Owulidde ku kookolo atatera kulabika ayitibwa Chordoma? Ka twogere ku nsonga eno!

Oyinza okuba nga towulirangako ku linnya lino "chordoma" emabegako. Ekyo tekyewuunyisa, kubanga kino kika kya kookolo ekitali kya bulijjo. Kyokka wadde nga tekitera kubaawo, kikulu nnyo okukimanya ku kino. Kubanga, ekizimba eky’ekika kino kiyinza okubeera mu mugongo gwaffe oba wansi w’ekiwanga. Kale leero, ka twogere mu bujjuvu era mu ngeri ennyangu ennyo ku chordoma eno kye ki, engeri gy’ekula, obubonero bwe buli, n’obujjanjabi bwe buli.

Chordoma kye ki? Ka tukizuule mu ngeri ennyangu!

Mu ngeri ennyangu, chordoma kizimba kya kookolo ekikolebwa mu magumba . Businga kukula mu mugongo gwo oba wansi w’ekiwanga kyo, amagumba agali waggulu w’ensingo ne wansi w’obwongo bwo. Abasawo bagiteeka mu kibinja ky’ekika kya kookolo ayitibwa sarcoma. Sarcoma kigambo kya bulijjo ekitegeeza kookolo akola mu magumba n’ebitundu ebigonvu (ebitundu ebiyunga).

Chordomas zitera kuba bizimba ebikula mpola . Wabula ekizibu kiri nti ziyinza okusoomoozebwako katono okuzijjanjaba kubanga zisangibwa kumpi nnyo n’obusimu bwaffe, kwe kugamba, obwongo n’omugongo, ne ziyingira mu bitundu ebigonvu ebizeetoolodde.

Ekirala ne bwe biba bimaze okujjanjabwa, ebizimba bino biba n’emikisa mingi okuddamu . Ebiseera ebisinga, kino kibaawo mu kifo kye kimu ekizimba ekyasooka we kyali. Ate era, mu bitundu 30% ku 40%, obutoffaali bwa kookolo wa chordoma busobola okusaasaana mu bitundu by’omubiri ebirala. Kino abasawo bakiyita ``metastasizing''.

Chordoma eyinza okusaasaana wa mu bitundu by’omubiri ebirala?

Singa chordoma esaasaana, kwe kugamba, n’esaasaana mu bitundu by’omubiri ebirala, ebifo ebisinga okusaasaana bye bino:

• Amawuggwe go
• Ensigo z’omusaayi okumpi n’ekizimba
• Amagumba amalala
• Ekibumba
• Omubiri

Chordoma eyinza okukula wa?

Chordoma esobola okubaawo wonna ku mugongo gwo, naye waliwo ebifo bisatu ebisinga okubeerawo:

1. Eggumba ly’omugongo: Lino lye ggumba ery’enjuyi essatu wakati w’amatabo go. Ebitundu nga 35% ebya chordomas bikula wano.

2. Omusingi gw’ekiwanga: Okusingira ddala, wansi w’ekiwanga kyo, mu magumba agawanirira obwongo bwo. Zino era ziyitibwa ``Clival chordomas'' kubanga zisinga kutondebwa mu ggumba lya ``Clivus'', erisangibwa wano. Ekika kino nakyo kikola ebitundu nga 35% ku chordoma zonna.

3. Mu mugongo ogutambula (`vertebrae`): Kwe kugamba, omugongo mu bulago bwo, mu kifuba, n'omugongo. Chordomas zibeera mu bitundu nga 30% ku bino. Zisinga kubeera mu mugongo ogw’okubiri ogw’omumwa gwa nnabaana. Era zisobola okubeera mu mugongo mu mugongo ogwa wansi (omugongo gw’omugongo) ne mu kifuba (omugongo ogw’omu kifuba).

Bika ki ebikulu ebya chordoma?

Ekitongole ky’ebyobulamu mu nsi yonna (WHO) kyawuddemu chordoma mu bika bisatu ebikulu. Ensengeka zino zeesigamiziddwa ku ngeri obutoffaali bwa kookolo gye bulabika wansi wa microscope (`histology`).

1. Classic/conventional chordoma: Kino kye kika ekisinga okubeerawo (80% ku 90% ku chordoma zonna). Obutoffaali obuli mu kika kino buba bwa kika kya butoffaali bwa njawulo obulina endabika ya "bubble" katono. Chondroid chordoma y’engeri endala ey’ekika kino. Kikola wakati wa 5% ne 15% ku chordoma zonna. Chondroid chordoma esinga kukula ku musingi gw’ekiwanga.

