Wi ɔl dɔn yɛri bɔt difrɛn kayn mɛrɛsin fɔ difrɛn sik dɛn, nɔto so? Tide wi go tɔk bɔt wan difrɛn klas we smɔl fɔ tek drɔgs. Dɛn kɔl dɛn tin ya ‘Protease Inhibitors’. Sɔntɛm yu nɔ yɛri bɔt dis nem, bɔt dis kayn mɛrɛsin impɔtant fɔ kɔntrol siriɔs vayral infɛkshɔn lɛk HIV/AIDS, Epataytis C, ɛn COVID-19. So lɛ wi tek tɛm luk wetin na dɛn tin ya, aw dɛn de wok, ɛn wetin na di impɔtant tin dɛn we yu nid fɔ no bɔt dɛn.
Fɔ tɔk am simpul wan, wetin na dɛn protease inhibitor ya?
Fɔ tɔk am simpul wan, protease inhibitors na wan kayn mɛrɛsin we dɛn kin yuz fɔ trit vayral infɛkshɔn . Dɛn men wok na fɔ stɔp wan vayrɔs fɔ mek kɔpi fɔ insɛf wans i dɔn go insay wi bɔdi, we min se i nɔ go ebul fɔ skata mɔ. Dis mɛrɛsin de essentially ‘blok’ di vayrɔs fɔ mek i nɔ skata.
Dɛn kin kɔl dis mɛrɛsin mɔ as antiretroviral drɔg we dɛn kin yuz fɔ mɛn HIV/AIDS. Dɛn kin yuz am bak fɔ mɛn epataytis C ɛn COVID-19.
sכmtεm dεn kin gi dεn proteas inhibito dεm ya dεn wan (monotherapy). Bɔt bɔku tɛm, dɛn kin gi dɛn togɛda wit ɔda antivayrɔs mɛrɛsin dɛn. Dɛn kin du dis fɔ mek di tritmɛnt wok fayn mɔ ɛn mɔ. insay dis kes, dεn kin kכl dεm bak "bכsta".
Wetin na di men tin dɛm wae dɛn kin trit wit dis mɛrɛsin?
Dɛn dɔn gri fɔ wan klas ɔf drɔgs we dɛn kɔl protease inhibitors fɔ trit sɔm patikyula vayral infɛkshɔn dɛn. Lɛ wi tek wan luk pan wetin dɛn bi.
| Mɛdikal kɔndishɔn | Aw fɔ yuz am |
|---|---|
| HIV/AIDS | We dɛn de trit HIV, dɔktɔ dɛn kin gi dɛn mɛrɛsin ya dɛn wan ɔ insay "kɔktɛl" wit sɔm ɔda mɛrɛsin dɛn. Dɛn kɔl dis kɔmbayn tritmɛnt dɛn antiretroviral therapy (ART) . Sɔntɛnde dɛn kin yuz dɛn bak fɔ mek dɛn nɔ gɛt di sik afta dɛn dɔn gɛt di vayrɔs (post-exposure prophylaxis). |
| Epataytis C we dɛn kɔl C | Dɛn kin yuz di protiz inhibito dɛn as pat pan di antivayral drɔg kɔmbaynshɔn fɔ kɔmplit wan fɔ mɛn di epataytis C infɛkshɔn. |
| COVID-19 we gɛt di sik | Dɔktɔ dɛn kin se dɛn fɔ jɔyn tu protease inhibitor (e.g. Paxlovid®) fɔ ridyus di risk fɔ gɛt siriɔs sik we COVID-19 infɛkshɔn kin kam wit. |
Aw dis mɛrɛsin de wok?
Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul. Imajin se vayrɔs na faktri we de mek wan lɔng chen we gɛt prɔtin. Fɔ yuz dis lɔng chen fɔ wok, dɛn nid fɔ kɔt am to smɔl smɔl pat dɛn we de wok. di spεshal ‘siza’ dεm we di vayrus de yuz fכ dis kכt na εnzym dεm we dεn kכl ‘proteases’ .
So, wetin wan klas dεm we dεn kכl ‘Protease Inhibitors’ de du na fכ stכp di akshכn fכ dεn ‘scissors’ dεm. I tan lɛk siza we de blunt. Dɔn di vayrɔs nɔ kin ebul fɔ kɔt di pat dɛn pan di prɔtin we i nid. Dis kin mek di vayrɔs nɔ ebul fɔ mek nyu kɔpi fɔ insɛf ɛn infɛkt wi sɛl dɛn.
