Ka tuyige ebisingawo ku butoffaali bwa ‘eosinophil’ mu mubiri gwo.

Wali owuliddeko ekigambo ‘Eosinophil’? Mpozzi omusawo yakwogerako ng’amaze okutunuulira ebyava mu musaayi gwo, oba olyawo erinnya lino ppya gy’oli. Wabula, eosinophils zino bajaasi bakulu nnyo mu mubiri gwaffe. Zikola omulimu munene mu kukuuma omubiri gwaffe nga mulamu bulungi. Kale, leero tugenda kwogera mu bujjuvu ku kika ky’obutoffaali buno obuyitibwa eosinophil, bye bukola, n’ekibaawo singa bufuuka wansi nnyo.

Eosinophil eno y’ani?

Mu ngeri ennyangu, eosinophil kika kya butoffaali obweru mu musaayi gwaffe. Nga bw’omanyi, obutoffaali obweru (leukocytes) bwe busirikale obukulu obw’abaserikale b’omubiri gwaffe, enkola etukuuma endwadde. Waliwo ebika by’obutoffaali buno obweru obw’enjawulo. Nga bwe waliwo regiments ez’enjawulo mu ggye.

Obutoffaali obweru bulina ebika bisatu ebikulu:

1. Ebiwuka ebiyitibwa granulocytes

2. Obusimu obuyitibwa lymphocytes

3. Ebiwuka ebiyitibwa Monocytes

Omukulu waffe, eosinophil, ali mu kibinja ekiyitibwa `granulocytes`. Erinnya `granulocytes` liva ku kuba nti obutoffaali buno bulina obutundutundu obutonotono munda. Ng’oggyeeko eosinophils, waliwo n’ebika ebirala bibiri ebya granulocytes ebiyitibwa `neutrophils` ne `basophils`. Obutoffaali buno bwonna bukolagana okulwanyisa abalabe abayingira mu mibiri gyaffe.

Omulimu gwa eosinophils naddala kwe kukomya okukula kw’ebiramu ebitali bimu naddala ebiwuka ebikweka munda mu butoffaali bwaffe ne bitulwaza.

Obutoffaali buno obwa eosinophil bukola ki?

Teebereza, ekintu ekigwira, gamba ng’obuwuka oba ekirungo ekiziyiza alergy, bwe kiyingira mu mubiri gwaffe, amangu ago obutoffaali bwaffe obweru buvaayo ne bukola. Okufaananako abaserikale abatendeke mu ngeri ey’enjawulo, banoonya era ne basaanyaawo omulumbaganyi nga tannakola bulabe ku butoffaali bwaffe obulala.

Obutoffaali bwa Eosinophil mu ngeri y’emu butendekebwa okuva mu busimu bwaffe obw’amagumba ne buyingira mu bitundu byaffe okukola ng’abakuumi. Munda mu butoffaali buno mulimu obutundutundu obutono obw’omusenyu bwe twayogeddeko emabegako. Munda mu butundutundu buno mulimu puloteyina ow'obutwa . Omulumbaganyi bw’ajja, obutundutundu buno bufulumya puloteyina eyo ey’obutwa, ne busaanyaawo omulumbaganyi era ne bubulya.

Eosinophils okusinga zikuuma emibiri gyaffe okuva ku:

• Yinfekisoni z’ebiwuka: Okugeza ebintu nga strongyloidiasis, pinworms.
• Okuva mu biramu ebikula munda mu butoffaali bwaffe: Ebika bya bakitiriya ebimu (intracellular bacteria) byekweka munda mu butoffaali bwaffe ne bireeta endwadde. Eosinophils nazo ziyamba okuzirwanyisa.
• Obutoffaali buno era buyamba okufuga ebikolwa eby’amangu eby’okuwulira ennyo ( allergens) ebiva mu kukwatibwa allergens .

Obutoffaali bwa eosinophil obusinga okusangibwa wa?

Eosinophils kika kya butoffaali obweru obubeera mu bitundu by’omubiri gwaffe. Zisinga kusangibwa mu:

• Mu musaayi
• Mu busimu bw’amagumba
• Mu bitundu by’amasavu (ebifo amasavu we gaterekebwa mu mibiri gyaffe) .
• Mu mawuggwe
• Ku lususu
• Mu lubuto

Obutoffaali bwa eosinophil bufaanana butya?

