Bɔku tɛm yu pikin kin gɛt fiva we yu nɔ ebul fɔ ɛksplen? Dis kin bi bikɔs ɔf SAID (Systemic Autoinflammatory Diseases)!

Yu smɔl pikin kin gɛt fiva ɔltɛm? Sɔntɛnde, dɛn kin gɛt fiva wan ɔ tu tɛm insay di mɔnt, bɔt di dɔktɔ dɛn kin se nɔ infekshɔn, dat min se, nɔ vayrɔs ɔ baktri de na di bɔdi. Dɛn kayn tɛm dɛn de, as mama ɔ papa, yu rili gɛt sɛns fɔ fil bɔku fred ɛn wɔri. "Wetin mek dis de apin to mi pikin?" I go mɔs bi se yu dɔn tink wan tawzin tɛm. Sɔntɛm di rizin fɔ dis na sɔntin we yu nɔ yɛri bɔt bifo. Tide, wi go tɔk bɔt SAID (Systemic Autoinflammatory Diseases), we at fɔ ɔndastand ɛn we kin mek pɔsin gɛt fiva bɔku tɛm. Trade, dɛn bin de kɔl dɛn tin ya `(Periodic Fever Syndromes)` ɔ `(Recurrent Fiver Syndromes)`.

Wetin na dɛn SAID ya (Systemic Autoinflammatory Diseases)?

Fɔ tɔk am simpul wan, SAID na wan grup fɔ sik dɛn we kin apin bikɔs ɔf wan prɔblɛm we nɔ de wok fayn ɔ we de kɔntrol wi bɔdi in natura l imyun sistɛm . Wetin kin apin na dat, if yu nɔ gɛt ɛni ɔda tin we kɔmɔt na do, dat na, vayrɔs ɔ baktri, di bɔdi kin jɔs mek inflamɛns. Na dat mek dis fiva we kin kam bɔku tɛm kin kam.

Naw yu kin de tink se, "O, dis na wan pan dɛn Ɔtoimyun Sik dɛm?" Nɔ, dɛn tu tin ya difrɛn smɔl. Fɔ ɛgzampul, pan Ɔtoimyun Sik, pan sik dɛm lɛk Rimatɔyd Atraytis ɔ Lupus, wi bɔdi in adaptiv imyun sistɛm kin mistek atak in yon wɛlbɔdi sɛl dɛm. Bɔt insay SAID, di prɔblɛm de wit di innate immune system.

SAID dεm kin bכku pas כtoimyun Sik dεm. Bɔku tɛm, dɛn tin ya na tin dɛn we pɔsin kin gɛt frɔm in mama ɛn papa , we min se na wan jɛnɛtik chenj ɔ difrɛn we de mek dɛn apin.

Dɛn SAID ya kin bigin (bɔt nɔto ɔltɛm) we yu pikin na bebi ɔ smɔl pikin . Di pikin go gɛt episod ɔ atak fɔ di sik sɔm tɛm. Insay dɛn kayn tin ya, di fiva ɛn ɔda sayn dɛn kin sho. כltu, bitwin dεn "atεk" dεm ya, di pikin kin nכ gεt di sik. Nɔr mɛrɛsin nɔr de fɔ SAID, bɔt bɔrku tɛm dɛn kin gɛt fayn tritmɛnt fɔ kɔntrol di sik.

Wetin na di men kayn SAID dɛm?

Risach pipul dɛm dɔn no lɛk 60 kayn SAID dɛm, ɛn dɛn de fɛn ɔda wan dɛm. Na sɔm pan di kayn dɛn we dɛn kin yuz mɔ:

• Famili Mɛditarenian fiva (FMF): Dis na di mɔs kɔmɔn pan di jɛnɛtiks ditarmin, rikɔrɛkt fiva sindrom. I kin mek di pikin in bɛlɛ, in chɛst, ɛn in jɔyn dɛn swel wit pen.
• Fiva we kin kam wan wan tɛm, aphthous-stomatitis, pharyngitis, adenitis (PFAPA): Dis kin bigin pan yɔŋ pikin dɛn, bɔku tɛm bifo dɛn rich 4. Bɔt pan sɔm pikin dɛn, dis sik kin dɔn afta dɛn dɔn ol 10 ia.
• Tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS): Dis kin apin frɔm we i smɔl te i yɔŋ, ɛn sɔm tɛm dɛn te i big.
• Mevalonate kinase deficiency (MKD): Dɛn bin de kɔl am Hyper-IgD syndrome, dis kin bigin bifo di pikin ol wan ia.
• NLRP3-associated autoinflammatory diseases: Dɛn bin de kɔl dis bifo tɛm Cryopyrin-associated periodic syndromes (CAPS). Tri ɔda sɔbtayp dɛn de insay dis.
• Still’s disease (AOSD) we kin bigin fɔ big pipul dɛn (AOSD): As di nem sho, dis sik kin bigin we pɔsin big. Na di adכlt fכm fכ wan kכndyushכn we dεn kכl sistεmik juvenile idiopathic arthritis (JIA).
• NOD-2-associated granulomatous disease (Blau syndrome): Dis kin bigin bak bifo i ol 4. I kin mɔs afɛkt di pikin in skin, in yay, ɛn in jɔyn dɛn.

