Yu no bɔt dis jenɛtik kɔndishɔn we de mek yu gɛt kansa mɔ ɛn mɔ? (MUTYH-Asosiet Polipɔsis - MAP)

Sɔntɛm sɔmbɔdi na yu famili dɔn gɛt kansa na yu kɔlon. Ɔ yu dɔktɔ dɔn tɛl yu i nɔ tu te yet se yu gɛt sɔm polip dɛn na yu kɔlon? Na nɔmal tin fɔ mek yu fil fred ɛn wɔri we yu yɛri sɔntin lɛk dis. Bɔt we wi no gud gud wan wetin de mek wi gɛt am, wi kin ɔndastand aw fɔ dil wit am. Tide wi go tɔk bɔt wan jenɛtik kɔndishɔn we kin mek dɛn kayn tin ya, bɔt dɛn nɔ kin tɔk bɔt am bɔku na sosayti. Dat na MAP.

Fɔ tɔk am simpul wan, wetin na MAP (MUTYH-Associated Polyposis)?

MAP, ɔ `(MUTYH-Associated Polyposis)` na wan rili rεs, inhεrit jεnεtik kכndishכn. Dis na we smɔl smɔl tin dɛn we nɔ de gro, ɔ nodul dɛn de gro na wi bɔdi, mɔ na di say we wi de it. We wi de tɔk bɔt mɛrɛsin, wi kin kɔl dɛn tin ya `(Polyps)`.

Naw yu kin de tink se, "Oh my God, yu tink se fɔ gɛt polip min kansa?" Nɔ, dɛn polip ya nɔto kansa. Bɔt, di impɔtant tin na dat, sɔm pan dɛn tin ya, if wi nɔ trit dɛn fayn, if wi nɔ pul dɛn, gɛt ay chans fɔ tɔn to kansa as tɛm de go.

dis ``Polyps`` kin fכm mכst na di bכdi fכ pכsin we gεt MAP:

• Kɔlɔn
• Rɛktum na di rɛktɔm
• Smɔl intestin
• Bɛlɛ

Fɔ gɛt MAP na risk fɔ gɛt kansa?

Yes, di ɔnɛs ansa to dis kwɛstyɔn na "yes." Pɔsin we gɛt MAP gɛt bɔku bɔku risk fɔ gɛt kɔlorektal kansa pas di avɛrej pɔsin. Infakt, sɔm stɔdi dɛn dɔn sho se lɛk af pan di pipul dɛn we dɛn fɔs no se gɛt MAP dɔn ɔlrɛdi gɛt kɔlorektal kansa.

Dɛn kansa ya kin apin bitwin 40 ɛn 60. Bɔt sɔntɛnde dɛn kin gɛt am ivin bifo tɛm. Dɔn bak, apat frɔm di kɔlon kansa, sɔm risk de fɔ mek yu gɛt duodenal kansa ɛn ɔda kayn kansa we de ausayd di dijestiv sistɛm.

I pɔsibul fɔ liv nɔmal wan wit dis sik?

I rili bi so. Dis na di impɔtant tin we yu fɔ mɛmba. Bɔrku pipul dɛm wae gɛt MAP kin liv nɔrmal, wɛl bɔdi, ful layf. Bɔt wan sikrit de fɔ dat. Dat na fɔ no di sayn dɛm kwik kwik wan ɛn gɛt tɛst fɔ chɛk di kansa ɔltɛm.

Dɛn tɛst ya kin no ɛn pul di polip dɛn we wi bin dɔn tɔk bɔt bifo dɛn tɔn to kansa. If yu du dat, dat kin mek yu nɔ gɛt kansa bad bad wan.

Wetin na di sayn dɛm fɔ MAP kɔndishɔn?

Dis na di say we bɔku pipul dɛn kin kɔnfyus. Nɔr sayn nɔr de wae yu kin si ɔr fil na do, wae na wan kayn tin wae de apin to MAP. Ivin if yu gɛt bɔku polip insay yu bɛlɛ, yu nɔ go fil ɛni pen ɔ nɔ fil fayn frɔm dɛn.

So, di prɛzɛns fɔ `(Polyps)` nɔmɔ nɔto gud indikɛtɔ fɔ gɛt MAP. Bɔku rizin dɛn de fɔ dis:

• Bɔrku pipul dɛn gɛt polyp bɔt nɔr gɛt MAP. Polips kin divεlכp bak bikoz fכ כda hεlth kכndyushכn dεm.
• כda jεnεtik sik dεm de we de mek `(Polyps)` lεk MAP. wan egzampl na `(Familial Adenomatous Polyposis - FAP)`.
• Sɔntɛnde, we dɛn no se pɔsin gɛt MAP, i nɔ kin ivin gɛt wan ``polyp'' na dɛn bɔdi.

Fɔ tɔk am simpul wan, na di jenɛtik tɛst nɔmɔ go ebul fɔ no fɔ tru if yu gɛt MAP, FAP, ɔ ɔda sik.

Wetin mek dis MAP de fɔm? Aw dɛn kin pas am fɔ lɔng lɔng tɛm?

MAP de kכz bay wan chenj, כ mכtεshכn, insay wan jin we dεn kכl `MUTYH` (dεn kכl am bak MYH). Tink bɔt wi bɔdi lɛk big buk we de tɔk bɔt aw fɔ mek it, ɛn na di jin dɛn na di rɛsipɛkt dɛn we de insay. If wan lɛta na di `MUTYH` rɛsipɛkt nɔ rayt, di prɔdak we i mek nɔ go wok fayn. MAP na so i bi.

wi kכl dis kכndyushכn we dεn inhεrit as ``autosomal recessive.'' Dis min se fכ yu gεt dis kכndyushכn, yu fכ gεt dis fכlt jin frכm yu mama εn papa, dat na frכm yu mama εn papa tu.

