Obulwadde bwa Felty Syndrome kye ki? Kino kikulu eri mmwe abalina obulwadde bw’endwadde z’enkizi!

Oyinza n’okulumwa ennyondo, okuzimba n’okukaluba katono mu bitundu byo ku makya, nedda? Ebiseera ebisinga, bino bisobola okuva ku bulwadde bw’endwadde z’enkizi. Naye obadde okimanyi nti waliwo ekizibu ekirala ekiyinza okujja n’embeera eno ey’endwadde z’enkizi, naye nga tekimanyiddwa nnyo, naye nga kikulu nnyo okumanya? Oyo ye bulwadde bwa Felty Syndrome. Katukwogere ku nsonga eno mu bujjuvu katono leero.

Ddala Felty Syndrome kye ki?

Mu ngeri ennyangu, Felty Syndrome embeera ssatu ezigatta awamu. Bbo bali:

• Rheumatoid Arthritis - Obuzimba bw’ennyondo bangi ku mmwe bwe mumanyi.
• Neutropenia - Kino kikendeeza ku muwendo gwa neutrophils, ekika ky’obutoffaali obweru mu musaayi.
• Splenomegaly - Kino kitegeeza nti enseke, ekitundu mu mubiri, efuuka ennene okusinga eya bulijjo.

Kitera okutandika n’obulwadde bw’endwadde z’enkizi (RA). Embeera endala ebbiri zibaawo ng’ebizibu bya RA. Abasawo bino babiyita ‘extra-articular manifestations’. Kwe kugamba, obulwadde bw’enkizi tebukoma ku binywa byokka, wabula bukosa ennyondo eziri ebweru wazo. Kino kiva ku nkola y’okuzimba ereeta endwadde z’enkizi. Wadde nga kya bulijjo ebikosa ebika bino okubeera ebweru w’ennyondo ezirina RA, Felty Syndrome mbeera etali ya bulijjo.

Kino kikukwatako kitya?

Obulwadde bwa Felty butandikira ku bulwadde bwa Rheumatoid Arthritis. Olwo n’ofuna obulumi obw’amaanyi n’okuzimba mu binywa. Olwo, embeera nga Neutropenia ne Splenomegaly bwe zibaawo, zikosa abaserikale b’omubiri gwo . Neutropenia kwe kukendeera kw’ekika ky’obutoffaali obweru obuyitibwa neutrophils. Neutrophils zino kika kya butoffaali kikulu nnyo ekikuuma omubiri gwaffe okuva ku ndwadde. Kale bwe zikendeera emikisa gy’okufuna endwadde gyeyongera. Ensigo egaziye nayo eyinza okuba ensonga endala evuddeko okukendeera kuno mu busimu obuyitibwa neutrophils.

Embeera eno ya bulijjo etya?

Obulwadde bwa Felty bubaawo mu bantu nga 2% abalina obulwadde bw’endwadde z’enkizi. Okufaananako ne RA, obulwadde bwa Felty’s syndrome businga emirundi nga esatu mu bakyala okusinga mu basajja. Ekyewuunyisa, kumpi abantu bonna abalina RA abafuna obulwadde bwa Felty’s syndrome ‘seropositive’. Kino kitegeeza nti okukeberebwa kukakasa nti balina ekintu ekiyitibwa rheumatoid factor antibodies mu musaayi gwabwe. abantu ‘seronegative’, ekitegeeza abantu abatalina buziyiza obwo, tebatera kufuna bulwadde bwa Felty.

Bubonero ki obulaga kino?

Ebiseera ebisinga, obubonero obusooka okulabika bwe buno bw’obulwadde bw’endwadde z’enkizi. Mu bino mulimu:

• Obulumi mu binywa
• Okuzimba kw’ennyondo
• Okukaluba kw’ennyondo naddala ku makya

Abantu abamu bayinza okufuna obubonero obulala ng’oggyeeko RA mu binywa byabwe. Okugeza nga:

• Ebizimba ebikola wansi w’olususu okumpi n’ennyondo (bino biyitibwa ebinywa ebiyitibwa rheumatoid nodules) .
• Ensigo ezizimba mu bifo ng’ensingo n’enkwawa
• Ekibumba kiyinza okuzimba era nga kiruma ng’okikwatako.
• Amaaso n’akamwa bikalu (kino kiyitibwa Sjogren’s syndrome) .
• Amaaso amamyufu, agazimba (kino kiyitibwa episcleritis) .
• Ebiwundu ku lususu naddala ku magulu
• Obubonero bw’okuvaamu omusaayi wansi w’olususu
• Okukaluubirirwa okussa olw’okuzimba amawuggwe
• Obulumi mu kifuba olw’okuzimba okwetooloola omutima
• Omusujja
• Obukoowu n’okukoowa
• Okubulwa apetite oba okugejja mu ngeri etategeerekeka

Ng’oggyeeko bino, obulwadde bwa Felty Syndrome nabwo bulina obubonero obulala. Oluusi obubonero buno buyinza okulabika ng’obubonero bwa RA tebunnatandika.

• Yinfekisoni ezitera okubaawo, eziwangaala. Eby’okulabirako mulimu omusujja, okutabuka mu lubuto, n’okukwatibwa endwadde z’olususu.
• Okuzimba kw’ennywanto. Kiyinza okuwulirwa mu ngalo era kiyinza okukuluma.
• Okukyusa langi y’olususu (nga amabala).

Naye ekyewuunyisa, oluusi osobola okuzuulibwa nti olina obulwadde bwa Felty Syndrome nga tolina bubonero bwonna. Okukebera omusaayi ne sikaani kiyinza okulaga nti olina embeera zonsatule nga tonnaba na kuwulira bubonero bwonna.

Kino kitera okutandika ku myaka ki?

Obulwadde bwa Felty Syndrome butera okubeera mu bantu abakadde, abali wakati w’emyaka 50 ne 70. Ku bantu abasinga obungi, Felty Syndrome elabika nga bamaze okufuna obubonero bw’endwadde z’enkizi okumala emyaka nga 10 ku 15.

Lwaki obulwadde bwa Felty Syndrome bubaawo?

Obulwadde bw’endwadde z’enkizi ‘bulwadde bw’abaserikale b’omubiri’. Kino kitegeeza nti abaserikale baffe bennyini balumba ebitundu by’omubiri gwaffe nga balinga omulabe. Bannasayansi bangi balowooza nti obulwadde bwa Felty Syndrome kizibu kya maanyi eri RA. Mu ndwadde zino ez’abaserikale b’omubiri, emibiri gyaffe gikola ‘antibodies’ ezilwanyisa obutoffaali obumu. Antibodies zino zigenda ne zikwata proteins ezo ne ziziwa akabonero nti zisaanawo. Eno y’engeri okuzimba gye kweyongera.

Obuziyiza buno buyinza obutabaawo bulijjo mu RA. Wabula mu bantu abalina obulwadde bwa Felty Syndrome, obuziyiza buno bubaawo ddala. Okubeerawo kw’obutafaali buno y’ensonga lwaki RA yeeyongera okuba ey’amaanyi ate n’ebikosa ebirala ebweru w’ennyondo (extra-articular manifestations) ne byeyongera. RA erimu obutoffaali obuziyiza endwadde eyitibwa ‘seropositive RA’. Okunoonyereza kulaga nti byombi seropositive RA ne Felty Syndrome bikwatagana n’ensonga ezimu ‘ez’obuzaale’. Kino kitegeeza nti zisobola okuyisibwa mu milembe okutuuka ku ddaala eritali limu.

Obulwadde bw’endwadde z’enkizi (RA) buleeta butya okukendeeza ku busimu obuyitibwa neutropenia n’okukendeera kw’ennywanto?

Engeri Neutropenia gy’ebaawo

Neutropenia kwe kukendeera kw’obutoffaali obweru obuyitibwa neutrophils. Waliwo ensonga bbiri enkulu eziviirako kino. Ekimu kiri nti obusimu bwo obw’amagumba tebukola busimu bumala. Oba, ebirungo ebiyitibwa neutrophils mu mubiri gwo biba bisaanawo. Mu Felty Syndrome, bino byombi bisobola okubaawo. Enkola y’obusimu obuziyiza endwadde eyayogeddwako emabegako esobola okutaataaganya okukola obusimu obuyitibwa neutrophils mu busimu bw’amagumba, era neutrophils ezaakolebwa edda zisobola okusaanawo. Ate era, enseke ezigaziye y’ensonga endala ereetera obuwuka obuyitibwa neutrophils okukendeera.

