Era owulira ng’amagulu go gagenda gazimba? Kino kiyinza okuba obulwadde bwa Lambert-Eaton Myasthenic Syndrome (LEMS)!

Oluusi owulira ng’amagulu ganafuye, ofuna obuzibu okusituka mu ntebe, owulira ng’okooye ng’olinnya amadaala? Oba owulira ng’okooye olw’obubonero ng’ebikowe ebizitowa, akamwa okukala, n’okulaba emirundi ebiri? Bino biyinza obutaba bukoowu bwokka. Leero tugenda kwogera ku mbeera gy’oyinza okuba nga towulirangako, naye nga esaanira nnyo okumanya, Lambert-Eaton Myasthenic Syndrome, oba ``(LEMS)`` nga bwe tugiyita mu bufunze.

Obulwadde bwa Lambert-Eaton Myasthenic Syndrome (LEMS) kye ki?

Mu ngeri ennyangu, obulwadde bwa Lambert-Eaton Myasthenic Syndrome (LEMS) bulwadde obuva ku busimu obuziyiza endwadde. Kati oyinza okuba nga weebuuza obuzibu bw’abaserikale b’omubiri (autoimmune disorder) kye ki . Emibiri gyaffe girina abaserikale b’omubiri. Kino kye kitukuuma nga tulwanyisa obuwuka obuleeta endwadde okuva ebweru. Kiringa amagye mu nsi yaffe. Naye oluusi abaserikale bano abaserikale bagenda bubi. Olwo ne kitandika okulumba obutoffaali bwaffe obulamu. Ekyo kye kibaawo mu LEMS.

Mu kino `(LEMS)`, abaserikale baffe abaserikale balumba akakwate wakati w'obusimu bwaffe obw'enkola n'ebinywa . Okubeera omutuufu, akakwate kano kayitibwa `neuromuscular junction`. Ekiyungo kino bwe kyonoonese, okutambuza obubaka okuva mu busimu okutuuka mu binywa kukosebwa. Wano we wabaawo obunafu bw’ebinywa.

Obunafu buno butera okutandikira mu bisambi byo ebya waggulu , naye busobola okusaasaana mpolampola mu mikono gyo, okussa, okumira, n’okwogera.

Ani asinga okukulaakulanya `(LEMS)` eno?

Waliwo ebibinja bibiri ebikulu ebikola `(LEMS)`.

1. Ebikwatagana ne kookolo: Abantu nga 60% abalina LEMS balina kookolo ow’engeri emu. Ekika ekisinga okumanyibwa ye kookolo w’amawuggwe ow’obutoffaali obutono . Ekyewuunyisa, oluusi obubonero bwa LEMS busobola okulabika ng’emyezi oba n’emyaka kookolo tannatandika. Abantu bano abasinga balina emyaka egisukka mu 60, basajja, era bakozesezza ebintu ebikolebwa mu taaba.

2. Tewali kookolo: Abantu abalala 40% abalina LEMS tebalina kookolo azuuliddwa. Abantu bano batera okuzuulibwa ku myaka nga 35 ate nate ku myaka nga 60.

LEMS mbeera ya bbula nnyo mu baana abato.

Kookolo w’amawuggwe ow’obutoffaali obutono (LEMS) yekka y’akwatagana ne kino?

Nedda Kookolo w’amawuggwe ow’obutoffaali obutono kye kika kya kookolo ekisinga okubeerawo, naye ebika bya kookolo ebirala nabyo bisobola okukwatagana ne LEMS. Eby’okulabirako mulimu kookolo w’enseke, thymoma, n’obuzibu bw’okukula kw’omusaayi. Olw’okuba obubonero bwa LEMS busobola okulabika ng’obubonero bwa kookolo tebunnalabika, kikulu okuba n’okukeberebwa okutuufu okukebera kookolo singa omusawo akuzuula nti olina LEMS.

LEMS ereetebwa enkyukakyuka mu buzaale?

Bannasayansi balowooza nti okutwalira awamu endwadde eziva ku busimu obuziyiza endwadde ziyinza okuba n’akakwate ku buzaale. Okuva LEMS bwe kiri nti nayo bulwadde obuva ku busimu obuziyiza endwadde, kisoboka okuba nti nayo erina akakwate ku buzaale, naye kino tekinnategeerekeka bulungi.

