Yu de gɛt strenj bɔmp dɛn na yu skin? Yu tink se dis kin bi Muir-Torre Syndrome?

Yu dɔn bigin fɔ gɛt smɔl smɔl bɔmp dɛn na yu skin wantɛm wantɛm? Yu go tink se dɛn tin ya na nɔmal tin. Bɔt sɔmtɛm dɛn chenj ya na di skin kin gɛt fɔ du bak wit prɔblɛm dɛn we de insay pɔsin in bɔdi. Tide wi go tɔk bɔt wan rare bɔt rili impɔtant kɔndishɔn fɔ no bɔt. Dɛn kɔl am Muir-Torre Syndrome.

Wetin na di sik we dɛn kɔl Muir-Torre Syndrome? Fɔ tɔk am simpul wan...

Muir-Torre Syndrome na wan sik wae nɔr kin bɔrku pan yu jɛnɛtiks wae kin mek yu gɛt difrɛn kayn kansa wae yu de liv yu layf. Pipul dεm we gεt dis sεndrכm kin gεt skin tכmכro, we na kεnsar כ benign (i.e., benign) na dεn skin. Dɛn kin gɛt wan ɔ mɔ kansa bak insay di bɔdi, mɔ na di gastrointestinal tract .

Tink bɔt dis, wi bɔdi gɛt bɔku bɔku smɔl smɔl sɛl dɛn. we dεn sεl dεm ya de sheb, sכmtεm sכmtεm sכm chenj dεm (mכtεshכn) kin apin na di jin dεm. Na dat de mek dis chenj na di jɛnɛtiks.

So yu tink se Muir-Torre Syndrome na di sem wit Lynch Syndrome?

Bɔku tɛm, na yɛs. Dɛn kin tek di sik we dɛn kɔl Moore-Torre syndrome as wan we fɔ gɛt di sik we dɛn kɔl Lynch syndrome . Lynch syndrome na wan sik bak we de mek di risk fɔ gɛt kansa bɔku bikɔs ɔf sɔm chenj dɛn na di jɛnɛtiks. Sɔntɛnde, dɔktɔ dɛn kin kɔl am bak Hereditary Non-Polyposis Colorectal Cancer (HNPCC). Dis min se kansa de divεlכp na di kכlon we nכ gεt polip. So, Moore-Torre na pat pan Lynch syndrome wae de sho spɛshal skin kwaliti dɛm.

Aw kɔmɔn tin dis kin apin? Wi fɔ wɔri bɔt dis na Sri Lanka?

Moore-Torre syndrome na rili wan sik we nɔ kin apin so ɔltɛm . Na lɛk 200 pipul dɛn nɔmɔ dɛn dɔn ripɔt ɔlsay na di wɔl. Bɔt dis nɔ min se wi nɔ fɔ no bɔt am. Na lɛk 9.2% pan pipul dɛm wae gɛt `HNPCC` kin sho dɛn Moore-Torre ficha ya. I tan lɛk bak se i kin afɛkt man dɛn smɔl pas uman dɛn (dat na lɛk 2 uman dɛn fɔ ɛvri 3 man dɛn). Pan ɔl we dɛn nɔ gɛt ɛni rayt statystik bɔt ɔmɔs pipul dɛn de na Sri Lanka, i impɔtant fɔ no bɔt dɛn kayn tin ya.

Wetin na di sayn dɛm wae de sho se yu gɛt Moore-Torre syndrome? Aw wi kin no am?

Dis kin bi mɔ bikɔs ɔf di lukin-grɔn ɔ chenj dɛn we de apin na di skin ɛn di sayn dɛn we de sho se pɔsin gɛt kansa we de insay pɔsin in bɔdi . Sɔntɛnde, prɔblɛm kin apin to yu skin bifo, di sem tɛm, ɔ afta yu gɛt kansa insay yu bɔdi. Bɔt bɔku tɛm, we pɔsin in skin chenj na di fɔs sayn we pɔsin kin notis . Ɔda kansa nɔr kin sho ɛni sayn na di fɔs stej.

Us chenj dɛn yu kin si pan di skin?