Wetin na di sayn dɛm fɔ SAID?

Di sayn dɛm fɔ SAID kin bigin we dɛn smɔl. Di men ɛn mɔs kɔmɔn sayn na fiva we kin kam wan wan tɛm ɔ we kin apin ɔltɛm . As wi bin dɔn tɔk, di pikin kin fayn di tɛm we fiva nɔ de. Bɔt ɔda sayn dɛn de we spɛshal fɔ ɛni kayn SAID:

• Insay FMF: di pikin in bɛlɛ, in chɛst, ɛn in jɔyn dɛn kin rili pen ɛn swel. Sɔntɛnde, i kin gɛt skin rash na di ɔnda leg ɔ ankles.
• Insay PFAPA: Trot de at, ɔlsa na yu mɔt, limf no dɛm we swel na di nɛk. Dis na di men sayn dɛm.
• Insay TRAPS: Di bɔdi kin kol ɛn fiva. Di pikin kin gɛt mɔsul pen na in bɔdi ɛn in an. Rɛd rash we de mek yu fil pen kin kɔmɔt, we kin kɔmɔt na di an dɛn to di leg dɛn ɛn afta dat i kin kɔmɔt na di bɔdi.
• Insay MKD: Yu kin gɛt sɔm kayn sik lɛk flu lɛk kol, ed pen, bɛlɛ at, nɔr kin want fɔ it, ɛn ɔda sayn dɛm.
• Insay NLRP3 sik dɛm: skin rash, ed pen, malaise, joyn pen, ɛn yay inflameshn (conjunctivitis) kin apin.
• Insay AOSD: skin rash, joyn pen, mɔsul pen. Sɔm pipul dɛn kin gɛt bak trot we de at, bɛlɛ kin at, taya, ɛn fil se dɛn wik.
• Insay Blau syndrome: Di pikin kin gɛt skin lɛsin na in an, in leg, ɔ midsekshɔn. Dɛn kin gɛt pen bak na dɛn jɔyn ɛn dɛn yay kin gɛt pen.

Imajin, Nalini in smɔl gyal pikin dɔn gɛt ay fiva fɔ tri to 4 dez ɛvri mɔnt fɔ di las sɔm mɔnt. Along wit dat, i de divεlכp sכm sכm sכm sכm dεm bak na in mכt εn lumps na in nεk. We i sho am to dɔktɔ, i se i kin bi PFAPA.

Wetin na di tin dɛn we kin mek pɔsin gɛt SAID?

Bɔku pan di SAID dɛn na sik dɛn we pɔsin kin gɛt we i kam pan jɛnɛtiks . Dis min se ɛni wan pan dɛn sik ya kin kam bikɔs wi jin dɛn kin chenj. Na di kayn SAID dεm we kכmכn pas כl εn di jin dεm we de afekt dεm:

• FMF: Di jin we dɛn kɔl `(MEFV)`. dis jin de instrכkt di prodyushכn fכ di protin `(pyrin)`.
• PFAPA: Dɛn nɔ dɔn no di rayt jin we de afɛkt dis yet.
• TRAPS: Di jin we dεn kכl `(TNFRSF1A)`. dis na di say we di instrכkshכn dεm fכ mek di protin `(tכmכr nεkrכsis fכktכ rεsεptכr - TNFR)` kכmכt.
• MKD: Di jin `(MVK)`. dis de instrכkt di prodyushכn fכ wan protin we dεn kכl `(mevalonic kinase)`.
• NLRP3 sik dεm: Di jin we dεn kכl `(NLRP3)`. dis de gi instrכkshכn fכ mek wan protin we dεn kכl `(cryopyrin)`.
• AOSD: Wi stil no sabi di ekzak rizin fo dis.
• Blau sindrom: Di jin `(NOD2)`. dis de instrכkt di prodyushכn fכ di protin `(NOD2)`.

