Wan mɛrɛsin fɔ bɛlɛ inflamɛns ɛn gastritis! Lɛ wi lan ɛksaktɔli bɔt Proton Pump Inhibitors (PPI)!

Yu kin gɛt at bɔn ɔr chɛst pen bak bɔku tɛm? Abi di dokta se "gastritis"? Wan kayn mɛrɛsin we dɔktɔ dɛn kin gi bɔku tɛm pan dɛn kayn tin ya na in dɛn kɔl `(Proton Pump Inhibitors)`. If wi bin fɔ tɔk blunt, sɔntɛm wi go kɔl am bak "mɛdisin fɔ gastritis." So, tide wi go tɔk bɔt `(Proton Pump Inhibitors)` ɔ PPI fɔ shɔt.

Wetin mek wi nid dɛn PPI ya? Wetin kin apin to di asid we de na di bɛlɛ?

Fɔ tɔk am simpul wan, `(Proton Pump Inhibitors)` na wan kayn mɛrɛsin we de ridyus di asid we de kɔmɔt na yu bɛlɛ, dat na di asid we de na yu bɛlɛ . Naw yu kin de tink se, "O, wetin na di pɔynt fɔ bɛlɛ asid? I nɔ fayn." Dat nɔto tru. Asid we de na di bɛlɛ rili impɔtant fɔ wi bɔdi. Na dis asid de ɛp wi fɔ digest di it we wi de it. Nɔto dat nɔmɔ, dis asid na di bɛlɛ de ɛp bak fɔ pwɛl di bad bad jem dɛn we wi kin it wit it we wi nɔ no.

Bɔt sɔm tɛm dɛn prɔblɛm kin bigin we di asid na di bɛlɛ go ɔp tumɔs, ɔ we di asid go na difrɛn say pas aw i fɔ go. I tan lɛk se dɛn kin se "If i bɔku, ivin nɛktɔ go gɛt pɔyzin." Na da tɛm de bɛlɛ ɔlsa (`ulcer`), ɔ as wi kin kɔl am, "gastritis ɔlsa" kin kam. Ɔda tin dɛm lɛk at bɔn ɛn sɔl teist na di trot kin apin bak. Na da tɛm de dɛn mɛrɛsin ya we dɛn kɔl PPI de ɛp wi. Dɛn kin yuz dɛn mɔ fɔ prɔblɛm dɛn we kin de fɔ lɔng tɛm we gɛt fɔ du wit asid na di bɛlɛ.

Us kayn sik dɛn kin yuz dɛn PPI ya fɔ?

Dɔktɔ dɛn kin yuz dɛn kayn mɛrɛsin ya mɔ (Proton Pump Inhibitors) fɔ trit tin dɛn lɛk we di pat dɛn na wi dijestiv sistɛm dɔn pwɛl ɛn inflamɛns, dat na di intestinal ɛn ɛsophagus, we kin kam wit asid na di bɛlɛ. Lɛ wi si wetin dɛn bi:

• GERD ɔr Chronic Acid Reflux Disease: Bɔrku tɛm yu kin gɛt at bɔn? Yu gɛt sɔl teys na yu trot? Na dat GERD bi. Fɔ tɔk am simpul wan, na di asid we de na yu bɛlɛ we de kam ɔp insay yu ɛsophagus. Dis kin pwɛl di layn na yu εsophagus, we dɛn kin kɔl bak erosive esophagitis. di PPI dεm de wok bay we dεn de ridyus di prodyushכn fכ di bεlε asid εn gi yu εsophagus tεm fכ hεl.
• Pεptik εn duodenal כlsa: Bεlε εn duodenal כlsa na כlsa we kin kכz fכ bεlε asid, we kin pwεl di prכtektiv layn na di bεlε. dεn kin mek כlsa bak na di fכs pat pan di sכmכl intestכn (dεn kכl am duodenum). PPI kin ɛp fɔ mɛn dɛn ɔlsa ya. Apat frɔm dat, sɔm pen kil, mɔ di nɔ-stɛroyd anti-inflammatory drugs (NSAID), kin gɛt fɔ du wit di risk fɔ gɛt ɔlsa. Stɔdi dɔn sho se lɛk 30% pan di pipul dɛn we de tek NSAID ɔltɛm kin gɛt ɔlsa. PPI kin ɛp fɔ mek yu nɔ gɛt ɔlsa ɛn mɛn am.
• H. pylori infεkshכn:Dis na wan kayn baktri we kin liv na wi bɛlɛ. Dis baktri kin mek yu bɛlɛ ɔlsa bak. We dɛn de trit H. pylori infɛkshɔn, dɔktɔ dɛn kin gi PPI wit antibayɔtik. dis na biכs di PPI dεm de chenj di pH lεvεl na di bεlε, we de mek i izi fכ antibaytik fכ kil di baktri dεm.
• Zollinger-Ellison syndrome: Dis na wan sik wae nɔr kin bɔrku. insay dis kכndyushכn, sכm kayn tכmכro dεm (`tכmכro`) de divεlכp na di bכdi εn mek di bכdi prodyuz tu mכch כmon we de mek di bכdi asid. Dis kin mek yu bɛlɛ gɛt bɔku asid. Dɛn kin yuz PPI bak fɔ trit dis kɔndishɔn.

