Yu dɔn ɛva gɛt bad bad nɔys ɛn vɔmit afta dɛn dɔn du yu ɔpreshɔn ɔ we dɛn de du ɔda big ɔpreshɔn? Ɔ yu bin gɛt mɔnin sik we yu nɔ go ebul fɔ bia we yu gɛt bɛlɛ? I kin so bad dat i kin mek wi layf nɔ fayn. Bɔt wan klas de fɔ mɛrɛsin we rili fayn we dɔktɔ dɛn kin yuz fɔ kɔntrol dis kayn nɔys ɛn vɔmit. Na dat wi go tɔk bɔt tide.
Fɔ tɔk am simpul wan, wetin na dis sɛrotonin antagonist?
Dis na di nem we dɛn kin gi wan klas fɔ mɛrɛsin. Fɔ tɔk am simpul wan, dɛn mɛrɛsin ya na mɛrɛsin dɛn we dɛn kin gi fɔ mek pɔsin nɔ gɛt nɔys ɛn vɔmit ɛn fɔ mɛn am. insay mεdikal tεm dεm, dεn kכl dεn tin ya `antiemetics`. Ivin if yu dɔktɔ nɔ bin tɔk bɔt dis nem dairekt wan, dɛn kin dɔn gi yu wan mɛrɛsin na dis klas.
Dɛn kin yuz bɔku ɔda nem dɛn fɔ dis klas fɔ drɔgs:
- Serotonin-rεsεptor antagonist dεm
- 5HT3 rεsεptכr antagonist dεm
- Serotonin blɔk dɛn
Pan ɔl we dɛn nem dɛn ya kin tan lɛk se dɛn kɔmplikt smɔl, dɛn ɔl min di sem tin. Dat min se dɛn mɛrɛsin ya de mek wan kemikal we de na wi bɔdi we dɛn kɔl sɛrotonin , nɔ de wok. Lɛ wi luk am smɔl mɔ.
Bɔku kayn mɛrɛsin dɛn de we dɛn kin yuz na Sri Lanka ɛn ɔlsay na di wɔl:
- Ondansetron - Dis na di wan we pipul sabi pas ɔl. I kam ɔnda di brand nem Zofran®.
- Granisetron - we de ɔnda di brand nem Kytril®.
- Palonosetron - we de ɔnda di brand nem Aloxi®.
- Dolasetron - Pan ɔl we dɛn bin de kɔl am Anzemet® fɔs, dɛn dɔn pul am naw fɔ yuz am na kɔntri dɛn lɛk Amɛrika.
Dis mɛrɛsin de insay ɔl tu di pil ɛn injɛkshɔn fɔm.
Wetin rili dɛn kin yuz dis mɛrɛsin fɔ?
Dɛn mɛrɛsin ya na dɛn fɔs we dɛn dɔn gri fɔ mek yu nɔ gɛt nauses ɛn vɔmit pan sɔm tin dɛn.
- Tritmɛnt fɔ kansa (Kɛmotɛrapi): Dɛn tin ya impɔtant fɔ kɔntrol di bad bad nɔys we bɔku pipul dɛn kin gɛt we dɛn de tek kimotɛrapi.
- Radiation therapy: Radiation therapy fɔ kansa kin mek yu nɔs bak.
- Afta Anestezi: Bɔku pipul dɛn kin vɔmit ɛn nɔs we dɛn kin no bak afta dɛn dɔn du anestezi fɔ ɔpreshɔn. Dɛn kin gi dis mɛrɛsin fɔ mek dis nɔ apin.
Dɔktɔ dɛn kin gi dɛn tin ya as i fayn fɔ big pipul ɛn pikin dɛn.
Sɔntɛnde, dɔktɔ dɛn kin yuz dɛn mɛrɛsin ya fɔ ɔda sik dɛn. Dɛn kɔl dis "ɔf-lɛbul" yus. Dat min se dɛn kin gi dɛn mɛrɛsin bikɔs dɔktɔ dɛn no se dɛn kin wok fɔ wan patikyula sik, pan ɔl we dɛn nɔ gri fɔ mek dɛn gɛt da sik de.