Dɛn kin si dɛn tin ya na pɔrsin wae gɛt Moore-Torre syndrome in skin:

• sebaceous adenomas: Dis na di prכblεm dεm we de kכmכn pan di skin (80% - 99%). Dis na tכmכro dεm we nכ de kεnsar (benign). Dɛn kin divɛlɔp na di sɛbas gland dɛm, we na di ɔyl gland dɛm na wi skin. Dɛn kin si dɛn na dɛn ed ɛn nɛk, ɛn pan pipul dɛn we gɛt Moore-Torre sik, dɛn kin de na dɛn chɛst, bɛlɛ, hip, ɛn bak . Dɛn kin tan lɛk smɔl, at, yɔlɔsh ɔ skin kɔlɔ bɔmp dɛn .
• Sebaceous carcinoma: Dis na kansa (malignant) tumor we de divεlכp na di sebaceous gland dεm. I kin tan lɛk sebaceous adenoma. Bɔt i kin skata kwik kwik wan, mɔ rawnd di yaylid dɛn . Dɛn tumbu ya kin blɔd ɔ kɔmɔt na wan tin we gɛt krɔs.
• Keratoacanthoma: Dis na ɔda kayn skin tumor. I kin divεlכp na di ed, nεk, trכnk, εn an dεm nia di ia fכlikul dεm. I kin bi kansa ɔ nɔ gɛt kansa . I tan lɛk smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl . I kin gro kwik kwik wan, i kin gɛt lɛk 3 sɛntimita insay sɔm wiks, dɔn i kin smɔl smɔl fɔ sɔm mɔnt ɔ ia. I kin bi se wan ɔ mɔ kin de.
• Fordyce spots: Bikɔs di sebaceous glands kin involv bɔku tɛm pan Moore-Torre syndrome, sɔm dɔktɔ dɛn kin tek dɛn "Fordyce spots" ya as sayn. Dɛn tin ya na swɛt gland dɛn we rayz, we dɔn big smɔl we de apin na say dɛn we nɔ gɛt ia, lɛk rawnd di lip dɛn . Stɔdi dɔn sho se dɛn kin mɔs pan Moore-Torre syndrome.

Mɛmba se if yu notis nyu lump ɔ chenj lɛk dis na yu skin, mɔ if i de gro kwik kwik wan, in kɔlɔ de chenj, ɔ blɔd de kɔmɔt, yu fɔ rili go to dɔktɔ.

Us kansa wae gɛt fɔ du wit Moore-Torre syndrome?

Difrɛn kayn kansa kin kam wit dis sik. De kansa wae kin pasmak ɛn de sayn dɛm wae dɛn kin gɛt na:

• Kansa we de na di kɔlorektal: Dis na di kayn kansa we bɔku pipul dɛn kin gɛt . I kin afɛkt lɛk af pan ɔl pipul dɛn. i kin bi we di kansa sεl dεm de gro na di layn na di kכlon כ rεktum. difrεnt frכm dat, wit Moore-Torre, dis kansa kin kam 15-20 ia bifo aw i kin bi, bכku tεm arawnd 50. I kin spre kwik bak . Di sayn dɛm na di bɛlɛ pen, blo, chenj na di bɔdi, ɛn blɔd na di stɔl .
• Bɛlɛ kansa: Dis na kansa bak we dɛn kin si wit Moore-Torre. Di sayn dɛm kin bi we yu bɛlɛ de pen, yu bɔdi de blo, yu blɔd de na yu stɔl, yu nɔ go ebul fɔ digest it, yu nɔ de fil fayn, ɛn yu nɔ go want fɔ it .
• Kansa we de na di urinary system:Dɛn kin kɔl am bak `(Urothelial carcinoma)` ɔ `(transitional carcinoma)`. Dis kin afɛkt di layn na di urinary system. I kin mek yu fil pen we yu de pis ɛn blɔd na yu urine .
• εndometrial kεnsar: Dis na kεnsar we de divεlכp na di εndometrium, we na di insay layn na di uterus . I kin mek yu bɛlɛ fil pen, yu bɛlɛ kin fil pen, ɛn yu kin gɛt wata we nɔ kɔmɔn na yu vagina ɔ blɔd kin kɔmɔt .

Apat frɔm dat, sɔm ɔda kayn kansa kin gɛt fɔ du wit dis sik, lɛk:

• Kansa na ovarian
• Prɔstat kansa
• Blada kansa
• Kidni kansa
• Smɔl intestinal kansa
• Kansa na di liva
• Kansa na di lɔng
• Blɔd kansa
• Bren kansa ɛn ɔda kayn kansa dɛn de.

