Yu kin fil bak se yu leg dɛn de go swɛ? Dis kin bi wan sik we dɛn kɔl Lambert-Eaton Myasthenic Syndrome (LEMS)!

Sɔntɛnde yu kin fil lɛk se yu leg dɛn wik, i nɔ kin izi fɔ yu fɔ grap na chia, yu kin fil taya we yu de klaym stej? Ɔ yu kin fil taya wit sɔm sayn dɛm lɛk wae yu aylid de ebi, yu mɔt de dray, ɛn yu de si tu tɛm? Sɔntɛm dɛn tin ya nɔto jɔs we pɔsin taya. Tide wi go tɔk bɔt wan kɔndishɔn we yu nɔ go dɔn yɛri bɔt, bɔt we rili fayn fɔ no bɔt, Lambert-Eaton Myasthenic Syndrome, ɔ ``(LEMS)`` as wi kɔl am fɔ shɔt.

Wetin na di sik we dɛn kɔl Lambert-Eaton Myasthenic Syndrome (LEMS)?

Fɔ tɔk am simpul wan, Lambert-Eaton Myasthenic Syndrome (LEMS) na wan sik we pɔsin kin gɛt we i de fɛt insɛf. Naw yu go de wɔnda wetin na ɔtoimyun disɔda. Wi bɔdi gɛt wan imyun sistɛm. Dis na wetin de protɛkt wi bay we wi de fɛt di jem dɛn we de mek wi gɛt sik frɔm ɔdasay. I tan lɛk di ami na wi kɔntri. Bɔt sɔntɛnde dis imyun sistɛm nɔ kin go fayn. Dɔn i kin bigin fɔ atak wi yon sɛl dɛn we gɛt wɛlbɔdi. Na dat kin apin na LEMS.

insay dis `(LEMS)`, wi imyun sistεm de atak di kכnεkshכn bitwin wi mכtal nεv dεm εn mכsul dεm . fכ bi prεsis, dεn kכl dis kכnεkshכn di `nyuromכskular jכnkshכn`. we dis jכnkshכn dכn pwεl, di transmishכn fכ mεsej frכm di nεv dεm to di mכsul dεm nכ de wok fayn. Dis na we di mɔsul dɛn kin wik .

Dis wikɛdnɛs kin bigin na yu ɔp pat na yu shɔl , bɔt i kin go smɔl smɔl to yu an, yu de blo, swɛla, ɛn yu mɔsul dɛn we de tɔk.

Udat kin gɛt dis `(LEMS)` mɔ?

Tu men grup de we mek op `(LEMS)`.

1. I gɛt fɔ du wit kansa: Na lɛk 60% pan di pipul dɛm wae gɛt LEMS gɛt sɔm kayn kansa. Di kayn we we pipul dɛn kin gɛt mɔ na smɔl sɛl kansa na in lɔng . I sɔprayz fɔ no se sɔntɛnde di sayn dɛm fɔ LEMS kin apia sɔm mɔnt ɔ ivin sɔm ia bifo di kansa bigin. Bɔku pan dɛn pipul ya dɔn pas 60 ia, dɛn na man dɛn, ɛn dɛn dɔn yuz tin dɛn we dɛn kin yuz fɔ smok.

2. Nɔr gɛt kansa: Di ɔda 40% pan di pipul dɛm wae gɛt LEMS nɔr gɛt kansa we dɛn dɔn no. Dɛn kin no bɔt dɛn pipul ya we dɛn ol lɛk 35 ia ɛn bak we dɛn ol lɛk 60 ia.

LEMS na wan sik we nɔ kin apin so ɔltɛm pan yɔŋ pikin dɛn.

Na smɔl sɛl lɔng kansa nɔmɔ (LEMS) gɛt fɔ du wit dis?

Nɔ, smɔl sɛl kansa na di lɔng kansa na di kayn kansa we bɔku pipul dɛn kin gɛt, bɔt ɔda kayn kansa kin gɛt fɔ du wit LEMS bak. Sɔm ɛgzampul dɛn na prɔstat kansa, taymoma, ɛn limfoproliferativ disɔda. Bikɔs di sayn dɛm fɔ LEMS kin apia bifo di sayn dɛm fɔ kansa sho, i impɔtant fɔ gɛt di rayt tɛst fɔ chɛk fɔ kansa if yu dɔktɔ no se yu gɛt LEMS.

Yu tink se na di chenj dɛn we de apin na di jɛnɛtiks de mek pɔsin gɛt LEMS?