Dis na ɛgzampul dɛn bɔt aw dɛn kin yuz dis mɛrɛsin we nɔ de na di lɛbl:
- Fɔ trit (nɔto jɔs fɔ mek yu nɔ gɛt) nɔs ɛn vɔmit afta dɛn dɔn du yu ɔpreshɔn.
- Fɔ kɔntrol di bad bad nɔys ɛn vɔmit (mɔnin sik) we yu gɛt bɛlɛ we at fɔ kɔntrol wit ɔda tritmɛnt dɛn.
Aw dis mɛrɛsin de wok insay wi bɔdi?
Fɔ ɔndastand dis, lɛ wi fɔs jɔs ɔndastand wetin na ‘serotonin’.
Serotonin na nyurotransmitta na wi bɔdi. I tan lɛk ‘mɛsenja’. Dis mɛsenja de kɔntrol bɔku tin dɛn lɛk aw wi de fil, aw wi de slip, ɛn aw wi de digest. 90% pan di sεrotonin na wi bכdi de fכn insay di sεl dεm na wi dijestiv sistεm (intestines).
Imajin, we wi gɛt sɔntin lɛk kemotɛrapi, di sɛl dɛn we de na wi intestinal kin pwɛl. Dɔn, dɛn sɛl dɛn de kin pul bɔku bɔku sɛrotonin wantɛm wantɛm na di blɔd. dis sεrotonin we pasmak de sεnd mεsej to di bren se, "Sכmtin nכ de ya!" Na da mɛsej de de mek wi fil ‘nɔs’ .
fכ mek dεn sεrotonin mεsej dεm ya rich di bren, dεn nid fכ tay pan spεsifi k ‘rεsεpכta dεm’ na wi gכt εn bren. Dɛn tin ya tan lɛk ‘kihol’ we ki fit insay. Sεrotonin na di ki, εn di rεsεpכta na di kihol. we dεn put di ki kכrekt wan, di domɔt de opin (i.e., dεn de sεnd di nכs mεsej).
`Serotonin Antagonist` mεdisin de wok bay we i de go na dεn kihol dεm (5-HT3 rεsεpכta dεm) εn blכk dεm. I tan lɛk se yu put fek ki na di kihol. Dɔn di rial ki (serotonin) nɔ kin ebul fɔ go insay di mɛsej nɔ kin go na di bren. Di rizɔlt? Di nɔys ɛn vɔmit kin stɔp.
Di sayd ɛfɛkt ɛn di risk dɛn we di mɛrɛsin dɛn kin gɛt
Dis mɛrɛsin kin jɔs rili sef. Bɔt lɛk ɛni mɛrɛsin, i gɛt sɔm bad bad tin dɛn ɛn sɔm tin dɛn we yu fɔ no bɔt.
Kɔmɔn sayd ɛfɛkt dɛn
- Ed de at
- Taya
- Banbɛlɛ
Bɔku tɛm, dɛn tin ya nɔ kin siriɔs, bɔt if dɛn de mɔna yu, tɔk to yu dɔktɔ.