Wetin na di kayn protease inhibitor dɛm?
Bikɔs ɛni vayrɔs gɛt in yon protease ɛnzaym, dɛn kin yuz difrɛn kayn protease inhibitor fɔ trit HIV, ɛpatitis C, ɛn COVID-19. Wan simpul we de bak fɔ no dɛn.
- Di nem dɛm fɔ di mɛrɛsin dɛm we dɛn kin yuz fɔ trit HIV kin dɔn wit "-navir" .
- Di nem dɛm fɔ di mɛrɛsin dɛm we dɛn kin yuz fɔ ɛpatitis C kin dɔn wit "-previr" .
Protease inhibitors fɔ HIV
dis dεm de blכk di proteas εnzym we dεn kכl HIV-PR, we di HIV vayrus de yuz fכ mek kכpi fכ insεf.
- Atazanavir we dɛn kɔl Atazanavir
- Darunavir we dɛn kɔl Darunavir
- Fosamprenavir we dɛn kɔl
- Indinavir we dɛn kɔl
- Lopinavir we dɛn kɔl
- Nɛlfinavir we dɛn kɔl
- Ritonavir we dɛn kɔl
- Saquinavir we dɛn kɔl Saquinavir
- Tipranavir we dɛn kɔl
Protease inhibitors fɔ ɛpatitis C
dis dεm de blכk wan εnzym we dεn kכl NS3/4A serin protease, we di epataytis C vayrus de yuz fכ mek kכpi fכ insεf.
- Boceprevir we dɛn kɔl Boceprevir
- Glekaprevir we dɛn kɔl Glecaprevir
- Grazoprevir we dɛn kɔl Grazoprevir
- Paritaprevir we dɛn kɔl
- Simeprevir we dɛn kɔl
- Telaprevir we dɛn kɔl Telaprevir
Protease inhibitors fɔ COVID-19
Paxlovid® na wan kɔmbaynshɔn fɔ tu protease inhibitor, nirmatrelvir ɛn ritonavir, we dɛn kin yuz fɔ trit COVID-19.
Aw a go pik di rayt mɛrɛsin fɔ mi?
Naw yu go de wɔnda wetin dɛn mɛrɛsin ya kin du fɔ mi.Na yu dɔktɔ nɔmɔ go disayd. I go tink bɔt bɔku tin dɛn we i de pik di mɛrɛsin we go fayn fɔ yu.
- Us patikyula vayral infɛkshɔn yu gɛt?
- Yu ɔl wɛl bɔdi ɛn ɛni ɔda mɛrɛsin we yu kin gɛt (e.g. dayabitis, at sik).
- Us ɔda mɛrɛsin yu de tek naw (as kin gɛt intarakshɔn bitwin dɛn tin ya).
- Yu dɔn tek ɔda mɛrɛsin fɔ dis sik bifo?
- Di sakses fɔ di mɛrɛsin de dipen pan di kayn vayrɔs we yu gɛt.
- Bɔt di sayd ɛfɛkt ɔ prɔblɛm dɛn we di mɛrɛsin kin kam wit.
So, i rili impɔtant fɔ ɛksplen klia wan ɔl di mɛrɛsin dɛn we yu de tek ɛn ɛni ɔda mɛrɛsin we yu gɛt we yu go to yu dɔktɔ. Dis kin ridyus di risk fɔ gɛt siriɔs sayd ɛfɛkt.
Wetin na di sayd ɛfɛkt ɛn bɛnifit dɛn we dɛn mɛrɛsin ya gɛt?
Lɛk ɛni mɛrɛsin, di protease inhibitors gɛt ɔl tu bɛnifit ɛn sayd ɛfɛkt.
Men advantej dɛn
- As pat pan ART tritmɛnt fɔ pɔsin we gɛt HIV, i de ɛp fɔ kip di amount of HIV vayrɔs na di bɔdi na di lɛvɛl we dɛn nɔ go ebul fɔ no.
- I de ɛp fɔ mɛn epataytis C infɛkshɔn.
- I de ɛp fɔ mek wan COVID-19 infɛkshɔn nɔ kam tranga.
