Yu bɔdi stif fɔ natin? Lɛ wi tɔk bɔt Stiff Person Syndrome!

Sɔntɛnde yu kin fil se yu mɔsul dɛn de tayt we yu nɔ go ebul fɔ ɛksplen, ɔ yu mɔsul dɛn de shek shek wit pen? Sɔntɛnde, i kin apin we yu yɛri lawd nɔys ɔ pɔsin bɔmp pan yu. If dɛn tin ya kin apin bɔku tɛm, i go fayn fɔ mek yu luk insay am. Tide wi go tɔk bɔt wan sik we nɔ kin apin so ɔltɛm we kin mek yu gɛt di sem kayn sik. Dɛn kɔl dat Stiff Person Syndrome (SPS) .

Wetin na Stiff Pɔsin Sindrom?

Fɔ tɔk am simpul wan, Stiff Person Syndrome (SPS) na wan sik we nɔ kin apin so ɔltɛm na di nyurolɔjik . I kin apin we di imyun sistɛm we de protɛkt wi frɔm sik, mistek atak wi yon wɛlbɔdi nɛv sɛl dɛn. Na wan ɔtoimyun kɔndishɔn. Dis kin mek di mɔsul dɛn we de na yu kɔr, mɔ yu bɛlɛ, yu chɛst, ɛn yu bak , kin stif ɔ stif . As tɛm de go, dis stiffness ɛn spasm kin spre to yu leg ɛn ɔda mɔsul dɛm. Dis kin mek i nɔ izi fɔ waka, i kin mek yu fɔdɔm bɔku tɛm, ɛn i kin mek yu gɛt injury.

Fɔs, dɛn bin de kɔl dis "stiff man syndrome," bɔt naw dɛn dɔn chenj da nem de bikɔs dis sik kin afɛkt ɛnibɔdi, ilɛksɛf i ol ɔ if na man ɔ uman.

Fɔ no se yu gɛt dis sik kin mek yu at pwɛl smɔl. Bɔt yu mɛdikal tim go mek wan tritmɛnt plan we go wok fɔ yu ɛn yu sik dɛn. Dis kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Di tin we impɔtant pas ɔl na fɔ go to yu dɔktɔ dɛn ɔltɛm, gɛt di sɔpɔt we yu nid, ɛn tray fɔ gɛt wɛlbɔdi.

Wetin na di sayn dɛm wae de sho se yu gɛt Stiff Person Syndrome (SPS)?

Tu men sayn de fɔ dis sik:

• Di mɔsul dɛn we stif ɔ rigid.
• Di mɔsul dɛn we kin mek pɔsin fil pen.

Pan ɔl we dɛn sik ya kin bigin pan ɛni ej, dɛn kin apin mɔ bitwin 30 ɛn 40 ia .

Di sayn dɛm wae de kam wit Stiff Person Syndrome kin pas to ɔda pat dɛm na di bɔdi ɛn kin wɔs as tɛm de go. Fɔ sɔm pipul dɛm, e kin tek sɔm mɔnt to sɔm ia fɔ mek dɛn si di sik. Fɔ ɔda pipul dɛn, di sayn dɛn kin stil de di sem fɔ lɔng lɔng tɛm. Fɔ sɔm pipul dɛm, di sayn dɛm kin wɔs smɔl smɔl ɛn mek dɛn nɔr kin ebul fɔ du tin dɛm ɛvride.

Di mɔsul dɛn we de stif

Bɔku tɛm, di fɔs sayn we yu kin notis wit Stiff Person Syndrome na we di mɔsul dɛn kin stiff na di trɔnk . Dis min se na say dɛn lɛk di bɛlɛ, di chɛst, ɛn di bak. Dis stiffness kin mek yu fil pen ɛn nɔr kin fil fayn. Dɛn sayn ya kin kam ɛn go fɔ no rizin. Di sik kin afɛkt di an ɛn leg bak. As di stif de go ɔp, sɔm pipul dɛn kin gɛt abnɔmal pozishɔn we kin mek i nɔ izi fɔ waka ɔ muv.

