Sɔntɛnde, yu kin fil bɔku prɛshɔn, ilɛksɛf na bikɔs yu gɛt ɛgzam we de kam, ɔ dɛn dɔn gi yu big wok na ɔfis, ɔ yu dɔn gɛt prɔblɛm na os? Yu chɛst de bit, yu de swet, ɛn yu de fil wan strenj we aw yu de wɔri. Sɔntɛnde lɛk dis, wi kin se, “A strɛs.” Bɔt yu dɔn ɛva wɔnda wetin rili kin apin insay wi bɔdi we dis ‘strɛs’ kin kam? Bihain ɔl dis na wan rili wɔndaful, ɔtomɛtik kɔntrol sistɛm na wi bɔdi. Tide wi go tok abaut dat.
Fɔ tɔk am simpul wan, wetin na di HPA aks?
di HPA Aks na wan rili imכtant kכmyunikeshn nεtwכk na wi bכdi. Fɔ tɔk di kɔrɛkt tin, na kɔnekshɔn bitwin tri men ɔgan dɛn na wi bɔdi. Na di men sistɛm we de manej strɛs na wi bɔdi. Tink bɔt am lɛk imejensi manejmɛnt tim insay wi bɔdi. Tri lida dɛn de na dis tim. Dɛn kin sɛn mɛsej to dɛnsɛf ɛn dɛn kin wok togɛda. Wi kin kɔl dis sistɛm di HPA aks.
insay mεdikal tεm, di HPA aks na nyuroεndokrin sistεm. Dat min se na wan sistεm we de rilis kεmikכl mεsenja dεm we dεn kכl כmon insay di bכdi fכ ansa to signal dεm we de kכmכt na wi nεv sεstem. Dɛn ɔmon ya kin tɛl wi bɔdi aw fɔ dil wit strɛs.
Udat na di tri lida dɛn na dis grup?
As wi bin dɔn tɔk, tri men ɔgan dɛn de na dis sistɛm. Na dis tri pipul ya de ron dis ol proses. Lɛ wi si udat na dɛn tri ya ɛn wetin na dɛn wok.
| Ɔgan | Di say we dɛn de ɛn di we aw dɛn de tɔk bɔt am | Wetin yu de du na simpul tin. |
|---|---|---|
| Hypothalamus we dɛn kɔl haypothalamus | Dis de dip insay wi bren. I kin ɛp fɔ balans bɔku tin dɛn na wi bɔdi, lɛk di tɛmpracha, angri, ɛn di we aw wi de fil. | Dis na di men kɔntrol rum . Dis na di fɔs pɔsin we kin disayd fɔ du sɔntin we ɛnitin apin we nɔ izi fɔ du. |
| Pituitary Gland we de na di bɔdi | Wan smɔl gland we tan lɛk bon we de ɔnda di haypothalamus. Pan ɔl we i smɔl, i de kɔntrol bɔku pan di ɔda gland dɛn na di bɔdi. | Dis na di Maneja . Na in de gi ɔda pipul dɛn ɔda tin dɛn frɔm di men kɔntrol rum. |
| Adrenal Gland dɛn we de na di bɔdi | Tu smɔl triangul gland dɛn we tan lɛk tu hat ɔp wi kidni dɛn. | Dis na di yunit we de wok . Na ya dɛn kin mek ɔmon dɛn we de mek pɔsin strɛs ɛn kɔmɔt na di blɔd, jɔs lɛk aw di manija tɛl dɛn fɔ du. |
Aw dɛn tri ya de wok togɛda?
Di arenjmɛnt fɔ dɛn tri ya rili fayn. I tan lɛk se na chen riakshɔn. Lɛ wi ɔndastand wit wan ɛgzampul.
Imajin se yu de waka na strit ɛn wantɛm wantɛm wan dɔg jomp pan yu. Yu de fred. Insay dɛn smɔl sɛkɔn dɛn de, dɛn tin ya kin apin insay yu bɔdi:
1. Fɔs step: Yu bren de intaprit wetin yu yay de si as "Dis na denja!" Wantɛm wantɛm, dɛn kin sɛn mɛsej to di haypothalamus (di men kɔntrol rum) tru di ɔtonomik nɛv sistɛm. di haypothalamus de rilis wan kεmikכl mεsej we dεn kכl `CRH` (Corticotrophin-releasing hormone) wantεm wantεm.
