Olina obuzibu bw’okukozesa eddagala eribudamya? Ka tuyige ku (Obulwadde bwa Pseudocholinesterase)?

Wali owuliddeko ng’otya katono olw’eddagala eribudamya abantu lye bakulongoosebwa? Kya bulijjo abantu abamu okuwulira bwe batyo. Naye teebereza ekyandibaddewo singa ezimu ku ddagala ly’okubudamya omuntu lye bakuweebwa terituukira ddala ku mubiri gwo. Leero tugenda kwogera ku mbeera emu bwetyo etali ya bulijjo, naye enkulu ennyo gy’olina okumanya. Eyo mbeera eyitibwa `(Pseudocholinesterase Deficiency)`.

`(Obulwadde bwa Pseudocholinesterase)` kye ki? Ka tukitegeere mu ngeri ennyangu, nedda?

Okay, erinnya lino liwulikika nga liwanvu katono, si bwe kiri? Tukikuume nga kyangu. `(Pseudocholinesterase)` ye enzyme ey'enjawulo `(Enzyme)` mu mubiri gwaffe. Omu ku mirimu emikulu egya `(Enzyme)` eno kwe kumenya (kwe kugamba, `(metabolize)`) mu mubiri ezimu ku ddagala eriweebwa okuwummuza ebinywa , naddala nga tubudamye (bino tubiyita `(Choline esters)`). Teebereza, ng’olongoosebwa, ebinywa byo byetaaga okusannyalala okumala akaseera. Lino lye ddagala eriweebwa olw’ekyo.

Kati, mu mbeera eyitibwa `(Pseudocholinesterase Deficiency)`, ekibaawo nti kino `(Enzyme)` ekiyitibwa `(Pseudocholinesterase)` mu mubiri gwo oba tekikolebwa kimala , oba tekikola bulungi . Kiki ekibaawo olwo? Eddagala eriweebwa okuwummuza ebinywa (`(Succinylcholine)` ne `(Mivacurium)` bye byokulabirako bibiri ku kino) teriggyibwa mu mubiri mangu. Zibeera mu mubiri okumala ebbanga ddene.

N’ekyavaamu, ebinywa byo biyinza okusigala nga biwunya okumala ebbanga eddene oluvannyuma lw’okubudamya, era oyinza n’okukaluubirirwa okussa. Kino kitegeeza nti oyinza obutasobola kutambula oba kussa ku bubwo okutuusa ng’ebiva mu ddagala biweddewo.

Embeera eno ya bulijjo etya?

Mu butuufu, embeera eno eyitibwa `(Pseudocholinesterase Deficiency)` si ya bulijjo nnyo . Ku kigero, abantu nga omu yekka ku buli bantu 3,200 oba 5,000 mu bantu be bafuna embeera eno. Kwe kugamba, omuwendo omutono ennyo.

Obubonero bwe buliwa? Kino okitegeera otya?

Abantu abasinga abalina embeera eno tebagimanyi okutuusa nga bafunye ekika ky'eddagala eribudamya lye nnayogeddeko emabegako, eriyitibwa ``Choline esters.'' Awo obubonero obukulu we bulabika:

• Ebinywa ebiwummudde ekisusse (i.e., ebitaliimu bulamu) okumala ekiseera ekiwanvu okusinga bwe kyandisuubiddwa mu budde obwa bulijjo.
• N'ebinywa ebikuyamba okussa bifuuka ebitali bikola okumala akaseera .

Kiyinza okutwala essaawa ntono obubonero buno okukka. Obudde buno bwawukana okusinziira ku muntu. Mu kiseera kino, ttiimu yo ey'abasawo ejja kukukuuma ng'oli wansi w'eddagala eribudamya era ejja kukuyamba okussa ng'oyita mu ``ventilator'', ekyuma eky'obutonde ekissa, okutuusa lw'onoosobola okussa ku bubwo.

Biki ebivaako? Kino kibaawo kitya?

Embeera eno (Pseudocholinesterase Deficiency) esobola okusikira (i.e. okusikira), oba eyinza okukula mu bulamu obw’oluvannyuma..