Di mɔsul dɛn we de spam

Di mɔsul dɛm we de mek yu fil pen na ɔda big sayn fɔ dis sik. Dɛn tin ya kin afɛkt di wan ol bɔdi, ɔ dɛn kin de na wan patikyula say. Dɛn spam ya kin las fɔ sɔm sɛkɔn, minit, ɔ ivin sɔm awa. Imajin, we yu jɔs tinap, wantɛm wantɛm yu leg ɔ yu bak kin fil tayt ɛn ting. Na ɛkspiriɛns we kin rili mek a fil pen.

Wetin na de tin wae kin mek yu gɛt Stiff Person Syndrome (SPS)?

Bɔku rizin dɛn de we mek sɔm kayn sik dɛn lɛk we yu mɔsul dɛn de shek shek kin apin wantɛm wantɛm:

• Wan nɔys we kin mek wantɛm wantɛm ɔ we kin mek lawd lawd wan. Imajin if yu de waka na strit ɛn motoka blo in ɔn wantɛm wantɛm, ɔ if sɔntin na os fɔdɔm na grɔn wit lawd bang.
• Fɔ tɔch yu bɔdi ɔ fɔ mek yu want fɔ du sɔntin. If pɔsin tɔch yu wantɛm wantɛm, i pat yu.
• Di chenj na di tɛmpracha, mɔ di say dɛn we kol. If yu go wantɛm wantɛm na say we kol, ɔ if kol wata fɔdɔm pan yu bɔdi.
• Tin dɛn we kin apin we kin mek pɔsin strɛs. Di tɛm dɛn we kin mek pɔsin vɛks ɛn we kin mek pɔsin fred.

Bikɔs dɛn mɔsul dɛn ya kin apin di tɛm we yu nɔ go ebul fɔ no, sɔm pipul dɛn we gɛt Stiff Person Syndrome kin gɛt wɔri ɛn agoraphobia . Agoraphobia na fɔ fred pasmak fɔ go na say dɛn we pipul dɛn kin bɔku, fɔ go na do, ɔ fɔ kɔmɔt na os. Bikɔs we yu dɔn kɔmɔt na do, i nɔ kin izi fɔ lɛ yu rɔnawe pan dɛn tin ya we de mek yu want fɔ du sɔntin.

Wetin kin mek pɔsin gɛt Stiff Person Syndrome (SPS)?

Risach pipul dɛm stil nɔ shɔ wetin de mek dis sik, bɔt dɛn biliv se na ɔtoimyun kɔndishɔn, we min se wi bɔdi in yon imyun sistɛm de atak wɛlbɔdi sɛl dɛm.

Risach dɔn sho se antibodi dɛn de insay dis. Bɔrku pipul dɛm wae gɛt Stiff Person Syndrome gɛt antibodi dɛm wae de agens wan ɛnzaym wae dɛn kɔl Glutamic Acid Decarboxylase (GAD) . dis εnzym (GAD) de εp fכ mek di nyurotransmitta gama-aminobutyric acid (GABA) . dis nyurotransmitta (GABA) de εp fכ kכntrכl di mכsul dεm fכ wok.

bכt di wan dεm we de du risach stil nכ כndastand gud gud wan aw di εnzym `(GAD)` de afekt di divεlכpmεnt εn prכgreshכn fכ Stiff Person Syndrome. Wan tin we yu fɔ mɛmba na dat we yu gɛt `(GAD)` antibodies na yu bɔdi nɔ min se yu gɛt Stiff Person Syndrome. sכm pasεnshכn pan di jεnarכl pכpulεshכn kin gεt dεn `(GAD)` antibodi dεm ya na dεn bכdi we nכ gεt nכ bad ifekt.

apat frכm GAD, dεn fכnshכn se כda antibodi dεm lεk glycine rεsεpכta, amphiphysin, εn DPPX (dipeptidyl peptidase-like protein 6) de sho se dεn gεt di sik. Dɔn bak, sɔm sik pipul dɛn nɔ kin gɛt ɛni wan pan dɛn antibodi ya. Dɛn de du mɔ risach fɔ no us ɔda antibodi dɛn kin gɛt fɔ du wit am.

