Omubiri gwo gukulukuta amazzi bwe gati? Ka twogere ku bulwadde bwa Capillary Leak Syndrome!

Wali owuliddeko ku bulwadde bwa Capillary Leak Syndrome? Erinnya lino liyinza okuwulikika nga lizibu katono. Naye mu ngeri ennyangu, mbeera ng’ekitundu ky’omusaayi eky’amazzi ekiyitibwa plasma kikulukuta okuva mu misuwa emitonotono egy’omusaayi mu mibiri gyaffe, egyayitibwa capillaries. Amazzi gano gakulukuta ne gayingira mu binywa byaffe, ebitundu by’omubiri, ebitundu by’omubiri, n’ebituli by’omubiri. Eno eyinza okuba embeera ey’amaanyi, n’olwekyo kikulu okugimanya.

Kino ekiyitibwa capillary leak syndrome kye ki?

Okay, katunnyonnyole katono. Kuba akafaananyi ng’omubiri gwo gulina enkola y’emidumu gy’amazzi. Payipu zino ze misuwa gyaffe. Payipu entonotono ennyo eziri mu kino ziyitibwa emisuwa. Zino ze ttanka omukka gwa oxygen n’ebiriisa mwe biyita mu bitundu by’omubiri byaffe byonna. Kale, mu `(Capillary Leak Syndrome)`, ekitundu ky’omusaayi eky’amazzi, kwe kugamba , plasma , kikulukuta okuyita mu misuwa gino emitono. Kiringa amazzi agakulukuta okuva mu payipu y’amazzi.

Okukulukuta kw’amazzi kuno kuleetera amazzi okukuŋŋaanyizibwa mu bitundu by’omubiri eby’enjawulo. Okugeza, amazzi gano gayinza okukulukuta ne gayingira mu binywa, ebitundu by’omubiri, ebitundu eby’enjawulo, oba ebifo (ebituli by’omubiri) ebitundu by’omubiri we biri.

Ebitundu bya kino `(Capillary Leak Syndrome)` bisobola okubaawo emirundi egiwerako mu mwaka, oba omulundi gumu gwokka mu bulamu. Kyokka singa tebujjanjabwa mangu, puleesa eyinza okukka mu bwangu ekivaako ebitundu by’omubiri okulemererwa n’oluusi n’okufa. Kale kino si kintu kya kutwalibwa ng’ekitono.

Tewali ddagala lya lubeerera eriwonya kino n’okutuusa kati. Kyokka kyetaagisa okugenda ew’omusawo mu bwangu okusobola okufuga obubonero obwo. Oluusi, kisoboka okuziyiza okulumbibwa mu biseera eby’omu maaso ng’osigala ng’okozesa eddagala oba ng’ofunye omunnyo.

Waliwo ebika byonna ebya kino? Baawukana batya?

Yee, waliwo ebika bibiri ebikulu ebya `(Capillary Leak Syndrome)`. Ka tulabe kye bali.

• Systemic Capillary Leak Syndrome: Era eyitibwa ``Primary Capillary Leak Syndrome'' oba ``Clarkson's disease'', eno mbeera ng'obulumbaganyi bubaawo enfunda eziwera , ne mu muntu omulamu obulungi.
• Secondary Capillary Leak Syndrome: Kino we wabaawo okulumba omulundi gumu olw’obulwadde obulala, embeera oba eddagala.

Mu ngeri ennyangu, ekimu kintu ekiyinza okubaawo obutasalako, ate ekirala kintu ekibaawo okumala akaseera olw’ensonga endala.

Ani asinga okulwala embeera eno?

``Systemic Capillary Leak Syndrome'' bulwadde obutatera kulabika nnyo.Abantu abatakka wansi wa 500 mu nsi yonna be bategeezebwa nti balina embeera eno. Businga kubeera mu bantu ab’emyaka egy’omu makkati. Butera nnyo mu baana abato. Kyokka olw’okuba abantu abalina embeera eno oluusi bazuulibwa mu bukyamu nti balina embeera endala, omuwendo gwennyini ogw’abantu abalina embeera eno guyinza okuba omunene ennyo.

Wabula ``Secondary Capillary Leak Syndrome'' esobola okubaawo mu bantu ab'emyaka gyonna. Yinfekisoni ezimu, embeera z’obujjanjabi, n’eddagala bisobola okubuleeta.

