Yu smɔl pikin kin jɔs gɛt fiva ɔltɛm? I kin wɛl afta i gɛt fiva fɔ sɔm dez, bɔt i kin gɛt ɔda fiva afta sɔm dez? Yu kin de wɔnda wetin mek dis kin apin if yu nɔ gɛt vayrɔs ɔ baktriyal infɛkshɔn. Dis kin bi bikɔs ɔf wan sik we nɔ kin apin so ɔltɛm we dɛn kɔl SAIDs (Systemic Autoinflammatory Diseases) , we bɔku pipul dɛn nɔ yɛri bɔt. Nɔ wɔri, lɛ wi tɔk bɔt am simpul wan ɛn ɔndastand ɔltin.
Wetin na SAID dɛn? Lɛ wi ɔndastand am simpul wan.
Fɔ tɔk am simpul wan, SAID na wan grup fɔ sik dɛn we kin mek pɔsin gɛt fiva ɔltɛm, we kin kam bak ɛn we nɔ gɛt ɛni infɛkshɔn (lɛk vayrɔs ɔ baktri). Di tin we kin mek dis apin na we wi pikin in innate immune system nɔ de wok fayn . Fɔs, dɛn bin de kɔl dis ‘Periodic Fever Syndromes’.
Naw yu kin de wɔnda, dis na ‘autoimmune’ sik? Bɔku tɛm wi kin yɛri bɔt ɔtoimyun sik dɛm lɛk Rimatɔyd Atraytis ɔ Lupus. Nɔ, dis difrɛn.
Imajin se wi gɛt difens ami insay wi bɔdi, we na wi imyun sistɛm. Dis ami gɛt tu men pat dɛn:
1. Innate Immune System: Dis na di ami we wi bɔn wit, ɛn na di fɔs wan we de atak ɛni jem.
2. Adaptive Immune System: Dis na ami we dɛn tren spɛshal fɔ fɛt difrɛn jem dɛn we wi de gro.
Insay SAID, di prɔblɛm de wit di innate immune system . Dat imyun sistɛm kin agyu ɛn bigin fɔ fɛt insay di bɔdi we nɔ gɛt ɛni ɛnimi. Di rizulyt fɔ dis fɛt na inflamɛns na di bɔdi ɛn fiva.
Bɔt pan di ɔtoimyun sik dɛm we wi bin tɔk bɔt, di prɔblɛm na di adaptiv ami we dɛn kin tren leta. Da ami de nɔ ebul fɔ no di gud sɛl dɛn we de na in yon bɔdi ɛn bigin fɔ atak dɛn.
SAID dεm nכ kin bכku pas כtoimyun sik dεm. Bɔku tɛm, na bikɔs ɔf di jɛnɛtiks, we min se dɛn kin gɛt dɛn frɔm dɛn gret gret granpa dɛn. Dɛn sayn ya kin bigin we pikin rili yɔŋ, lɛk we i smɔl ɔ we i smɔl. Di pikin kin gɛt wan episɔd ɔ atak sik wantɛm wantɛm wit fiva ɛn ɔda sayn dɛm, we kin dɔn insay sɔm dez. Di pikin kin gɛt wɛlbɔdi ɔlsay we i nɔ sik. Pan ɔl we no mɛrɛsin nɔ de fɔ mɛn am, sɔm tritmɛnt dɛn de we go ebul fɔ kɔntrol di sik dɛn.
Wetin na di men kayn SAID dɛm?
Risach pipul dɛn dɔn no lɛk 60 kayn SAID dɛn te naw, ɛn dɛn de fɛn nyu kayn dɛn ɔltɛm. Na sɔm pan di kayn dɛn we pipul dɛn kin gɛt.
| Nem fɔ di sik (Type of SAID) . | Wan shɔt introdukshɔn |
|---|---|
| Famili Mɛditarenian Fiva (FMF) . | Dis na di kayn SAID we dɛn kin no bɔt di jɛnɛtiks, we kin mek di bɛlɛ, di chɛst, ɛn di jɔyn dɛn gɛt pen. |
| Fiva we kin apin wan wan tɛm, Afthous-Stomatitis, Faryngitis, Adenitis (PFAPA) . | I kin bigin pan yɔŋ pikin dɛm, mɔ bifo dɛn rich 4. Di sayn dɛm lɛk trot we de at, mɔt so, ɛn gland dɛm we de swel na dɛn nɛk kin kam wit di fiva. Bɔku tɛm, i kin go afta i dɔn ol 10 ia. |
| Tumor Nεkrכsis Fכktכr Risεptor-Asכsiet Pεriכdik Sεndrכm (TRAPS) . | Dis kin bigin we dɛn smɔl ɔ ivin we dɛn yɔŋ. |
| Mevalonate kinase Dɛfisiɛns (MKD) . | Dis kin bigin bifo di pikin ol wan ia. |
| NLRP3-Asosiet Ɔtoinflammatory Diziz (CAPS) . | Dis na rili tri difrɛn sik dɛn we dɛn jɔyn togɛda. |
| Di sik we dɛn kɔl Still’s Disease (AOSD) we kin bigin frɔm big pipul dɛn . | As di nem sho, dis na sik we kin bigin we pɔsin big. |
| Blau Sindrom we gɛt di sik | Dis kin apin to pikin dɛn we nɔ rich 4 ia yet.I kin mɔs afɛkt di skin, dɛn yay, ɛn di jɔyn dɛn. |
Wetin na di kɔmɔn sayn dɛm fɔ dɛn sik ya?