Wetin na di tin dɛm wae kin mek pɔrsin gɛt Stiff Person Syndrome (SPS)?

Stiff person syndrome na tu tɛm pas di wan we uman dɛn kin gɛt . I kin apin bak wit ɔda ɔtoimyun kɔndishɔn dɛn. Fɔ ɛgzampul:

• Tayp 1 dayabitis
• Autoimyun tayroyd sik
• Vitiligo we gɛt di sik
• Anemia we kin pwɛl pɔsin in bɔdi
• Siliak sik we dɛn kin gɛt

Aw kɔmɔn tin na Stiff Pɔsin Sindrom (SPS)?

Dis na tin we nɔ kin apin so ɔltɛm . Dɛn se na wan pan ɛvri milyɔn pipul dɛn nɔmɔ gɛt dis sik. Dat min se na sik we nɔ kin bɔku.

Aw dɛn kin no se pɔsin gɛt Stiff Person Syndrome (SPS)?

Dɔktɔ kin no dis sik bay sɔm patikyula sayn dɛn, ɛgzam, ɛn tɛst. Dɛn go aks yu bɔt yu sik dɛn, du ɛgzam fɔ yu bɔdi, ɛn du nyurolɔjik ɛgzam.

If di dɔktɔ sɔspɛkt Stiff Person Syndrome, dɛn kin du tɛst lɛk:

• Antibodi blɔd tɛst: Dis kin ɛp fɔ chɛk fɔ si if antibodies to (GAD) (ɔ ɔda antibodies we gɛt fɔ du wit am) de ɛn fɔ pul ɔda mɛrɛsin kɔndishɔn dɛn.
• Electromyography (EMG): Dis de mek yu no aw yu mɔsul dɛn de wok wit ilɛktrik. Dis kin ɛp fɔ pul ɔda tin dɛn we kin mek yu gɛt di sik.
• Lumbar pancture (spinal tap): Insay dis tεst, dכkta de yuz nidul fכ tek sεmpl fכ wata frכm yu spεnal kכd εn tεst am fכ antibodi dεm to GAD. Dis impɔtant bak fɔ pul ɔda kɔndishɔn dɛn.

Stiff Person Syndrome kin tranga fɔ no bikɔs i nɔ kin bɔku ɛn in sayn dɛm kin tan lɛk ɔda ɔtoimyun sik dɛm, lɛk ankylosing spondylitis ɛn multiple sclerosis.

Sɔm kayn Stiff Pɔsin Sindrom (SPS) de?

Bɔku difrɛn sɔbtayp dɛn de fɔ dis sik:

• Klasik stiff pɔrsin sindrom: Dis na di kayn we we dɛn kin gɛt mɔ. Bɔku tɛm i kin gɛt fɔ du wit GAD antibodi dɛm, bɔt risach dɔn sho se ɔda antibodi dɛm bak kin involv.
• Stiff pɔsin sεndrכm vεryכnt dεm:כnda dis, vεryכnt dεm de we de afekt כnli spεsifi k pat dεm na di bכdi, כ we de sho mכr simptom dεm lεk fכ lכs kכntrכl we yu de waka (`ataxia`).
• Progrεsiv εnεsεfalomaylaytis wit rigiditi εn myoklonus (PERM): PERM na wan mכr siriכs fכm fכ stiff pכsin sεndrכm. I kin mek yu nɔr no natin, yu ay muvmɛnt prɔblɛm, ataxia, ɛn aw yu nɔr de woke fayn. Autonomic dysfunction nid fɔ de na ɔspitul fɔ pipul dɛn we gɛt PERM.

Aw dɛn kin trit Stiff Person Syndrome (SPS)?

Tu men we dɛn de fɔ trit dis:

• Mɛrɛsin ɛn tritmɛnt fɔ kɔntrol di sayn dɛm.
• Immunotherapy, ɔ tritmɛnt we de chenj di sik.

Di tritmɛnt we dɛn kin pik kin difrɛn difrɛn wan bay di sayn dɛm we yu gɛt. Di men gol fɔ tritmɛnt na fɔ kɔntrol di we aw yu sik dɛn kin afɛkt yu ɛn fɔ mek yu ebul fɔ muv ɛn fil fayn.

