Lɛ wi lan bɔt dis denja sik we kin apin wantɛm wantɛm we dɛn de du ɔpreshɔn: Malignant Hyperthermia!

If yu ɔ pɔsin we yu sabi gɛt fɔ du ɔpreshɔn, sɔntɛm yu dɔn yɛri di wɔd anestezi. I min se dɛn kin put wi na slip we dɛn de du ɔpreshɔn. Bɔt yu dɔn ɛva tink se sɔm pipul dɛn kin gɛt wan bad bad tin we kin apin to dɛn we dɛn de tek dɛn mɛrɛsin ya we kin mek dɛn nɔ fil fayn? Dat na wan pan dɛn kayn sik ya we nɔ kin apin so ɔltɛm, bɔt we rili siriɔs we dɛn kɔl Malignant Hyperthermia. Di nem kin tan lɛk se yu de mek yu fred smɔl, bɔt if dɛn tɛl yu gud gud wan bɔt am, yu kin avɔyd bɔku prɔblɛm dɛn. So, lɛ wi tɔk bɔt am ditayli tide.

Wetin na Malignant Hyperthermia?

Fɔ tɔk am simpul wan, `Malignant Hyperthermia` na wan jenɛtik kɔndishɔn . Dat min se na bikɔs ɔf wan chenj we de apin na wi jin dɛn. We dɛn gi pɔsin we gɛt dis sik sɔm mɛrɛsin dɛn fɔ anestez, in bɔdi kin riak bad bad wan. Dis na imejensi we kin ivin mek pɔsin in layf de pan denja.

Di bɛst pat na dat, pan ɔl we dis na sɔntin we dɛn kin pas frɔm wan jɛnɛreshɔn to ɔda jɛnɛreshɔn, tritmɛnt dɛn de fɔ am . Ɛn, if yu no bɔt dis risk kwik, yu kin protɛkt yusɛf frɔm am.

Wi no se we dɛn gi wi jenɛral anestezi, wi nɔ kin fil natin we dɛn de du di ɔpreshɔn. Difrɛn kayn mɛrɛsin dɛn de fɔ gi dis anestezi. Bɔt na smɔl pan dɛn drɔgs ya kin mek dis sik we dɛn kɔl `Malignant Hyperthermia`. Bɔku pan di mɛrɛsin dɛn we dɛn kin yuz fɔ mek pɔsin nɔ fil fayn nɔ kin mek dis apin.

Wan ɔda impɔtant tin na dat sɔmtɛm pɔrsin nɔr kin no se i gɛt di jenɛtik muteshɔn wae kin mek i gɛt Malignant Hyperthermia, bikɔs i nɔr kin sho ɛni sayn te i gɛt di patikyula drɔgs wae dɛn tɔk bɔt.

Udat dɛn kin gɛt dis sik mɔ?

Lɛ wi si udat de pan ay risk fɔ gɛt dis `Malignant Hyperthermia` kɔndishɔn.

Essentially, if sɔmbɔdi na yu famili dɔn gɛt `Malignant Hyperthermia` , den ɔda pipul dɛm na da famili de kin de pan denja bak. Na patikyula, if yu fambul we de na yu fɔs digri (i.e. mama, papa, brɔda ɛn sista, pikin dɛm) dɔn gɛt di kɔndishɔn, dɛn kin tek yu as `susceptible`.

So, if yu ɛva gɛt fɔ du ɔpreshɔn, i rili impɔtant fɔ tɛl di dɔktɔ we de anestez if ɛnitin lɛk dis dɔn apin to ɛnibɔdi na yu famili.

Imajin, lɛ wi se yu famili nɔ ɛva gɛt `Malignant Hyperthermia` riakshɔn lɛk dis. Bɔt pipul dɛn we gɛt sɔm mɔsul sik dɛn kin gɛt mɔ prɔblɛm bak. Sɔm pan dɛn sik ya na:

• `Sɛntral kɔr sik`
• `Multiminikɔr sik`
• `King-Denborough sindrom`
• `STAC3 dizayd`

Pan ɔl we dis kin tan lɛk se i nɔ izi fɔ du, i fayn fɔ mek di wan dɛn we gɛt dɛn sik ya no bɔt dis.

Aw dis sik kin kɔmɔn?

Aw kɔmɔn dis `Malignant Hyperthermia`? Pan ɔl we di statystik dɛn miks smɔl, dɛn kin tɔk se dis sik kin apin pan lɛk wan pan ɛvri 100,000 ɔpreshɔn dɛn we big pipul dɛn kin du. Pan pikin dɛn, dis nɔmba na lɛk wan pan ɛvri 30,000 ɔpreshɔn dɛn. I fayn bak fɔ no se af pan di sik pipul dɛn we dɛn dɔn no nɔ rich 19 ia yet.