2. Dedifferentiated chordoma: Kino kika kya bbula nnyo (ekitakka wansi wa 5%). Kimanyiddwa olw’okutabula kw’obutoffaali okutali kwa bulijjo. Ekika kino kikula mangu, kya bukambwe, era kitera okusaasaana mu bitundu by’omubiri ebirala okusinga ebika ebirala.

3. Chordoma etali ya njawulo bulungi: Kino nakyo tekitera kubaawo nnyo . Abalwadde abatakka wansi wa 60 be baakawandiikibwa mu biwandiiko by’abasawo okutuusa kati. Ekintu eky’enjawulo eky’ekika kino kiri nti obuzaale obuyitibwa `(SMARCB1)` oba `(INI1)` tebukola (okusazaamu). Ekika kya chordoma kino kisinga kulabibwa mu baana n’abavubuka.

Ani asinga okulwala obulwadde bwa chordoma?

Chordoma esobola okubaawo ku myaka gyonna, mu muntu yenna. Wabula kisinga kubeera mu bantu abakulu abali wakati w’emyaka 50 ne 80. Abaana bakosebwa emisango mitono gyokka, nga 5% ku balwadde bonna.

Era kizuuliddwa nti abasajja batera okulwala obulwadde bwa chordoma emirundi nga 1.5 okusinga abakyala.

Kino kya bulijjo kitya?

Chordoma kookolo atatera kulabika nnyo . Bukwata abantu nga omu ku buli bukadde buli mwaka. Ekyo kitegeeza nti, okugeza, mu Amerika, abantu abapya nga 300 bokka be bazuulibwa buli mwaka.

Chordomas zikola wakati wa 1% ne 4% ku bizimba byonna eby’amagumba ebisookerwako.

Bubonero ki obulaga nti omuntu alina obulwadde bwa chordoma?

Chordoma bw’ekula, esobola okussa akazito ku mugongo oba obwongo obugyetoolodde. Puleesa eno ereeta obubonero . Obubonero era busobola okwawukana okusinziira ku kifo ekizimba we kiri mu mugongo.

Obubonero obutera okulabika mu chordoma mulimu obulumi, obunafu, ne/oba okuzirika mu mugongo, emikono oba amagulu .

Ebifaananyi by’ekiwanga ekiyitibwa skull base chordoma:

Bw’oba ​​olina ‘chordoma’ wansi w’ekiwanga kyo, ekiri wansi w’obwongo bwo, oyinza okufuna obubonero nga:

• Okulaba emirundi ebiri (Diplopia) .
• Okulaba okutali kwa maanyi
• Okulumizibwa omutwe
• Okuzimba mu maaso oba okulumwa

Ebifaananyi by’ekiwuka ekiyitibwa chordoma mu ggumba ly’omukira/omugongo:

Bw’oba ​​olina ekirwadde kya chordoma ku kitundu ekisinga wansi eky’omugongo, okumpi n’omugongo, oyinza okufuna obubonero nga:

• Ekizimba oba ekizimba ekifuluma mu lususu
• Okukaluubirirwa okufulumya omusulo oba okufulumya omusulo (obutakola bulungi mu kibumba oba ekyenda) .
• Obulumi mu kitundu kya wansi w’omugongo oba mu bisambi

Kijjukire nti oluusi obubonero buno buyinza okutabulwa n’embeera endala ez’obujjanjabi eza bulijjo. Eno y’ensonga lwaki kikulu okugenda mu basawo amagezi bw’oba ​​olina obubonero bwonna obutasalako, obutali bwa bulijjo.

Lwaki chordoma eno ekula? Biki ebivaako?

Abanoonyereza n’okutuusa kati tebamanyi kituufu kivaako chordoma, naye balowooza nti enkyukakyuka mu buzaale obuyitibwa TBXT zeenyigiddemu.

Wabaddewo ebigambibwa nti amaka agawerako galina obulwadde bwa chordoma. Bwe baakeberebwa, baazuulibwa nga basikira okuddiŋŋana kw’obuzaale bwa `(TBXT)`. Era, enkyukakyuka mu ggiini ya `(TBXT)` zizuuliddwa mu bantu abalina chordoma naye nga tewali muntu yenna mu maka alina bulwadde buno.

Chordoma ekula okuva mu butoffaali mu nsengekera eyitibwa ``notochord.`` Eno ``notochord`` nsengekera ya kaseera buseera ekulu nnyo mu nkula y'omugongo gw'embuto ng'ekula. Ebiseera ebisinga, ``notochord`` eno ebula nga wayise wiiki nga munaana ng'oli lubuto. Naye mu bantu abatono ennyo, obumu ku butoffaali buno obwa ``notochord`` buyinza okusigala mu magumba g'omugongo oba omusingi gw'ekiwanga.