Sɔm sayd ɛfɛkt dɛn we pɔsin kin gɛt
Di sayd ɛfɛkt dɛn kin dipen pan di mɛrɛsin we yu de tek, ɔda mɛrɛsin dɛn we yu de tek, ɛn yu wɛlbɔdi. I impɔtant fɔ tɔk to yu dɔktɔ bɔt dis ɛn fɔ no bɔt dis.
| Tayp fɔ di sayd ɛfɛkt | Ɛgzampul dɛn |
|---|---|
| Di sayd ɛfɛkt dɛn we dɛn kin si bɔku tɛm | |
| Prɔblɛm dɛn we kin apin | Bɛlɛ de at, nɔs ɛn vɔmit, dayarɛa |
| Rash na di skin | |
| Kɔf, taya, strenj teist na di mɔt | |
| Kidni ston dɛn | |
| di chenj dεm we de apin na di bכdi fεt distribushכn (lipodystrophy) . | |
| Siriɔs sayd ɛfɛkt dɛn we nid fɔ pe atɛnshɔn wantɛm wantɛm | |
| Siriɔs prɔblɛm dɛn we kin apin | Liva dɔn pwɛl, blɔd de kɔmɔt insay |
| Siriɔs sik na yu skin wit pen, blista rash (Stevens-Johnson syndrome) . | |
| Di shuga we de na di blɔd (haypa glycemia), di kɔlɔstrel we bɔku (hayperlipidemia) . | |
| At atak (myocardial infarction), prɔblɛm wit di at in ilɛktrik sistɛm | |
Wetin a go du fɔ mek i izi fɔ mi?
We yu de du dis tritmɛnt, sɔm tin dɛn de we yu kin du fɔ mek yu nɔ gɛt sɔm pan di sayd ɛfɛkt dɛn ɛn mek di tritmɛnt izi.
- Tek yu mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu, di rayt tɛm, insay di rayt doz. Nɔ skip wan doz.
- Drink bɔku wata. Dis kin ridyus di impak pan di kidni dɛm.
- Nɔ tek ɔda mɛrɛsin dɛn we go miks wit yu mɛrɛsin. Aks yu dɔktɔ bɔt dis.
- Sɔm mɛrɛsin dɛn kin wok fayn we dɛn tek dɛn wit it . Sɔm kin nid fɔ it tin dɛn we gɛt fat. Aks yu dɔktɔ aw fɔ tek yu mɛrɛsin ɛn fala da advays de.
Ustɛm a fɔ go to di dɔktɔ?
If yu gɛt ɛni sayd ɛfɛkt we yu nɔ bin de ɛkspɛkt we yu de trit yu ɔ yu gɛt ɛnitin fɔ wɔri bɔt di tritmɛnt, kɔl yu dɔktɔ wantɛm wantɛm.
Na mɔtalman, if yu gɛt ɛni wan pan dɛn bad bad sayd ɛfɛkt ya, go to dɔktɔ wantɛm wantɛm ɛn nɔ de te ɔ go na di ɔspitul Imejɛnsi Dipatmɛnt (ETU) we de nia yu.
- Fiva
- Kɔnfyushɔn ɔ chenj na in maynd
- Yu skin ɔ yu yay de yɔlɔ (jaundice) .
- Blistering, penful, ɔ rash we de ɔlsay
- Bɛlɛ pen bad bad wan
- Fɔ vɔmit bad bad wan
Mɛsej we dɛn kin kɛr go na os
- Protease inhibitors na wan rili pawaful klas fɔ drɔgs we dɛn kin yuz fɔ trit vayral infɛkshɔn lɛk HIV, ɛpatitis C, ɛn COVID-19.
- dis de stכp di vayrus fכ mכltipl (mek kכpi) na di bכdi.
- Dɛn mɛrɛsin ya fɔ tek ɔnda dɔktɔ advays nɔmɔ . I rili impɔtant fɔ fala di doz ɛn di tɛm we di dɔktɔ tɛl yu fɔ du gud gud wan.
- Sɔm sayd ɛfɛkt dɛn kin apin, frɔm smɔl smɔl tin dɛn we kin mek pɔsin nɔ fil fayn to siriɔs prɔblɛm dɛn. If yu si ɛni siriɔs sayn, go to dɔktɔ wantɛm wantɛm.
- Yu nɔ fɔ stɔp fɔ tek mɛrɛsin ɔ chenj di doz we yu nɔ gɛt dɔktɔ advays fɔ ɛni rizin.
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