`(LEMS)` ya bulijjo etya?

LEMS bulwadde obutatera kulabika nnyo . Kiteeberezebwa nti embeera eno ekosa abantu nga obukadde bubiri n’obukadde 800 mu nsi yonna. Mu Amerika, waliwo abantu nga 400 abategeezeddwa nti balina obulwadde bwa LEMS. Wadde nga tewali bibalo bituufu ku bantu bameka abali mu ggwanga lyaffe, kyeyoleka lwatu nti eno embeera etatera kubaawo.

Bubonero ki obwa `(LEMS)`?

Katutunuulire obubonero bwa `(LEMS)` bumu ku bumu. Obubonero buno bwonna tebubaawo mu kiseera kye kimu mu buli muntu, obubonero obumu buyinza okulabika nga bukyali, obumu buyinza okulabika oluvannyuma.

• Okunafuwa kw’ebinywa n’okukoowa: naddala mu magulu aga waggulu.
• Okukaluubirirwa okutambula: Okukaluubirirwa okulinnya amadaala oba okusituka okuva mu ntebe.
• Okulumwa ebinywa oba okukaluba.
• Okuwulira ng’ebitundu by’omubiri bizimba.
• Ebikowe by’amaaso ebigwa (ptosis): Kino kiyinza okulabika ng’otulo.
• Okulaba ebintu bibiri omulundi gumu (diplopia).
• Akamwa n’amaaso okukalu (xerostomia): okukendeera kw’amalusu, amaziga okukendeera mu maaso.
• Obuteeyabya.
• Okukendeera kw’entuuyo.
• Okugejja.
• Okukaluubirirwa okufulumya omusulo.
• Obuzibu bw’okusituka mu basajja.
• Obuzibu mu kwogera (dysarthria) n’okukaluubirirwa okumira (dysphagia): Buno butera kuba bubonero obulabika oluvannyuma mu bulwadde.
• Obuzibu mu kussa (okusannyalala) n’okusannyalala mu kussa: Buno era kabonero akatatera kulabika, ka maanyi akayinza okubaawo mu mitendera egy’oluvannyuma egy’obulwadde.

Ekikulu: Bw’oba ​​olina obubonero buno bumu oba obusingawo, tokitwala nti LEMS. Kyokka obubonero buno bwe busigala nga bukyaliwo, kiba kya magezi okugenda ew’abasawo amagezi.

LEMS etera okulabika etya n’okukulaakulana etya?

LEMS etera okusooka okukosa ebinywa by'ebisambi . Olwo kiyinza okukosa ebinywa by’ebibegabega, ebinywa by’emikono n’amagulu, ebinywa ebiyamba mu kwogera n’okumira, n’ebinywa by’amaaso.

Obulwadde buno nga bukyali, oyinza okukaluubirirwa okusituka okuva mu ntebe, okulinnya amadaala oba obusozi, oba okukola emirimu egy’amaanyi egyetaagisa okukozesa amagulu.

Obubonero butera okulabika mpola, okumala wiiki ntono okutuuka ku myezi . Wabula bw’oba ​​olina LEMS ne kookolo, obubonero buyinza okukula amangu.

Kiki ekivaako LEMS?

Nga bwe twayogeddeko emabegako, LEMS bulwadde obuziyiza endwadde . Kino kitegeeza nti ebiziyiza omubiri gwo (antibodies) bilumba ebitundu byo ebiramu. Mu LEMS, obuziyiza buno bulumba ekifo obutoffaali bw’obusimu n’ebinywa we bisisinkanira, ekifo ekigatta obusimu obuyitibwa neuromuscular junction. Okusingira ddala, zilumba emikutu gya kalisiyamu egyo. Emikutu gino egya kalisiyamu gyetaagisa nnyo obubaka bw’obusimu okutambuzibwa.

Kilowoozeeko ng’olunyiriri lwa domino. Obulumbaganyi buno butandikawo ebintu ebiwerako:

1. Obuziyiza buno bwesiba ku mikutu gya kalisiyamu ku nkomerero z’obutoffaali bw’obusimu ne buziziyiza.

2. Emikutu gya kalisiyamu bwe gikendeera, obungi bwa acetylcholine, ekirungo ekitambuza obusimu, obufulumizibwa bukendeera. Acetylcholine ono ddagala lyetaagisa nnyo mu kukola emirimu gy’ebinywa.