Obutoffaali buno obwa eosinophil butono nnyo, era busobola okulabibwa wansi wa microscope yokka. Zibeera za nkulungo. Mu budde obwabulijjo, mu mibiri gyaffe, tezirina langi, ekitegeeza nti tezirina langi. Naye bwe kitunuulirwa mu microscope, bwe bateekamu langi ey’enjawulo (acidic dye) langi y’obutoffaali buno ekyuka, ne kiba kyangu okwekenneenya. Langi eno efuula obutoffaali langi ya pinki eya kakobe.

Eosinophils zibeera nnene katono okusinga obutoffaali obulala. Ekimu ku bintu ebisinga okwanguyirwa okuzitegeera ye nyukiliya yazo . Kiringa amatondo g’amazzi abiri agayungiddwa ku muguwa, nga galiko ebimuli bibiri. Omanyi munda mu nucleus we wali DNA y’obutoffaali. Byonna bikwata ku bintu ebikulu. Nucleus eno etengejja mu protein eringa omusenyu (granules ze tubadde twogerako).

Eosinophils mmeka mu mubiri gwaffe?

Eosinophils kika kya butoffaali obweru. Obutoffaali obweru bukola ebitundu nga 1% ku butoffaali bwonna mu mibiri gyaffe. Ku butoffaali obweru obutambula mu mubiri gw’omuntu omukulu omulamu obulungi, eosinophils zikola ebitundu ebitakka wansi wa 5% . Ekyo kitegeeza nti wadde nga batono nnyo, empeereza gye bawa si ntono.

Eosinophils zikolebwa wa?

Obutoffaali buno obukulu bukolebwa mu bitundu ebigonvu ebiri munda mu magumba gaffe, ebiyitibwa obusigo bw’amagumba . Oluvannyuma lw’okukula mu busimu bw’amagumba, eosinophils zigenda mu bitundu by’amasavu ebiri mu mubiri gwaffe, gamba ng’olubuto.

Embeera ki ezitera okukosa eosinophils?

Embeera ezikosa eosinophils tezitera kubaawo. Waliwo embeera bbiri enkulu ezikosa omuwendo gwa eosinophil omutono n’omungi.

Okukendeera kw’ebirungo ebiyitibwa eosinophils: Eosinopenia

Eosinopenia bwe tuba n’obutoffaali bwa eosinophil obutono okusinga obwa bulijjo mu mibiri gyaffe. Waliwo embeera eziwerako eziyinza okuvaako kino:

• Obulwadde bwa Cushing: Kino kibaawo ng’omubiri gukola nnyo obusimu obuyitibwa cortisol ate nga tebukola butoffaali bwa eosinophil bumala. Cortisol busimu obufuga ssukaali mu musaayi gwaffe n’okufuula emmere amaanyi.
• Sepsis: Sepsis mbeera ya bujjanjabi ya maanyi nnyo ereeta okuzimba n’okuzimba omusaayi mu mubiri gwonna. Ebiseera ebisinga kiva ku bulwadde bwa bakitiriya, ffene, obuwuka obusirikitu oba akawuka.

Ekikulu: Oluusi, ne bwe kiba nti omuwendo gwa eosinophil gwo guba mutono omulundi gumu buli luvannyuma lwa kaseera, kiyinza obutaba kya bulabe nnyo eri obulamu. Kino kiri bwe kityo kubanga obutoffaali obulala mu baserikale baffe abaziyiza endwadde buyamba okusasula ebbula lino erya eosinophil. Wabula okubeera n’emiwendo gya eosinophil emitono okumala ebbanga eddene kya bulabe. Kyetaaga okujjanjabibwa mu bwangu.

