Sɔntɛnde yu kin fil lɛk se yu bon dɛn wik smɔl ɛn dɛn kin brok pas ɔda wan dɛn? Yu kin brok yu bon wit ivin smɔl tin? Ɔ yu smɔl pikin in pikin tit kin fɔdɔm bifo tɛm? Tide wi go tɔk bɔt wan kɔndishɔn we wi nɔ de tɔk bɔt bɔku, bɔt i rili impɔtant fɔ no bɔt. Dɛn kɔl dis Hypophosphatasia, ɔ HPP fɔ shɔt tɛm.
Wetin rili na Hypophosphatasia (HPP)?
Fɔ tɔk am simpul wan, Hypophosphatasia (HPP) na wan sik we nɔ kin apin so ɔltɛm, we wi kin gɛt frɔm wi mama ɛn papa (jɛnɛtik) we kin afɛkt di we aw wi bon ɛn tit dɛn de divɛlɔp. fכ mek wi bon dεm strכng εn wi tit dεm go εp wi fכ it εn chεw it fayn fayn wan, dεn nid fכ ad minral dεm lεk kalsiכm εn fכsfכr to dεm. dis prכsεs dεn kכl am ``minralization''.
insay HPP, dis prכsεs we dεn kכl `mineralization` nכ de apin fayn fayn wan. dis kin mek di bon dεm εn di tit dεm nכ kin strכng, bכt dεn kin sכft εn i kin izi fכ brok. Pan ɔl we dis sik kin jɔs afɛkt sɔm pipul dɛn, i kin bi siriɔs, layf pan denja fɔ ɔda pipul dɛn.
Wetin kin mek pɔsin gɛt HPP?
Dis na smɔl tin we sayɛnsman dɛn de tɔk bɔt, bɔt lɛ wi ɔndastand am simpul wan. Imajin se wi bɔdi tan lɛk big faktri. Ɔltin gɛt fɔ de in ɔda. Fɔ mek bon dɛn strɔng, wi nid di minral dɛn we dɛn kɔl kalsiɔm ɛn fɔsfɔr we wi bin dɔn tɔk bɔt.
Bɔt tumɔs pan dis `mineralization` prɔses nɔ gud bak. Fɔ ɛgzampul, i nɔ fayn fɔ mek dɛn minral dɛn ya gɛda na di blɔd. So wi gɛt kemikal dɛn na wi bɔdi fɔ kɔntrol dis.
Bɔt bon ɛn tit dɛn nid fɔ gɛt di rayt amɔnt pan dɛn minral dɛn ya. Wan spɛshal ɛnzaym de na wi bɔdi we de ɛp fɔ du dis impɔtant wok. Dɛn kɔl am alkaline phosphatase (ALP) . dis εnzym de mek di kεmikכl dεm we de na di bon dεm εn di tit dεm we de mek dεn minral dεm de nכ de wok. Dɔn di minral dɛn we nid kin gɛda na di bon ɛn tit, ɛn dis kin mek dɛn strɔng.
pipul dεm we gεt HPP gεt mכtεshכn na di jin we dεn kכl `ALPL`, we de mek di ALP εnzym nכ de prodyuz fayn fayn wan. dis kin mek di kεmikכl dεm we de mek di minral dεm we de mek di minral dεm nכ de kכmכt na di bon dεm, we de mek di bon dεm nכ de abzכp di kalsiכm εn fכsfכr we dεn nid. Dis kin mek di bon dɛn saf ɛn wik instead fɔ strɔng.
Wetin na di sayn dɛm fɔ HPP?
Di sayn dɛm fɔ HPP kin difrɛn bad bad wan. dεn dipכnt pan aw mכch ALP εnzym de na di bכdi. as di εnzym lεvεl dεm de dכn, di sayn dεm kin bi mכr siriכs. Dis sik kin apin ɛnitɛm frɔm we dɛn bɔn am te i big.
We dɛn kin no se sɔm big pipul dɛn gɛt HPP, dɛn kin mɛmba se dɛn bin gɛt di sem kayn sik frɔm we dɛn smɔl, bɔt dɛn nɔ bin no am fayn da tɛm de.
Lɛ wi si wetin na di men sayn dɛm.
| Di sayn we de sho se di sik de | Tɔk bɔt |
|---|---|
| Prɔblɛm dɛn we gɛt fɔ du wit dɛn tit | Fɔ lɔs di pikin in tit bifo i ol 5 ia ɔ fɔ lɔs di tit we yu nɔ bin de ɛkspɛkt pan ɛni ej. (Dis na di fכm we kכmכn pas כl - di "odonto" fכm) |
| Di chenj dɛn we de apin na di bon dɛn | di an dεm we dεn butu, di sכt ayt, di bon dεm we sכft, wik כ difכm, di wrist εn ankכl jכint dεm we wayd. |
| Prɔblɛm dɛn we pikin dɛn kin gɛt | we di pikin dεn nכ gεt כ gro fayn, fכ fכm di sכkul bon dεm bifo tεm (we kin mek di prεshכn go bכku pan di bren), di mכsul dεm wik (hypotonia) we de mek di pikin dεm luk ‘fכ fכlכ’, εn i kin at fכ brith. |
| Fraktrɔs dɛn | Bɔn dɛn kin brok izi wan we dɛn yɔŋ, mɔ na di fut ɛn fut, ɛn dɛn kin tek lɔng tɛm fɔ wɛl. |
| Ɔda tin dɛn we de apin | Pen na bon ɛn joyn, i nɔ kin izi fɔ waka, di kalsiɔm we de na di blɔd kin bɔku (i kin mek yu vɔmit, kɔnstipɛshɔn, yu kidni prɔblɛm), yu kin gɛt sik, at at sik we kin kam wantɛm wantɛm. |
Aw fɔ no bɔt dis sik?
