd sεl kכnt de dכn: If dis kכndyushכn kam tranga, i kin mek yu gεt siriכs infεkshכn. If yu gɛt sayn dɛn we de sho se yu gɛt di sik lɛk fiva, kol, kɔf, ɛn taya pasmak , tɛl yu dɔktɔ wantɛm wantɛm.
Dis nɔto ɔl di pɔsibul sayd ɛfɛkt dɛm we Tzield kin gɛt. If yu gɛt ɛni sayn we de mɔna yu, mek shɔ se yu go to yu dɔktɔ fɔ advays yu.
Aw yu go no if di mɛrɛsin de wok?
Di rizin fɔ Tzield na fɔ delay di biginin fɔ di sik. So, yu nɔ go notis bɔku difrɛns afta yu dɔn tek di tritmɛnt. Dis na wan tɛm tritmɛnt fɔ 14 dez. Afta dat, yu dɔktɔ go chɛk yu dayabitis ɔltɛm fɔ si aw i de. Nɔ ɛva stɔp fɔ tek di tritmɛnt ɔ chenj di schedule if yu dɔktɔ nɔ advays yu.
Ɛni prɔblɛm de wit ɔda mɛrɛsin dɛn?
Bifo yu bigin fɔ tek Tzield tritmɛnt, i rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek (inklud vaytamɛn, sɔpɔtmɛnt, Ayurveda ɔ ɛbul mɛrɛsin).
Na mɔtalman, yu fɔ tek tɛm fɔ gɛt vaysin we yu de tek Tzield. Sɔm vaysin dɛn nɔ kin wok fayn, ɛn sɔm nɔ kin sef. So , bifo yu gɛt ɛni vaysin, tɛl yu dɔktɔ se yu de tek Tzield.
Mɛsej we dɛn kin kɛr go na os
- Tzield (Teplizumab) na nyu mɛrɛsin wae kin delay fɔ bigin fɔ gɛt di sik ɛn nid fɔ gɛt insulin fɔ sɔm ia pan pipul dɛm wae gɛt stej 2 tayp 1 dayabitis.
- dis de wok bay we i de slo di rεt we di bכdi in imyun sistεm de pwεl di beta sεl dεm we de prodyuz insulin na di pankrias.
- Yu dɔktɔ go no if dis tritmɛnt fayn fɔ yu afta yu dɔn du spɛshal blɔd tɛst.
- Smɔl sayd ɛfɛkt lɛk skin rash ɛn ed we de at kin apin ɛn dɛn kin ebul fɔ kɔntrol am. Bɔt if yu gɛt siriɔs sayn lɛk fɔ mek yu nɔ ebul fɔ blo ɔ yu gɛt fiva, go to dɔktɔ wantɛm wantɛm.
- Mek shɔ se yu tɔk to yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin ɛn vaysin dɛn we yu de tek.
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