Dis list kin tan lɛk se i de mek pɔsin fred. Bɔt di impɔtant tin na dat nɔto ɔl dɛn kansa ya go de pan ɔlman. Ɛn, if dɛn no dɛn kwik kwik wan, dɛn kin trit dɛn .

Wetin mek dis Moore-Torre syndrome kin apin? Wetin na di kɔz?

Fɔ tɔk am simpul wan, Moore-Torrell syndrome kin kam bikɔs wan pan yu jin dɛn chenj . Muteshon na chenj dεm na di sikεns fכ wi DNA. dis DNA de kכpi we wi sεl dεm de sheb εn mek nyu sεl dεm. Sɔntɛnde, mistek kin apin. If da kayn nɔmal sɛl de kɔntinyu fɔ sheb, i kin mek pɔsin gɛt difrɛn sik dɛn lɛk kansa.

Us difrɛns dɛn we de na di jɛnɛtiks kin afɛkt dis?

Tu kayn dɛn de mɔ:

• Tayp 1 Moore-Torre syndrome (Type 1 MTS): Dis kin kam bikɔs wan pan di jin dɛn we de mek mistek na yu DNA sikyud chenj . we dεn jin dεm ya nכ kin ebul fכ mek di mistek dεm, di sεl dεm we nכ nכmal kin kכmכt na di tisu dεm. insay 90% pan di kes dεm, di jin we dεn kכl MSH2 de afekt. כltu, sεvεra כda jin dεm lεk MLH1, MSH6, εn PMS2 kin involv.
• Tayp 2 Moore-Torrell Syndrome (MTS): dis kin kכz fכ wan mכtεshכn na di MUTYH jin. dis jin de rispansabl fכ ripεr כksidεtiv damej to wi DNA. Na lɛk wan pat pan tri pipul dɛm wae gɛt MTS gɛt dis kayn. כksidεshכn de mek chenj dεm na di DNA mכlekyul, we kin mek di sεl dεm we dεn nכ kכntrol (i.e., kεnsar). We di jin we dɔn chenj nɔ ebul fɔ mek dis damej, di damej kin kɔntinyu.

Dis na sɔntin we kɔmɔt frɔm jɛnɛreshɔn?

I go mɔs bi se, yes, na frɔm dɛn gret gret granpa dɛn . Bɔt sɔntɛnde, pɔsin kin gɛt nyu jin we nɔ gɛt ɛnibɔdi na di famili bifo. Na lɛk 60% pan di sik pipul dɛn kin fɛn famili histri bɔt Moore-Torre syndrome. Bɔt bikɔs nɔto ɔlman we gɛt dis jin muteshɔn kin gɛt di sik, dis famili link nɔ kin klia ɔltɛm.

Sɔm pipul kin gɛt dis sik wae nɔr kin gɛt sɔm kayn sik, ɛn nɔr kin ivin no am. כlso, sכmtεm we di imyun sistεm wik, dis `latent MTS` kin aktibכt. Sɔm pipul dɛn dɔn gɛt dis kɔndishɔn afta dɛn dɔn gɛt `sɔlid ɔgan transplant` ɛn tek imyunosuprɛsant mɛrɛsin.

Aw dis kin pas fɔ lɔng lɔng tɛm?

• Tayp 1 MTS na ``autosomal dominant'' kכndishכn. Dis min se yu jɔs nid fɔ gɛt wan kɔpi fɔ di jin we dɔn chenj fɔ mek yu gɛt di sik. If wan pan yu mama ɛn papa gɛt dis jin muteshon, yu gɛt 50% chans fɔ gɛt am bak. Bɔt di we aw yu kin gɛt di sik kin difrɛn frɔm di mama ɔ papa we yu gɛt di jin frɔm.
• Tayp 2 MTS na ``ɔtosomal rεsεsiv`` kכndishכn. Dis min se fɔ mek yu gɛt di sik, yu mama ɛn papa ɔl tu fɔ gɛt di sem jin chenj. Dis nɔ kin apin so ɔltɛm. כltu, mama εn papa dεm we nכ gεt wan kכpi fכ dis ``autosomal recessive`` jin kin nכ gεt εni simptom, so dεn nכ no se dεn gεt am.