Yu mɛdikal tim kin gɛt sɔm spɛshal pipul dɛn, lɛk:

• Nyurolɔg, mɔ di nyuroimyunɔlɔjis.
• Di wan dɛn we de mɛn pipul dɛn we gɛt wok ɛn di wan dɛn we de mɛn pipul dɛn we gɛt bɔdi.
• Fizikal mɛrɛsin ɛn rihabiliteshɔn spɛshal pipul dɛn.
• Di wan dɛn we de mɛn pipul dɛn we de tɔk.
• Spɛshal pipul dɛn we sabi bɔt mental wɛlbɔdi biznɛs, fɔ ɛgzampul, pipul dɛn we de stɔdi bɔt pɔsin in maynd.

Mɛrɛsin ɛn tritmɛnt dɛn

Mεdikeshכn dεm lεk dis kin εp fכ ridyus di mכsul dεm we de stif, stif, εn di mכsul dεm we de mek yu fil pen:

• Benzodiazepines: Dis na wan klas ɔf mɛrɛsin wae dɛn kin yuse fɔ trit difrɛn kayn sik dɛm, lɛk wae pɔrsin kin wɔri, wae pɔrsin kin gɛt ɛpilepshɔn, ɛn wae pɔrsin nɔr kin slip. dεn de afekt di nyurotransmitta (GABA) signal. Bɔku tɛm, dɔktɔ dɛn kin gi yu dayazepam as di fɔs tritmɛnt fɔ Stiff Person Syndrome.
• Di tin dɛn we de mek di mɔsul rilaks: Mɛrɛsin lɛk Baclofen kin ɛp fɔ mek di mɔsul dɛn swɛt. Dɛn kin mek di mɔsul dɛn rilaks ɛn mek di mɔsul dɛn nɔ stif.
• Nyuropatik pen mεdikeshכn dεm: Mεdikeshכn dεm lεk gabapentin εn pregabalin de afekt GABA signal dεm bak εn εp wit di simptom dεm.

Ɔda tritmɛnt dɛm wae kin ɛp fɔ kɔntrol de sik na:

• Fizik tɛrapi ɔ ɔkupeshɔn tɛrapi.
• Masaj we yu de du.
• Haydrotɛrapi (wata tɛrapi).
• Ɔt tɛrapi.
• Akupankcha we dɛn kin du.

Imyunotɛrapi

Sɔm pruf de fɔ se intravenɔs imyunoglobulin (IVIg) tritmɛnt (we na wan kayn imyunotɛrapi bak) kin ɛp fɔ ridyus di sayn dɛm fɔ Stiff Person Syndrome. IVIg gɛt imyunoglobulin (natural antibodies) we bɔku bɔku pipul dɛn we gɛt wɛlbɔdi imyun sistɛm dɔn gi.

Yu tink se dɛn kin mɛn Stiff Person Syndrome (SPS)?

Naw, no mɛrɛsin nɔr de fɔ Stiff Person Syndrome. Tritmɛnt kin jɔs ɛp fɔ kɔntrol di sayn dɛm.

Wetin na de luk fɔ Stiff Person Syndrome (SPS)?

Dis na wan sik wae de kam wae yu de liv yu layf (krεse) . Di we aw pipul dɛn kin si tin kin difrɛn frɔm wan pɔsin to ɔda pɔsin dipen pan sɔm tin dɛn:

• Di kayn we aw di sik kin siriɔs.
• Di spid we di sik bin de skata.
• Aw di tritmɛnt kin wok fayn?

I impɔtant fɔ bigin tritmɛnt jɔs lɛk aw di sik bigin. Dis kin ɛp fɔ mek yu nɔr gɛt ɔr ridyus di sik ɛn ɛp fɔ mek yu nɔr gɛt prɔblɛm dɛn we go de fɔ lɔng tɛm. Pan ɔl we bɔku pipul dɛn kin gɛt fridɔm wit mɛrɛsin, sɔntɛnde i kin at fɔ kɔntrol di tin dɛn we kin mek dɛn mɔsul dɛn swɛt.

