Endwadde zino eziyitibwa Motor Neuron Diseases ze ziruwa? Ka tubitegeere mu ngeri ennyangu.

Wali weebuuzizzaako engeri gye kyangu okukola ebintu bino nga tutambula, nga twogera ne mukwano gwaffe, oba nga tukamula emmere yaffe? Emabega wa buli ntambula, buli kikolwa, waliwo ekibinja ky’ababaka abakulu ennyo mu mubiri gwaffe. Zino ze tuyita obusimu obuyitibwa motor neurons. Balinga ekibinja ky'abaweereza okuva mu bwongo bwaffe nga bagamba ebinywa byaffe "okukola kino."

Naye, okufaananako n’ebitundu by’omubiri gwaffe ebirala, n’ababaka bano basobola okwonooneka. Wano we tufuna embeera eziyitibwa ‘endwadde z’obusimu obukola emirimu’. Oboolyawo owuliddeko ku ALS. Eyo y'emu ku ndwadde enkulu mu kiti kino. Naye waliwo n’ebika ebirala ebiwerako eby’endwadde z’obusimu obukola emirimu gy’omubiri (motor neuron diseases) ze tutawulira nnyo. Kale leero, ka tubyogereko mu ngeri ennyangu.

‘Obusimu obuyitibwa motor neurons’ buno be baani?

Mu ngeri ennyangu, obusimu obuyitibwa motor neurons kika kya butoffaali bwa busimu. Omulimu gwabwe omukulu kwe kutambuza obubaka emibiri gyaffe bwe gyetaaga okutambula. Bino birina ebika bibiri ebikulu.

1. Obusimu obukola emirimu egy’okungulu: Buno buli mu bwongo bwo . Ziweereza obubaka okuva ku bwongo bwo okutuuka ku mugongo gwo. Nga bboosi mu ofiisi ennene.

2. Obusimu obuyitibwa lower motor neurons: Buno busangibwa mu mugongo gwo . Baggya obubaka mu bwongo ne bagamba ebinywa byaffe nti, "Okay, tandika okukola kati." Kiba nga maneja ku ttabi.

Kati lowooza ku kiki ekibaawo ng’ofunye obulwadde bwa motor neuron. Obutoffaali buno obw’obusimu butandika okufa mpolampola. Olwo obubaka bw’amasannyalaze obuva mu bwongo tebusobola kutuuka bulungi ku binywa. Okutambuza obubaka kuyimirira wakati mu kkubo. Ekiseera bwe kigenda kiyitawo, ebinywa binafuwa ne bitandika okukendeera kubanga tebirina mugaso gwonna gye bikola. Kino abasawo bakiyita ‘atrophy’, oba okusaasaana kw’ebinywa.

Kino bwe kibaawo, tubulwa obuyinza ku ntambula zaffe. Kyeyongera okukaluba okutambula, okwogera, okumira, era okukkakkana n’okussa.

Bika ki ebikulu eby’obulwadde bw’obusimu obuyitibwa motor neurone?

Kati katutunuulire ezimu ku ndwadde ezimanyiddwa ennyo era ezitamanyiddwa nnyo mu kiti kino.

Obulwadde bw’okusannyalala mu bitundu by’omubiri ebiyitibwa Amyotrophic Lateral Sclerosis (ALS) .

Buno bwe bulwadde obusinga okulabika mu bantu abakulu.ALS ekosa obusimu obuyitibwa motor neurons obwa waggulu n’obwa wansi. Kino kireetera ebinywa ebifuga okutambula, okwogera, okukamula, okumira n’okussa okunafuwa mpolampola ne bikendeera. Okukaluba kw’ebinywa n’okunyiganyiga nakyo kiyinza okubaawo.

Ebiseera ebisinga, tewali nsonga ntongole eyinza kuzuulibwa ku ALS. Abasawo bakiyita ‘sporadic’. Kino kitegeeza nti omuntu yenna asobola okukikulaakulanya. Wabula wakati wa 5% ne 10% ku balwadde ba nsikirano . Obubonero butera okulabika wakati w’emyaka 40 ne 60.