Engeri Splenomegaly Gy’ebeerawo

Omulimu gw’ennywanto yo kwe kusengejja obutoffaali bw’omusaayi obukadde obutaliimu mugaso okuva mu musaayi gwo. Naye ennywanto yo bw’ekula ennyo (splenomegaly), esukkiridde okukola n’etandika okuggyawo obutoffaali obulungi obw’omusaayi bungi. Obulwadde bw’endwadde z’enkizi oluusi busobola okuvaako ennywanto okugaziwa. Ekituufu ekivuddeko tekinnategeerekeka bulungi. Ensigo nayo esobola okugaziwa nga tewali neutropenia. Ate era, si bulijjo nnyo, Felty Syndrome esobola okubaawo nga tewali nnywanto egaziye.

Bizibu ki eby’obulabe ebiva mu bulwadde bwa Felty Syndrome?

Olw’okuba obulwadde bwa Felty Syndrome bunafuya abaserikale b’omubiri gwo, oli mu bulabe bwa maanyi okufuna yinfekisoni enfunda eziwera era ez’amaanyi . Ne bw’oba ​​otera okuba n’obulwadde obutonotono obwangu okujjanjabibwa, embeera eno eyinza okufuuka ey’amaanyi ennyo n’esigala ng’egenda mu maaso n’oluusi n’eteeka obulamu bw’omuntu mu matigga. Obulwadde bwa bakitiriya obutafugibwa buyinza okuvaako embeera ey’akabi eyitibwa sepsis. Abantu abalina obulwadde bwa Felty Syndrome nabo bali mu bulabe bwa maanyi okufuna ebika bya kookolo ebimu, gamba nga lymphoma.

Naye totya ng’owulira ebintu bino. Obulabe buno buliwo, naye busobola okufugibwa nga bujjanjabiddwa bulungi era nga bufaayo.

Kino tukitegeera otya?

Abasawo bazuula obulwadde bwa Felty Syndrome bwe bakizuula nti obulwadde bw’endwadde z’enkizi, okukendeeza ku busimu obuyitibwa neutropenia, n’okukendeera kw’ennywanto byonna biriwo. (Tekitera kubaawo, okuzuula obulwadde buno kuyinza okukolebwa nga tewali nnywanto egaziye.)

Ebigezo ebitera okukolebwa bye bino:

• Okukebera omusaayi: Okubala omusaayi mu bujjuvu, naddala okukebera omuwendo gwa neutrophils.
• X-rays z’ennyondo: Kebera oba temuli bulwadde bwa arthritis.
• Sikaani z’ennywanto: Okugeza, okukebera amaloboozi agayitibwa ultrasound oba CT scan.
• Okukebera obusigo bw’amagumba:Kino kiyamba okulaba nga tewali mbeera ndala ya bujjanjabi.

Bujjanjabi ki eri kino?

Waliwo ebiruubirirwa ebikulu bisatu ng’ojjanjaba obulwadde bwa Felty Syndrome:

• Okufuga embeera y’obulwadde bw’endwadde z’enkizi (Rheumatoid Arthritis).
• Singa obulwadde bwa neutropenia buba bwa maanyi, bujjanjabe butereevu.
• Okuziyiza yinfekisoni n’okuzijjanjaba singa zibaawo.

Obulwadde bwa Felty Syndrome buyinza okuba nga buva ku bulwadde bw’endwadde z’enkizi (RA) obutajjanjabiddwa oba obutafugibwa bulungi. Ku bantu bangi, neutropenia nayo etereera nga RA yaabwe etereera. N’olwekyo, abasawo basooka kutunuulira kulonda ddagala erikola obulungi eriziyiza endwadde ezikyusa endwadde (DMARDs) eri RA. Era bagezaako okwewala eddagala eriweweeza ku busimu obuziyiza endwadde nga bwe kisoboka.

