Tulina okweraliikirira kookolo w’enkwaso (Epithelial Ovarian Cancer)?

Wali owuliddeko ku Epithelial Ovarian Cancer? Erinnya lino liyinza okuwulikika nga lizibu katono, naye kika kya kookolo w’enkwaso atera okubeera mu bakyala. Ka tukyogereko mu ngeri ennyangu, mu ngeri gy’osobola okutegeera. Kubanga kikulu nnyo okubeera n’obwegendereza ku bintu nga bino.

Kookolo w’enkwaso (Epithelial Ovarian Cancer) kye ki?

Mu ngeri ennyangu, kookolo w’enkwaso ow’omubiri (epithelial ovarian cancer) kye kika kya kookolo w’enkwaso ekisinga okubeerawo. Kookolo ono akula mu kitundu ekigonvu eky’ebweru ekibikka enkwaso, ekiyitibwa epithelial tissue. Kilowoozeeko ng’oluwuzi olugonvu olwetoolodde enkwaso.

Teyakoma awo, naye oluusi kookolo ono asobola n’okukula mu lining y’enseke oba wadde mu peritoneum, ekitundu ekibikka ebitundu by’omubiri mu lubuto. Abasawo era bateeka kookolo w’enseke z’omu lubuto ne kookolo w’olubuto omukulu mu kiti kye kimu ne kookolo w’enkwaso ow’omubiri (epithelial ovarian cancer) kubanga obubonero n’obujjanjabi bw’embeera zino bifaanagana nnyo.

Kookolo ono atera kubaawo atya?

Kookolo w’enkwaso ye kookolo ow’okubiri mu kusinga okutawaanya abakyala, oluvannyuma lwa kookolo wa nnabaana/omu lubuto. Omukyala owa bulijjo alina emikisa 1 ku buli 78 okukwatibwa kookolo w’enkwaso mu bulamu bwe.

Mu mwaka gwa 2021 gwokka, abantu abasoba mu 21,400 be baazuulibwa ne kookolo w’enkwaso. Ku bano mwenda ku kkumi baloopebwa nga kookolo w’enkwaso ow’omubiri (epithelial ovarian cancer). Kookolo ono atera nnyo mu bakyala abasukka mu myaka 65.

Bika ki ebya kookolo w’enkwaso (epithelial ovarian cancer)?

Ebitundu nga bisatu ku bina ebya kookolo w’enkwaso ow’omubiri (epithelial ovarian cancers) ye kookolo w’enkwaso ow’omutindo ogwa waggulu (HGSOC). "High-grade" kitegeeza nti obutoffaali buno bwa kookolo bukula ne busaasaana mangu okusinga kookolo "wa low-grade".

Abakugu mu by’obujjanjabi balowooza nti ekika kya HGSOC kino kisooka kukula mpola, naye kiyinza okutwala emyaka mukaaga n’ekitundu okusaasaana okuva mu nseke okutuuka mu nkwaso. Naye bwe bumala okutuuka mu nkwaso, busaasaana mangu nnyo. Kitera okukosa olubuto oluli mu lubuto (peritoneum) n’ebitundu by’omubiri ebirala. Abalwadde ba HGSOC nga 70% bazuulibwa n’obulwadde buno ku mutendera 3 oba 4. Kino kitegeeza nti kookolo asaasaanidde okusukka ekizimba ekyasooka era kati kookolo agenda mu bitundu ebirala.

Waliwo ebika ebirala ebitali bya bulijjo ebya kookolo w’enkwaso (epithelial ovarian cancer):