Kale, endowooza eriwo kati eri nti singa wabaawo enkyukakyuka mu ggiini ya `(TBXT)` eyayogeddwako emabegako, obutoffaali buno obusigaddewo obwa `(notochord)` buyinza okutandika okukula mu ngeri etaali ya bulijjo ne bukola chordoma.

Era, abantu abalina embeera y'obuzaale eyitibwa ``Tuberous sclerosis`` bali mu bulabe obw'okufuna obulwadde bwa chordoma. Embeera eno eya ``Tuberous sclerosis`` esobola okuleeta obulwadde bw'okusannyalala, okulwawo okukula, n'ebizimba mu bitundu by'omubiri eby'enjawulo. Kino kiva ku nkyukakyuka mu buzaale bubiri obuyitibwa ``TSC1`` ne ``TSC2``.

Otegeera otya ekirwadde kya chordoma?

Bw’oba ​​olina obubonero bw’obulwadde bwa chordoma, omusawo ajja kusooka kukubuuza ku bubonero bwo n’ebyafaayo by’obujjanjabi. Oluvannyuma bajja kukola okukebera omubiri n’okukeberebwa obusimu.

Singa omusawo ateebereza ekizimba, ajja kulagira okukeberebwa ebifaananyi nga X-ray, computed tomography (CT) scan, oba MRI scan. MRI scan eno etera okuyamba okuzuula obulwadde bwa chordoma.

Olwo, omusawo wo kirabika ajja kukusindika ew’omukugu mu kookolo w’amagumba okukakasa nti ozudde era afune endowooza eyookubiri. Era bayinza okwongera okukebera ebifaananyi okuzuula ekifo ekituufu chordoma w’eri, okulaba oba esaasaanidde mu bitundu by’omubiri ebirala, n’okukola okukebera okulala.

Kyokka, engeri yokka ey’okuzuulamu ddala obulwadde bwa chordoma kwe kukeberebwa omubiri . Kino kizingiramu okutwala akatundu akatono ku kizimba ekyo, ebiseera ebisinga nga bakozesa ekyuma ekikebera empiso, n’okukikebera ng’okozesa microscope. Olwo lwokka omukugu asobola okutegeera obulungi oba chordoma.

Bujjanjabi ki obwa Chordoma?

Obujjanjabi obukulu era obusinga obulungi ku chordoma kwe kuggyawo ekizimba kyonna nga bayita mu kulongoosebwa . Kino abasawo bakiyita ``En bloc resection.`` Singa ekizimba kiggyibwawo ddala mu ngeri eno, omulwadde alina emikisa egisinga okuwangaala okumala ebbanga eddene.

Wabula okusinziira ku kifo ebizimba we biri, kino kiyinza okuba ekizibu ennyo okukikola. Okusingira ddala, emirundi mingi tekisoboka kuggyawo ddala chordomas ezisangibwa wansi w’ekiwanga.

Kubanga chordoma mu mugongo esobola okwonoona omugongo gwo n’obusimu n’emisuwa ebikulu ebigyetoolodde. Singa kino kyonooneka nga balongoosebwa, kiyinza okuvaako okulema okumala ebbanga eddene oba n’okufa. Ate era, chordoma eri wansi w’ekiwanga kizibu okugiggyawo ddala kubanga eri kumpi nnyo n’ekikolo ky’obwongo, obusimu bw’omutwe n’omugongo. Abasawo abalongoosa obusimu bagezaako okuggyawo ekizimba ekinene nga bwe kisoboka, ate nga tebalina bulabe nga bwe kisoboka.

Ebiseera ebisinga chordomas teziddamu bulungi ku bujjanjabi bwa radiation oba chemotherapy ng’obujjanjabi obusookerwako. Kyokka oluvannyuma lw’okulongoosebwa, ttiimu y’abasawo bayinza okukuwa amagezi okukozesa eddagala eriyitibwa radiation therapy okutangira ekizimba okuddamu.

Mu kiseera kino abanoonyereza bali mu kunoonyereza ku bujjanjabi obupya obw’obulwadde bwa chordoma, gamba ng’obujjanjabi obugendereddwamu n’obujjanjabi obuziyiza endwadde. Wayinza n’okubaawo okugezesebwa okw’obujjanjabi kw’osobola okwetabamu.

Chordoma esobola okuziyizibwa?

Mu butuufu, tewali ky’oyinza kukola kuziyiza chordomas okukula. Ebiseera ebisinga, zikula mu ngeri ya kimpowooze.

Wabula singa omuntu mu maka go abadde n'obulwadde bwa Chordoma, oba bw'oba olina embeera eyitibwa ``Tuberous sclerosis,'' kikulu okulaba omusawo buli kiseera okwekebejjebwa. Olwo basobola okukulondoola okulaba oba olina obubonero bwa Chordoma. Kino gye kikoma okuzuulibwa amangu, gye kikoma okuba nti obujjanjabi bujja kuba bulungi.