Sayɛnsman dɛn biliv se di sik dɛn we pɔsin kin gɛt we i de fɛt insɛf kin gɛt sɔm jɛnɛtik link. Bikɔs LEMS na ɔtoimyun sik bak, i pɔsibul se i gɛt jɛnɛtik inflɔwɛns bak, bɔt dɛn nɔ ɔndastand dis gud gud wan yet.

Aw kɔmɔn tin na `(LEMS)`?

LEMS na sik we nɔ kin bɔku . Dɛn se dis sik kin afɛkt lɛk 2.8 milyɔn pipul dɛn ɔlsay na di wɔl. Insay Amɛrika, na lɛk 400 pipul dɛn we dɛn dɔn ripɔt se gɛt LEMS. Pan ɔl we dɛn nɔ gɛt ɛni rayt statystik bɔt ɔmɔs pipul dɛn de na wi kɔntri, i klia se dis na tin we nɔ kin apin so ɔltɛm.

Wetin na di sayn dɛm fɔ `(LEMS)`?

Lɛ wi luk di sayn dɛm fɔ `(LEMS)` wan bay wan. Nɔto ɔl dɛn sik ya kin apin di sem tɛm pan ɔlman, sɔm sik kin kam bifo, sɔm kin kam leta.

• di mכsul dεm wik εn taya: spεshal wan na di כp leg dεm.
• I nɔ izi fɔ waka: I nɔ izi fɔ klaym stej ɔ fɔ grap na chia.
• Mɔsul dɛn de pen ɔ stiff.
• Fɔ fil se yu an ɛn fut dɛn de swɛ.
• Di aylid dɛm we de drɔp (ptosis): Dis kin tan lɛk se yu de slip.
• Fɔ si tu tin wan tɛm (diplopia).
• Mɔt ɛn yay dray (xerostomia): di saliva de dכn, di yay dεm de dכn.
• Banbɛlɛ.
• Di swet we de go dɔŋ.
• We yu de lɔs yu wet.
• I nɔ kin izi fɔ yu fɔ pis.
• Erectile dysfunction na man dɛn.
• I nɔ kin izi fɔ tɔk (dysarthria) ɛn i nɔ kin izi fɔ swɛla (dysphagia): Dɛn tin ya kin bi sayn dɛm wae kin kam leta pan di sik.
• I nɔ kin izi fɔ yu fɔ blo (dyspnea) ɛn we yu nɔ kin ebul fɔ blo fayn: Dis na tin bak we nɔ kin apin so ɔltɛm, we kin rili bad we kin apin na di let stej fɔ di sik.

Impɔtant: If yu gɛt wan ɔ mɔ pan dɛn sik ya, nɔ tink se na LEMS. Bɔt if dɛn sik ya kɔntinyu fɔ de, i go fayn fɔ mek yu go to dɔktɔ.

Aw LEMS kin apia ɛn go bifo?

LEMS kin afɛkt di mɔsul dɛn na di shɔl fɔs . Dɔn i kin afɛkt di mɔsul dɛn na di sɔl, di mɔsul dɛn na di an ɛn leg, di mɔsul dɛn we de ɛp fɔ tɔk ɛn swɛla, ɛn di mɔsul dɛn na di yay.

We di sik bigin, i nɔ kin izi fɔ yu fɔ grap na chia, fɔ klaym stej ɔ il, ɔ fɔ du tranga wok we yu nid fɔ yuz yu leg.

Bɔrku tɛm, de sik kin kam smɔl smɔl, fɔ sɔm wiks to mɔnt . Bɔt if yu gɛt LEMS wit kansa, di sayn dɛm kin kam kwik kwik wan.

Wetin kin mek pɔsin gɛt LEMS?

As wi bin dɔn tɔk bifo tɛm, LEMS na wan sik we pɔsin kin gɛt we i de fɛt insɛf . dis min se yu bכdi in yon difεns (antibodi dεm) de atak yu כwn hεlty tisu dεm. insay LEMS, dεn antibodi dεm ya de atak di ples usay di nεv sεl dεm εn di mכsul fayb dεm de mit, di nyuromכskular jכnkshכn. spεshal wan, dεn de atak di kalsiכm chεnal dεm we de de. dis kalsiכm chεnal dεm implεnt fכ mek di nεv mεsej dεm fכ transmit.

Tink bɔt am lɛk wan row we gɛt domino dɛn. Dis atak de mek bɔku tin dɛn apin:

1. di antibodi dεm de tay pan di kalsiכm chεnal dεm na di εnd dεm na di nεv sεl dεm εn blכk dεm.

