Yu gɛt wan sik we dɛn kɔl Myasthenia Gravis (MG)? Dɔn yu go dɔn no gud gud wan aw dis mɔsul wik, yu yaylid we de drɔp, i nɔ izi fɔ tɔk, ɛn swɛla kin gɛt prɔblɛm na yu layf. Yu fɔ yuz bɔku difrɛn mɛrɛsin fɔ kɔntrol dis sik. Bɔt wan tin we yu kin gladi fɔ na dat, dis biɛn tɛm, dɛn dɔn kam wit nyu mɛrɛsin fɔ mɛn dis sik. Tide, wi go tɔk bɔt Zilbrysq, we na nyu injɛkshɔn we yu kin yuz na os.
Fɔs, lɛ wi si wetin na Myasthenia Gravis (MG).
Fɔ tɔk am simpul wan, Myasthenia Gravis (MG) na wan sik we pɔsin kin gɛt we i de fɛt insɛf. Dis min se wi yon bɔdi in difɛns sistɛm, ɔ imyun sistɛm, kin mistek bigin fɔ atak wi yon wɛlbɔdi sɛl dɛn.
Imajin se wi bren de sɛn mɛsej to wan mɔsul fɔ ‘kɔntrakt’. Dis mɛsej de travul wit wan nerv. di ples we di nεv εn di mכsul de kכnekt de lεk ‘jכnkshכn’. wi kכl dis di nyuromכskular jכnkshכn. na dis jכnkshכn, spεshal ‘rεsεptor’ dεm de we de gεt di nεv mεsej. insay MG, wi imyun sistεm de atak dεn rεsεpכta dεm ya we dεn kכl ‘asetilkolin rεsεpכta dεm’. Dɔn di mɛsej we de kɔmɔt na di bren nɔ de tek di mɔsul fayn fayn wan. Dis kin mek di mɔsul taya kwik kwik wan ɛn i kin wik.
Nɔto ɔlman wae gɛt MG kin gɛt di sem kayn sik. Sɔm pipul dɛn kin gɛt di sik kin bigin wantɛm wantɛm , ɛn ɔda wan dɛn kin gɛt di sik kin bɔku smɔl smɔl as di ia dɛn de go. Sɔmtɛm, sɔm tɛm dɛn kin de we di sik kin dɔn (we di sayn dɛn kin go).
| Di Kɔmɔn Simptom dɛm fɔ Myasthenia Gravis (MG) . | |
|---|---|
| Di pat na di bɔdi we dɛn afɛkt | Sɔm sayn dɛn we kin apin |
| Di mɔsul dɛn na di yay | Dabl vishɔn, aylid dɛn we de drɔp. |
| Di mɔsul dɛn na di fes ɛn di mɔt | Fɔ tɔk smɔl smɔl we yu de tɔk, i nɔ kin izi fɔ it ɛn swɛla it, i kin chenj yu vɔys, ɛn i nɔ kin izi fɔ kɔntrol di we aw yu de mek yu fes. |
| Nek, an ɛn fut | I nɔ kin izi fɔ waka, i nɔ kin ebul fɔ yuz an ɛn finga dɛn nɔmal wan, i nɔ kin izi fɔ ol di ed tinap stret. |
| Di sistɛm we de mek pɔsin ebul fɔ blo | Sɔm pipul dɛm (lɛk 20%) kin gɛt wan sik we kin kam wantɛm wantɛm, we kin rili bad, ɛn bɔku tɛm we kin mek dɛn layf de pan denja we dɛn kɔl ``myasthenic crisis''. Dis na imejensi we nid fɔ go to dɔktɔ wantɛm wantɛm. |
`Myasthenic crisis` na imejensi kכndishכn we di mכsul dεm we de fכ blo kin wik εn yu nכ kin ebul fכ brith. I kin kam bikɔs ɔf infekshɔn, strɛs, ɔ sɔm mɛrɛsin dɛn. If dis apin, i impɔtant fɔ go na di ɔspitul we de nia yu in imejensi dipatmɛnt (ETU) wantɛm wantɛm.
Aw di drɔg Zilbrysq de wok?
di men gol fכ trit MG na fכ rεstכr di transmishכn fכ di nεv mεsej dεm tru di asetilkolin rεsεpכta. Dɛn kin yuz mɛrɛsin lɛk pyridostigmine (Mestinon), stɛroyd lɛk prednisone, ɛn immunosuppressants fɔ du dis.