Aw dɛn mɛrɛsin ya we dɛn kɔl PPI de wok? I wɔndaful, nɔto so?

Imajin se smɔl "mashin" de na wi bɛlɛ we de mek asid. wi kכl dis mashin di ``haydrojen-potashכm ATPase pכmp'', כ di ``proton pכmp'' fכ sכt. jכs lεk aw wata pכmp de pul wata כp, dis protכn pכmp na in de du di kεmikכl prכsεs we nid fכ mek bεlε asid.

So, wetin dεn `(Proton Pump Inhibitors)` כ PPI dεm de du na fכ stכp di fכnshכn fכ di proton pכmp fכ sכm tεm . Dat min se, dɛn de "inhibit" am, dat na, dɛn de intafya wit am. Dɔn di asid we de na di bɛlɛ kin go dɔŋ.

Bɔt dis nɔ de stɔp di asid na di bɛlɛ kpatakpata, nɔto so? Yu stil gɛt inof asid we lɛf fɔ dayjɛst it. if yu tek wan PPI fכ lεk fayv dez insay wan rכw, di prodakshכn fכ bכdi asid go rεdכks bay lεk 65%. di rεst 35% pan di asid na infεkt fכ digεst it.

Wetin na dɛn PPI ya?

Sɔm pan dɛn PPI ya yu kin bay ɔva-di-kɔnta (OTC) na di famasi we yu nɔ gɛt prɛskrishɔn, bɔt sɔm pan di wan dɛn we strɔng pas am nid fɔ gɛt prɛskrishɔn frɔm dɔktɔ (Rx nɔmɔ).

PPI dɛm we dɛn kin tek wit ɔ atɔl dɔktɔ in prɛskrishɔn (OTC ɛn Rx):

• Ɛsomɛprazɔl (Nɛksiɔm®) .
• Lansoprazol (Prɛvasid®) we dɛn kɔl .
• Ɔmɛprazɔl (Prilosec®) we dɛn kɔl .
• Ɔmɛprazɔl/sɔdiɔm baykabɔnɛt (Zegerid®) .

PPI dεm we de כnli wit dכkta in prεskrishכn (Rx nכmכ):

• Dɛkslansɔprazɔl (Dɛksilant®) .
• Pantoprazol (Protonix®) we dɛn kɔl .
• Rabeprazol (AcipHɛks®) we dɛn kɔl .

Aw a go tek dis mɛrɛsin? Aw bɔku a fɔ tek?

Dɛn mɛrɛsin ya kin kam insay tablɛt ɔ kapsul. Yu de tek dɛn bay mɔt. Sɔm kayn kapsul dɛn gɛt paoda we dɛn kin miks insay it lɛk apul sos, dɔn dɛn kin tek am. Dis na big ɛp fɔ pipul dɛm wae gɛt prɔblɛm fɔ swɛla pils.

