Omwagalwa wo, oboolyawo maama wo, taata wo, jjajja wo oba jjajja wo alina obulwadde bwa Alzheimer? Ffenna tumanyi ennaku n’obutaba na buyambi ebiva mu kufiirwa okujjukira mpolampola n’okwerabira ffeesi z’omanyi. Obulwadde bwa Alzheimer mu butuufu mbeera eyinza okuvaako okubulwa okujjukira, okwonooneka kw’obwongo n’okutuuka n’okufa. Wadde nga tewali ddagala eriwonya bulwadde buno, waliwo eddagala eriyinza okubukendeeza ku bulwadde buno n’okuwa omulwadde obuweerero. Leero tugenda kwogera ku kiraasi emu ey’enjawulo ng’eyo ey’eddagala. Oyo ye NMDA Receptor Antagonists . Wadde erinnya lino lizibu katono, ka tulitegeere mu ngeri ennyangu.
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Emboozi entono ey’eddagala egenda mu maaso mu bwongo
Obwongo bwaffe kifo kya kyewuunyo. Kirimu obuwumbi n’obuwumbi bw’obutoffaali bw’obusimu, oba obusimu obuyitibwa neurons. Obutoffaali buno bukola ku mawulire, bujjukira amawulire, era ne bubuulira ebitundu by’omubiri ebirala eky’okukola nga buweereza obubonero bw’amasannyalaze n’eddagala okudda n’okudda eri buli omu.
Ababaka abatambuza obubonero buno obw’eddagala tubayita neurotransmitters. Omu ku babaka abo ye glutamate .
Lowooza ku glutamate ng’eryato eritwala obubaka okuva mu katoffaali k’obusimu akamu okudda mu kalala. Eryato lino lyetaaga omwalo ogw’enjawulo okugenda mu kasenge akalala n’okusimba. Omwalo ogwo gwe tuyita NMDA receptor (N-methyl-D-aspartate receptor. Eryato eriyitibwa glutamate bwe lyekwata ku mwalo guno ogwa NMDA, lisindika ekintu ekirala ekikulu ekiyitibwa calcium mu katoffaali. Calcium ono y’amaliriza obubaka obwo era atuyamba okuyiga n’okujjukira ekintu.Eno nkola ya bulijjo mu bwongo obulamu obulungi.
Kale kiki ekibaawo mu bulwadde bwa Alzheimer?
Mu butoffaali bw'obwongo bw'omuntu alina obulwadde bwa Alzheimer , glutamate omungi ennyo atandika okukolebwa . Ekibaawo nti kalisiyamu omungi ennyo akulukuta mu butoffaali obwo obw’obusimu. Teebereza ekibaawo singa ojjuza ttanka y’amazzi amazzi amangi? Kijjula. Mu ngeri y’emu, kalisiyamu omungi bw’akuŋŋaanyizibwa munda mu butoffaali, obutoffaali obwo butandika okwonooneka. Okwonooneka kuno kwe kwongera mpolampola obubonero bw’obulwadde bwa Alzheimer’s.
Laba engeri NMDA Receptor Antagonists gye ziyambamu
Ekika ky’eddagala eriyitibwa NMDA receptor antagonists kikola nga kikendeeza ku bifo amaato ago aga glutamate ag’enjawulo we gasobola okusimba ku NMDA receptor. Kwe kugamba, eddagala lino liziba ezimu ku myalo. Naye ekisinga obukulu eddagala lino lisobozesa obubaka obukulu okukulukuta . Kwe kugamba, zifuga okuyingira kwa kalisiyamu okuzikiriza kwokka nga tezireese kutaataaganyizibwa kwonna kwa maanyi mu nkola ya bulijjo ey’obwongo. Kino kikendeeza ku kwonooneka kw’obutoffaali bw’obusimu n’okufuga sipiidi y’obulwadde.
Mu kujjanjaba obulwadde bwa Alzheimer, abasawo basinga kukozesa ddagala erigenderera eddagala eddala erikwata ku busimu obuyitibwa acetylcholine. Naye NMDA receptor antagonists kibiina kikulu eky’eddagala erikola mu ngeri ey’enjawulo.
