Ddala omanyi ku hormone eno "rogue" eyitibwa Adiponectin?

Ffenna tuwulidde ku bika by’obusimu eby’enjawulo mu mibiri gyaffe. Ebimu ku byo tubyogerako buli kiseera, era n’abasawo babyogerako. Naye owulidde ku busimu obuyitibwa Adiponectin ? Mpozzi nga tolina. Naye kikola kinene nnyo mu mibiri gyaffe naddala mu bintu ng’obuzito bwaffe ne ssukaali mu musaayi. Kale, leero, ka twogere ku Adiponectin mu ngeri ennyangu, ennyangu.

Adiponectin kye ki? Kyangu nnyo!

Mu ngeri ennyangu, adiponectin busimu bwa puloteyina obusinga kukolebwa obutoffaali bw’amasavu oba amasavu mu mibiri gyaffe. Era kiyitibwa adipokine , kubanga kikolebwa nga kikwatagana n’amasavu. Kyokka tekikolebwa butoffaali bwa masavu bwokka, wabula ne mu bitundu by’omubiri gwaffe ebirala ebimu.

Ggaayi ono ayitibwa Adiponectin yazuulibwa mu myaka gya 1990. Ekyo kitegeeza nti bannassaayansi bakyayiga bingi ku nsonga eno. Mpozzi waliwo ebintu ebirala obusimu buno by’ekola bye tutannamanya. Okusinziira ku kye tuzudde, okusinga kiyamba okwongera ku buzibu bw’omubiri gwaffe ku insulini n’okukendeeza ku buzimba mu mubiri .

Migaso ki eya Adiponectin eri omubiri gwaffe?

Mukwano gwaffe ono ayitibwa Adiponectin yeenyigira mu nkola nnyingi enkulu mu mubiri gwaffe. Ka tulabe ebibiri ebisinga obukulu.

1. Engeri y’okumanyisa omubiri gwaffe ku insulini

Omanyi insulin kye ki? Mu ngeri ennyangu, insulini eringa ekisumuluzo ekiggulawo oluggi okuyingiza ssukaali (glucose) mu butoffaali bw’omubiri gwaffe. Okubeera omuwulize ku insulini kitegeeza nti ekisumuluzo kino kisobola okuggulawo obulungi oluggi. Olwo omubiri gusobola bulungi okukozesa ssukaali n’okukuuma ssukaali mu musaayi ng’ali ku mutindo omutuufu.

Kale, eno y’engeri Adiponectin gy’ayambamu:

• Ebinywa byo eby’amagumba n’ekibumba biyamba omubiri gwo okuddamu obulungi insulini.
• Okwongera okufulumya insulini okuva mu pancreas.
• Kiyimiriza okutereka ssukaali ayitibwa glycogen mu kibumba mu ngeri eteetaagisa.
• Ayamba okumenya asidi z’amasavu n’okuleeta amaanyi.

Lowooza ku kino, obutoffaali bw’omubiri gwo bulinga amayumba. Insulini y’etwala emmere eyitibwa sukaali mu mayumba ago. Adiponectin ayamba okuleeta emmere eno ng’eyita mu mulyango. Olwo ennyumba n’efuna emmere, nedda?

2. Engeri y’okukendeeza ku buzimba mu mubiri

Okuzimba kwe kusindika abaserikale baffe obutoffaali okulwanyisa ekintu nga bakitiriya oba okuwonya ekiwundu. Oluusi kino kyetaagisa. Naye okuzimba okutambula obutasalako, Ekyo kitegeeza nti si kirungi omubiri bulijjo okuba n'okuzimba okutono munda. Teebereza nti bulijjo olina omuliro omutono munda mu mubiri gwo... Ekyo kye kiyitibwa okuzimba okutambula obutasalako.

Adiponectin ayamba okukendeeza ku buzimba mu bitundu bino wammanga:

• Macrophages (ekika ky’obutoffaali obweru obuzinga n’okutta ebintu nga bakitiriya ne akawuka) .
• Endothelial tissue (buno butoffaali obukola oluwuzi olugonvu olukola layini munda mu mutima n’emisuwa) .
• Obutoffaali bw’ebinywa
• Obutoffaali obuyitibwa epithelial cells (buno bwe butoffaali obubikka ku ngulu zonna munda n’ebweru w’omubiri) .

Nga akendeeza ku buzimba mu ngeri eno, Adiponectin ekuuma ebitundu bino:

• Enkola y’emisuwa
• Omutima
• Amawuggwe
• Kolon

Adiponectin ekolebwa wa mu mubiri gwaffe?