Bifo yu tek di mɛrɛsin, yu fɔ tek tɛm rid di instrɔkshɔn dɛn we de na di paket.Na da tɛm de yu go gɛt di rizɔlt dɛn we kɔrɛkt pas ɔl. Sɔm PPI dɛn de we yu fɔ tek af awa ɔ wan awa bifo yu it, pan ɛmti bɛlɛ. We yu tek dɛn da tɛm de, di mɛrɛsin kin gɛt tɛm fɔ wok bifo yu bɛlɛ bigin fɔ mek asid we yu de it.

Na yu dɔktɔ nɔmɔ go ebul fɔ tɛl yu ɔmɔs mɛrɛsin yu nid (`dose`) ɛn ɔmɔs tɛm insay di de yu fɔ tek am. I go gi yu wan doz we go kɔntrol yu sik dɛn wit di smɔl chans fɔ gɛt sayd ɛfɛkt. Fɔ sɔm pipul dɛn, fɔ tek wan pil bifo dɛn it brɛf, na in go du fɔ dɛn. Fɔ ɔda pipul dɛn, if dɛn tek am tu tɛm insay di de, bifo dɛn it brɛf ɛn bifo dɛn it ivintɛm it, dat kin du fɔ dɛn. Sɔntɛnde, fɔ tek am ɛvri ɔda de kin du fɔ yu.

As tɛm de go, yu go nid fɔ ridyus di doz fɔ yu mɛrɛsin. Yu dɔktɔ go advays yu bɔt dis bak.

Aw lɔng i kin tek fɔ mek dɛn PPI ya wok?

Afta yu tek wan PPI mɛrɛsin, i kin tek ɛnisay frɔm 24 awa to 4 dez fɔ fil in ful ɛfɛkt.

If yu gɛt at bɔn ɔ yu chɛst pen wantɛm wantɛm ɛn yu nid fɔ gɛt rilif kwik, i bɛtɛ fɔ yuz wan antasid (lɛk Digene, Acidex) ɔ wan histamin blɔk (H2 blɔk) (lɛk Pepcid® ɔ Tagamet®) pas PPI. Imajin se yu at pwɛl wantɛm wantɛm afta yu it wan it we gɛt spays. Dɔn, if yu tek dis kayn mɛrɛsin, i go mek yu fil fri insay sɔm minit ɔ sɔm awa. Bɔt di ifɛkt we i gɛt nɔ de las fɔ lɔng tɛm lɛk di PPI dɛn.

PPI dεm bεst if yu gεt lכng tεm, krεse bεlε asid prכblεm.

Ɛni sayd ɛfɛkt de we yu de yuz dɛn PPI ya?

Bɔrku pipul nɔr kin gɛt ɛni big prɔblɛm wae dɛn de tek PPI. Bɔt lɛk ɛni mɛrɛsin, dɛn kin mek sɔm bad tin dɛn apin. Dɛn tin ya na:

• Bɛlɛ de at
• Banbɛlɛ
• Rɔnbɛlɛ
• Diziz we pɔsin kin gɛt
• Dray mɔt
• Ɛd we de at
• Fiva
• Bloating/Gas we de blo
• Layt-hed we pɔsin kin gɛt
• I de it ɛn rash
• Fɔ vɔmit

Pan ɔl we dɛn kin tek PPI as sef, sɔm pipul dɛn we de stɔdi bɔt dis dɔn kam fɔ no se i kin mek sɔm prɔblɛm dɛn, mɔ we dɛn yuz am fɔ lɔng tɛm . Lɛ wi tek wan luk pan wetin dɛn bi:

• Clostridioides difficile (C. diff) infεkshכn: PPI dεm kin chenj di bεlε bitwin gud εn bad baktri dεm na yu gכt, we de mek yu risk fכ gεt infεkshכn lεk C. diff.
• Fraktrɔs: PPI kin mek yu bɔdi nɔ ebul fɔ tek di kalsiɔm, we na wan minral we de ɛp fɔ mek wi bon dɛn strɔng. Di U.S. Food and Drug Administration (FDA) wɔn se PPI kin mek di hip, an, ɔ spayna brok.
• Kidni sik:Dɛn tin ya kin mek yu gɛt mɔr sik fɔ gɛt krɛse sik (CKD), ɔr kin mek di kɔndishɔn wae de naw wɔs.
• di nyutrishכnal dεfisit: PPI dεm kin rεdכks yu sכm sכm intestכn in abiliti fכ abzכp magnεsium כ vaytam in B12. Magnesium na wan minral we de ɛp wi mɔsul ɛn nerv dɛn fɔ wok fayn fayn wan. Vitamin B12 impɔtant fɔ wi nervɔs sistɛm ɛn rɛd blɔd sɛl dɛn.