2. we di kalsiכm chεnal dεm dכn rεdכks, di amoun f כ asetilkolin, we na nyurotransmitta, we de kכmכt de dכn. Dis asetilkolin na kemikal we impɔtant fɔ mek di mɔsul dɛn wok.

3. we nכ inof asetilkolin kכmכt, di "mεsej" dεm to di mכsul fayb dεm nכ de pas fayn fayn wan. Dɔn yu mɔsul dɛn nɔ kin ebul fɔ wok fayn fayn wan.

4. Dis kin mek di mכsul dεm nכ de wok nכmal, we kin mek di mכsul dεm wik.

Na so pipul dεm wae gεt sכm sכm sεl lכng kεnsar kin gεt LEMS: We yu gεt kεnsar na yu bכdi, di antibodi dεm kin gεt signal fכ "go to wכ." Bɔt insted fɔ atak di kansa sɛl dɛn (spɛshal wan, di kalsiɔm chanɛl dɛn we de na di kansa sɛl dɛn), dɛn antibodi dɛn ya kin mistek atak di kalsiɔm chanɛl dɛn we de na di ɛnd dɛn na di nɛv sɛl dɛn. Dɔn di sem chenj we kin apin kin apin.

Sayɛnsman dɛn biliv se di tin we kin mek pipul dɛn we nɔ gɛt lɔng kansa gɛt LEMS na jɔs bikɔs di imyun sistɛm nɔ de wok fayn. Bɔt i nɔ klia yet wetin mek dis kin apin.

Aw fɔ no `(LEMS)`?

Di fɔs tin we yu fɔ du fɔ no if yu gɛt LEMS na fɔ mek yu dɔktɔ tek tɛm chɛk yu. Bɔku tɛm dis go gɛt fɔ du wit nyurolɔjis, ɔ dɔktɔ we spɛshal pan sik dɛn na di nerv ɛn mɔsul dɛm. Pat pan dis prɔses na fɔ aks bɔt yu sik, yu mɛdikal histri, ɛn ɛni mɛrɛsin wae yu de tek. dεn de du ditayla nyurolכjik egzamεn fכ luk fכ di patεn dεm fכ wik εn sayn dεm we kכnsist wit LEMS.

Di nɛks tin we yu fɔ du na fɔ tɛst. Test fɔ `(LEMS)` inklud:

• Blɔd tɛst: Dis kin chɛk if yu gɛt anti-kalsiɔm chanɛl antibodi dɛn na yu blɔd. Na lɛk 85% pan di pipul dɛm wae gɛt LEMS gɛt dɛn antibodi ya na dɛn blɔd.
• Ilɛktromayografi (EMG): Dis tɛst de luk aw yu mɔsul ɛn nerv dɛn de wok togɛda fayn fayn wan. Insay LEMS, di EMG tɛst gɛt rili spɛshal tin dɛn we dɛn dɔn fɛn, so i kin ɛp fɔ kɔnfɔm di diagnosis.
• Lכng εks-ray `(X-ray)` כ CT skan `(CT skan)` כ MRI skan `(MRI)` (fכ di chεst): Bikɔs wan kכndyushכn we dεn kכl `(LEMS)` kin kam pan pipul dεm we gεt sכm sכm sεl lכng kεnsar, dεn tεst dεm ya de luk fכ sayn dεm fכ lכng kεnsar.

Di sayn dɛm fɔ LEMS kin bigin frɔm mɔnt to siks ia bifo kansa bigin. So, afta dɛn dɔn no se yu gɛt LEMS, yu fɔ gɛt kansa skrinin ɛvri tri to siks mɔnt fɔ at le tu ia. Yu dɔktɔ go tɛl yu fɔ mek yu gɛt tɛm fɔ du di skrinin we go fayn fɔ yu.

Aw dɛn kin trit LEMS?

Bɔku tritmɛnt dɛn de fɔ LEMS.

• Fɔ trit di kansa we de ɔnda am: If LEMS gɛt fɔ du wit kansa, lɛk smɔl sɛl lɔng kansa, fɔ trit da kansa de kin ridyus di LEMS simptom dɛn bak. Di tritmɛnt fɔ kansa kin inklud kemotɛrapi, redyushɔn tɛrapi, ɛn/ɔ ɔpreshɔn. Dis kin dipen pan di kayn kansa ɛn wetin yu dɔktɔ tɛl yu fɔ du.
• Spɛshal tritmɛnt fɔ (LEMS): Dɛn tin ya na mɛrɛsin dɛn we de pul di sik ɛn mɛrɛsin dɛn we de kɔntrol di imyun sistɛm.