Adiponectin okusinga ekolebwa era n’efulumizibwa obutoffaali obuyitibwa adipocytes, obutereka amaanyi mu bitundu byaffe eby’amasavu ebyeru . White adipose tissue kye kika ky’amasavu ekikulu mu mibiri gyaffe. Kisangibwa mu:

• Amasavu agali wansi w’olususu - kwe kugamba, oluwuzi lw’amasavu ge tuwulira nga tugakwatako.
• Amasavu g’omu lubuto - Gano ge masavu agali munda mu lubuto agayinza okuba ag’akabi katono.
• Obusigo bw’amagumba (amasavu mu busimu) .

Adiponectin era esobola okukolebwa ebika by’obutoffaali ebirala:

• Obutoffaali bw’ebinywa by’amagumba
• Obutoffaali bw’ebinywa by’omutima
• Obutoffaali bw’omubiri (endothelial cells).

Emiwendo gya adiponectin gifugibwa gitya?

Nga bwe nnagambye emabegako, adiponectin kintu kipya nnyo ekizuuliddwa. Kale bannassaayansi bakyaginoonyerezaako. N’okutuusa kati, obusimu obuwerako buzuuliddwa nga buyamba okutereeza emiwendo gya adiponectin.

Wadde nga kirabika obusimu obuyitibwa insulin bwe buzingiramu mu kino, si buli muntu nti bakkiriziganya ku ngeri entuufu gye kibaawo.

Ensonga y’okukula eringa insulini (IGF-1) n’obusimu obukula (GH) bifuga okufulumya eddagala lya adiponectin okuva mu bitundu by’amasavu. Leptin (obusimu obulala obukolebwa obutoffaali bw’amasavu) nayo eyinza okukwatibwako.

Okebera otya emiwendo gya Adiponectin?

Osobola okukebera emiwendo gya Adiponectin gyo ng'okebera omusaayi .

Abasawo oluusi batabulatabula obulwadde bwa sukaali obw’ekika eky’okubiri n’obulwadde bwa metabolic syndrome.Okukebera omusaayi gwa adiponectin kuyinza okukozesebwa okuyamba okuzuula embeera nga:

Emiwendo gya adiponectin egya bulijjo girina kuba gitya?

Emiwendo gya adiponectin egya bulijjo gyawukana okusinziira ku kikula kyo ne Body Mass Index (BMI) , nga buno bwe buzito bwo okusinziira ku buwanvu bwo.

Ebika bya Adiponectin ebya bulijjo eri abasajja bye bino wammanga:

• Singa BMI eba wansi wa 25: 5 ku 37 micrograms/milliliter (5 ku 37 ug/mL) .
• Singa BMI eba wakati wa 25 ne 30: 5 ne 28 ug/mL
• Singa BMI esukka 30: 2 ku 20 ug/mL

Ebika bya Adiponectin ebya bulijjo eri abakyala bye bino wammanga:

• Singa BMI eba wansi wa 25: 5 ku 37 ug/mL
• Singa BMI eba wakati wa 25 ne 30: 4 ku 20 ug/mL
• Singa BMI esukka 30: 4 ku 22 ug/mL

Ekikulu nti ennamba zino zisobola okwawukana katono okusinziira ku muntu n’okuva ku laabu okudda ku ndala. Kale, kebera range eyabulijjo ku lipoota yo eya laabu. Bw’oba ​​olina ekibuuzo kyonna ku bivudde mu kunoonyereza kwo, kakasa nti obuuza omusawo oba nnansi wo.

Endwadde ki eziyinza okuvaamu ng’omuwendo gwa adiponectin teguli gwa bulijjo?

Waliwo embeera z’obulamu eziwerako ezibadde zikwatagana n’emiwendo gya adiponectin egitaali gya bulijjo. Mu bino mulimu:

• Omugejjo n’obuzito obutono
• Okuziyiza insulini
• Obulwadde bw’emisuwa
• Obulwadde bw’amasavu

Embeera zino nnyingi zikwatagana n'obungi bwa adiponectin obutono .

Adiponectin n’Omugejjo

Abantu abagejjulukuka balina ekirungo kya adiponectin ekitono. Ate abantu abagonvu ennyo, ka babeere nga bava ku mbeera nga anorexia nervosa oba endya embi, balina ekirungo kya adiponectin ekiwera.

Mu ngeri ennyangu, amasavu g’omubiri gw’omuntu bwe geeyongera, omuwendo gwa adiponectin gwe gukendeera. Mu ngeri y’emu, amasavu mu mubiri bwe gakendeera, omuwendo gwa adiponectin gwabwe gweyongera. Omuntu omugejjo bw’akendeeza ku mugejjo, eddagala lye erya adiponectin lyeyongera.

Okuziyiza Adiponectin ne Insulin

Olw’okuba adiponectin eyamba okwongera ku insulini, abantu abalina obuziyiza insulini batera okuba n’emiwendo gya adiponectin emitono. Okuziyiza insulini bwe buba obutoffaali bw’omubiri gwo bwe butaddamu bulungi insulini, ekivaako omubiri gwo okufulumya insulini omungi (hyperinsulinemia).