Aw dɔktɔ dɛn kin no se pɔsin gɛt Muir-Torre Syndrome?

If yu gɛt smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. I go aks yu bak bɔt ɔda sayn dɛm wae kin sho se yu gɛt kansa na yu bɔdi, ɛn if ɛnibɔdi na yu famili gɛt kansa.

Us kayn tɛst dɛn kin du fɔ dis?

Yu dɔktɔ kin du sɔm fɔs tɛst dɛn bifo yu tɛl yu fɔ du yu jenɛtik tɛst. Fɔ ɛgzampul:

• Immunohistochemistry (IHC): Dɛn kin tek smɔl sampul pan wan lump na yu skin, stain am wit spɛshal day, ɛn chɛk am ɔnda maykroskɔp fɔ si if di sampul gɛt sɔm patikyula jɛnɛtik muteshon.

Wit di rizulyt fɔ dɛn tɛst ya ɛn ɔda infɔmeshɔn, yu dɔktɔ kin tɛl yu fɔ du di jenɛtik tɛst fɔ chɛk fɔ si if di jin dɛn we gɛt fɔ du wit Moore-Torre syndrome dɔn chenj. afta dat dεn go tek sεmpl fכ yu bכdi εn luk fכ mכtεshכn dεm na di mismatch ripa jin dεm MSH2, MLH1, MSH6, PMS2, כ di bays εksizishכn ripa jin MUTYH.

Us kayn kansa skrinin pɔrsin wae gɛt Moore-Torre syndrome fɔ de du ɔltɛm?

I rili impɔtant fɔ mek pipul dɛn we gɛt dis sik kin gɛt kansa skrinin ɔltɛm , bikɔs if dɛn no am kwik, dat kin mek dɛn gɛt mɔ chans fɔ gɛt tritmɛnt fayn fayn wan. Di tɛst dɛn we dɔktɔ dɛn go se fɔ du na:

• Kolonoskopi: Fɔ chɛk di big intestinal.
• כp εndoskopi (EGD): fכ egzamin di εsophagus, bεlε, εn fכs pat pan di sכmכl intestin.
• Prostate exam ( fɔ man dɛn) .
• Mamogram: .Brɔst kansa skrinin (fɔ uman dɛn) .
• Pelvik ɛgzam ( fɔ uman dɛn) .
• Pap smear: Skrin fɔ sɛvikal kansa (fɔ uman dɛn) .
• Urine cytology: Fɔ kansa dɛn na di urinary system.
• Test fɔ di wok we di liva de du
• Kɔmplit blɔd kɔnt (CBC) .
• Fɔ ɛgzam fɔ yu bɔdi
• Skin egzam
• X-ray na di chɛst

Yu dɔktɔ go disayd aw ɔltɛm yu nid fɔ du dɛn tɛst ya.

Wetin na di tritmɛnt dɛm fɔ Moore-Torre syndrome?

Di men tin we dɛn kin du fɔ mɛn di Moore-Torre syndrome na fɔ fɛn ɛn pul kansa if i apin . Yu go nid fɔ gɛt kansa skrinin ɔltɛm ɛn tek bayɔpsi fɔ ɛni tisu we yu tink se yu go gɛt. If yu dɔktɔ fɛn kansa, dɛn go trit am akɔdin to in kayn ɛn stej. Bɔku tɛm, ɔpreshɔn fɔ pul di kansa na di fɔs tritmɛnt .

Ɔda tritmɛnt dɛn fɔ kansa kin bi:

• Kimotɛrapi
• Redyushɔn tɛrapi
• Ɔmon tɛrapi
• Imyunotɛrapi
• Targeted therapy
• Fɔ transplant bon mɛrɔ

pan tap dat, wan rεtinoyd we dεn kin it we dεn kכl isotretinoin kin εp fכ mek nyu skin lεsin dεm nכ fכm. If yu kɔlon skɔpi fɛn bɔku kɔlon polip (we gɛt bɔku risk fɔ gɛt kansa), yu dɔktɔ kin tɛl yu fɔ du prɔfylaktik kɔlektɔmi, we min se yu fɔ pul pat ɔ ɔl di kɔlon.