Zilbrysq de pan wan nyu klas fɔ drɔgs we de wok difrɛn we. wi kכl dεn ya 'kכmpliment inhibito dεm'.
Yu mɛmba we a bin se wi imyun sistɛm de atak wi mɔsul dɛn? wan tin de we dεn kכl ``kכmpliment path`` we de ple imכtant rol insay dis atak prכsεs. Wetin Zilbrysq de du na fɔ blok di aktiviti fɔ dis kɔmplimɛnt sistɛm. afta dat di imyun sistεm de ridyus di bad bad atak dεm we de pan di rεsεpכta dεm. dis kin mek di nεv mεsej dεm kin bigin fכ go to di mכsul dεm fayn fayn wan bak, εn di mכsul dεm trεnk de bכku bak.
Yu tink se ɔlman we gɛt MG kin yuz Zilbrysq?
Nɔ, nɔto ɔlman kin ebul. dis mεdisin na כnli apruv fכ pipul dεm we gεt wan spεsifi k antibodi we dεn kכl ``anti-acetylcholine receptor antibody'' na dεn bכdi. כl di pipul dεm we gεt MG (bכt 80%-90%) gεt dis antibodi. Bɔt if yu nɔ gɛt dis na yu blɔd, dis mɛrɛsin nɔ go rili ɛp yu. So, bifo yu bigin fɔ tek dis mɛrɛsin, yu dɔktɔ go du spɛshal blɔd tɛst fɔ chɛk if yu gɛt dis antibodi.
Aw yu kin yuz dis mɛrɛsin?
Zilbrysq na wan likwid mɛrɛsin we dɛn kin injɛkt ɔnda di skin ɛvride. Dɛn kin injekt am na di shɔl, bɛlɛ, ɔ bak na di ɔp an.
- Fɔ kip am: Dɛn fɔ kip dis mɛrɛsin na frij.
- Bifo yu yuz am: Put di vaysin na frij 30-45 minit bifo yu injekt am ɛn lɛ i kam na rum tɛmpracha. Dis go mek yu nɔ fil fayn we yu de inj yu.
- Trenin: We yu fɔs gɛt dis mɛrɛsin, yu dɔktɔ ɔ nɔs go sho yu aw fɔ injɛkt am ɛksaktɔli. I rili impɔtant fɔ injɛkt di mɛrɛsin jɔs lɛk aw dɛn tɛl yu fɔ gɛt di rayt doz. If ɛnitin de we yu nɔ shɔ bɔt, aks yu dɔktɔ bak.
Spɛshal tin dɛn we yu fɔ no bifo yu bigin fɔ tek di mɛrɛsin
Dis na pat we rili impɔtant, so pe atɛnshɔn gud wan.
Dis mɛrɛsin kin mek yu gɛt sɔm siriɔs infɛkshɔn, mɔ di meningococcal infection . Bikɔs ɔf dis risk, dis mɛrɛsin de nɔmɔ tru wan spɛshal sefty program we dɛn kɔl Zilbrysq REMS program. Yu ɛn yu dɔktɔ ɔl tu fɔ rayt na dis program.
As pat pan dis program, yu dɔktɔ go tich yu bɔt meningococcal infection, aw fɔ avɔyd am, aw fɔ no di sayn dɛm, ɛn di impɔtant tin fɔ go to dɔktɔ wantɛm wantɛm if di sayn dɛm apin.
- Vaksin: Fɔ ridyus di risk fɔ gɛt infɛkshɔn, yu dɔktɔ go mek shɔ se yu dɔn gɛt di meningococcal vaysin at le tu wik bifo yu bigin Zilbrysq. If yu nid fɔ stat di mɛrɛsin kwik kwik wan ɛn yu nɔ gɛt di vaysin, yu go nid fɔ tek antibayɔtik te di vaysin bigin fɔ wok.
- Sefty Kad: Dɛn go gi yu spɛshal ‘Patient Safety Card’. Yu fɔ kip dis kad wit yu ɔltɛm. I impɔtant fɔ kip am wit yu we yu de tek di mɛrɛsin, ɛn bak fɔ tu mɔnt afta yu dɔn stɔp di mɛrɛsin. Yu kin sho dis kad to ɛni ɔda dɔktɔ we de trit yu.