Okwongera ku biwuka ebiyitibwa eosinophils: Eosinophilia

Eosinophilia bwe tuba n’obutoffaali bwa eosinophil bungi mu musaayi gwaffe okusinga ogwa bulijjo. Omusawo ajja kuzuula embeera eno okusinziira ku kifo eosinophils we zisangibwa:

• Eosinophilic gastrointestinal disorders (EGID): Zino mbeera ezikosa enkola yaffe ey’okugaaya emmere. Mu kino, ekibinja ky’obutoffaali bwa eosinophil kikuŋŋaana mu kitundu ekikoseddwa, ne kireeta okuzimba. Eno y’embeera esinga okukwatagana ne eosinophils. Embeera zino (EGID) zisobola okukosa ekyenda ekinene (eosinophilic colitis), ekyenda ekinene (eosinophilic esophagitis), olubuto (eosinophilic gastritis), olubuto n’ekyenda ekitono (eosinophilic gastroenteritis), n’ekibumba (eosinophilic cystitis).
• Obuzibu bw’amawuggwe obuyitibwa eosinophilic lung disorders: Kino kizingiramu asima ow’ekika kya eosinophilic, obulwadde bw’amawuggwe n’ekifuba. Embeera efaananako n’obulwadde bwa asima obw’amaanyi, obulwadde bw’ennyindo n’ekifuba. Mu mbeera eno, amawuggwe gajjula obutoffaali obuzimba ne gazimba. Kino kizibuwalira nnyo okussa.
• Obuzibu bw’omusaayi n’ebitundu by’omubiri (eosinophilic blood disorders): Buno bukosa ebitundu ebiyunga wansi w’olususu lwaffe (eosinophilic fasciitis), olususu (eosinophilic pustular folliculitis), n’obutoffaali obuli mu musaayi gwaffe, emisuwa, n’ebitundu ebikulu ng’omutima n’ensigo (eosinophilic granulomatosis with polyangiitis, eyali emanyiddwa nga Churg-Strauss syndrome). Embeera zino zibaawo nga eosinophils nnyingi nnyo ziyingirira emisuwa ne zoonoona. Singa kino tekijjanjabwa kiyinza okuvaako omusaayi okutambula obubi mu mubiri gwonna.

Bubonero ki obutera okulabika ku mbeera ezeekuusa ku eosinophil?

Obubonero buno butera okulabika nga bukwatagana n’ekifo obuvune we bubeera. Bino bye bimu ku bubonero obutera okulabika:

• Obukoowu, obukoowu
• Ebiwundu ku lususu, okusiiyibwa
• Ebizimba ebijjudde amasira ku lususu
• Okukaluubirirwa okussa, okussa obubi
• Obulumi mu lubuto n’olubuto
• Ekibobe

Biki ebivaako obulwadde bwa eosinophilia?

Waliwo ensonga eziwerako ezikosa obungi bwa eosinophils mu musaayi gwaffe:

• Okutamiira omwenge
• Obulwadde bwa alergy
• Obuzibu mu lubuto n’ekyenda
• Leukemia (ekika kya kookolo w’omusaayi) .
• Okukola ennyo obusimu obuyitibwa cortisol
• Yinfekisoni z’ebiwuka

Eosinophilia eva ku yinfekisoni?

Okweyongera kw’ebirungo ebiyitibwa eosinophils (eosinophilia) kuyinza okuba nga kiva ku bulwadde, naye si bulijjo nti kye kisinga okuvaako . Ebiwuka bisobola okuleeta okweyongera kw’ebirungo ebiyitibwa eosinophils. Ebiwuka bino bisobola okusiigibwa okuva ku muntu okudda ku mulala oba okuva ku nsolo okudda ku mulala naddala okuva mu mbwa okutuuka ku ppamba. Omusawo ajja kukukebera alabe oba olina obulwadde obuyitibwa parasitic infection. Bwe kiba bwe kityo, okukijjanjaba ebiseera ebisinga kijja kuzza emiwendo gyo egya eosinophil mu mbeera eya bulijjo.

Biki ebikeberebwa ebitera okukebera obulamu bw’obutoffaali bwo obwa eosinophil?