Dɛn stil de stɔdi di link bitwin PPI ɛn dɛn risk factor ya. Bɔt bɔku tɛm, dɔktɔ dɛn kin se yu fɔ yuz di doz we smɔl pas ɔl ɛn fɔ shɔt tɛm te yu sik dɛn bɛtɛ. Dis go ridyus di risk fɔ dɛn tin ya we kin mek pɔsin gɛt prɔblɛm.

Ustɛm a fɔ go to mi dɔktɔ?

If dɔktɔ dɔn gi yu PPI, mek shɔ se yu aks yu dɔktɔ if yu gɛt ɛni kwɛstyɔn bɔt aw fɔ tek di mɛrɛsin, ustɛm fɔ stɔp, ɔ aw fɔ ridyus di doz.

If yu de tek PPI ova di kɔwnta frɔm famasi ɛn yu fil se yu nid am ɛvride fɔ kɔntrol yu sik dɛn, yu fɔ stil go to dɔktɔ. I kin advays yu bɔt di rayt doz ɛn di lɔng tɛm we yu fɔ tek di mɛrɛsin.

Dɔn bak, if yu gɛt ɛni wan pan dɛn bad bad tin ya, go to dɔktɔ wantɛm wantɛm:

• Alɛji riakshɔn (skin rɔsh, rɛd, swɛlin) .
• Sayn dεm we de sho se yu kidni dεm dεn dεm (we yu de pis sכmtεm pas aw yu bin de pis bifo, yu an εn fut de swεla, yu ankכl dεm) .
• Di sayn dɛm we de sho se yu nɔ gɛt magnɛsiɔm (we yu de shek shek, yu at nɔ de bit ɔltɛm, yu mɔsul dɛn de twitch) .
• Di sayn dɛm wae de sho se yu nɔr gɛt vaytamɛn B12 (di pen na yu an ɛn fut, yu de swɛla, yu de swɛt, yu de tɔn diziz, yu de kɔnfyus) .
• If di skin rɛd, blista, ɔ i tan lɛk se i de pul
• If yu gɛt siriɔs dayarɛa
• If yu gɛt fiva

So, wetin na di las mɛsej we dɛn kin kɛr go na os?

If yu gɛt bɔku asid na yu bɛlɛ, ɔ yu gɛt am na di rɔng ples, i kin rili mek yu fil pen. I kin pwɛl yu dijestiv sistɛm bak. Laki, bɔrku mɛrɛsin de wae kin ɛp yu if yu gɛt dɛn sik ya.

Fɔ shɔt tɛm rilif, wan antasid ɔ H2 blɔk na di bɛst. Bɔt if yu at kin bɔn ɔltɛm ɔ yu gɛt ɔlsa na yu bɛlɛ, yu dɔktɔ kin gi yu wan kayn PPI. Dɛn mɛrɛsin ya dɔn de fɔ lɔng lɔng tɛm ɛn dɛn kin tek dɛn as tritmɛnt we nɔ bad ɛn we go wok fayn. Bɔku pipul dɛn kin fil fayn wit dɛn mɛrɛsin ya.

Di tin we impɔtant pas ɔl na dat, dɛn fɔ jɔs yuz dis mɛrɛsin ɔnda di advays we dɔktɔ gi am, di doz we dɛn gi am ɛn fɔ di tɛm we dɛn gi am.If yu tray fɔ yuz am di we aw yu want, prɔblɛm kin kam. So, i fayn fɔ lisin to wetin di dɔktɔ se ɔltɛm ɛn tek di mɛrɛsin di rayt we.

` PPI dεm, gastritis, bεlε inflameshn, asid rεfluks, bεlε כlsa, omeprazol, pantoprazole