Di men ɛn kɔmɔn sayn fɔ SAID na fiva we de kam bak . Bɔt apat frɔm fiva, ɔda sayn dɛn kin apin bak dipen pan di kayn sik.
De impɔtant tin na dat, dɛn sayn ya kin apin nɔmɔ pan wan tɛm we pɔsin de sik. We da tɛm de dɔn, di pikin kin gɛt wɛlbɔdi ɔlsay ɛn nɔ gɛt ɛni sayn.
| Nem fɔ di sik (Type of SAID) . | Simptom dɛm fɔ wach fɔ |
|---|---|
| FMF | Bɔku pen na di bɛlɛ, chɛst, ɛn di jɔyn dɛn. Skin lεsin dεm na di lכw leg כ ankles. |
| PFAPA we de na di wɔl | Trot we de at, ɔlsa na yu mɔt, di limf no dɛm we de swel na di nɛk. |
| TRAP DƐN | Di bɔdi kin fil kol ɛn i kin shek shek. Pen kin de na di mɔsul dɛm na di bɔdi, mɔ na di trɔnk ɛn an. Rɛd spat dɛn we de mek yu fil pen kin apia ɔlsay na di bɔdi. |
| MKD | Di bɔdi kin fil kol ɛn shek shek, wit ed we kin at, bɛlɛ kin at, i nɔ kin want fɔ it, ɛn i kin gɛt sayn dɛn we fiba di wan we pɔsin kin gɛt we i gɛt kol. |
| NLRP3 Sik dɛn we pɔsin kin gɛt | Skin rash, ed we de at, taya, joyn pen, ɛn yay infɛkshɔn (kɔnjɔktiviti). |
| Blau Sindrom we gɛt di sik | Skin lεsin dεm na di pikin in an, in leg, כ in trכnk. Jɔyn pen ɛn yay pen. |
Wetin mek dɛn sik ya kin apin? Wetin na di tin dɛn we kin mek i apin?
As wi bin dɔn tɔk, bɔku SAID dɛn na sik dɛn we dɛn kin gɛt frɔm dɛn jɛnɛtiks . dis min se dεn sik ya de kכz fכ wan mכtεshכn (vεryכnt) insay wan patikyula jin.
| Nem fɔ di sik (Type of SAID) . | Jin we gɛt fɔ du wit am |
|---|---|
| FMF | MEFV jin |
| PFAPA we de na di wɔl | Dɛn nɔ dɔn fɛn di rayt rizin yet. |
| TRAP DƐN | TNFRSF1A jin |
| MKD | MVK jin |
| NLRP3 Sik dɛn we pɔsin kin gɛt | NLRP3 jin |
| AOSD | Dɛn nɔ dɔn fɛn di rayt rizin yet. |
| Blau Sindrom we gɛt di sik | NOD2 jin |
Wetin kin apin if dɛn nɔ gɛt di rayt tritmɛnt?
Dis na tin we rili impɔtant. I impɔtant fɔ kɔntrol dis sik bay we yu tek di rayt tritmɛnt. Bikɔs, if kɔntinyu inflamɛns de na di bɔdi lɛk dis, i kin mek pɔsin gɛt wan sik we dɛn kɔl Amyloidosis . Fɔ tɔk am simpul wan, wan kayn prɔtin kin de na wi kidni, ɛn dis kin mek di kidni dɛn pwɛl sote go. So, i rili impɔtant fɔ no di sik ɛn trit am kwik kwik wan.
Aw dɔktɔ kin no bɔt dis sik?
Fɔ tɔk tru, fɔ no bɔt SAID kin tranga smɔl bikɔs di sayn dɛm kin tan lɛk ɔda siriɔs sik dɛm lɛk lupus.
So, di tin we impɔtant pas ɔl na fɔ go to dɔktɔ we spɛshal pan dɛn kayn sik ya. Dɛn kɔl dɔktɔ we spɛshal pan sik dɛn we gɛt fɔ du wit di jɔyn dɛn ɛn di imyun sistɛm Rimatɔlɔjis .
Yu dɔktɔ go tink bɔt sɔm tin dɛn fɔ no if yu gɛt di sik. I go mɔs bi se i go aks bɔt yu pikin in sik ɛn if na famili histri bɔt dis sik. Yu dɔktɔ kin sɔprayz se yu gɛt SAID, mɔ if:
- If di pikin kin gɛt fiva ɔltɛm.