Wetin na di prɔgnosis fɔ pɔrsin wae gɛt Moore-Torre syndrome?

Yu prɔgnosis de dipen pan ɔmɔs kansa yu de gɛt ɛn aw fa dɛn de skata. Statistikin sho se lɛk af pan pipul dɛm wae gɛt Moore-Torre syndrome kin gɛt pas wan kansa. Mɔ pas af pan dɛn kin gɛt mɛtastas kansa (kansa we dɔn skata to ɔda pat dɛn na di bɔdi ɛn i nɔ kin izi fɔ trit).

Kansa wae gɛt Moore-Torre syndrome kin apun arawnd wae dɛn ol 50. Dɛn kansa ya kin gro ɛn wɔs kwik pas di jenɛral pipul dɛm. So, i impɔtant fɔ no di pɔsin kwik kwik wan . Dɔn bak, chans de fɔ mek kansa kam bak ivin afta dɛn dɔn pul am. So, i impɔtant fɔ chɛk-ap ɔltɛm afta dɛn dɔn gɛt tritmɛnt.

Yu tink se we de fɔ mek dis nɔ apin?

Bɔku tɛm, nɔto so. Dis na bikɔs na kɔndishɔn we dɛn bɔn yu wit. Bɔt nɔto ɔlman go gɛt dis sik. Ivin di wan dɛn we kin gɛt di sik kin gɛt dis sik pas dɛn mama ɛn papa. Sayɛnsman dɛn nɔ shɔ yet wetin mek dis kin apin. Bɔt dɛn dɔn si se di sik kin wɔs if di imyun sistɛm wik .

We yu no se yu gɛt dis jenɛtik muteshɔn, dat kin ɛp yu fɔ disayd fɔ du sɔm tin dɛn fɔ mek yu nɔ gɛt dis sik. Fɔ ɛgzampul, fɔ tɛst yu jɛnɛtiks ɛn fɔ advays yu jɛnɛtiks kin ɛp yu fɔ mek yu nɔ pas di sik to yu pikin dɛn. Dɔn bak, fɔ no dis kin ɛp yu fɔ no kansa kwik ɛn bigin fɔ trit am, ɛn dis kin mek bad tin nɔ apin.

Pan ɔl we Moore-Torre syndrome nɔ kin bɔku, i nɔ kin izi fɔ bia wit di sik lɛk dis. I kin tan lɛk se i nɔ izi fɔ fɛt sɔntin we de insay wi DNA. Bɔt, fɔ no na pawa . If yu no ɛn trit yu di rayt tɛm, yu ɛn yu dɔktɔ kin gɛt dis prɔblɛm.

Fɔ dɔn, mɛsej we yu kin kɛr go na os

Okay, so lɛ wi sɔma sɔm pan di tin dɛn we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt:

• Muir-Torre Syndrome na wan jεnεtik kכndyushכn we de inkrεs di risk fכ gεt skin tכmכro εn intanεt kεnsar (sεf na di dijestiv trakt).
• If yu notis nyu tin we nɔ kɔmɔn na yu skin, mɔ na yu trɔnk, go to dɔktɔ wantɛm wantɛm. I kin bi natin, bɔt i bɛtɛ fɔ mek dɛn chɛk am.
• Dis na wan kayn we fɔ gɛt di sik we dɛn kɔl Lynch syndrome. If ɛnibɔdi na yu famili gɛt kansa, tɛl yu dɔktɔ bɔt am bak.
• Fɔ no am kwik kwik wan ɛn fɔ chɛk am ɔltɛm rili impɔtant. Dis kin ɛp fɔ no kansa kwik ɛn trit am fayn fayn wan.
• We dɛn de tɛst di jɛnɛtiks ɛn advays dɛn kin ɛp fɔ no if dis sik de ɛn if i kin afɛkt di wan dɛn we de na di famili.
• Nɔ fred, bɔt na fɔ no. Nɔto yu wan de, ɛn dɔktɔ dɛn de fɔ ɛp yu.

A op se dis infɔmeshɔn go yusful to yu. Stay wit wɛlbɔdi!

` Muir-Torre Sindrom, Lynch Sindrom, Skin Kansa, Jɛnɛtik Sik, Gastrointestinal Kansa, Kansa Skrin, Jɛnɛtik Muteshɔn