Okuzuula embeera ezikwata ku eosinophil kutandika n’okubala omusaayi mu bujjuvu (CBC) . Kino kizingiramu okukwata sampuli y’omusaayi gwo n’obala obutoffaali obugirimu naddala obutoffaali obweru okulaba oba butono nnyo oba bungi nnyo. Okugatta ku ekyo, waliwo ebigezo ebirala:

• Absolute eosinophil count: Kino nakyo kikebera musaayi. Kifaananako n’okubala omusaayi mu bujjuvu. Epima mu ngeri ey’enjawulo omuwendo gwa eosinophils mu sampuli y’omusaayi gwo. Omusawo aggya omusaayi omutono mu musuwa n’atunuulira sampuli ng’akozesa ekyuma ekirabika obulungi. Bassaamu langi okusobola okulaba ng’obutoffaali buno bulabika bulungi, era omusawo abala omuwendo gwa eosinophils ku butoffaali 100. Omuwendo gwa eosinophil ogw’enkomeredde gubalirirwa nga okubisaamu ebitundu ebyo ku buli kikumi n’omuwendo gwo gwonna ogw’obutoffaali obweru.
• Okukebera obusimu bw’amagumba: Mu kukebera kuno, omusawo akozesa empiso okuggya akatundu akatono ku busimu bwo obw’amagumba. Oluvannyuma kikeberebwa okulaba omuwendo, omutindo n’ekifo obutoffaali obuli mu mubiri gwo.

Okusobola okuzuula ekifo ekituufu ekirwadde kya eosinophilia we kiri, omusawo ayinza okukola ebigezo ebirala eby’enjawulo:

• X-ray y’ekifuba
• Okukebera enkola y’ekibumba
• Okukebera sampuli y’omusulo
• Okukebera ebitundu by’omubiri (tissue biopsy).
• Okukebera omusulo

Omutindo gwa eosinophil ogwa bulijjo guli gutya?

Omuntu omulamu obulungi alina okuba n’obutoffaali bwa eosinophil wakati wa 30 ne 350 buli microliter y’omusaayi. Singa buli microliter y’omusaayi ebaamu obutoffaali obusukka mu 500, kiba kya muwendo munene. Singa wabaawo obutoffaali obutakka wansi wa 30, kiba muwendo gwa wansi.

Jjukira nti okukendeera omulundi gumu mu muwendo gwa eosinophil, ne bwe kiba nga kikendedde kyokka, kiyinza obutaba kya bulabe nnyo. Obutoffaali obulala obweru mu baserikale b’omubiri gwo buyamba okukola ku bbula lino.

Omutindo gwa eosinophil ogw’amaanyi kye ki?

Omusawo wo ajja kugabanya obuzibu bw’obulwadde bwa eosinophilia, okusinziira ku bivudde mu kubala eosinophil okujjuvu:

• Obutaffaali butono: Obutoffaali bwa eosinophil wakati wa 500 ne 1,500 buli microliter y’omusaayi.
• Eky’ekigero: Eosinophils wakati wa 1,500 ne 5,000 buli microliter y’omusaayi.
• Ekizibu: Eosinophils ezisoba mu 5,000 buli microliter y’omusaayi.

Omutindo gwa eosinophil omungi kabonero ka kookolo?

Wadde nga kino tekitera kubaawo, omuwendo gwa eosinophil ogw’amaanyi obutasalako guyinza okuba akabonero akalaga nti olina kookolo . Emiwendo gya eosinophil egy’amaanyi giyinza okuba nga gikwatagana n’ebika bya kookolo ebiwerako:

• Kookolo w’amabeere
• Kookolo w’olubuto n’omumwa gwa nnabaana
• Kookolo w’omumwa gwa nnabaana
• Obulwadde bwa Hodgkin lymphoma
• Kookolo w’enkwaso
• Kookolo w’enseke

Singa omusawo wo atebereza kookolo, ajja kukola ebirala ebikeberebwa, gamba ng’okukebera omubiri, okwongera okukebera omusaayi oba okukuba ebifaananyi, okuzuula obulwadde buno n’okutandika okujjanjabibwa.

Bujjanjabi ki obumanyiddwa ennyo ku miwendo gya eosinophil egy’amaanyi?

Obujjanjabi bw’embeera ezirimu eosinophil omungi bwawukana okusinziira ku kifo n’obuzibu bw’obulwadde. Obujjanjabi bw’okukendeeza ku bungi bwa eosinophil mulimu:

• Bw’oba ​​olina obulwadde bw’omumwa gwa nnabaana, weewale emmere ezimu (emmere erimu ebizigo, eby’akawoowo, asidi).
• Bw’oba ​​olina eddagala erikwata ku ddagala, lekera awo okumira eddagala oba kyusa ddoozi.
• Okumira eddagala eriziyiza okuzimba.