3. Acetylcholine bw'atafuluma, "obubaka" obugenda mu binywa tebuyita bulungi. Olwo ebinywa byo ne bitasobola kukola mu bujjuvu.

4. N’ekyavaamu, ebinywa tebikola bulungi ekivaamu okunafuwa.

Laba engeri abantu abalina kookolo w'amawuggwe ow'obutoffaali obutono gye bafunamu LEMS: Bw'oba olina kookolo mu mubiri gwo, obutoffaali obuziyiza endwadde bufuna akabonero akalaga nti "ogenda mu lutalo." Naye mu kifo ky’okulumba obutoffaali bwa kookolo (naddala, emikutu gya kalisiyamu ku ngulu w’obutoffaali bwa kookolo), obuziyiza buno bulumba emikutu gya kalisiyamu ku nkomerero z’obutoffaali bw’obusimu mu nsobi. Olwo olujegere lwe lumu olw’ebintu ne lubaawo.

Bannasayansi balowooza nti ekivaako LEMS mu bantu abatalina kookolo w’amawuggwe, abaserikale b’omubiri obutakola bulungi. Naye tekinnategeerekeka lwaki kino kibaawo.

Oyinza otya okuzuula `(LEMS)`?

Omutendera ogusooka mu kuzuula obulwadde bwa LEMS kwe kuba nti omusawo akukebere bulungi. Kino kijja kutera okuzingiramu omusawo w’obusimu, oba omusawo mukugu mu ndwadde z’obusimu n’ebinywa. Ekitundu ku nkola eno kizingiramu okubuuza ku bubonero bwo, ebyafaayo byo eby’obujjanjabi, n’eddagala lyonna ly’omira. Okukebera obusimu mu bujjuvu kukolebwa okunoonya enkola z’obunafu n’obubonero obukwatagana ne LEMS.

Ekiddako kwe kugezesa. Ebigezo bya `(LEMS)` mulimu:

• Okukebera omusaayi: Kino kiyinza okukebera oba olina obutoffaali obuziyiza emikutu gya calcium mu musaayi gwo. Abantu nga 85% abalina LEMS balina obutoffaali buno mu musaayi gwabwe.
• Electromyography (EMG): Okukebera kuno kutunuulira engeri ebinywa n’obusimu bwo gye bikolaganamu obulungi. Mu LEMS, okukebera kwa EMG kulina ebizuuliddwa ebitongole ennyo, kale kuyinza okuyamba okukakasa okuzuula obulwadde.
• Lung X-ray `(X-ray)` oba CT scan `(CT scan)` oba MRI scan `(MRI)` (ey'ekifuba): Olw'okuba embeera eyitibwa `(LEMS)` esobola okukula mu bantu abalina kookolo w'amawuggwe ow'obutoffaali obutono, okukebera kuno kunoonya obubonero bwa kookolo w'amawuggwe.

Obubonero bwa LEMS busobola okutandika emyezi okutuuka ku myaka mukaaga nga kookolo tannafuna. N’olwekyo, oluvannyuma lw’okuzuulibwa nti LEMS, olina okwekebejjebwa kookolo buli luvannyuma lwa myezi esatu oba mukaaga okumala waakiri emyaka ebiri. Omusawo ajja kukuwa amagezi ku nteekateeka y’okukeberebwa ekusaanira.

LEMS ejjanjabwa etya?

Waliwo obujjanjabi obuwerako ku LEMS.

• Okujjanjaba kookolo ali wansi: Singa LEMS ekwatagana ne kookolo, gamba nga kookolo w’amawuggwe ow’obutoffaali obutono, okujjanjaba kookolo oyo nakyo kiyinza okukendeeza ku bubonero bwa LEMS. Obujjanjabi bwa kookolo buyinza okuli obujjanjabi bw’eddagala, obujjanjabi obw’amasannyalaze, ne/oba okulongoosa. Kino kisinziira ku kika kya kookolo n’ebyo omusawo by’akugamba.
• Obujjanjabi obw’enjawulo ku (LEMS): Mu bino mulimu eddagala eriwummuza obubonero n’eddagala erifuga abaserikale b’omubiri.