2. Step 2: Dis `CRH` mɛsej de go dairekt to di pituitary gland (di manija) . we i gεt da mεsej de, di pituitary gland de rilis כda כmon we dεn kכl `ACTH` (Adrenocorticotropic hormone) insay di bכdi. Dis na lɛk kɔmand fɔ "Go!"
3. Step 3: di כmon `ACTH`, we de travul tru di bכdi, de rich di adrenal gland dεm (di aktin yunit) . We di adrenal gland dɛn gɛt da kɔmand de, dɛn kin mek bɔku pan wi men ɔmon we de mek wi strɛs, we na kɔtisol, ɛn dɛn kin pul am na di blɔd.
Kɔtisol nɔto jɔs bad ɔmon. If ɛnitin apin we nɔ izi fɔ wi, dis ɔmon kin mek wi bɔdi gɛt mɔ shuga, i kin mek wi blɔd prɛshɔn go ɔp, ɛn i kin stɔp sɔm pan di wok dɛn we wi bɔdi de du fɔ sɔm tɛm. Dɛn kin du ɔl dis fɔ gi wi di ɛnaji we wi nid fɔ go tru di imejensi (fɔ rɔnawe pan di dɔg). Dɛn kɔl dis "Fight-or-Flight" rispɔns.
Bɔt dis sistɛm nɔ fɔ de ɔp ɔltɛm. Afta di dɔg dɔn kɔmɔt, dat min se afta di denja dɔn pas, dis sistɛm fɔ stɔp. Ɛn i kin apin insay wan we we rili strenj. we di kכtisol lεvεl na di bכdi inkrεs, i de sεnd signal bak to di bren (di haypothalamus εn di pituitary gland) we se, "Okay, naw di prכblεm dεn sכlv, stכp fכ sεnd dεn `CRH` εn `ACTH` mεsej dεm." Dis na wetin wi kɔl negatif fidbak lɔp . I tan lɛk se yu dɔn ɔf swich we dɛn dɔn di wok.
I pɔsibul se dis sistɛm nɔ de wok fayn?
Yɛs, i rili ebul fɔ du am. Tu men we dɛn de we dis sistɛm we balans fayn fayn wan kin ambɔg. Wan na bay we i de du tin pasmak, ɛn di ɔda wan na bay we i nɔ de du bɛtɛ tin.
HPA Aks Disfכnkshכn
Imajin, yu kin strɛs ɔltɛm. I tan lɛk dɔg we de jomp ɔltɛm. Prɔblɛm na ɔfis, prɔblɛm na os, mɔni prɔblɛm... We yu gɛt dis kayn lɔng tɛm, krɛse strɛs, da sistɛm de nɔ gɛt rɛst. I de on ɔltɛm . Dɔn di kɔtisol lɛvɛl kin ay ɔltɛm . Dis kin rili ambɔg wi bɔdi.
| Sistɛm we dɛn afɛkt | Prɔblɛm dɛn we kin apin |
|---|---|
| Imyun sistɛm | Di imyun sistɛm wik, sik ɔltɛm, inflamɛns na di bɔdi kin bɔku, ɛn i kin mek i gɛt prɔblɛm dɛn we i kin gɛt fɔ insɛf . |
| Mental wɛlbɔdi biznɛs | Risk fɔ gɛt mɛntɛl hεlth kכndyushכn lεk pwεl hat, wɔri hat, εn post-traumatic stress disorder (PTSD) . |
| Metabolism we dɛn kin yuz fɔ mek tin dɛn | Di risk fɔ gɛt dayabitis, fɔ fat, ɛn sɔm kayn kansa kin bɔku. |
| At ɛn blɔd vesel dɛn | Ay blɔd prɛshɔn ɛn risk fɔ mek di blɔd vesel pwɛl. |
Apat frɔm dat, sɔm pipul dɛn we de stɔdi bɔt dis biliv se we di HPA aks nɔ de wok fayn fɔ lɔng tɛm, dat kin mek i nɔ ebul fɔ mɛmba fayn ɛn i kin mek i nɔ ebul fɔ mɛmba nyuro ɛn i kin mek i gɛt sik dɛn lɛk Alzaima .
HPA Aks Sɔpreshɔn
Dis na di ɔda say. Dat min se di sistεm nכ de wok fayn ivin we i fכ ansa strεs. Di men rizin fɔ dis na sɔm kayn mɛrɛsin wae dɛn kin tek frɔm ɔdasay.