Bɔt sayɛnsman dɛm tink se pipul dɛm wae gɛt dis `Malignant Hyperthermia` kɔndishɔn kin gɛt mɔr chans fɔ de na sosayti. Bikɔs bɔku pipul dɛn nɔ kin gɛt di patikyula drɔgs we kin mek dɛn gɛt am ɔlsay na dɛn layf, dɛn nɔ kin ivin no se dɛn de pan denja.

Wetin na di sayn dɛm fɔ dis?

Di sayn dɛm fɔ `Malignant Hyperthermia` kin difrɛn smɔl frɔm wan pɔrsin to ɔda pɔrsin. Dɛn kin apia we dɛn de du di ɔpreshɔn ɔ we yu de wɛl afta dɛn dɔn du di ɔpreshɔn. Fɔ ɛgzampul, if yu de ɔnda anestezi ɛn dɛn sayn ya de sho we dɛn de du di ɔpreshɔn, yu nɔ go fil am. Bɔt yu dɔktɔ we de anestez ɔ di nɔs we de anestez kin rili wach bɔt dis. Dɛn kin tek tɛm wach ɔlman we de ɔnda anestezi. As dɛn notis dɛn sayn ya so, dɛn go bigin fɔ trit `Malignant Hyperthermia` wantɛm wantɛm.

Sayn dɛn we kin apin fɔs

Dis na di fɔs sayn dɛn we yu go notis:

• di inkrεs we dεn nכ εksplen pan di at rεt (tachycardia). Di at rit kin go ɔp wantɛm wantɛm.
• Di kabon dayɔgzayd we de kɔmɔt na di bɔdi kin bɔku wantɛm wantɛm . Dɛn kin trit dis bak wit mɛrɛsin ikwipmɛnt.
• Inkris rεt fכ brith (tachypnea). Yu bigin fɔ blo kwik kwik wan, lɛk se yu de blo fɔ blo.
• Muscle stiffness, stiffness (`mכsul rigiditi`). Di mɔsul dɛn na di bɔdi kin stif lɛk se rɔk de krɔs dɛn.
• Di tɛmpracha na di bɔdi kin go ɔp wantɛm wantɛm . Di bɔdi bigin fɔ wam.

Di sayn dɛm wae kin kam leta

As de sik de wɔs, yu kin si sayn dɛm bak lɛk:

• We di bɔdi in tɛmpracha go ɔp pas di nɔmal fiva .
• Dak urine . I kin ivin tɔn brawn.
• Blɔd tɛst dɛn sho se di mɔsul dɛn dɔn brok .
• At ritm irɛgyulariti (arithmia). Di at de bit di we aw i de bit.
• Blɔd we de kɔmɔt .
• Kɔndishɔn dɛn lɛk we pɔsin kin gɛt sik .

Wetin mek malignant hyperthermia kin apin?

Naw lɛ wi si wetin mek dis kɔndishɔn we dɛn kɔl `Malignant Hyperthermia` kin apin.

Pipul dεm wae gεt dis kכndyushכn gεt wan abnכmal protin na dεn mכsul sεl dεm. Dis kin bi bikɔs dɛn jin dɛn chenj, we dɛn kɔl jɛnɛtik muteshɔn .

Fɔ tɔk am simpul wan, wi DNA tan lɛk "instruction book" we gɛt di infɔmeshɔn we di sɛl dɛn na wi bɔdi nid fɔ du dɛn wok. If smɔl infɔmeshɔn nɔ de sɔmsay na dis DNA, ɔ if sɔntin dɔn pwɛl, na da tɛm de sik dɛn lɛk dis kin apin.

Dis jεnεtik mכtεshכn nכ de mek εni simptom dεm na nכmal layf. כltu, if pכsin we gεt dis mכ tεshכn de εkspos to di spεsifi k anεsthεtik dεm we wi bin dכn mεnshכn – כ, i nכ kin bכku, if i εkspos to ay tεmprachכ כ if dεn de du strכng εksεsayz – dεn mכsul sεl dεm de bigin fכ rilis kalsiכm abnכmal wan.

dis de mek di mכsul dεm de kכntinyu fכ kכntrakt εn tεns כ rigid, di bכdi in mεtabolism εn di bכdi tεmprachכ de inkrεs abnכmal. Afta sɔm tɛm, di mɔsul sɛl dɛn kin day, ɛn bɔku bɔku potashɔm kin gɛda na di blɔd. Dis kin mek yu gɛt ɔda sayn ɛn prɔblɛm dɛn.

Di mɛrɛsin dɛn we de mek pɔsin nɔ fil fayn kin mek i gɛt dis sik.