Sayd ɛfɛkt ɛn aw fɔ mɛn dɛn?
Lɛk ɛni mɛrɛsin, Zilbrysq kin mek sɔm sayd ɛfɛkt, bɔt bɔku pan dɛn kin bi.
| Sayd ɛfɛkt we pɔsin kin gɛt | Aw fɔ manej |
|---|---|
| Riakshכn dεm na di sayt we dεn injεkshכn (rεd, it, swεla) . | Nɔ injekt na di sem ples ɛvride, bɔt chenj di ples. Yuz ɔda say dɛn lɛk di shɔl, bɛlɛ, ɛn ɔp an. Nɔ injekt na say dɛn we gɛt wund, brus, swel, ɔ skata. |
| Baktri infεkshכn (nos, trot, lכng) . | Dɛn kin avɔyd dɛn tin ya bay we dɛn gɛt di vaysin dɛn we dɛn nid. Wash yu an ɔltɛm. Stay away frɔm pipul dɛn we sik. |
| Pankriaytis we gɛt sik | Yu dɔktɔ go tɛst yu blɔd bifo i bigin fɔ tek di mɛrɛsin. If yu gɛt siriɔs pen na yu bɛlɛ we de ɔp (we de rayt to yu bak), kɔl yu dɔktɔ wantɛm wantɛm. |
| Risk fɔ gɛt sik dɛn we pɔsin kin gɛt we i de du mami ɛn dadi biznɛs lɛk gɔnoria | Dis mɛrɛsin kin mek yu gɛt sik dɛn we pɔsin kin gɛt we i de du mami ɛn dadi biznɛs lɛk gonoria smɔl. I impɔtant fɔ praktis sef sɛks (e.g., yuz kɔndɔm) ɛn gɛt tɛst ɔltɛm. Tɔk to yu dɔktɔ bɔt dis. |
Aw kwik a go ebul fɔ ɛkspɛkt fɔ gɛt rizɔlt?
If Zilbrysq rayt fɔ yu, yu kin si sɔm impɔtant tin dɛn pan yu sik dɛn insay di fɔs wik we yu bigin fɔ tek di mɛrɛsin. Bɔrku pipul kin si di bɛst rizɔlt insay di fɔs mɔnt.
I rili impɔtant:Nɔ stɔp fɔ tek dis mɛrɛsin ɔ ɛni ɔda mɛrɛsin fɔ MG wantɛm wantɛm we yu nɔ tɔk to yu dɔktɔ. Nɔ du dat ilɛksɛf yu sik dɛn de bɛtɛ. If nɔto dat, di sik kin kam tranga mɔ ɛn mɔ.
If yu nɔ si ɛni impɔtant tin pan yu sik dɛn afta yu dɔn tek di mɛrɛsin fɔ wan ɔ tu mɔnt, tɔk to yu dɔktɔ. I go tɔk to yu bɔt ɔda tritmɛnt dɛn we yu go yuz.
Mɛsej we dɛn kin kɛr go na os
- Zilbrysq (Zilucoplan) na nyu injεkshכn we dεn kin gi sכbkutan evride fכ di wan dεm we fit fכ gεt Myasthenia Gravis (MG).
- dis de wok bay we i de blכk di ‘kכmpliment sistεm’ we de pat pan di imyun sistεm, εn i de ridyus di damej we di mכsul dεm de pwεl.
- Dis mεdisin na pipul dεm we gεt wan antibodi we dεn kכl ‘anti-AChR antibody’ na dεn bכdi kin yus am.
- Bikɔs ɔf di risk fɔ gɛt siriɔs infɛkshɔn, dis mɛrɛsin de ɔnda wan spɛshal program nɔmɔ we dɛn kɔl REMS program. I fɔ gɛt di meningococcal vaccine bifo yu bigin di mɛrɛsin.
- Ɔltɛm kip di ‘Patient Safety Card’ we dɛn gi yu wit yu.
- Nɔ stɔp fɔ tek ɛni mɛrɛsin fɔ MG ɔ chenj di doz we yu nɔ gɛt dɔktɔ advays.
- Nɔ shem fɔ tɔk to yu dɔktɔ bɔt ɛni sayd ɛfɛkt ɔ prɔblɛm we yu go gɛt.
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