Emikisa ki egy’okuwona ekirwadde kya chordoma? (Okuteebereza)

Enteebereza oba endowooza, ku chordoma esinziira ku nsonga eziwerako:

• Ekifo ekizimba we kiri n’obungi bw’ebiyinza okuggyibwamu ng’olongoosebwa: Singa ekizimba kisobola okuggyibwawo ddala, emikisa gy’okuwona giri waggulu. Singa obujjanjabi obulala bwokka bwe bukozesebwa awatali kulongoosebwa, emikisa giba mitono.
• Oba kookolo asaasaanidde mu bitundu by’omubiri ebirala (asaasaana mu bitundu by’omubiri): Singa asaasaanidde mu bifo eby’ewala, emiwendo gy’abawona giyinza okukendeera.
• Emyaka gyo ng’ozuuliddwa: Okutwalira awamu, emiwendo gy’abawona giba wansi katono eri abantu abasukka mu myaka 60.
• Oba ekizimba tekiwuddwamu oba nedda: Ebika nga ``Poorly differentiated chordoma`` birina okuteebereza okubi okusinga ``conventional chordoma``.

Ttiimu yo ey’abasawo esobola okukuwa amawulire agasinga obutuufu ku by’osuubira okusinziira ku mbeera gy’olimu, n’olwekyo totya kubabuuza bibuuzo.

Kino kiyinza okutta omuntu?

Yee, chordoma eyinza okutta omuntu. Ebiseera ebisinga, okufa kubaawo oluvannyuma lw’ekizimba okuddamu, ne kisaanyaawo ebitundu ebiri mu mugongo gwo, obwongo oba ekikolo ky’obwongo.

Okunoonyereza okwakolebwa ku balwadde ba chordoma 357 kwalaga nti emiwendo gy’abawona gyali bwe giti:

• Oluvannyuma lw’emyaka esatu: 80.5%
• Oluvannyuma lw’emyaka etaano: 68.4%
• Nga wayise emyaka kkumi: 39.2%

Naye jjukira nti zino za average zokka. Ttiimu yo ey’abasawo esobola okukuwa ebisingawo ku miwendo gy’abawona okusinziira ku mbeera yo entongole.

Chordoma Cancer Oba Kizimba kya Bulijjo?

Chordoma mazima ddala ya malignant (cancerous). Tewali n’emu ku bika byayo ebitonotono etwalibwa ng’etali ya kookolo.

Ddi lwe nnina okulaba omusawo?

Chordoma esobola okuddamu ne bwe wabaawo obujjanjabi, ne bwe wayise emyaka. N’olwekyo, okugoberera okumala ebbanga eddene ne ttiimu yo ey’abasawo kikulu nnyo.

Bw’ofuna obubonero bwonna obupya, oba singa obubonero bwo obuliwo bweyongera , kakasa nti oyogera n’omusawo wo.

N’ekisembayo, ebintu ebitonotono by’olina okujjukira (Obubaka bw’okutwala awaka) .

Kya bulijjo okuwulira ng’otya n’okubeera ku situleesi ng’otegedde nti olina kookolo w’amagumba atatera kukwatibwa. Chordoma kookolo muzibu okujjanjaba olw’ekifo w’ali.

Kyokka, weesige nti ttiimu yo ey’abasawo ejja kutondawo enteekateeka y’obujjanjabi enzijuvu ekukwatako era ejja kukuyamba okujjanjaba chordoma yo n’okutumbula omutindo gw’obulamu bwo .

• Kikulu okumanya obubonero nga bukyali: funa amagezi g’abasawo singa oba olina obulumi obutasalako, okuzirika oba enkyukakyuka mu kulaba.
• Noonya amagezi g’abasawo abakugu: Okuva bwe kiri nti obulwadde bwa chordoma bulwadde obutatera kulabika, kikulu nnyo okunoonya obujjanjabi okuva mu ttiimu y’abasawo abalina obumanyirivu.
• Okwekebeza buli kiseera kyetaagisa ne bwe kiba nga bamaze okujjanjabwa: Olw’okuba waliwo akabi ak’okuddamu okukwatibwa obulwadde buno, genda mu kukeberebwa ng’abasawo bwe babalagira.

Nsuubira nti amawulire gano osanga nga gayamba. Bw’oba ​​olina ekibuuzo kyonna, tolwawo kubuuza musawo wo.

` Chordoma, kookolo, kookolo w’amagumba, omugongo, ekiwanga, sacrum, clivus