Kiki ekituuka ku mubiri nga kino kituuse? (Emitendera esatu)

Ebibaawo mu mubiri gwaffe mu kiseera ky'okulumbibwa ``Capillary Leak Syndrome'' bisobola okwawulwamu emitendera esatu. Ka tulabe kye bali.

Omutendera ogusooka: Ng’obubonero tebunnalabika (Prodromal phase) .

Kino kye kiseera ekiri wakati w’olunaku n’ennaku bbiri nga tonnalumba. Mu kiseera kino, oyinza okutandika okufuna obubonero obumu.

• Okuwulira ng’okooye
• Ennyonta y’amazzi okweyongera
• Ebintu ng’okugejja mu bwangu bisobola okubaawo.

Omutendera ogwokubiri: Omutendera gw’okukulukuta oba okuzuukusa

Wano ddala obulumbaganyi we bubaawo. Ekibaawo amazzi ne albumin (ekika kya puloteyina mu musaayi) bikulukuta okuva mu misuwa gyo ne biyingira mu bifo ebiri wakati w’ebitundu byo. Kino kikendeeza ku bungi bw’omusaayi ogutambuza omukka gwa oxygen. Puleesa yo ekka, obutoffaali obumyufu ne bukuŋŋaana wamu, ne kifuula omusaayi gwo okubeera omugonvu. Amazzi gano agakulukuta galeeta okukendeera kw’obungi bw’omusaayi, ekiyitibwa hypovolemia .

Omutendera ogwokusatu: Oluvannyuma lw'okulumba `(Post-leak phase oba recruitment phase)`

Kino kye kiseera ng’obulumbaganyi buwedde. Ekibaawo nti emisuwa gyo emisuwa gitandika okuddamu okunyiga amazzi ne albumin okuva mu bitundu by’omubiri. Wabula mu kiseera kino, omubiri gwo gusobola okukuŋŋaanya amazzi amangi (fluid overload) . N’ekyavaamu, omubiri gwo gusobola okufulumya omusulo omungi (polyuria) ate amawuggwe go ne gajjula amazzi (pulmonary edema).

Lowooza ku kino, kiringa sipongi anywa amazzi. Okusooka, amazzi ago gava mu mubiri, olwo bwe gaddamu okuganyiga amangu ennyo, ganyiga bingi okusinga bwe galina.

Kiki ekivaako kino?

Kati katutunuulire ekiyinza okuvaako kino `(Capillary Leak Syndrome)`.

Ebivaako `(Systemic Capillary Leak Syndrome)`

Mu butuufu, ekituufu ekivaako obulwadde bwa Systemic Capillary Leak Syndrome tekinnategeerekeka. Abanoonyereza balowooza nti kiyinza okuba nga kiva ku ngeri abaserikale baffe abaserikale gye bakwatamu obulwadde oba yinfekisoni ezimu.

Ebivaako `(Secondary Capillary Leak Syndrome)`

Waliwo ensonga eziwerako eziviirako kino. Ekisinga okuvaako embeera eyitibwa sepsis . Kwe kugamba, ekizibu ekiyinza okutta omuntu ekiva ku yinfekisoni. Okugatta ku ekyo, waliwo n’ebirala ebivaako:

• Endwadde z’abaserikale b’omubiri:Ekibaawo mu kino kwe kuba nti abaserikale baffe bennyini balumba obutoffaali bwaffe obulamu.
• Differentiation syndrome: Ekizibu ekiyinza okubaawo nga bajjanjabwa ebika by’omusaayi ebimu (acute promyelocytic leukemia oba acute myeloid leukemia).
• Engraftment syndrome: Ekizibu ekiyinza okubaawo oluvannyuma lw’okusimbuliza obusigo bw’amagumba.
• Hemophagocytic lymphohistiocytosis: Embeera eyinza okuteeka obulamu mu matigga ereetebwa abaserikale b’omubiri okukola ennyo.
• Ovarian hyperstimulation syndrome: Ekizibu ekiyinza okubaawo mu kiseera ky’obujjanjabi bw’okuzaala.
• Obutwa bwa Ricin.
• Okulumwa omusota.
• Viral hemorrhagic fevers: Ekibinja ky’endwadde ezisiigibwa ezireetebwa akawuka.

Eddagala erimu, gamba ng’eddagala eriweweeza ku kookolo erya gemcitabine (gemcitabine - Gemzar®) ne tagraxofusp (tagraxofusp - Elzonris®) , nalyo liyinza okuleeta kino (Secondary Capillary Leak Syndrome).