- If ɛnibɔdi na di famili dɔn gɛt sik dɛn we tan lɛk flu we kin kam bak lɛk dis.
- Bikɔs dɛn sik ya kin bɔku pan sɔm etnik grup dɛn, dɛn de tink bɔt dat bak.
Us tɛst dɛn dɛn kin du?
Di dɔktɔ kin tɛl yu fɔ du bɔku tɛst fɔ no if yu gɛt di sik.
- Blɔd tɛst (Lab tɛst): Tɛst lɛk C-reactive protein (CRP) ɛn CBC (Full Blood Count) kin chɛk fɔ inflamɛns na di bɔdi. Dɛn lɛvɛl ya kin go ɔp we yu sik ɛn kin kam bak to nɔmal lɛvɛl we di bɔdi wɛl.
- Yurin tεst: I de chεk fכ εlevεt di protin lεvεl dεm na di urine. pan sɔm sik dεm lεk MKD, urine tεst kin fכ no spεshal asid dεm.
- Jεnεtik tεst: Dis tεst kin no di jεnεtik mכtεshכn. Bɔt sɔm tɛm, pikin kin gɛt SAID bɔt di jenɛtik tɛst nɔ kin no am. So, ivin if di tɛst rizɔlt nɔ fayn, dɛn nɔ kin se 100% se di sik nɔ de.
Wetin na di tritmɛnt dɛm fɔ dis?
Di tritmɛnt fɔ SAID dɛn kin dipen pan di kayn ɛn aw di sik bad. Pan ɔl we dɛn nɔ kin ebul fɔ mɛn dɛn sik ya ɔltogɛda, mɛrɛsin kin kɔntrol di sayn dɛn bad bad wan.
- FMF: Dɛn kin yuz wan mɛrɛsin we dɛn kɔl Kɔlchisin fɔ dis. I de ridyus di inflamɛns na di bɔdi. If da drɔg de nɔ wok fɔ di pikin, dɛn kin tɔn to drɔgs lɛk Canakinumab .
- PFAPA: Dɛn kin gi stɛroyd lɛk Prednisone fɔ shɔt tɛm fɔ ridyus di tɛm we di sik kin tek kwik kwik wan.
- TRAP DƐN: KanakinumabDi drɔg kin rili wok. Dɔn bak, dɛn kin yuz anti-inflammatory drɔgs lɛk glucocorticoids .
- MKD: Di drɔg Canakinumab de wok fɔ dis bak. NSAID (painkillers) ɔr stɛroyd kin ɛp wae pɔrsin sik.
- NLRP3 Sik dɛm: Dɛn kin yuz mɛrɛsin dɛm we de chenj di imyun bɔdi lɛk Canakinumab , Rilonacept , ɛn Anakinra fayn fayn wan fɔ dis.
- Blau Syndrome: I kin dipen pan di sayn dɛm, dɛn kin yuz immunosuppressants, TNF inhibitors, ɛn ay mɛrɛsin dɛm.
Yu tink se dis sik go wɛl kpatakpata?
Sɔm SAID dɛn kin de fɔ ɔl yu layf. Bɔt sɔm, lɛk PFAPA, kin go fɔ dɛnsɛf as di pikin de big. Pan ɔl we dɛn kin bi tin dɛn we kin apin to pɔsin fɔ ɔl in layf, di frɛkuɛns we pɔsin kin sik ɛn di kayn we aw i kin tranga kin go dɔŋ as tɛm de go. Yu dɔktɔ go gi yu patikyula tin dɛn bɔt yu pikin in kɔndishɔn.
Fɔ kia fɔ pikin we gɛt dis sik kin tranga. Bɔt if di rayt spɛshal pipul dɛn ɛp yu, yu kin ebul fɔ kɔntrol di sik dɛn we yu pikin gɛt ɛn gi am di bɛst pikin tɛm we pɔsin kin gɛt.
Mɛsej we dɛn kin kɛr go na os
- If yu pikin kin gɛt fiva bɔku tɛm fɔ no rizin, nɔ jɔs ignore am ɛn go to dɔktɔ wantɛm wantɛm.
- SAID na wan grup fɔ sik dɛn we nɔ kin bɔku we kin kam bikɔs ɔf prɔblɛm we de na di pat we dɛn bɔn wit di imyun sistɛm.
- Dɛn tin ya nɔto sik dɛn we pɔsin kin pas; bɔku tɛm na di tin dɛn we de mek pɔsin gɛt jɛnɛtiks kin mek i apin.
- I rili impɔtant fɔ go to dɔktɔ we de mɛn di sik (dɔktɔ we spɛshal pan jɔyn ɛn di imyun sistɛm) fɔ no di sik kɔrɛkt wan.
- Pan ɔl we dɛn nɔ go ebul fɔ mɛn dɛn tin ya ɔltogɛda, mɛrɛsin kin ɛp fɔ kɔntrol di sik dɛn ɛn mek yu liv nɔmal layf.
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