Ekirungo ekikulu ekiziyiza NMDA receptor mu kiseera kino ekikkirizibwa okujjanjaba obulwadde bwa Alzheimer ye memantine (erinnya ly’ekika Namenda XR). Kitera okulagirwa abasawo ku mitendera egy’ekigero oba egy’amaanyi egy’obulwadde buno. Oluusi, memantine eweebwa nga egattibwa wamu n’ebiziyiza ebyayogeddwako emabegako ebya cholinesterase inhibitors, ebyongera ku muwendo gwa acetylcholine. Kino kiyinza okuvaamu ebirungi mu balwadde abamu.
Naye jjukira nti eddagala lino terikola kye kimu ku buli muntu.
Era ka tubeere bamanyi ebizibu ebivaamu.
Okufaananako n’eddagala lyonna, lino liyinza okuba n’ebizibu ebitonotono.
- Okuziyira bwe bubonero obusinga okulabika.
- Ng’oggyeeko ekyo, ebintu ng’okulumwa omutwe n’okuziyira nabyo biyinza okubaawo.
- Tekitera nnyo, wabaawo okusobola okutabulwa mu bwongo .
Singa ggwe oba omulwadde wo mufuna ekimu ku bino, olina okutegeeza omusawo wo mu bwangu . Si kirungi n’akatono okulekera awo okumira eddagala oba okukyusa eddagala ku bubwo.
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Check Availability →Eddagala eddala mu maka gano n’enkozesa yaalyo
Waliwo eddagala eddala mu famire eno eriyitibwa NMDA receptor antagonists. Ebimu ku byo tubiraba mu bulamu obwa bulijjo. Ebimu biba bya bulabe katono, era bikozesebwa bubi ng’ebiragalalagala. Bannasayansi era banoonyereza ku migaso gy’eddagala ery’ekika kino eri endwadde endala ez’obusimu, gamba ng’obulwadde bwa Parkinson ne ALS (amyotrophic lateral sclerosis).
Ka tuyige ebisingawo ku nsonga eno okuva ku kipande ekiri wansi.
| Erinnya ly’eddagala | Enkozesa enkulu | Ensonga enkulu n’akabi akayinza okuvaamu |
|---|---|---|
| Ekirungo kya Dextromethorphan | Kibeera mu siropu z’okusesema. | Okutwalira awamu tekirina bulabe, naye kiyinza okuba eky’obulabe singa kimira mu ddoozi nnyingi. |
| Ekirungo kya ketamine | Eddagala eriweweeza ku bulwadde (eri abantu n’ebisolo). | Ekozesebwa okumalawo obulumi nga balongoosebwa. Naye nga yatulugunyizibwa nga "kiragala kya kiraabu". Ayinza okuleeta ebirooto n’okuwulira nga yeekutudde ku mubiri. Okunoonyereza kugenda mu maaso ku nkozesa yaayo mu mbeera ng’okwennyamira. |
| Ekirungo kya phencyclidine (PCP) . | Akozesebwa obubi ng’ekiragalalagala. | Mu kusooka yakolebwa ng’eddagala eribudamya, yaggyibwa mu kukozesebwa olw’ebizibu eby’amaanyi (okulaba ebirooto, okutabulwa). Eddagala ery'obulabe erimanyiddwa nga "Angel Dust". Ekwatagana n’enneeyisa ey’effujjo. |
Obubaka Obutwala Awaka
- Wadde ng’obulwadde bwa Alzheimer tebusobola kuwona ddala, eddagala eriziyiza NMDA receptor antagonist nga memantine liyinza okuyamba okuddukanya emitendera egy’ekigero oba egy’amaanyi egy’obulwadde nga likendeeza ku kwonooneka kw’obutoffaali bw’obwongo.
- Eddagala lino likola nga likuuma obutoffaali bw’obusimu okuva ku glutamate ayitiridde mu bwongo.
- Nga bwe kiri ku ddagala lyonna, ebizibu ng’okuziyira bisobola okubaawo. Bulijjo kino kiteese n’omusawo wo. Tokyusa mu ddoozi oba okulekera awo okumira eddagala ku bubwo.
- Ebiragala eby’ekika kino nga Ketamine ne PCP, bikozesebwa bubi ng’ebiragalalagala era bya bulabe nnyo. Waliwo enjawulo nnene wakati w’eddagala lino n’eddagala eriwandiikibwa ku bulwadde bwa Alzheimer.
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