• Kookolo w’endwadde z’omu lubuto:Ekika kino kisinga kubeera mu bantu abalina obulwadde bwa endometriosis, obukosa olubuto lwa nnabaana (endometrium). Kiddamu bulungi obujjanjabi bw’eddagala okusinga ebika ebirala ebimu.
• Low-grade serous ovarian carcinoma (LGSOC): Ono kookolo akula mpola. Bubeera mu bakyala abato ennyo (abali wakati w’emyaka 45 ne 57). Kikola ebitundu nga 10% ku kookolo w’enkwaso ow’omubiri (epithelial ovarian cancers). Obulwadde buno butera okukula nga buzuuliddwa, era tebuddamu bulungi ku ddagala. Wadde nga kookolo ow’omutindo ogwa wansi akula mpola, tatera kufuuka kookolo wa mutindo gwa waggulu.
• Mucinous carcinoma: Ebizimba bino bya njawulo ku bika ebirala era bikola bulungi ku bujjanjabi. Zitera okuba ennene (nga yinsi 8 oba sentimita 20). Zitera okukosa enkwaso zokka.
• Ovarian clear cell carcinoma (OCCC): Abakyala mu Asia n’abo abalina endometriosis bali mu bulabe bwa maanyi okukwatibwa kookolo ono. Obulwadde buno butera okugenda mu maaso nga buzuuliddwa. Tekikola bulungi ku ddagala lya ddagala.
• Primary squamous cell carcinoma (SCC) of the ovary: Ekika kya SCC kino kitera okuva mu mbeera ezitali za kookolo/ezitali za kookolo. Okugeza, kiyinza okuva mu bizimba by’enkwaso, endometriosis, oba ebizimba bya Brenner (okukula okukalu, okutali kwa bulijjo mu nkwaso). Singa ekwatibwa nga bukyali, ekola bulungi ku bujjanjabi.

Kiki ekivaako kookolo w’enkwaso (epithelial ovarian cancer)?

Mu butuufu, ekituufu ekivaako kookolo abasinga obungi, nga mw’otwalidde ne kookolo w’enkwaso ow’omubiri (epithelial ovarian cancer), tekinnategeerekeka. Kyokka okunoonyereza okupya kulaga nti kookolo w’enkwaso asinga mu butuufu atandikira mu butoffaali obuli ku nkomerero z’enkwaso. Olwo ne zisaasaana ne zituuka mu nkwaso.

Biki ebiyinza okuleeta kookolo ono?

Abasoba mu kitundu ku abo abazuuliddwa nga balina kookolo w’enkwaso basukka emyaka 65 era nga bayise mu nsonga z’ekikyala ekitegeeza nti ensonga zaabwe ziyimiridde.

Ensonga ezimu ziyinza okwongera ku bulabe bw’okukwatibwa kookolo w’enkwaso. Bbo bali:

• Singa omuntu mu maka go abadde ne kookolo w’enkwaso, kookolo w’amabeere, oba kookolo w’olubuto n’omumwa gwa nnabaana/olubuto olunene.
• Bw’oba ​​osikira enkyukakyuka (mutation) mu BRCA gene.
• Bw’oba ​​osikira obuzaale obukwatagana n’obulwadde bwa kookolo obw’amaka, gamba ng’obulwadde bwa Lynch.
• Bw’oba ​​omira eddagala ly’obusimu okufuga obubonero bw’okuggwaamu amaanyi mu nsonga.
• Okuzaala omwana oluvannyuma lw’emyaka 35 oba nga tositula mwana kutuusa mu kiseera ekijjuvu.
• Obunene .

Bubonero ki obulaga kookolo w’enkwaso (epithelial ovarian cancer)?

Kino kizibu eri abantu bangi. Kookolo w’enkwaso ow’omubiri (epithelial ovarian cancer) atera okuba n’obubonero butono nnyo mu ntandikwa. Obubonero bulabika ng’obulwadde bumaze okusaasaana katono. Bwe busaasaana ku luwuzi olubikka ebitundu by’olubuto (peritoneum), amazzi ag’amazzi gasobola okukuŋŋaanyizibwa mu lubuto. Kino kiyitibwa ascites.

Okugatta ku ekyo, obubonero buno buyinza okulabika:

• Obulumi mu lubuto.
• Okukaluubirirwa okulya oba okuwulira ng’okkuta oluvannyuma lw’okulya akatono.
• Okuziyira n’okusiiyibwa.
• Okuzimba omubiri.
• Obulumi mu kifuba.

Waliwo n’obubonero obutatera kulabibwa:

• Urge incontinence oba okufulumya omusulo ennyo (overactive bladder).
• Okuvaamu omusaayi mu bukyala mu ngeri etaali ya bulijjo.