Dis kכndyushכn kin apin, spεshal wan we yu de tek k כtikostεroyd (e.g., Prednisolone), we dεn kin yus fכ kכndyushכn lεk asma, COPD, at at, kεnsar, εn afta dεn transplant כgan, fכ lכng tεm.
Wetin kin apin na jɔs dis: we wi gi wisɛf dɛn mɛrɛsin ya na do, wi bɔdi kin tink se, "O, wi nɔ nid fɔ mek kɔtisol igen, wi kin gɛt am frɔm do." afta dat wi adrenal gland dεm (faktri dεm) kin les sכmtεm εn dεn kin rεdכks di prodakshכn fכ kכtisol.
Wetin mek dis denja na dat if wan big tin we de mek pɔsin strɛs wantɛm wantɛm (lɛk aksidɛnt ɔ big infɛkshɔn) apin, di bɔdi nɔ go ebul fɔ mek di kɔtisol we i nid fɔ dil wit am. Dis na imejensi tin we kin ivin mek pɔsin in layf de pan denja. Wi kin kɔl dis adrenal kraysis .
Na dat mek dɔktɔ se nɔ fɔ stɔp fɔ tek sterɔyd mɛrɛsin wantɛm wantɛm. Yu fɔ du am akɔdin to yu dɔktɔ in instrɔkshɔn, ɛn smɔl smɔl yu fɔ ridyus di doz.
So aw wi go protɛkt dis valyu sistɛm?
Risach bɔt di HPA aks stil de go bifo, bɔt di bɛst we fɔ kɔntrol di strɛs na fɔ manej am fayn fayn wan . Wi nɔ go ebul fɔ pul strɛs kɔmɔt na wi layf kpatakpata. Bɔt wi kin kɔntrol am so dat i nɔ go kɔmɔt na wi kɔntrol. Na sɔm simpul tin dɛn we yu kin du fɔ ɛp:
- Du tin dɛn we go mek yu maynd kol: Praktis tin dɛn lɛk fɔ tink gud wan, yoga, ɛn ɛksesaiz fɔ blo dip dip wan ɛvride.
- Tek kia ɔf yu bɔdi gud gud wan: It tin dɛn we gɛt fayn fayn tin dɛn fɔ it, ɛksesaiz ɛvride, ɛn slip fayn. Dɛn tri tin ya rili impɔtant.
- Tink gud wan: Tink bɔt di gud tin dɛn we de apin na layf. Aksept se yu nɔ go ebul fɔ kɔntrol ɔltin. We yu de wɔri bɔt tin dɛn we yu nɔ go ebul fɔ chenj, dat go jɔs mek yu strɛs mɔ ɛn mɔ.
- Yuz fɔ se "nɔ": Nɔ tek nyu rispɔnsibiliti we yu pasmak.
- Mek yu gɛt kɔnekshɔn wit ɔda pipul dɛn:I kin rili fayn fɔ tɔk bɔt wetin de na yu maynd wit yu padi ɔ fambul we de nia yu ɛn we ɔndastand yu.
If yu stil gɛt prɔblɛm fɔ kɔntrol yu strɛs afta yu dɔn du dɛn tin ya, nɔ shem fɔ am ɔ sɔfa yu wan. Tɔk to yu famili dɔktɔ bɔt am. I go ebul fɔ gi yu di gayd we yu nid fɔ win dis prɔblɛm.
Mɛsej we dɛn kin kɛr go na os
- di HPA aks na nכchכral εn imכtant sistεm we de rεspכnd to strεs na wi bכdi.
- Lכng tεm (krכnik) strεs kin mek dis sistεm de wok pasmak, we kin mek yu gεt bכku hεlth prכblεm dεm lεk dayabεtis, hεy blכd prεshכn, εn mεntal sik.
- Sɔm kɔtikosterɔyd kin stɔp di HPA aks. Yu nɔ fɔ ɛva bigin ɔ stɔp fɔ tek dɛn kayn mɛrɛsin ya if yu nɔ gɛt dɔktɔ advays.
- Fɔ kɔntrol strɛs ɛvride na di bɛst we fɔ mek dis valyu sistɛm gɛt wɛlbɔdi.
- If i nɔ izi fɔ yu fɔ bia wit strɛs, go to yu dɔktɔ wantɛm wantɛm fɔ advays.
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