Waliwo ebika bya DMARD ebiwerako ebiyinza okukozesebwa ku Felty Syndrome:

• Methotrexate ne folic acid (okukendeeza ku buzibu obuva mu methotrexate) .
• Abatacept
• Eddagala lya Rituximab
• Ekirungo kya Leflunomide

Naye singa obusimu bwo tebutereera na DMARD zino, oba singa obusimu bwo buba bwa maanyi nnyo, oba bw’oba ​​olina dda yinfekisoni, omusawo wo ajja kugezaako obujjanjabi obulala okwongera ku muwendo gw’obusimu bwo. Mu bino biyinza okuli:

• Eddagala erigema eriyitibwa G-CSF (granulocyte colony-stimulating factor).
• Eddagala lya corticosteroid ery’ekiseera ekitono.
• ‘Splenectomy’ - Kino kitegeeza okulongoosa okuggyamu enseke ezisukkiridde.

Ekirala abasawo bajja kukola emitendera egy’enjawulo okukukuuma obutakwatibwa yinfekisoni naddala singa obujjanjabi bwo bukosa abaserikale b’omubiri. Bayinza okuteesa ku bintu nga:

• Okumira eddagala eritta obuwuka erya broad-spectrum.
• Okufuna okugema okwetaagisa.
• Faayo nnyo ku bulamu bw’akamwa n’amannyo go.

Singa omuntu alina obulwadde bwa Felty Syndrome afuna yinfekisoni, abasawo bagitwala nga kikulu nnyo. Kino bwe kikutuukako olina okufuna obujjanjabi amangu ago . Omusawo ajja kukuwa eddagala ery’amaanyi.

Omuntu alina obulwadde bwa Felty Syndrome buwangaazi ki?

Tewali bibalo bikwata ku bulamu bw’abantu abalina obulwadde bwa Felty Syndrome mu kiseera kino. Kyokka okutwalira awamu, obujjanjabi bulongooseddwa nnyo mu myaka egiyise. Kale waliwo omukisa omulungi nti obujjanjabi bwonna bujja kukutuukako. Obulabe obusinga okufa mu bulwadde bwa Felty Syndrome bukyali bwa yinfekisoni ez'amaanyi . N’olwekyo, okukola emitendera okwekuuma yinfekisoni kiyinza okuleeta enjawulo nnene mu bulamu bwo obw’ekiseera ekiwanvu.

Felty Syndrome kizibu ekitatera kulabika era ekitera okubuusibwa amaaso eky’obulwadde bw’endwadde z’enkizi (RA). Bw’oba ​​olina RA nga tofugibwa okumala ebbanga eddene, oba eddagala lyo bw’olekera awo okukola obulungi nga bwe lyali likola, oyinza okufuna obulwadde bwa Felty Syndrome. Abantu abamu bagifuna nga tebalina bubonero bwonna. Kiyinza okukutabula katono okukimanya nti obulwadde obukwata ennyondo zo busobola n’okukosa obutoffaali bwo.

Bw’oba ​​okolagana dda ne RA, mpozzi n’obubonero obulala, kiyinza okukuzitoowerera okufuna ekizuuliddwa ekipya. Naye Felty Syndrome tereeta bubonero bupya bungi, era eyinza obuteetaagisa bujjanjabi bulala. Ekikulu kwe kumanya akabi akali mu kukola. Bw’okolagana n’omusawo wo okujjanjaba RA yo n’okuziyiza yinfekisoni, osobola okuddukanya Felty Syndrome.

N’ekisembayo, ebintu by’olina okujjukira

Felty Syndrome mbeera eyinza okubaawo mu bantu abamu abalina obulwadde bw’endwadde z’enkizi (RA). Kimanyiddwa olw’okukendeera kw’obutoffaali obweru obuyitibwa neutrophils mu musaayi gwo (neutropenia) n’okugaziwa kw’ennywanto (splenomegaly).

• Obulabe obusinga obuli mu kukwatibwa yinfekisoni enfunda eziwera, n’olwekyo kikulu nnyo okwekuuma obutakwatibwa yinfekisoni.
• Wadde nga kino kiyinza okulabika ng’ekitiisa katono, embeera eno esobola okufugibwa obulungi ng’ofunye obujjanjabi obutuufu n’okubuulirirwa .
• Bw’oba ​​olina RA, beera ku bunkenke okulaba obubonero buno obw’enjawulo. Bw’oba ​​olina ekikweraliikiriza , kakasa nti oyogera n’omusawo wo. Bajja kusobola okukuyamba.

` Felty Syndrome, Endwadde z’enkizi, Neutropenia, Splenomegaly, Endwadde z’enkizi, Okuzimba kw’ennyondo, Neutrophils, Ensigo, Obusimu obuziyiza endwadde