Ekikulu: Okubeera n’obubonero buno tekitegeeza nti olina kookolo. Kyokka bwe zigumiikiriza, kiba kirungi okugenda ew’omusawo akuwe amagezi.

Kookolo w’enkwaso ow’omubiri (epithelial ovarian cancer) azuulibwa atya?

Ebyembi, tewali kukeberebwa kwonna okukeberebwa okuyinza okuzuula kookolo w’enkwaso mu mitendera gye egy’olubereberye. Okukebera kutera kukolebwa singa oba olina obubonero oba ng’oli mu bulabe obw’amaanyi. Omusawo ayinza okusooka okukebera ekisambi okukebera oba waliwo ebizimba oba okuzimba ebitali bya bulijjo.

Olwo, osobola okwekebeza omusaayi okukebera omutindo gwa puloteyina eyitibwa `CA-125`. Kino `CA-125` kitegeeza kookolo antigen 125. Singa omutindo guba waggulu, ojja kwetaaga okukola okukebera okusingawo.

Okukebera ebifaananyi nga kuno kuyinza okuyamba okuzuula kookolo w’enkwaso:

• Okukeberebwa mu ngeri ya ultrasound okuyita mu bukyala.
• Okukeberebwa mu CT scan.
• Okukebera MRI (MRI).
• Okukebera omukka oguyitibwa positron emission tomography (PET).
• X-ray z’ekifuba (okulaba oba kookolo asaasaanidde mu mawuggwe).

Oluusi enkola eyitibwa laparoscopy eyinza okukolebwa. Kino kiringa okulongoosa, naye kikolebwa nga tebatemye kinene. Kino kisobozesa omusawo okutunuulira ebitundu byo eby’okuzaala. Era bayinza okuggya sampuli y’ebitundu by’omubiri (biopsy) okuva mu kizimba okulaba oba waliwo obutoffaali bwa kookolo bwonna awo. Biopsy eno y’engeri yokka gy’oyinza okumanyamu obukakafu oba olina kookolo w’enkwaso.

Mitendera ki egya kookolo w’enkwaso (epithelial ovarian cancer)?

Okumanya omutendera gwa kookolo kiyamba abasawo okutegeera enkulaakulana ya kookolo. Era kikulu okuzuula oba kookolo asaasaanidde n’okusalawo ku bujjanjabi. Omutendera gwa kookolo gusalibwawo okukeberebwa kwe kumu okukozesebwa okuzuula kookolo.

Kookolo w’enkwaso alina emitendera ena emikulu. Emitendera egimu girina emitendera emitonotono. Omuwendo gw’omutendera gye gukoma okuba omungi, kookolo gy’akoma okukula.

• Omutendera 1: Kookolo ali mu nkwaso emu yokka oba mu nseke emu yokka.
• Omutendera 2: Kookolo asaasaanidde mu nnabaana oba mu kisenge ky’olubuto (peritoneal cavity).
• Omutendera 3: Kookolo asaasaanidde mu bitundu ebirala ebiri ebweru w’ekisambi, mu nnywanto oba byombi.
• Omutendera 4: Obutoffaali bwa kookolo bubeera mu mazzi ageetoolodde amawuggwe, ennywanto mu kitundu ky’ekisambi, ebitundu ebirala oba ebitundu by’omubiri ebirala.

Kookolo w’enkwaso ow’omubiri (epithelial ovarian cancer) asobola okuwona?

Abasawo abalongoosa bakola okulongoosa okuggyamu kookolo omungi nga bwe kisoboka. Kino kigobererwa eddagala eriweweeza ku bulwadde (chemotherapy). Wadde ng’abantu abasinga bawona mu kusooka, obulwadde buno busobola okudda mu bantu bangi oluvannyuma.

Abalwadde abato bayinza okusalawo okuggyamu enkwaso n’enkwaso zokka ezirwadde.