Ebivaako eby’obusika

Abantu abazaalibwa n’embeera eno balina enkyukakyuka, oba enkyukakyuka, mu buzaale obuyitibwa `(BCHE)`. Ensengekera eno eya `(BCHE)` y’egamba omubiri gwaffe okukola enziyiza ya `(Pseudocholinesterase)`. Kale, bwe wabaawo enkyukakyuka mu ggiini eno, oba omubiri gwo gukola kitono nnyo ku enzyme eno, oba guyinza obutagikola n’akatono.

Ebivaako ebikula mu bulamu (Acquired) .

Oluusi, embeera eno (Pseudocholinesterase Deficiency) esobola okubaawo mu bulamu bwonna. Kiyinza okuva ku ndwadde ez’enjawulo n’eddagala erimu.

Ezimu ku ndwadde eziyinza okuleeta embeera eno:

• Endya embi
• Ebisago eby’amaanyi eby’okwokya
• Obulwadde bw’ekibumba
• Obulwadde bw’ekibumba
• Obulwadde bwa Hypothyroidism (thyroid obutakola bulungi) .
• Kookolo
• Okufuna olubuto

Eddagala erimu eriyinza okwongera ku bulabe bw’embeera eno mulimu:

• Ebiziyiza MAO (e.g. Phenelzine (Nardil®)) .
• Empeke eziziyiza okuzaala (Eddagala eriziyiza okuzaala) .
• Amatondo g’amaaso aga Echothiophate
• Eddagala lya Metoclopramide
• Ekirungo kya Cyclophosphamide
• Eddagala lya Pyridostigmine

Abasawo kino bakizuula batya?

Bw’oba ​​olina obuzibu okufuga ebinywa oba okussa oluvannyuma lw’okubudamya, omusawo ayinza okuteebereza nti olina obuzibu bwa pseudocholinesterase. Okukakasa kino, basobola okukebera omusaayi okukebera emiwendo gyo egy’ekirungo kya pseudocholinesterase.

Singa omuntu mu maka go alina embeera eno, omusawo asobola okukola okukebera obuzaale okuzuula oba naawe olina. Kino kizingiramu okutwala omusaayi n’okukebera okulaba oba olina enkyukakyuka y’obuzaale (BCHE).

Singa omusawo wo ateebereza nti olina embeera eno, ajja kukozesa ebika ebirala eby'eddagala eriwummuza ebinywa ebiteesigama ku enzyme ``Pseudocholinesterase''.

Obujjanjabi bwe buliwa?

Bw’ofuna obubonero bwa `(Pseudocholinesterase Deficiency)` ng’omaze okuweebwa eddagala eribudamya abantu bonna, oyinza okwetaaga okujjanjabibwa mu bwangu. Ttiimu y’abasawo ejja kukulondoola nnyo okutuusa lw’onoodda engulu. Bwe kiba kyetaagisa, bajja kukukuuma ng’olina eddagala eribudamya era bakozese ekyuma kya `` mechanical ventilation`` okukuyamba okussa okutuusa lw’onoosobola okussa ku bubwo.

Kiki ky’osaanidde okusuubira singa oba olina embeera eno?

Bw’oba ​​ozuuliddwa nti olina `(Pseudocholinesterase Deficiency)`, ekisinga obulungi ky’oyinza okukola kwe kutegeeza abasawo bo ku nsonga eno – naddala abasawo abagenda okukulaba okulongoosebwa .

Ate era, kino naawe olina okukibuulira ab’omu maka go., olwo era zisobola okukeberebwa okulaba oba zirina enkyukakyuka y’obuzaale eya `(BCHE)`. Bwe kiba bwe kityo, era balina okutegeeza abasawo baabwe nga tebannaba kulongoosebwa kwonna.

Era kirungi okwambala akakomo akalaga endagamuntu y’abasawo abasawo basobole okumanya oba weetaaga okulongoosebwa mu bwangu.

Kino kisobola okuziyizibwa?