Tritmɛnt fɔ di sayn dɛm

• Amifampridine (Firdapse®), Guanidine: Dɛn drɔgs ya de mek di mɔsul dɛn gɛt trɛnk. dεn de inkrεs di rilis fכ di nyurotransmitta asetylcholine na di nyuromכskular jכnkshכn, we de impruv signal to di mכsul dεm.
• Pyridostigmine (Pyridostigmine - Mestinon®): Pyridostigmine de wok bay we i de mek di asetilkolin nɔ brok na di nyuromɔskular jɔnkshɔn. dis de mek di asetilkolin signal dεm bak εn i de mek di mכsul dεm trεnk bכku. Sɔntɛnde dɛn kin gi pyridostigmine togɛda wit amifampridine fɔ mek di mɔsul dɛn wok fayn ɛn fɔ trit di sayn dɛn we de sho se pɔsin gɛt LEMS lɛk we yu mɔt dray, yu yay we dray, we yu nɔ gɛt bɛlɛ, we yu nɔ de du mami ɛn dadi biznɛs, ɛn we yu nɔ de swet. Bɔt fɔ yuz pyridostigmine fɔ LEMS na ɔf-lɛbul yus, we min se di U.S. Food and Drug Administration (FDA) nɔ dɔn gri fɔ di mɛrɛsin fɔ dis kɔndishɔn.

Imyun-modulating tritmɛnt

• Di tin dɛn we de mek di bɔdi nɔ ebul fɔ fɛt di sik:Dɛn drɔgs ya de ɛp fɔ stɔp ɔ kɔntrol di "difens" wok we yu imyun sistɛm de du. Yu dɔktɔ kin gi yu dɛn mɛrɛsin ya if ɔda mɛrɛsin nɔr de kɔntrol yu sik. Fɔ ɛgzampul, dɛn kin gi wan mɛrɛsin we dɛn kɔl prednisone wit ɔ atɔl azathioprine ɔ cyclosporine.
• Plasma exchange: Insay dis prosidur, wan mashin de separet di likwid pat na yu blɔd (plasma) frɔm di blɔd sɛl dɛn. Yu antibodi dɛn de insay dis plasma. Afta di separeshɔn, dɛn kin put di blɔd bak insay yu bɔdi. Yu dɔktɔ kin tink bɔt dis tritmɛnt if yu gɛt siriɔs sik ɛn nid tritmɛnt kwik kwik wan.
• Immunoglobulin: Fɔ sɔm pipul dɛn, di tritmɛnt we dɛn kin gi dɛn bɔku bɔku imyunoglobulin kin ɛp fɔ mek di sik nɔ wɔs.

Yu tink se dɛn kin mek dɛn nɔ gɛt LEMS?

Dɛn nɔr ɔndastand gud gud wan yet wetin kin mek pɔsin gɛt LEMS, so dɛn nɔ no if we de fɔ mek dɛn nɔ gɛt dis sik.

Bɔt bikɔs LEMS kin kam pan pipul dɛn we gɛt lɔng kansa, yu kin ɛp fɔ mek dɛn nɔ gɛt lɔng kansa bay we yu:

• Nɔ smok. If yu de yuz tin dɛn we dɛn kin yuz fɔ smok, aks yu dɔktɔ fɔ ɛp yu fɔ lɛf fɔ smok.
• Nɔ smok sɛkɔn-han smok.
• Chek yu os fɔ si if radɔn gas de. If yu gɛt redɔn gas fɔ lɔng tɛm, dat kin mek yu gɛt kansa na yu lɔng.

Yu kin du tin dɛn bak fɔ mek yu kɔntinyu fɔ liv fayn layf:

• It mɔ frut ɛn vɛjitebul dɛn. Fɔ fala di Mɛditarenian ɔ DASH it.
• Mek yu gɛt wɛlbɔdi wet.
• Ɛksesaiz lɛk aw yu dɔktɔ advays yu.
• Gɛt inof slip - ɔltɛm na sɛvin to nayn awa.
• Ridyus yu strɛs. Stret kin mek di sayn dɛm wɔs.
• Nɔ was insay ɔt wata. Ɔt kin mek di sayn dɛm fɔ LEMS wɔs.
• Si yu dɔktɔ ɔltɛm, ɛn mek dɛn no wantɛm wantɛm if yu wɛlbɔdi chenj ɔ if yu gɛt nyu sayn dɛn.

Yu tink se dɛn kin mɛn LEMS ɔltogɛda?