Ku bantu abalina kookolo ow’amaanyi, okulongoosa okukendeeza ku bunene (debulking surgery) kutera okukolebwa okuggyamu ebitundu by’omubiri nga:

• Okuggyawo enseke zombi n’enkwaso zombi (bilateral salpingo-oophorectomy).
• Okuggyawo nnabaana (hysterectomy).
• Okuggyawo amasavu (omentum) agabikka olubuto (omentectomy).
• Okuggyawo ennywanto ezitwetoolodde.
• Okuggyawo ebitundu ebirala ebirwadde (nga ekyenda ekitono, ekyenda ekinene oba enseke).

Bujjanjabi obulala bwe buruwa?

Okusinziira ku kika kya kookolo, oyinza okuweebwa emu oba eziwera ku bujjanjabi buno oluvannyuma lw’okulongoosebwa:

• Chemotherapy: Okutta obutoffaali bwa kookolo. Kino kikozesa eddagala nga ebirungo bya platinum (carboplatin) ne paclitaxel (Taxol®) oba docetaxel (Taxotere®).
• Enzijanjaba y’enkwaso mu lubuto: Okujjanjaba kookolo w’enkwaso ow’omutendera ogw’okusatu, eddagala lya cisplatin ne paclitaxel lifukibwa butereevu mu lubuto nga liyita mu kituli ekiyingizibwa mu lubuto nga balongooseddwa (ekyuma ekigonvu era ekirimu ekituli).
• Enzijanjaba ezigendereddwamu: Eddagala nga Bevacizumab (Avastin®) liremya obutoffaali bwa kookolo okukula n’okweyongera.
• Obujjanjabi bw’amasannyalaze: Bukozesa emisinde gya X-ray egy’amaanyi amangi okusaanyaawo obutoffaali bwa kookolo.

Kookolo w’enkwaso ow’omubiri (epithelial ovarian cancer) asobola okuziyizibwa?

Okunoonyereza kulaga nti abakyala abamira empeke z’obusimu eziziyiza okuzaala okumala emyaka etaano n’okusoba basobola okukendeeza ku bulabe bwa kookolo w’enkwaso nga kitundu.

Okulongoosa okumu era kuyinza okukendeeza ku bulabe bwa kookolo. Okulongoosa okuziyiza kookolo kuyitibwa okulongoosa okuziyiza kookolo. Kino kizingiramu okuggyamu enseke n’enkwaso, nga nnabaana olina oba nga talina. Kino kitera okulowoozebwako ku bakyala abali mu bulabe obw’amaanyi olw’ebyafaayo by’amaka (nga abo abalina enkyukakyuka ya BRCA oba Lynch syndrome). Kyokka abasawo bawa amagezi nti emitendera gino gikolebwe singa kiba kyetaagisa mu by’obujjanjabi. Kino kiri bwe kityo kubanga okuggyamu enkwaso kiyinza okuvaako okugenda mu nsonga nga bukyali, ekiyinza okukosa omubiri obubi.

Okulongoosa kuno tekumalawo ddala bulabe bwa kookolo. Abantu abamu bayinza okuba nga balina kookolo atazuulibwa mu kiseera we balongoosebwa. Abantu abalina enkyukakyuka mu buzaale bwa BRCA bakyasobola okufuna kookolo w’olubuto omukulu ne bwe kiba nti enseke n’enkwaso zaabwe ziggyiddwamu. Buuza omusawo wo ku kukebera BRCA okumanya oba olina obuzaale bwa BRCA.

Endowooza etya eri abantu abalina kookolo w’enkwaso mu bitundu by’omubiri (epithelial ovarian cancer)?

Abantu abasoba mu 13,000 be bafa kookolo w’enkwaso buli mwaka. Kye kitundu eky’okutaano ekisinga okutta abakyala kookolo. Wabula waliwo essuubi ly’obujjanjabi obupya mu kiseera kino obugezesebwa mu malwaliro. Abanoonyereza era bakola okuzuula obulwadde buno nga bukyali.

Singa kookolo w’enkwaso ow’omubiri (epithelial ovarian cancer) azuulibwa nga tannasaasaana, omuwendo gw’abantu abawangaala mu myaka etaano gusukka ebitundu 90%. Wabula kookolo bw’amala okusaasaana (metastasized), omuwendo guno gukka okutuuka ku bitundu nga 30%.