Obulwadde bw’okusannyalala mu mabbali obusookerwako (PLS) .

PLS efaananako ne ALS, naye ekosa obusimu obuyitibwa upper motor neurons bwokka . Kino kifuula obulwadde buno okubeera empola ennyo okusinga ALS. Obubonero buno mulimu okunafuwa n’okukaluba mu mikono n’amagulu, okutambula mpola, n’okubulwa bbalansi n’okukwatagana. Okwogera kuyinza okuba nga kugenda mpola era nga tekufuuse kizibu. Si kya maanyi nga ALS, era tekitta bantu.

Obulwadde bw’okusannyalala mu bitundu by’omubiri (PBP) .

Mu butuufu eno ngeri ya ALS. Abantu bangi abalina PBP okukkakkana nga bafunye ALS, ekosa obusimu obukola emirimu mu kikolo ky’obwongo, ekisangibwa wansi w’obwongo.

Obusimu buno obuli mu kikolo ky’obwongo butuyamba okukamula, okumira n’okwogera. N’olwekyo PBP bw’ekula, ebigambo biba bifuuse bifuuse, emmere efuuka nzibu okumira, era kizibu okufuga enneewulira . Oyinza okuseka oba okukaaba amangu ago awatali nsonga.

Okukendeera kw’ebinywa okugenda mu maaso

Ekika kino si kya bulijjo nga ALS oba PBP. Okusinga kikosa obusimu obukola emirimu egy'omubiri egya wansi . Obunafu butera kutandikira mu ngalo. Oluvannyuma busaasaana mu bitundu by’omubiri ebirala. Ebinywa binafuwa era okuzimba kuyinza okubaawo. Obulwadde buno era oluusi busobola okufuuka ALS.

Okukendeera kw’ebinywa by’omugongo (SMA) .

Eno mbeera ya buzaale . SMA ereetebwa ekikyamu mu buzaale obuyitibwa `SMN1`. Ensengekera eno ekola puloteyina ekuuma obusimu obuyitibwa motor neurons. Puloteeni eyo bw’ebula, obusimu obuyitibwa motor neurons bufa. Kino kikosa obusimu obuyitibwa motor neurons obwa wansi. SMA egabanyizibwamu ebika ebiwerako okusinziira ku myaka obubonero gye bulabika.

Obulwadde bwa Kennedy

Buno era bulwadde bwa nsikirano. Naye eky'enjawulo ku kino kiri nti obulwadde buno bukosa basajja bokka . Enkazi ne bwe ziba n’obuzaale obuyamba ku bulwadde buno (abasitula), tezifuna bubonero. Wabula waliwo emikisa 50% nti omwana omusajja owa maama oyo ajja kusikira obulwadde buno.

Abasajja abalina embeera eno bayinza okukankana emikono, okunyiga ebinywa n’okusannyalala, okunafuwa mu maaso, emikono n’amagulu. Era bayinza okukaluubirirwa okumira n’okwogera.

Obeera otya n'obulwadde nga buno?

Ebiseera by’omu maaso eby’omuntu abeera n’obulwadde bwa motor neurone bisinziira ku kika ky’obulwadde. Nga bwe tulabye, ebika ebimu bikula mpola ate nga tebirina maanyi nnyo okusinga ebirala.

Eddagala eririwo kati n’enkola ez’enjawulo ez’obujjanjabi (e.g., obujjanjabi bw’omubiri, obujjanjabi bw’okwogera) bisobola okufuga obubonero n’okulongoosa ennyo omutindo gw’obulamu . N’olwekyo, bw’oba ​​ggwe oba omuntu gw’omanyi afuna obubonero buno, ekisinga obulungi kwe kulaba omusawo alina ebisaanyizo amangu ddala nga bwe kisoboka okuzuula ekituufu n’okukola enteekateeka y’obujjanjabi.