Bubonero ki obusooka obulwadde buno okutandika?

Mu budde obutuufu, nga wabulayo ennaku emu oba bbiri okulumbibwa ``Capillary Leak Syndrome'', kwe kugamba, mu kiseera kya ``prodromal phase'', oyinza okufuna obubonero nga:

• Obulumi mu lubuto oba okulumwa ebinywa (myalgia).
• Obukoowu oba obunafu obuyitiridde.
• Okulumizibwa omutwe .
• Ennyonta y’amazzi okweyongera.
• Okunyiiga, okusunguwala amangu.
• Ekikeeto.
• Okugejja mu bwangu.
• Obubonero bw’okukwatibwa akawuka oba okukwatibwa mu nkola y’okussa eya waggulu.

Bw'oba ofuna obubonero nga buno, tokitwala nga kitono, ng'ogamba nti, "Oh, osanga omusujja gwokka," naddala ng'obaddeko n'ebintu ebifaananako bwe bityo.

Bubonero ki obubaawo ng’olina obulwadde?

Mu kiseera ky'okulumba kwa `(Capillary Leak Syndrome)`, kwe kugamba, mu kiseera kya `(omutendera gw'okukulukuta oba okuzuukusa)`, obubonero buyinza okwawukana okusinziira ku muntu. Wabula bino wammanga bye bimu ku bubonero obutera okulabika:

• Okuzimba naddala mu bitundu by’omubiri (peripheral edema).
• Embiro.
• Puleesa ekka (hypotension).
• Okuzimba omusaayi (hypercoagulability) - Kino kiyinza okuva ku kweyongera kw’obutoffaali obumyufu (hematocrit) oba okweyongera kw’obutoffaali obweru (leukocytosis).

Kino abasawo bakitegeera batya?

Omusawo ajja kuzuula obulwadde bwa Capillary Leak Syndrome ng’abuuza ku byafaayo byo eby’obujjanjabi n’okukeberebwa omubiri. Bajja kukebera okulaba oba puleesa yo eri wansi.

Ate era nga tonnakakasa nti eno ye Capillary Leak Syndrome, embeera endala zeetaaga okugobwa. Bayinza okukola okukebera omusaayi okuwerako okukola kino:

• Kebera oba hematocrit (omuwendo gw’obutoffaali obumyufu mu musaayi) bungi.
• Kebera oba hemoglobin (puloteyina esangibwa mu butoffaali obumyufu) mungi nnyo.
• Kebera oba puloteyina ntono mu musaayi (hypoalbuminemia).

Okugatta ku ekyo, okukebera omusaayi kuyinza okukolebwa okukebera oba puloteyina y’abaserikale b’omubiri etali ya bulijjo eyitibwa ``monoclonal gammopathy, oba M protein'' mu musaayi. Abantu abalina ``Capillary Leak Syndrome'' bayinza okuba ne ``M protein'' eno etali ya bulijjo mu musaayi gwabwe.

Kijjanjabwa kitya? Kisobola okuwona?

Ebyembi, tewali ddagala lya lubeerera eriwonya obulwadde bwa Capillary Leak Syndrome. Abasawo bagezaako okufuga obubonero n’okutangira ebizibu.

Mu kiseera ky'okulumba ``Capillary Leak Syndrome'', abasawo bagezaako okufuga puleesa n'okukuuma omusaayi okutambula obulungi mu bitundu by'omubiri. Era bagezaako okutangira okuzimba okuyitiridde n’okukuŋŋaanyizibwa kw’amazzi. Bayinza okukozesa:

• Glucocorticoids: Zino kika kya steroid ekiyamba okukendeeza ku mazzi agakulukuta okuva mu misuwa.
• Amazzi agayingira mu misuwa: Ebintu ng’omunnyo biweebwa okwongera okutambula kw’omusaayi mu bitundu by’omubiri ng’ensigo.

Ebiseera ebisinga ojja kwetaaga okuweebwa ekitanda mu ddwaaliro oluvannyuma lw’okulumbibwa. Mu kiseera ky’obujjanjabi, omusawo ajja kwongera okulondoola puleesa ne puleesa okukakasa nti tolina mazzi mangi mu mubiri gwo ekiyinza okuvaako ebizibu ebirala, gamba ng’okuzimba amawuggwe n’omutima okusiba amangu.