Ensonga nnyingi ezikwata ku kuteebereza kookolo:

• Ekigero kookolo w’asaasaanidde.
• Obuwanguzi mu bujjanjabi.
• Ekifo, obunene, n’omuwendo gw’ebizimba bya kookolo (omutendera gwa kookolo).

Ddi lw’osaanidde okulaba omusawo?

Bw’oba ​​olina obubonero buno, laba omusawo mu bwangu:

• Enkyukakyuka mu mirundi oba mu bwangu bw’okufulumya omusulo.
• Okubulwa apetite oba okuwulira ng’ojjudde oluvannyuma lw’okulya akatono.
• Obulumi obutasalako mu lubuto oba mu kitundu ky’ekisambi awatali nsonga.

Bibuuzo ki by’osaanidde okubuuza omusawo wo?

Osobola okubuuza omusawo ebibuuzo nga bino:

• Nkole okukeberebwa kwa BRCA?
• Kika ki ekya kookolo w’enkwaso (epithelial ovarian cancer) gwe nnina?
• Bujjanjabi ki obusinga okunkwatako?
• Biki ebiva mu bujjanjabi obwo?
• Ndi mu bulabe bwa kookolo agenda okusaasaana? Nnyinza ntya okukendeeza ku bulabe obwo?
• Nsaanidde okweraliikirira ebizibu ebiyinza okuvaamu?

Kiki ekisinga okulumwa kookolo w’enkwaso?

Kookolo w’enkwaso ow’omutindo ogwa waggulu (HGSOC) kika kya kookolo w’enkwaso ow’amaanyi ennyo. Wadde kookolo ono mu kusooka akula mpola mu nseke, asaasaana mangu nnyo ng’amaze okutuuka mu nkwaso. Ebyembi, abantu bangi abalina HGSOC balina kookolo w’enkwaso agenda mu maaso/agenda mu bitundu ebirala nga bazuuliddwa.

Kisoboka okuba n’ebizimba by’enkwaso ebitali bya kookolo (benign) epithelial ovarian cysts?

Yee. Mu butuufu, ebizimba by’enkwaso ebisinga obungi eby’omubiri (epithelial ovarian tumors) si bya kookolo. Ebizimba ebimu biyitibwa borderline tumors oba atypical proliferating tumors. Bino edda byayitibwanga ebizimba ebiyinza okuba ebizibu ebitono.

Mu bizimba eby’ensalo, obutoffaali obutali bwa bulijjo bukula ne buyingira mu bitundu by’omubiri ebiyitibwa epithelial tissue naye tebuyingira mu bitundu ebiwanirira enkwaso (stroma). Obutoffaali buno butera okusangibwa mu nkwaso yennyini era tebutera kufuuka kookolo. Singa kookolo akola, ssatu ku nnya zibeera mu mutendera gwa 1 (ezisibiddwa mu nkwaso era nga nnyangu okujjanjaba). Ebizimba bino bitera okukwata abantu abato.

Obubaka Obutwala Awaka

Kookolo w’enkwaso ow’omubiri (epithelial ovarian cancer) ye kika kya kookolo w’enkwaso asinga okubeerawo. Mulimu ne kookolo w’omumwa gwa nnabaana ne kookolo w’omu lubuto (primary peritoneal cancer). Kookolo w’enkwaso atera okuba n’obubonero butono nnyo mu biseera bye ebisooka. Obulwadde buno butera okuba obw’omulembe ennyo nga tebusobola kuzuulibwa we buzuuliddwa. Kino kituufu naddala ku kika kya kookolo w’omubiri ekisinga okumanyibwa, ayitibwa `HGSOC`.

Bw’oba ​​olina emikisa mingi egy’okufuna kookolo w’enkwaso (nga ebyafaayo by’amaka), kikulu okubuuza omusawo wo oba enkola z’okuziyiza kookolo zikusaanira. Bulijjo faayo ku mubiri gwo. Tobuusa maaso bubonero bwonna obutali bwa bulijjo. Noonya amagezi g’abasawo.

` Kookolo w'enkwaso, kookolo w'enkwaso, obulamu bw'abakyala, obubonero bwa kookolo, obujjanjabi bwa kookolo, BRCA gene, gynecology