I sɔri fɔ no se, no mɛrɛsin nɔ de fɔ LEMS. Dɛn dɔn sho se fɔ trit di ɔndalayn kansa we gɛt fɔ du wit LEMS kin mek di simptom dɛm fɔ LEMS bɛtɛ. Immunosuppressive drugs kin ɛp fɔ kɔntrol di ɔtoimyun atak, ɛn tritmɛnt dɛn de bak we kin ɛp fɔ pul di sik dɛn bay we dɛn de mek di amount of acetylcholine na di nerve endings ɛn mek di mɔsul dɛn strɔng.

If yu gɛt LEMS we nɔ gɛt kansa, yu kin ɛkspɛkt fɔ liv nɔmal layf. If yu gɛt LEMS ɛn kansa, yu sik kin bɛtɛ as tɛm de go (pan ɔl we nɔto ɔl) if dɛn no di kansa ɛn mɛn am kwik kwik wan.

Yu kwaliti layf kin dipen mɔ pan aw yu sik dɛn kin tranga.

Ustɛm a fɔ kɔntakt mi dɔktɔ if a gɛt `(LEMS)`?

If chenj de na yu wɛl bɔdi, ɔ if yu sik de wɔs, kɔl yu dɔktɔ ɛnitɛm . Nɔ fred, nɔ panik. Dɔktɔ dɛn de fɔ ɛp yu.

Wetin na di difrɛns bitwin `(LEMS)` ɛn `(Myasthenia Gravis - MG)`?

Lambert-Eaton myasthenic syndrome (LEMS) ɛn myasthenia gravis (MG) gɛt sɔm kayn sik dɛn we fiba. Dɛn tu tin ya kin mek di mɔsul dɛn wik ɛn taya.

Bɔt di myasthenia gravis (MG) kin fɔs afɛkt di mɔsul dɛn we de rawnd yu yay ɛn di mɔsul dɛn we dɛn kin yuz fɔ swɛla. Leta, i kin afekt di mכr jεnarכl mכsul dεm, inklud di mכsul dεm fכ brith εn di mכsul dεm na di limb dεm.

LEMS kin bigin wit wik we yu ɔpa shɔl, dɔn i kin muf go na yu an. LEMS kin mek yu yay mɔsul dɛn wik bak, bɔt i kin smɔl pas myasthenia gravis (MG).

Insay myasthenia gravis (MG), we yu wik bad bad wan pan di mɔsul dɛm we yu de blo (di mɔsul dɛm we de ɛp yu fɔ blo) kin kil yu. Dis nɔ kin apin so ɔltɛm na LEMS.

Pipul dεm we gεt myasthenia gravis (MG) nכ kin sho bכku simptom dεm fכ כtonom nεv sεstem dεm we de wok fayn (e.g., dray yay, dray mכt, kכnstεpshכn, dεn swet dεm we de dכn, sεks dεm we dεn nכ de wok fayn). Difrɛn frɔm dat, pipul dɛm wae gɛt LEMS kin gɛt dɛn kayn kɔmplen ya, ɛn sɔmtɛm dɛn kin ɛp fɔ no difrɛns bitwin di tu sik dɛm.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Bay naw yu go dɔn ɔndastand se Lambert-Eaton Myasthenic Syndrome (LEMS) na sik we de kam bikɔs ɔf di imyun sistɛm we de wok pasmak. yu nεv sεl dεm nכ de sεnd inof mεsej to yu mכsul fayb dεm fכ "kכntrakt." Di rizɔlt na we di mɔsul dɛn wik ɛn ɔda sayn dɛn.

Mɛmba se, lɛk 60% pan di pipul dɛn we gɛt LEMS gɛt smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. If yu gɛt LEMS bɔt yu nɔ gɛt kansa, mek shɔ se yu ɛn yu dɔktɔ gɛt kansa skrinin ɛvri sɔm mɔnt fɔ at le tu ia afta dɛn dɔn no se yu gɛt kansa.

Tritmɛnt dɛn de. Dɛn tin ya na fɔ trit di kansa if i de, ɛn fɔ tek drɔgs we de mek di nerve cell-muscle fiber communication bɛtɛ. If yu tɔk fayn to yu, dat kin mek yu mɔsul dɛn strɔng ɛn ɔda sayn dɛn.

A op se dis infɔmeshɔn go yusful to yu.Mɛmba ɔltɛm se if yu gɛt ɛnitin fɔ wɔri bɔt yu wɛlbɔdi biznɛs, i go fayn fɔ mek yu tɔk to dɔktɔ we sabi bɔt am.

` Lambert-Eaton myasthenic syndrome, LEMS, כtoimyun sik dεm, mכsul dεm we wik, sכm sכm sεl lכng kεnsar, nyuromכskular jכnkshכn, asetilkolin