Obutabeera na Pseudocholinesterase mbeera ya buzaale era nga tesobola kuziyizibwa. Wabula singa omuntu mu maka go akifuna, osobola okukeberebwa okuzuula enkyukakyuka mu buzaale bwa BCHE nga tonnafuna bujjanjabi bwa kubudamya. Kino kiyinza okuyamba okuziyiza ebizibu nga balongoosebwa.

Bw’oba ​​olina enkyukakyuka mu buzaale, omusawo wo kirabika ajja kubuuka Choline esters n’alonda eddagala ery’enjawulo eribudamya. Rocuronium lye ddagala erisinga okukozesebwa mu kubudamya abantu abalina obulwadde bwa Pseudocholinesterase Deficiency.

Oyinza okukendeeza ku bulabe bw’okufuna obulwadde bwa Acquired Pseudocholinesterase Deficiency ng’ogenda mu maaso ng’ojjanjaba embeera ezikusibukako, gamba ng’endya embi oba obulwadde bw’ekibumba obutawona (CKD). Ekirala bw’oba ​​omira eddagala lyonna erikendeeza ku kukola enziyiza ya Pseudocholinesterase, oyinza okwogera n’omusawo wo ku ky’okukyusa eddagala lyo.

Biki ebiziyiza, kwe kugamba, ddagala ki eritali ddungi kukozesa eri abantu abalina embeera eno?

Bw’oba ​​ozuuliddwa n’obulwadde bwa `(Pseudocholinesterase Deficiency)`, olina okwewala ebika by’eddagala eriweweeza ku bulwadde buno wammanga :

• Succinylcholine `(Succinylcholine)`
• Ekirungo kya Mivacurium
• Eddagala lya Procaine
• Ekirungo kya Chloroprocaine
• Eddagala lya Benzocaine
• Eddagala lya Tetracaine

Ebibuuzo by’olina okubuuza omusawo wo

Bwoba olina embeera eyitibwa ``Pseudocholinesterase Deficiency'', oba wazaalibwa nayo oba yafuna oluvannyuma, oyinza okwagala okubuuza omusawo wo ebibuuzo ebimu nga:

• Biki ebituufu ebinziyiza, kwe kugamba, ddagala ki lye nnina okwewala?
• Embeera eno kintu kye nazaalibwa nakyo oba kiva ku bulwadde obulala?
• Kirungi okukebera obuzaale ku maka gange?

Okugenda mu kulongoosebwa kiyinza okukuleetera okunyigirizibwa katono. Bangi ku ffe essira tulitadde nnyo ku kulongoosebwa ne kiba nti tetulowooza na ku ky’okusobola okukosa eddagala erisumulula. Tewali ddagala eriwonya obulwadde bwa Pseudocholinesterase Deficiency. Wabula okumanya oba olina kiyinza okukuyamba okwewala okunafuwa kw’ebinywa okumala akaseera n’okukaluubirirwa mu kussa ebiyinza okubaawo oluvannyuma lw’okulongoosebwa. Bw’oba ​​olina obulwadde bwa Pseudocholinesterase Deficiency, bubuulire ab’omu maka go. Era basobola okukeberebwa obuzaale ne beewala ebizibu byonna ebiteetaagisa ebiyinza okuva mu lugendo lwabwe olw’obulamu.

N’ekisembayo, ebintu by’olina okujjukira

Kale, `(Pseudocholinesterase Deficiency)` linnya eritiisa katono, naye kikulu nnyo okulimanya. Naddala bw’oba ​​ogenda kulongoosebwa, oba omuntu mu maka go bw’aba afunye ekintu nga kino , kirungi okwogera n’abasawo bo ku nsonga eno. Jjukira nti okumanyisa abantu emirundi mingi y’engabo esinga obulungi eyinza okutuwonya ebizibu ebiteetaagisa!

` Okubudamya, pseudocholinesterase, obutaba na enzyme, ebizibu ebiva mu kulongoosa, embeera y’obuzaale, obutakola bulungi binywa, eddagala eribudamya