Obujjanjabi bw’obubonero

• Amifampridine (Firdapse®), Guanidine: Eddagala lino lyongera amaanyi g’ebinywa. Ziyongera okufuluma kw’ekirungo ekitambuza obusimu ekiyitibwa acetylcholine ku nkulungo y’obusimu, ne zitereeza obubonero eri ebinywa.
• Pyridostigmine (Pyridostigmine - Mestinon®): Pyridostigmine ekola nga etangira okumenya kwa acetylcholine ku nkulungo y’obusimu. Kino nakyo kyongera ku bubonero bwa acetylcholine n’okulongoosa amaanyi g’ebinywa. Pyridostigmine oluusi eweebwa nga egattibwa wamu ne amifampridine okulongoosa enkola y’ebinywa n’okujjanjaba obubonero bwa LEMS ng’akamwa akakala, amaaso okukala, okuziyira, obutakola bulungi mu kwegatta, n’okukendeeza ku ntuuyo. Wabula okukozesa eddagala lya pyridostigmine ku LEMS nkozesa etali ya mutindo, ekitegeeza nti ekitongole kya U.S. Food and Drug Administration (FDA) tekikkirizza ddagala lino ku mbeera eno.

Obujjanjabi obukyusa obusimu obuziyiza endwadde

• Eddagala eriziyiza obusimu obuziyiza endwadde:Eddagala lino liyamba okuyimiriza oba okufuga omulimu gwa "defense" ogw'abaserikale b'omubiri gwo. Omusawo ayinza okukuwa eddagala lino singa eddagala eddala terifuga bubonero bwo. Okugeza, eddagala eriyitibwa prednisone liyinza okuweebwa nga lirimu oba nga tewali azathioprine oba cyclosporine.
• Okuwanyisiganya omusaayi: Mu nkola eno, ekyuma kyawula ekitundu ky’omusaayi gwo eky’amazzi (plasma) ku butoffaali bw’omusaayi. Antibodies zo ziri mu plasma eno. Oluvannyuma lw’okwawukana, omusaayi guddamu okuteekebwa mu mubiri gwo. Omusawo ayinza okulowooza ku bujjanjabi buno singa oba olina obubonero obw’amaanyi era nga weetaaga obujjanjabi obw’amangu.
• Immunoglobulins: Ku bantu abamu, obujjanjabi bwa immunoglobulin obw’amaanyi buyinza okuyamba okuziyiza obulwadde okweyongera.

LEMS esobola okuziyizibwa?

Ekituufu ekivaako obulwadde bwa LEMS tekinnategeerekeka bulungi, n’olwekyo tekimanyiddwa oba waliwo engeri y’okuziyiza obulwadde buno.

Wabula olw’okuba LEMS esobola okukula mu bantu abalina kookolo w’amawuggwe, osobola okuyamba okuziyiza kookolo w’amawuggwe ng’okozesa:

• Tonywa ssigala. Bw’oba ​​okozesa ebintu ebikolebwa mu taaba, saba omusawo akuyambe okulekera awo.
• Weewale omukka ogw’omulembe.
• Kebera amaka go oba temuli ggaasi wa Radon. Bw’omala ebbanga eddene ng’olina omukka gwa Radon kiyinza okwongera ku bulabe bw’okufuna kookolo w’amawuggwe.

Osobola n’okukola emitendera gy’okukuuma obulamu obulungi:

• Lya nnyo ebibala n’enva endiirwa. Goberera emmere ya Mediterranean oba DASH.
• Kuuma omugejjo omulungi.
• Dduyiro ng’omusawo bw’akuwadde amagezi.
• Otulo otumala - ebiseera ebisinga essaawa musanvu ku mwenda.
• Kendeeza ku situleesi yo. Situleesi esobola okwonoona obubonero.
• Weewale okunaaba mu mazzi agookya. Ebbugumu liyinza okwonoona obubonero bwa LEMS.
• Laba omusawo buli kiseera, era mutegeeze mangu singa obulamu bwo bukyuka oba bw’ofuna obubonero obupya.

LEMS esobola okuwona ddala?

Ebyembi, tewali ddagala lya LEMS. Okujjanjaba kookolo alina akakwate ku LEMS kiraze nti kitereeza obubonero bwa LEMS. Eddagala eriweweeza ku busimu obuziyiza endwadde liyinza okuyamba okufuga okulumba kw’abaserikale b’omubiri, era waliwo n’obujjanjabi obuyinza okuyamba okumalawo obubonero nga byongera ku bungi bwa acetylcholine mu nkomerero z’obusimu n’okulongoosa amaanyi g’ebinywa.