Risk dɛn we yu fɔ no mɔ bɔt
| Risk sityueshɔn | Wetin fɔ no |
|---|---|
| Di tin dɛn we kin apin to pɔsin in at | If yu gɛt prɔblɛm wit yu at ritm lɛk Long QT syndrome , Ventricular arrhythmia , ɔ ɔda at sik, mek shɔ se yu tɛl yu dɔktɔ bifo yu tek dis mɛrɛsin. Sɔm pipul kin gɛt chenj na dɛn at rit bikɔs ɔf dis mɛrɛsin. |
| Sɛrotonin Sindrɔm we pɔsin kin gɛt | Dis na di sik we denja pas ɔl ɛn we kin apin wantɛm wantɛm. We dɛn tek am wit ɔda mɛrɛsin dɛm we de mek di sɛrotonin lɛvɛl go ɔp (e.g., SSRI, SNRI fɔ pwɛl hat), di sɛrotonin lɛvɛl na di bɔdi kin bi denja. I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek. |
| We uman gɛt bɛlɛ | Pan ɔl we dis mɛrɛsin nɔ de kɛr big risk fɔ bɔn pikin dɛn we nɔ fayn, dɛn dɔn ripɔt se smɔl inkris pan di at pwɛl hat ɛn cleft palata. So, dɛn fɔ jɔs yuz am we uman gɛt bɛlɛ bay di advays we dɔktɔ gi am if di bɛnifit dɛn pas di prɔblɛm dɛn we i go gɛt. |
Smɔl mɔ bɔt Serotonin Syndrome
Dis na siriɔs sik we kin ivin mek pɔsin in layf de pan denja. Yu fɔ no bɔt dɛn sik ya we de kam biɛn ya. If yu gɛt wan ɔ mɔ pan dɛn tin ya, go na ɔspitul in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.
- Nɔr de rɛst, fɔ wɔri
- Nɔs ɛn vɔmit
- Rɔnbɛlɛ
- di pupil dεm na di yay dεm de big
- Di bɔdi we de shek shek
- Mɔsul dɛn de twitch, stiffness
- Swet, fil kol
- Kɔnfyushɔn, we pɔsin nɔ de no natin
- Di at we de blo
- Di ay blɔd prɛshɔn
- Di bɔdi in tɛmpracha go ɔp (we pas 101.3°F / 38.5°C)
- Di sik dɛn we kin mek pɔsin sik
- Lɔs fɔ no bɔt sɔntin
Ustɛm a fɔ go to di dɔktɔ bak?
If yu de tek dis mɛrɛsin fɔ lɔng tɛm, i impɔtant fɔ de tɔk to yu dɔktɔ ɔltɛm. Mek shɔ se yu tɔk to yu dɔktɔ pan dɛn tin ya:
- If di sayd ɛfɛkt dɛn bigin fɔ mɔna yu.
- If yu nɔs ɛn vɔmit nɔ de bɛtɛ ɔ i de wɔs.
- If yu de tink fɔ stɔp di mɛrɛsin (nɔ ɛva stɔp fɔ tek di mɛrɛsin we yu nɔ aks yu dɔktɔ).
Nɔs na tin we nɔ kin rili fayn. Bɔt di gud nyus na dat, mɛrɛsin dɛn de we rili fayn tide fɔ kɔntrol dɛn kayn tin ya. If yu gɛt dis prɔblɛm, tɔk to yu dɔktɔ bɔt am opin wan ɛn gɛt di tritmɛnt we go fayn fɔ yu.
Mɛsej we dɛn kin kɛr go na os
- Serotonin Antagonist na wan mɛrɛsin we rili wok we de kɔntrol di nɔs ɛn vɔmit we kin kam bikɔs ɔf kansa tritmɛnt, redyushɔn tɛrapi, ɛn ɔpreshɔn.
- Dɛn tin ya de wok bay we dɛn de blok di akshɔn we wan mɛsenja we dɛn kɔl sɛrotonin de du na di bɔdi.
- If yu gɛt at sik ɔ yu de tek ɔda mɛrɛsin (especially antidepressant), mek shɔ se yu tɛl yu dɔktɔ bifo yu tek dis mɛrɛsin.
- Yu fɔ no di sayn dɛm wae de sho se yu gɛt Serotonin Syndrome (wɔri, yu de swet pasmak, yu mɔsul dɛn de stif, yu at de bit kwik kwik wan) ɛn go na ɔspitul in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm if yu tink se yu gɛt dis kayn sik.
- Ɔltɛm, na ɔnda dɔktɔ advays nɔmɔ yu fɔ gɛt ɛn yuz dɛn mɛrɛsin ya.
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