Di ditel dɛm fɔ dɛn jin ya kin tan lɛk se i kɔmplikt smɔl to yu. Fɔ tɔk am simpul wan, dɛn jin ya kin afɛkt di we aw dɛn kin mek sɔm prɔtin dɛn we kin kɔntrol di inflamɛns na wi bɔdi. Na dat mek di bɔdi de mek inflammatory kɔndishɔn fɔ natin.

Wetin kin apin if dɛn nɔ trit SAID dɛn fayn fayn wan?

I rili impɔtant fɔ gɛt di rayt tritmɛnt fɔ dɛn SAID ya. biכs if di inflameshn na di bכdi kכntinyu, wan kכndyushכn we dεn kכl `(amyloidosis)` kin apin. Dis min se wan kayn prɔtin kin de na wi kidni, we kin mek di kidni dɛn pwɛl sote go . So, if sɔm sayn dɛn de, i rili impɔtant fɔ go to dɔktɔ ɛn nɔ fɔ pe atɛnshɔn to dɛn.

Aw dɔktɔ dɛn kin no if pɔsin gɛt SAID?

Fɔ no bɔt SAID kin tranga bikɔs di sayn dɛm kin tan lɛk ɔda siriɔs sik dɛm, lɛk lupus ɔ lymphoma. So , i bɛtɛ fɔ go to dɔktɔ we de mɛn yu pikin, we na dɔktɔ we gɛt spɛshal trenin fɔ gɛt sik dɛn we de mek yu bɔdi wam , fɔ no di sik we yu pikin gɛt ɛn kɔntrol am kɔrɛkt wan.

Yu pikin in rεumatכlכg go luk pan sεvεra tin dεm fכ no di SAID dεm. I go aks yu bɔt yu pikin in sik ɛn if ɛnibɔdi na yu famili gɛt histri fɔ kol ɔltɛm. Di dɔktɔ kin sɔprayz se dis sik if:

• If di pikin gɛt fiva ɔltɛm .
• If ɛnibɔdi na di famili gɛt histri fɔ gɛt fiva bɔku tɛm .
• If di pikin kɔmɔt na etnik grup we kin gɛt dis kayn fiva bɔku tɛm.

Us tɛst dɛn dɛn kin yuz?

Fɔ mek yu no se yu gɛt di sik, di dɔktɔ we de mɛn yu pikin kin tɛl yu fɔ du bɔku tɛst dɛn. Sɔm pan dɛn tin ya na:

• Lab tεst: Blכd tεst lεk `(C-reactive protein - CRP)` εn `(Kכmplit bכdi kכnt - CBC)` kin chεk fכ inflameshn na di bכdi. Dɛn tɛst ya na `(positiv)` we yu gɛt fiva ɛn kam bak to nɔmal we di fiva dɔn stɔp.
• Yurin tɛst: Dɛn kin chɛk di urine fɔ si if i gɛt bɔku prɔtin. if MKD, dεn de chεk di urine bak fכ hכy lεvεl fכ wan כrganik asid we dεn kכl ``mεvalכnik asid''.
• Jεnεtik tεst: jεnεtik tεst kin chεk fכ di jεnεtik vεryכnt dεm we wi bin dכn tכk bכt. Bɔt sɔm pikin dɛn we gɛt SAID nɔ kin gɛt di jɛnɛtik we dɛn dɔn fɛn, so di tɛst rizɔlt kin bi negatif.

Wetin na di tritmɛnt fɔ SAID?

Di tritmɛnt fɔ SAID dɛn dipen pan di kayn ɛn aw di sik siriɔs . Nɔr mɛrɛsin nɔr de fɔ dɛn kayn sik ya, bɔt mɛrɛsin kin ɛp fɔ kɔntrol yu pikin in sik . If yu pikin kin gɛt sɔm atak dɛn nɔmɔ insay wan ia, yu kin ɔltɛm ebul fɔ kɔntrol di sik dɛn wit mɛrɛsin dɛn we de mek pɔsin fil pen ɛn di mɛrɛsin dɛn we nɔ de mek pɔsin fil pen (NSAID). Bɔt if di sik rili bad, yu dɔktɔ kin tɛl yu fɔ du ɔda tritmɛnt dɛn:

• FMF: Dɛn kin trit dis wit wan mɛrɛsin we dɛn kɔl `(Colchicine)` fɔ ridyus inflamɛns. If dɛn nɔ ebul fɔ gi di pikin `(Colchicine)`, yu kin tray wan `(biologic)` kayn mɛrɛsin we dɛn kɔl `(Canakinumab)`.
• PFAPA: Stroyd dεm lεk prεdnison kin sכt di tεm we PFAPA "atכk" de tek. Cimetidine, we na wan mɛrɛsin we dɛn kin gi sɔm pikin dɛn fɔ gɛt ɔlsa na dɛn bɛlɛ, kin ɛp bak fɔ mek dɛn nɔ gɛt di sik.
• TRAPS: Di drɔg `(Canakinumab)` rili wok fɔ TRAPS. Dɔn bak, dɛn kin kɔntrol di sik dɛn wit anti-inflammatory drɔgs lɛk `(glucocorticoids)` we di dɔktɔ gi.
• MKD: `(Canakinumab)` na fayn tritmɛnt bak fɔ MKD. `(NSAIDs)` ɔ `(steroids)` kin ɛp we dɛn de "atak".
• NLRP3 sik dɛm: Dɛn dɔn yuz imyunomoduletɔ dɛm lɛk Canakinumab, Rilonacept, ɛn Anakinra fayn fayn wan fɔ trit sik dɛm we gɛt fɔ du wit NLRP3.
• AOSD: Dɛn kin yuz difrɛn anti-inflammatory mɛrɛsin dɛn lɛk stɛroyd, sik-modifying anti-rheumatic drugs (DMARDs), ɛn biologics fɔ trit AOSD.
• Blau sindrom: I kin dipen pan di pikin in simptom dɛm, dɛn kin tray fɔ yuz imyunosuprɛsant, tumor necrosis factor (TNF) inhibitors, ɛn/ɔ topical eye medications.

We yu rid bɔt dɛn mɛrɛsin ya, dat kin mek yu fred smɔl. Bɔt mɛmba se dɛn kin gi ɔl dɛn mɛrɛsin ya ɔnda di strikt sɔpɔtishɔn we dɔktɔ de gi, di we we go fayn fɔ di pikin. So, i impɔtant fɔ fala di tritmɛnt jɔs lɛk aw di dɔktɔ se.

Yu tink se SAIDs stetɔs de go fa?

Sɔm SAID dɛn na tin dɛn we kin apin to pɔsin in layf . Ɔda wan dɛn kin las fɔ sɔm ia ɛn dɛn kin go we dɛn ol . Sɔm kayn tin kin de fɔ ɔl yu layf, bɔt as tɛm de go, di frɛkuɛns fɔ atak kin stɔp ɛn di sayn dɛm kin nɔr kin tranga. Yu dɔktɔ go ɛksplen to yu di patikyula tin dɛn we de apin to yu pikin.

Fɔ kia fɔ pikin we gɛt SAID kin tranga. If yu dɔn SAID yusɛf, yu kin yuz yu ɛkspiriɛns fɔ ɛp fɔ kia fɔ yu pikin. Yu ɔndastandin impɔtant bak fɔ ɛp yu pikin fɔ liv wit dis sik we de apin to am ɔl in layf.

Di tin we impɔtant pas ɔl na fɔ fɛn tritmɛnt frɔm dɔktɔ dɛn we gɛt ɛkspiriɛns ɛn we sabi bɔt SAID. Dɛn kin ɛp fɔ kɔntrol yu pikin in sik ɛn ɛp am fɔ gɛt di bɛst pikin tɛm.

Di tin dɛn we impɔtant pas ɔl fɔ mɛmba (Take-Home Message) .

Okay, so lɛ wi rikap sɔm pan di men pɔynt dɛn we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt:

• If yu pikin gɛt fiva ɔltɛm, we yu nɔ kin ɛksplen , i kin bi sayn fɔ SAID.
• SAID nɔto infɛkshɔn , bɔt na prɔblɛm wit di bɔdi in yon imyun sistɛm.
• Dis na sik dɛn we nɔ kin apin so ɔltɛm we bɔku tɛm na bikɔs ɔf di jɛnɛtiks .
• Di sayn dɛm kin difrɛn difrɛn wan bay di kayn SAID, bɔt fiva ɔltɛm na di men sayn .
• I impɔtant fɔ go to Riumatɔlɔjis fɔ gɛt kɔrɛkt diagnosis ɛn tritmɛnt.
• Pan ɔl we di tritmɛnt nɔ go ebul fɔ mɛn di sik kpatakpata, dɛn kin kɔntrol di sayn dɛn fayn fayn wan .
• Nɔ ignore di sayn dɛm, bikɔs dɛn kin mek yu kidni pwɛl if dɛn nɔ trit yu.

If yu gɛt ɛni ɔda kwɛstyɔn bɔt dis, nɔ shek fɔ tɔk to yu famili dɔktɔ ɔr dɔktɔ we de mɛn yu bɔdi. Dɛn go ebul fɔ ɛp yu mɔ.

` SAID, fiva sindrom we kin kam ɔltɛm, fiva we kin kam bak, ɔtoinflammatory sik, fiva, fiva na pikin dɛn, jɛnɛtik sik