Bw’oba ​​olina LEMS nga tolina kookolo, osobola okusuubira obulamu obwa bulijjo. Bw’oba ​​olina LEMS ne kookolo, obubonero bwo buyinza okutereera okumala ekiseera (wadde nga si mu bujjuvu) singa kookolo azuulibwa n’addukanyizibwa nga bukyali.

Omutindo gw’obulamu bwo okusinga gusinziira ku buzibu bw’obubonero bwo.

Ddi lwe nnina okutuukirira omusawo wange bwe mba nnina `(LEMS)`?

Singa wabaawo enkyukakyuka mu bulamu bwo, oba singa obubonero bwo bweyongera, tuukirira omusawo wo essaawa yonna . Totya, tosattira. Abasawo baliwo okukuyamba.

Njawulo ki eri wakati wa `(LEMS)` ne `(Myasthenia Gravis - MG)`?

Obulwadde bwa Lambert-Eaton myasthenic syndrome (LEMS) ne myasthenia gravis (MG) bulina obubonero obumu obufaanagana. Zombi zireeta obunafu bw’ebinywa n’okukoowa.

Wabula obulwadde bwa myasthenia gravis (MG) butera okusooka okukosa ebinywa ebyetoolodde amaaso go n’ebinywa ebikozesebwa okumira. Oluvannyuma, kiyinza okukosa ebinywa ebisingawo eby’awamu, omuli ebinywa by’okussa n’ebinywa by’ebitundu by’omubiri.

LEMS etera okutandika n’obunafu mu bisambi byo ebya waggulu, oluvannyuma n’egenda mu mikono gyo. LEMS era esobola okuleeta obunafu mu binywa by’amaaso go, naye ebiseera ebisinga eba nnyangu okusinga myasthenia gravis (MG).

Mu myasthenia gravis (MG), obunafu obw’amaanyi obw’ebinywa by’okussa (ebinywa ebikuyamba okussa) buyinza okutta. Kino tekitera kubaawo mu LEMS.

Abantu abalina myasthenia gravis (MG) batera obutalaga bubonero bungi bwa autonomic nervous system dysfunction (e.g., amaaso okukalu, akamwa okukala, okuziyira, okukendeera kw’entuuyo, obutakola bulungi mu kwegatta). Okwawukanako n’ekyo, abantu abalina LEMS batera okuba n’okwemulugunya kuno, era obubonero buno oluusi busobola okuyamba okwawula endwadde zino zombi.

N’ekisembayo, ebintu by’olina okujjukira (Obubaka bw’okutwala awaka) .

We tutuukidde kati osanga okitegedde nti obulwadde bwa Lambert-Eaton Myasthenic Syndrome (LEMS) bulwadde obuva ku baserikale b’omubiri abakola ennyo. Obutoffaali bwo obw'obusimu tebuweereza bubaka bumala eri ebinywa byo "okukwatagana." Ekivaamu kwe kunafuwa kw’ebinywa n’obubonero obulala.

Jjukira nti abantu nga 60% abalina LEMS balina kookolo w’amawuggwe ow’obutoffaali obutono. Bw’oba ​​olina LEMS naye nga tolina kookolo, kakasa nti ggwe n’omusawo mukeberebwa kookolo buli luvannyuma lwa myezi mitono okumala waakiri emyaka ebiri oluvannyuma lw’okuzuulibwa.

Waliwo obujjanjabi. Mu bino mulimu okujjanjaba kookolo singa aba aliwo, wamu n’okumira eddagala erirongoosa empuliziganya y’obutoffaali bw’obusimu n’ebinywa. Okulongoosa empuliziganya kiyinza okulongoosa amaanyi g’ebinywa n’obubonero obulala.

Nsuubira nti amawulire gano ga mugaso gy’oli.Bulijjo jjukira nti bw’oba ​​olina ekikweraliikiriza mu by’obulamu, kirungi n’oyogera n’omusawo amanyi ku nsonga eyo.

` Lambert-Eaton myasthenic syndrome, LEMS, endwadde z’abaserikale b’omubiri, obunafu bw’ebinywa, kookolo w’amawuggwe ow’obutoffaali obutono, okukwatagana kw’obusimu, acetylcholine