Pɔsin we gɛt di jenɛtik prɛdispɔz fɔ di kɔndishɔn `Malignant Hyperthermia` kin gɛt dis riakshɔn if dɛn gi am dɛn anestetik drɔgs ya:

Di mɛrɛsin dɛn we pɔsin kin inhal:

• `Halotan`
• `Desflurane`
• `Sɛvoflurane`
• `Isoflurane`

Di mɛrɛsin dɛn we dɛn kin put insay di bɛlɛ:

• Succinylcholine – Dis na fast-akt mכsul rilaksant.

Aw yu no dis?

If yu gɛt ɔpreshɔn we yu de yuz wan denja anestetik we yu nɔ no se yu gɛt prɛdispɔzishɔn fɔ `Malignant Hyperthermia`, yu ɔ di anestezilɔg nɔ go no se yu gɛt am te afta di riakshɔn apin.

Bɔt we dɛn gi yu ɔ ɔda pɔsin anestezi, di dɔktɔ ɔ nɔs go wach yu impɔtant sayn dɛn ɛn yu wɛlbɔdi gud gud wan we dɛn de du di ɔpreshɔn ɛn afta dɛn dɔn du di ɔpreshɔn. If yu gɛt `Malignant Hyperthermia`, dɛn go no am bay di abnɔmal vital sayn dɛm ɛn riakshɔn dɛm we wi bin dɔn tɔk bɔt. Dat na:

• Hat rit we de go ɔp fɔ natin.
• Di tɛmpracha na di bɔdi kin go ɔp kwik kwik wan.
• Di kabon dayɔgzayd we de kɔmɔt na di bɔdi kin bɔku wantɛm wantɛm.
• Di mɔsul dɛn we de tayt.

Dɛn tren di wan dɛn we de anestez fɔ no dɛn chenj ya kwik kwik wan . Dɔn dɛn kin ebul fɔ du sɔntin kwik kwik wan to dis imejensi. Di fast we dɛn kin no di sik, na di mɔ dɛn kin gɛt tritmɛnt ɛn kɔntrol di sik.

Aw yu go no bifo tɛm if yu gɛt dis risk?

If yu ɔ yu dɔktɔ tink se yu kin de pan denja fɔ gɛt Malignant Hyperthermia, ilɛksɛf na bikɔs ɔf yu famili histri ɔ fɔ ɔda rizin, sɔm spɛshal tɛst dɛn de we dɛn kin du fɔ kɔnfirm dis:

• Caffeine halothane contracture test (CHCT) : Fɔ dis tɛst, dɛn kin tek smɔl pat pan yu mɔsul (muscle biopsy) ɛn dɛn kin put di tisu sɛmpul pan sɔlvushɔn dɛn we gɛt halothane ɛn caffeine fɔ si if i de ansa to wan anestetik gas.
• jεnεtik tεst : dεn tεst ya kin no di mכtεshכn dεm na di jin dεm na di DNA we dεn kכl RYR1, STAC3, εn CACNA1S. Dɛn dɔn no mɔ pas 45 muteshon dɛm we kin mek pɔsin gɛt Malignant Hyperthermia.

כltu, dεn tεst dεm ya fכ no wan prεdispכzishכn fכ `Malignant Hyperthermia` dεn rili dia , εn dεn kin כnli du dεm na fכ spεshal labכtכri dεm. fכ egzampl, di `CHCT` tεst de כnli na fכ say dεm na Amɛrika. So, if yu nid fɔ gɛt imejensi ɔpreshɔn ɛn yu fambul we de nia yu dɔn gɛt `Malignant Hyperthermia` bifo, di wan dɛn we de anestez kin yuz anestetik we sef instead ɔf dɛn drɔgs dɛn de we gɛt prɔblɛm.

Wetin na di tritmɛnt dɛm fɔ dis?

Di men tritmɛnt fɔ malign haypatɛmia na di drɔg we dɛn kɔl dantrolene (brand nem Dantrium®).

As soon as di wan dεm we de anεsthεsi sכspεkt wan kכndyushכn we dεn kכl `Malignant Hyperthermia`, dεn de gi dis `dantrolene` dכg. Na di sem tɛm, dɛn kin stɔp fɔ gi di anestetik drɔg we mek di riakshɔn, ɛn di dɔktɔ we de du di ɔpreshɔn kin dɔn di ɔpreshɔn kwik kwik wan.

apat frכm dat, di anεsthεsia εn כspitul tim de trit כda simptom dεm εn kכmplikεshכn dεm bak we `Malignant Hyperthermia` de kכz. Sɔm pan dɛn tritmɛnt ya na:

• Dɛn kin trit haypatɛmia wit we fɔ kol , lɛk fɔ gi kol IV wata ɛn fɔ put ays pak.
• Dɛn kin gi ɔksijɛn tru wan fes mask ɔ wan tiub we dɛn put na di trakya.
• If di at nɔ de bit ɔltɛm (arrhythmia), dɛn kin gi am mɛrɛsin fɔ am.