Imajin se na wan pɔsin nɔmɔ yu gɛt dis fɔlt jin. Fɔ ɛgzampul, na frɔm yu mama nɔmɔ. Dɔn yu nɔ go gɛt MAP sik. Bɔt dɛn kɔl yu MAP "carrier". Dis min se yu gɛt di jin we nɔ fayn, bɔt yu nɔ gɛt di sik. If yu na pɔsin we gɛt di sik, yu kin pas dis jin to wan pan yu pikin dɛn.

Dɛn se bitwin 1% ɛn 2% pan di pipul dɛn na di wɔl na pipul dɛn we de kɛr MAP. Di wan dɛn we gɛt kansa kin gɛt smɔl ay risk bak fɔ gɛt kɔlon kansa pas di jenɛral pipul dɛn, bɔt nɔ kin bɔku lɛk pɔsin we gɛt MAP.

Wetin kin apin to di pikin dɛn if dɛn mama ɛn papa ɔl tu na pipul dɛn we de kɛr MAP?

Dis rili izi fɔ ɔndastand. If mama ɛn papa dɛn ɔl tu na pipul dɛn we de kɛr pikin dɛn, tri tin dɛn de we dɛn kin du fɔ ɛni pikin we dɛn gɛt.

Aw a go no gud gud wan if a gɛt MAP?

Di diagnosis fɔ MAP kin bi insay sɔm step dɛm.

1. Famili mɛdikal istri: Fɔs, yu dɔktɔ go aks yu famili in wɛlbɔdi istri. Dis kin inklud ɛni histri bɔt kansa ɔ ɔda sik dɛn we yu mama ɛn papa, grani ɛn granpa, ɛn brɔda ɛn sista dɛn gɛt.

2. Jɛnɛtik Tɛst: If yu dɔktɔ sɔspɛkt se yu gɛt jɛnɛtik kɔndishɔn bay yu famili istri, i kin rifer yu fɔ mek dɛn du yu jenɛtik tɛst. dis tεst kin no if yu gεt mכtεshכn na di `MUTYH` jin כ כda jεnεtik kכndishכn dεm we de inkrεs yu risk fכ kεnsar.

Dɔktɔ go tipikul se dɛn fɔ du di jenɛtik tɛst pan dɛn kayn tin ya:

• If ɛnibɔdi na yu famili gɛt jenɛtik sik lɛk MAP ɔ FAP.
• If sɔm pipul dɛn na yu famili dɔn gɛt kansa na yu kɔlon.
• wan pan yu brɔda ɔ sista dɛn gɛt bɔku bɔku polip na dɛn kɔlon, bɔt dɛn mama ɛn papa nɔ gɛt am (dis kin mek pipul dɛn sɔprayz se di mama ɛn papa kin bi di wan dɛn we de kɛr di sik).

If di jenɛtik tɛst kɔnfyus se yu gɛt MAP ɔ yu na pɔsin we gɛt di sik, yu dɔktɔ go tɔk to yu ditayli bɔt di nɛks tin dɛn we yu fɔ du ɛn di tɛst dɛn we yu nid fɔ du fɔ protɛkt yusɛf frɔm kansa. I rili impɔtant bak fɔ sheb dis infɔmeshɔn wit di ɔda pipul dɛn na yu famili, bikɔs i go ɛp dɛn fɔ gɛt tɛst if dɛn want.

Tritmɛnt ɛn manejmɛnt fɔ MAP

Naw, nכ "kyu" de fכ di jεnεtik mכtεshכn we de mek MAP. Bɔt bɔku tɛst ɛn tritmɛnt dɛn de we kin ɛp wi fɔ mek wi nɔ gɛt kansa, ɔr fɔ no ɛn trit kansa kwik kwik wan.

If yu gɛt MAP, yu kin nid fɔ du kansa skrinin tɛst bifo tɛm ɛn bɔku tɛm pas di avɛrej pɔsin.

Ɔda tin dɛn fɔ no we yu de dil wit dis sik

A go ebul fɔ mek dis nɔ apin to mi pikin dɛn?

no we nכ de fכ mek di mכtεshכn na di MUTYH jin nכ. Bɔt sɔm we dɛn de we dɛn kin ɛp fɔ bɔn pikin we kin ridyus di risk fɔ mek pikin gɛt MAP tumara bambay. wan egzampl na wan prosidכs we dεn kכl prεimplantεshכn jεnεtik diagnosis (PGD) we dεn kin du wit in vitro fεtilayzεshכn (IVF). dis min se dεn de tεst di εmbrayo fכ si if i gεt jεnεtik sik bifo dεn put am na di mama in uterus. Bɔt dis na tin we rili kɔmpleks fɔ disayd, pan mɔni biznɛs ɛn pan aw pɔsin de fil. If yu intres pan dis, i go fayn fɔ tɔk to wan kwalifay riprodaktiv ɛndokrinɔlɔjis.

Aw fɔ kɔntinyu fɔ gɛt strɔng maynd?

We yu kam fɔ no se yu gɛt bɔku chans fɔ gɛt kansa, yu go de wɔri, fred, ɛn ivin pwɛl at. Dis na nɔmal tin. Bɔt nɔ tray fɔ dil wit dɛn filin ya yu wan. Tɔk to yu dɔktɔ bɔt am. Tɔk tritmɛnt ɛn if nid de, mɛrɛsin de.

Dɔn bak, i go fayn fɔ ɛp yu if yu kin jɔyn sɔpɔt grup dɛn usay yu kin tɔk to pipul dɛn we dɔn gɛt di sem kayn ɛkspiriɛns. Mɛmba se nɔto yu wangren de.