If yu ɔ yu pikin gɛt dɛn sik ya, yu dɔktɔ go aks yu bɔt yu famili mɛdikal istri ɛn du wan kɔmplit ɛgzam fɔ yu bɔdi. Apat frɔm dat, dɛn go ɔda fɔ mek dɛn tek ɛkstrem rayt ɛn blɔd tɛst.
di mכst imכtant tεst ya na fכ mכsu di lεvεl fכ di ALP εnzym na di bכdi.Insay di kes fɔ HPP, dis lɛvɛl kin ɔltɛm smɔl.
Sɔntɛnde, dɛn kin du wan jenɛtik tɛst fɔ no if yu gɛt HPP. Bɔt dis tɛst nɔ de ɔlsay ɛn i kin dia. Bɔt bɔku tɛm, yu dɔktɔ kin no di sik wit ɔda tɛst dɛn.
Bikɔs dis na sik we nɔ kin bɔku, sɔntɛnde i kin tek sɔm tɛm fɔ no if i gɛt di sik. So if yu ɔ yu pikin gɛt dɛn sik ya, i impɔtant fɔ no gud gud wan ɛn tɔk to yu dɔktɔ opin wan .
Wetin na di tritmɛnt dɛm fɔ HPP?
Laki, naw tritmɛnt dɛn de fɔ HPP. Fɔ HPP, mɔ di wan dɛn we dɛn no se dɛn gɛt am we dɛn smɔl ɔ we dɛn smɔl, dɛn kin yuz wan mɛrɛsin we dɛn kɔl asfotase alfa (Strensiq) . Dis na injɛkshɔn we dɛn kin gi ɔnda di skin. i de wok bay we i de riples di ALP εnzym we nכ de na di bכdi (εnzym riplesmεnt tεrapi).
Apat frɔm dis men tritmɛnt, dɛn kin du sɔm ɔda tin dɛn fɔ kɔntrol di sik dɛn we de sho se dɛn gɛt am.
- Fɔ gi pen kil (NSAID) lɛk paracetamol ɔ ibuprofen fɔ bon ɔ jɔyn pen.
- If di prɛshɔn na di skel ay, ɔpreshɔn fɔ ridyus am.
- Gi vaytam in B6 fɔ kɔntrol di sik we sɔm pipul dɛn kin gɛt.
- Di it kɔntrol ɔ mɛrɛsin fɔ kɔntrol di blɔd kalsiɔm lɛvɛl.
- Ɔltɛm tek kia ɔf yu tit wɛlbɔdi ɛn aks fɔ advays frɔm yu tit.
- Fizik tritmɛnt kin mek di mɔsul dɛn strɔng ɛn i kin mek dɛn muv fayn fayn wan.
- Fɔ put mɛtal stik dɛn insay bon dɛn we kin brok bɔku tɛm.
- Wan tin we yu fɔ mɛmba mɔ na dat, bisphosphonate-type drugs, we dɛn kin yuz fɔ trit ɔda bon sik dɛn lɛk ɔstioporosis, kin mek HPP wɔs. So, dɛn fɔ avɔyd dɛn.
Dɛn tritmɛnt ya kin dia, so i impɔtant fɔ tɔk to yu dɔktɔ bɔt di gud tin dɛn, bad tin dɛn, ɛn di kɔst fɔ di tritmɛnt dɛn.
Fɔ gɛt sɔpɔt we yu de liv wit HPP
Fraktrɔs, pen, ɛn ɔda sayn dɛm kin mek ɛvride layf tranga. Fɔ liv wit wan sik wae nɔr kin bɔrku kin min fɔ no bɔt yu sik ɛn tɔk fɔ yusɛf. Dis kin apin to yu ɔ yu pikin.
Ɔndastand ɛn rɛspɛkt di tin dɛn we yu nɔ ebul fɔ du na yu bɔdi. Rɛst we yu nid fɔ du dat. Fɔ trit HPP kin nid fɔ gɛt tim we gɛt bɔku difrɛn tin dɛn. Dis kin inklud dɔktɔ we de mɛn pikin dɛn, dɔktɔ we de mɛn ɔtpidik, dɔktɔ we de mɛn dɛnt, ɛn dɔktɔ we de mɛn dɛn bɔdi.
Ɔda kɔmɔn sik dɛn de we gɛt di sem sayn lɛk HPP, so if yu nɔ shɔ bɔt wetin yu dɔktɔ dɔn no, nɔ fred fɔ gɛt sɛkɔn opinion frɔm ɔda spɛshal pɔsin.Na yu rayt.
Pan ɔl we di tritmɛnt kin tek sɔm ia, dɛn kin kɔntrol di sik dɛn bad bad wan as tɛm de go.
Mɛsej we dɛn kin kɛr go na os
- Hypophosphatasia (HPP) na wan sik we nɔ kin bɔku, we pɔsin kin gɛt frɔm in mama ɛn papa, we kin mek di bon ɛn tit wik.
- Di sayn dɛm kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin, frɔm we dɛn tut kin lɔs kwik kwik wan pan yɔŋ pikin dɛm to siriɔs bon dɛm we kin pwɛl.
- bכdi tεst fכ chεk fכ di lכw lεvεl fכ di ALP εnzym na di bכdi rili imכtant fכ no di sik.
- Naw, fayn tritmɛnt dɛn de we de kɔntrol di sik dɛn, lɛk fɔ tek ɛnzaym riplesmɛnt tɛrapi.
- If yu ɔ yu pikin gɛt dɛn sik ya, nɔ panik ɛn tɔk to yu dɔktɔ wantɛm wantɛm. Fɔ gɛt di rayt diagnosis ɛn tritmɛnt rili impɔtant.
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