Embeera ezirina emiwendo gya eosinophil egy’amaanyi ennyo zibeera za chronic , ekitegeeza nti zeetaaga okujjanjabwa n’okuziddukanya okumala ebbanga eddene.

Bujjanjabi ki obumanyiddwa ennyo ku miwendo gya eosinophil emitono?

Obujjanjabi bw’embeera ezirina emiwendo gya eosinophil emitono mulimu:

• Okumira eddagala eriyitibwa corticosteroids.
• Okukendeeza ku kunywa omwenge.

Ebiseera ebisinga, omubiri gwo gujja kutegeera obutaba na ddagala lya eosinophils era abaserikale b’omubiri abasigadde bajja kuyamba okumalawo ebbula lino. Wabula singa emiwendo gyo egya eosinophil tegidda mu mbeera ya bulijjo olw’embeera y’obulamu gy’olina, obujjanjabi obw’ekiseera ekiwanvu buyinza okwetaagisa.

Nkuuma ntya obutoffaali bwange obwa eosinophil nga bulamu bulungi?

Bino bye bimu ku bintu by’oyinza okukola okukuuma obutoffaali bwo obwa eosinophil nga bulamu bulungi:

• Weewale ebirungo ebivaako alergy.
• Lya emmere ennungi. Emmere fumba bulungi era ogifumbe okutuuka ku bbugumu erituufu ery’omunda nga tonnalya.
• Kkomya ku kunywa omwenge.
• Goberera enkola entuufu ey’obuyonjo, gamba ng’okunaaba engalo enfunda eziwera.

Acidophils kye ki?

Acidophils linnya eddala, naye nga si lya bulijjo, eriyitibwa eosinophils. Erinnya "acidophil" liva mu kigambo "acidophilic," ekitegeeza "ayagala asidi." Erinnya lino liva ku ngeri obutundutundu obuli ku butoffaali bwa eosinophil gye bukyusa langi wansi wa microscope nga busiigiddwa langi ya asidi. Langi eno efuula obutoffaali obwa pinki oba kakobe, ne kiba kyangu okulaba.

Kale, eosinophils kitundu kikulu nnyo mu baserikale baffe abaserikale b’omubiri. Zikola kinene nnyo mu kukuuma emibiri gyaffe okuva ku balumbaganyi abagwira. Singa omusawo ateebereza nti eosinophil zo zivudde ku mutindo ogwa bulijjo, ajja kukukebera omusaayi okukebera obulamu bw’obutoffaali bwo. Ebiseera ebisinga, emiwendo gya eosinophil emitono si nsonga nkulu, kubanga obutoffaali obulala buyamba okukola ku bbula n’okukuuma omubiri gwo nga gukola.

Katujjukire ebintu ebisinga obukulu (Take-Home Message)

Okay, kale ka tufunze ebintu ebikulu by’olina okujjukira okuva mu bye twogeddeko.

• Eosinophils kika kya butoffaali obweru. Zino kitundu ku baziyiza baffe.
• Okusinga zilwanyisa yinfekisoni eziva mu biwuka, ebiramu ebikula munda mu butoffaali, n’okulwala alergy .
• Okukendeera kw’omuwendo gwa eosinophils (eosinopenia) oba okweyongera kw’omuwendo gwa eosinophils (eosinophilia) kiyinza okuva ku mbeera z’obujjanjabi ez’enjawulo.
• Okukebera omusaayi kuyinza okukolebwa okuzuula emiwendo gy’ekirungo kya eosinophil.
• Mu budde obwabulijjo, omuntu omulamu obulungi alina obutoffaali bwa eosinophil wakati wa 30 ne 350 buli microliter y’omusaayi.
• Bw’olaba enkyukakyuka mu miwendo gy’eddagala lya eosinophil, kirungi obutatya n’olaba omusawo akuwe amagezi.

Nsuubira nti olina okutegeera okulungi ku eosinophils. Okumanya ebintu nga bino kiyamba nnyo mu kulabirira obulamu bwaffe.

` Eosinophil, obutoffaali obweru, abaserikale b’omubiri, alergy, yinfekisoni y’ebiwuka, eosinophilia, eosinopenia, okukebera omusaayi