Wae yu kɔndishɔn dɔn stebul, dɛn go kip yu na di intensiv kia yunit (ICU) fɔ at le wan de fɔ mek dɛn wach yu . Di mɛdikal tim go du ɔda tɛst (e.g. blɔd tɛst) ɛn gi ɔda tritmɛnt if nid de.

Yu tink se dɛn go ebul fɔ stɔp dis?

Malignant Hyperthermia na smɔl tin fɔ mek yu nɔ gɛt am, pas yu no se yu gɛt di jenɛtik mutation wae de kɔz am , ɔr sɔmbɔdi na yu famili gɛt dis sik ɛn yu dɔn tɛl yu anestezi dɔktɔ. If na so i bi, di dɔktɔ we de mɛn pipul dɛn we de anestez nɔ go yuz dɛn mɛrɛsin dɛn de we gɛt prɔblɛm wit yu anestezi plan.

Bɔt, di sɔri tin na dat, bɔku tɛm pipul dɛn kin jɔs no se dɛn de pan denja fɔ Malignant Hyperthermia afta i dɔn apin to dɛn.

Wetin kin apin afta dis sik? Yu tink se dɛn kin mɛn am?

If dɛn no di sayn dɛm fɔ `Malignant Hyperthermia` kwik ɛn trit dɛn fayn, i pɔsibul fɔ mek pɔsin wɛl ful wan . Di akshɔn we di anestesia ɛn ɔspitul tim de du kwik kwik wan rili impɔtant ya.

Bɔt wi fɔ mɛmba bak se sɔntɛnde, ivin if dɛn trit am kwik kwik wan, bɔku ɔgan dɛn kin pwɛl ɛn ivin day.

Us ɔda kɔmplikeshɔn dɛn kin apin bikɔs ɔf di malignant hyperthermia?

Malignant Hyperthermia kin mek yu gɛt siriɔs prɔblɛm lɛk:

• Mɔsul dɛn we dɔn pwɛl
• Kidni we nɔ de wok fayn
• Liva nɔ de wok fayn
• Blɔd we de kɔmɔt
• Di at we de mek di at nɔ de wok
• Di sik dɛn we kin mek pɔsin sik
• Kɔma
• Day

Yu tink se dis kin kil pɔsin?

If dɛn nɔ trit am, `Malignant Hyperthermia` na wan sik we kin kil pɔsin . Ivin wit di rayt tritmɛnt, di ripɔt we dɛn ripɔt se di pipul dɛn we de day de bitwin 3% ɛn 5%. So, dis nɔto sɔntin we wi fɔ tek am layt.

Ustɛm a fɔ go to dɔktɔ bɔt dis?

If yu de rɛdi fɔ ɔpreshɔn, i rili impɔtant fɔ tɛl di dɔktɔ dɛn if ɛnibɔdi na yu famili bin dɔn gɛt ɛni prɔblɛm wit anestezi bifo .

Dɔn bak, if dɛn jɔs no se yu gɛt wan jenɛtik muteshɔn we de mek yu gɛt Malignant Hyperthermia na yu fambul na yu blɔd (bayolojikal fambul), ɔ if yu kam fɔ no se da pɔsin de dɔn gɛt wan sik we dɛn kɔl Malignant Hyperthermia, i rili impɔtant fɔ tɛl yu dɔktɔ ɛn mek wan not bɔt dis na yu mɛdikal rɛkɔd.

Di impɔtant tin dɛn we yu fɔ mɛmba na dis atikul

Malignant Hyperthermia na siriɔs, kin mek yu layf de pan denja fɔ sɔm kayn anestetik drɔgs.

Di gud nyus na dat dɛn kin trit am ɛn if yu no se yu de pan denja, dɛn kin avɔyd am.

If i pɔsibul, no ɔl di ditel dɛn bɔt di mɛdikal istri fɔ yu fambul dɛn we gɛt blɔd. Sheb da infɔmeshɔn de wit yu dɔktɔ. Bikɔs `Malignant Hyperthermia` na wan jɛnɛtik muteshon we de pas dɔŋ tru jɛnɛreshɔn, if sɔmbɔdi na yu famili gɛt am, yusɛf de pan ay risk.

If yu gɛt ɛni kwɛstyɔn ɔ wɔri bɔt ɔpreshɔn ɛn di anestezi we dɛn go gi yu, nɔ ɛva shem fɔ aks yu dɔktɔ. Dɛn de de fɔ ɛp yu. Yu awareness ɛn opin kɔmyunikeshɔn wit yu mɛdikal tim na di bɛst protɛkshɔn fɔ yu.

` malignant hyperthermia, anestezi, ɔpreshɔn, jɛnɛtik sik, famili histri, anestesia kɔmplikeshɔn, ay bɔdi tɛmpracha