Oluvannyuma lw’okulumbibwa obulwadde bwa Capillary Leak Syndrome obumanyiddwa nga post-leak phase oba recruitment phase, omusawo ayinza okukuwa eddagala erifulumya omusulo (eddagala erikuleetera okufulumya omusulo omungi) okukendeeza ku mazzi ag’enjawulo mu mubiri gwo.

Obulwadde bwa Systemic Capillary Leak Syndrome (SCLS) busobola okuziyizibwa okuddamu?

Tosobola kuziyiza Systemic Capillary Leak Syndrome kubaawo mu kifo ekisooka. Naye, bw’omala okulumbibwa, omanya nti olina embeera.

Wabula okumira eddagala buli kiseera oba okuweebwa omunnyo kiyinza okuyamba okuziyiza okulumbibwa mu biseera eby’omu maaso n’okukendeeza ku buzibu bwalyo. Obujjanjabi buno buyinza okuli:

• Okufuna buli mwezi eddagala eriyitibwa immune globulin (IVIG) eriweebwa mu misuwa .
• Eddagala eriweebwa mu kamwa eriwonya asima, gamba nga theophylline (theophylline - Elixophyllin®), terbutaline (terbutaline - Brethine®), ne montelukast (montelukast - Singulair®) .
• Okukendeeza ku kuzimbaEbirungo ebiyitibwa Steroids.

Biki eby’omu maaso eri abo abawangaalira n’embeera eno? `(Endowooza)`

Systemic Capillary Leak Syndrome etera okuddukanyizibwa n’obujjanjabi obw’okuziyiza. Obujjanjabi businga kuba bulungi ng’embeera eno ezuuliddwa nga bukyali ate ng’ebizibu ebivaamu bitono. Ebimu ku bizibu eby’amaanyi ebiyinza okuva mu bulwadde bwa Capillary Leak Syndrome mulimu:

• Compartment syndrome: Puleesa yeeyongera munda mu binywa n’omusaayi okukendeera.
• Okukuŋŋaanyizibwa kw’amazzi okwetoloola omutima n’amawuggwe (cardiac tamponade, pericardial effusion, ne pleural effusion).
• Omutima okulemererwa.
• Okulemererwa kw’ekibumba.
• Obulwadde bw’obusimu.
• Okuzimba kw’amawuggwe.
• Rhabdomyolysis: Ekibumba okulemererwa olw’ebinywa okwonooneka.
• Storoko.

Bino biyinza okuwulikika ng’ebitiisa, naye nga bwe kyayogeddwako emabegako, okujjanjaba amangu n’okubiddukanya obulungi kikulu nnyo.

Ddi lwe nnina okulaba omusawo?

Bw’oba ​​olowooza nti olina obulwadde bwa Capillary Leak Syndrome, laba omusawo amangu ago. Ziyinza okuyamba okuddukanya obubonero bwo n’okukuwa obuweerero.

Jjukira nti wadde nga eno embeera etatera kubaawo, kikulu okumanya obubonero n’okufuna amagezi mu bwangu omusawo bw’oba ​​obuusabuusa.

Obubaka Obutwala Awaka

Okay, kale ka tuddemu okukubaganya ebirowoozo ku nsonga ezisinga obukulu ku `(Capillary Leak Syndrome)` ze twayogeddeko:

• Kino kye kitundu ky’omusaayi eky’amazzi (plasma) bwe kikulukuta okuva mu misuwa emitonotono (capillaries) mu mubiri gwaffe.
• Kino kiyinza okubaawo omulundi gumu oba enfunda n’enfunda.
• Singa tebujjanjabwa, ebizibu eby’amaanyi bisobola okubaawo, n’olwekyo kyetaagisa okugenda mu ddwaaliro mu bwangu.
• Wadde nga tewali ddagala lya lubeerera, waliwo obujjanjabi obufuga obubonero n’okuziyiza okulumbibwa mu biseera eby’omu maaso.
• Bw’oba ​​oteebereza nti waliwo obubonero buno, laba omusawo mu bwangu. Gy’okoma okuzuula amangu obulwadde n’otandika okujjanjabwa, emikisa gyo egy’okuwona gye gikoma okubeera emirungi.

Kale, nsuubira nti amawulire gano ga mugaso gy’oli. Sigala nga oli mulamu bulungi!

` Obulwadde bwa Capillary Leak Syndrome, Okukulukuta mu Plasma, Puleesa Entono, Obulwadde bwa Clarkson, Edema, Okukulukuta kw’Amazzi mu Mubiri