Olw’obutaziyiza insuliniPrediabetes, Type 2 diabetes , ne sukaali ow’olubuto bisobola okukula. Kino kitera okukwatagana n’omugejjo. Wabula abantu abatalina mugejjo nabo basobola okufuna obulwadde bwa insulini. Ekyewuunyisa abantu abagumira insulini nga tebagejjulukuka nabo balina ekirungo kya adiponectin ekitono. Kino kiraga nti waliwo ensonga y’obuzaale eyeenyigira mu kuziyiza insulini ne adiponectin.

Adiponectin n’obulwadde bw’emisuwa

Obulwadde bw’emisuwa (atherosclerosis) mbeera nga obuwuka buzimba munda mu misuwa gyo, ne gizibikira. Kiringa obusagwa obuzimba munda mu payipu y’amazzi.

Adiponectin alina eddagala eriziyiza okuzimba, erikuuma omutima n’emisuwa. Kale, emiwendo gya adiponectin bwe giba mitono, obulabe bw’okufuna endwadde z’omutima nga okuzimba emisuwa n’okulwala omutima buyinza okweyongera.

Adiponectin ne Lipodystrophy

Lipodystrophy bulwadde obutatera kulabika nnyo obuleetera amasavu okukendeera mu bitundu by’omubiri ebimu ate mu birala okukuŋŋaanyizibwa kw’amasavu agasukkiridde.

Obulwadde bwa lipodystrophy buyinza okubaawo okuva lwe yazaalibwa, oba buyinza okukula nga bukyali mu bulamu. Emiwendo gya adiponectin giba mitono mu bulwadde bwa lipodystrophy obuzaalibwa n’obukwatagana ne siriimu . Kino kiyinza okuba nga kiva ku kuba nti eddagala lya adiponectin lyenyigira mu ngeri omubiri gye guterekamu amasavu.

Waliwo obujjanjabi obujjanjaba omuwendo gwa adiponectin ogutali gwa bulijjo?

Mu butuufu waliwo obujjanjabi obw’obutonde obuyinza okuyamba okulongoosa emiwendo gya adiponectin. Mu bino mulimu dduyiro buli kiseera n’okugejja mu ngeri ennungi. Wabula bulijjo olina okwogera n’omusawo wo nga tonnaba kukola nkyukakyuka yonna ya maanyi mu mmere yo oba mu nkola ya dduyiro.

Eddagala lya sukaali nga metformin ne thiazolidinediones lizuuliddwa nti lyongera ku muwendo gwa adiponectin.

Mu kiseera kino bannassaayansi bali mu kunoonyereza ku ddagala erikola mu ngeri y’emu ne Adiponectin okujjanjaba embeera z’okuzimba ezitawona. Ekyo kiyinza okuba amawulire amalungi gye tuli mu kiseera ekitali kya wala!

Njawulo ki eriwo wakati wa Adiponectin ne Leptin?

Leptin ne Adiponectin byombi busimu obukolebwa era ne bufulumizibwa amasavu go, ekika kya adipokines. Leptin akola ng’ayamba omubiri okukola obulungi n’okukendeeza ku njagala y’okulya.

Okufaananako ne adiponectin, emiwendo gya leptin egitali gya bulijjo nagyo gikwatagana n’omugejjo - naye mu ngeri ey’enjawulo. Emiwendo gya leptin gyeyongera ng’amasavu mu mubiri geeyongera. Wabula emiwendo gya adiponectin gikendeera ng’amasavu mu mubiri geeyongera. Kyangu okujjukira, nedda?

N’ekisembayo, ekisinga obukulu

Oboolyawo we tutuukidde kati otegedde engeri adiponectin gy’eri enkulu eri emibiri gyaffe. Okuva bwe kiri nti ekintu ekipya ekizuuliddwa, bannassaayansi bakyayiga ebisingawo ku nsonga eno.

Bw’oba ​​olina embeera y’okukyusakyusa emmere ng’omugejjo oba sukaali ow’ekika eky’okubiri, oyinza okuba ng’owulidde omusawo wo ng’ayogera ku ddagala lya adiponectin. Bw’oba ​​olina ekibuuzo ku kigambo omusawo ky’ayogera, totya kubuuza. Bali wano okuyamba.

Tewali kye weeraliikirira bwe kituuka ku miwendo gya adiponectin gyo. Emize emirungi egy’obulamu, emmere ennungi, n’obulamu obw’okukola ennyo bitera okuba engeri ezisinga obulungi ez’okukuuma obusimu buno nga buteredde. Kale, faayo ku mubiri gwo, kubanga obulamu bwe businga obukulu!

` Adiponectin, Adiponectin, Hormone, Insulin, Ssukaali, Omugejjo, Okuzimba, Enkyukakyuka mu mubiri, Obutoffaali bw’amasavu