I kin at fɔ waka as tɛm de go. Di ebul fɔ du tin dɛn we pɔsin kin du ɛvride kin go dɔŋ bak smɔl smɔl. As di sik de go bifo, di risk fɔ lɛ pɔsin fɔdɔm de go ɔp. Yu go nid fɔ yuz tik, tin fɔ waka, ɔ ivin wilchia.

Dɛn kin ebul fɔ avɔyd Stiff Person Syndrome (SPS)?

Bikɔs dis na sik we pɔsin kin gɛt we i de fɛt insɛf, natin nɔ de we yu go du fɔ mek i nɔ gɛt am .

Aw a go tek kia ɔf misɛf if a gɛt Stiff Person Syndrome (SPS)?

If i pɔsibul, tray fɔ fɛn dɔktɔ we spɛshal fɔ du risach ɛn trit Stiff Person Syndrome. Dis sik nɔ kin bɔku, so i kin tranga smɔl. If yu want fɔ gɛt di bɛst mɛrɛsin ɛn gɛt di bɛst kwaliti layf, yu go gɛt fɔ tɔk ɛn gɛt pashɔn bɔt am.

Na kɔmɔn tin fɔ lɛ pipul dɛm wae gɛt dis sik kin gɛt prɔblɛm wit dɛn maynd, lɛk fɔ wɔri ɔr pwɛl hat . If yu de gɛt dɛn kayn sik ya, i impɔtant fɔ tɔk to yu dɔktɔ ɔr pɔrsin wae sabi bɔt yu maynd, lɛk pɔrsin wae de stɔdi bɔt yu maynd.

If yu ɛn yu famili ebul, yu kin jɔyn sɔpɔt grup bak usay yu kin mit ɔda pipul dɛn we ɔndastand yu ɛkspiriɛns.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt Stiff Person Syndrome, yu fɔ mit wit yu mɛdikal tim ɔltɛm fɔ si if yu tritmɛnt dɔn wok fayn ɛn fɔ wach aw yu de si yu sik.

If yu notis nyu sayn ɔr gɛt sayd ɛfɛkt frɔm mɛrɛsin, tɛl yu dɔktɔ.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

If yu gɛt Stiff Person Syndrome, i go fayn fɔ aks yu dɔktɔ dɛn kwɛstyɔn ya:

• Us tritmɛnt dɛn yu kin advays fɔ mi sik dɛn?
• Wetin a kin du na os fɔ ɛp wit mi sik dɛn?
• Us sayn dɛm fɔ kɔmplikeshɔn a fɔ luk fɔ?
• Aw a go tink se mi wɛlbɔdi go tan lɛk tumara bambay?
• Klinik trial de fɔ Stiff Person Syndrome?

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Fɔ no se yu gɛt wan sik wae nɔr kin bɔrku lɛk Stiff Person Syndrome nɔr kin izi. Yu kin fil bad, wɔri, ɛn yu nɔ kin no wetin go apin tumara bambay. Bɔt yu nɔ nid fɔ fes dis yu wan. Yu mɛdikal tim de ya fɔ ansa ɛni kwɛstyɔn wae yu gɛt ɛn ɛp yu fɔ kɔntrol yu sik dɛn.

Pan ɔl we yu tritmɛnt de pe atɛnshɔn pan yu bɔdi wɛlbɔdi, mɛmba yu maynd wɛlbɔdi bak . Di sayn dɛm kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin. Bɔt fɔ liv wit pen, nɔr kin fil fayn, ɛn yu mɔsul dɛn kin spam yu nɔr kin no bifo tɛm kin tek yu maynd fayn fayn wan. Dis sik kin mek i nɔ izi fɔ go na do ɛn du tin dɛn we pɔsin kin du ɛvride. So, if yu nid sɔpɔt, nɔ shem fɔ go to dɔktɔ apat frɔm di wan dɛn we yu lɛk. Mɛmba se nɔto yu wangren de.

` Stiff Person Syndrome, mכsul stiffness, nyurolכjik sik dεm, כtoimyun, GAD antibodi dεm, GABA, mכsul twitch, SPS simptom dεm