Oluusi omusawo ayinza okukugamba nti waliwo enkyukakyuka entono mu buzaale bwo, eyitibwa ‘Robertsonian Translocation’. Oyinza okutya ng’owulira ebigambo bino. Kya bulijjo okulowooza ebintu nga, ‘Buno bulwadde bwa maanyi? Kinaaba kizibu eri abaana bange?’. Naye totya. Kino kintu abantu bangi kye bamanyi naye kirungi okumanya. Embeera eno etatera kubaawo nnyo, ekitegeeza nti ku kigero, omuntu omu yekka ku buli bantu 900 y’asobola okubufuna. Leero, tugenda kukyogerako mu ngeri ennyangu ennyo, mu ngeri gy’osobola okutegeera.
Mu ngeri ennyangu, obuzaale ne chromosomes kye ki?
Kino nga tetunnakitegeera, katulabe engeri emibiri gyaffe gye gikolebwamu. Kuba akafaananyi ng’emibiri gyaffe tterekero ly’ebitabo eririmu ekisenge ekinene eky’ebitabo. Buli kitabo ekiri mu tterekero lino kirimu ebiragiro ebyatutonda.
Ebitabo bino bye tuyita chromosomes mu busawo. Zino ze zitereka amawulire gaffe gonna ag’obuzaale - ensengeka y’ebiragiro ebisalawo buli kimu okuva ku langi y’enviiri zaffe, langi y’amaaso, obuwanvu, ne langi y’olususu.
Mu budde obwabulijjo, omuntu omulamu obulungi alina ensengekera z’obutonde (chromosomes) 46. Ku bano, tufuna 23 okuva ku maama waffe ate endala 23 okuva ku kitaffe.
Kale okukyusakyusa kuno okwa Robertsonian kubaawo kutya?
Ku chromosomes 46 eziri mu mubiri gwaffe, chromosomes 13, 14, 15, 21, ne 22 za njawulo katono. Ziyitibwa chromosomes eziyitibwa acrocentric chromosomes . Chromosomes zino zirina ‘omukono’ gumu nga mumpi nnyo. Ekisinga obukulu, omukono guno omumpi kumpi teguliimu mawulire ga buzaale geetaagisa mu nkola y’omubiri gwaffe.
Kati, mu Robertsonian Translocation, ekibaawo kiri nti emikono emimpi egya chromosomes bbiri ku ttaano eza acrocentric ze nnayogeddeko emabegako gikutuka, era emikono emiwanvu egya chromosomes ezo ebbiri ne gikwatagana. Kiba ng’okumenya obutundutundu bubiri obutono obw’emiggo ebiri n’obuggyamu, n’oluvannyuma n’osiiga obutundutundu obunene obubiri obusigaddewo. Olwo emikono egyo emitono ebiri egitalina mugaso ne giweddewo.
Chromosomes bbiri bwe zigattibwa wamu mu ngeri eno, kati omuwendo gw’ensengekera z’obutonde bw’omuntu oyo guba 45, so si 46. Naye tajja kuba na buzibu bwonna mu bulamu. Kubanga obutundutundu obutonotono obutaliimu buzaale bukulu bwe bwabula.
Waliwo ebika bya kino?
Yee, embeera eno esobola okwawulwamu ebika bibiri ebikulu. Ojja kukitegeera mangu ng’otunuulira emmeeza eno.
| Okuwandiika | Okunnyonnyola |
|---|---|
| Okukyusa kwa Robertsonian okutebenkevu (okutebenkevu) . | Abantu abalina embeera eno tebalina bubonero wadde obuzibu mu bulamu. Bawangaala obulamu obuwanvu era nga balamu bulungi. Ebiseera ebisinga, tebamanyi na nti bagirina. Abantu bano bayitibwa ‘abasitula’ kubanga tebalina mbeera eno, naye basobola okubuyisa mu baana baabwe. |
| Okukyusa Robertsonian okutali kwa bbalansi (Okutali kwa bbalansi) . | Wano we wayinza okuvaamu ebizibu. Wano omwana w’afunira obuzaale obuyitiridde oba obutono. Kino kitera okuzuulibwa ng’omwana amaze okuzaalibwa. Oluusi ne bwe kiba nti ensengekera z’abazadde zibeera za bulijjo, embeera eno esobola okubaawo ng’omwana akula mu lubuto. Tekitera nnyo, omu ku bazadde aba musitula era omwana asobola okufuna embeera eno. |
Omwana asikira atya embeera eno?
Omukwasi wa Robertsonian Translocation bw’aba n’omwana n’omuntu omulala, obuzaale buno busobola okusikira mu ngeri ssatu enkulu. Teebereza nti ggwe asitula.
1. Omwana omulamu obulungi ddala: Omwana wo asobola okusikira ensengekera y’obutonde (chromosomes) eya bulijjo okuva gy’oli ne munno. Olwo omwana tajja kuba na buzibu bwonna mu buzaale. Kijja kuba kya bulamu ddala.
2. Omwana naye ajja kuba musitula: Omwana, nga ggwe, ayinza okusikira chromosome translocated ne chromosomes ezabulijjo. Olwo omwana tajja kuba na buzibu bwonna mu bulamu. Naye naye ajja kufuuka omusitula nga ggwe mu biseera eby’omu maaso.
3. Embeera etali ya bbalansi: Eno omwana bw’afuna obuzaale obw’enjawulo oba obutono. Ng’ekyokulabirako, omwana ayinza okufuna chromosome eya bulijjo wamu ne chromosome ey’enjawulo. Kino kiyinza okuleetera omwana okuba n’embeera z’obuzaale ezimu, gamba ng’obulwadde bwa translocation Down syndrome oba Patau syndrome . Kyokka, obutonde n’obuzibu bw’embeera eno bisinziira ku chromosomes entuufu ezifunibwa.
Waliwo akabi akalala akayinza okuvaamu?
Omukyala alina obulwadde bwa Robertsonian translocation ayinza okuba n’obulabe obusingako katono ku bwa bulijjo obw’okuvaamu olubuto. Ekirala abasajja abamu abalina embeera eno bayinza okufuna ensigo okukendeera oba obusobozi bw’okufulumya ensigo okukendeera.
Otegeera otya embeera eno?
Abantu bangi tebamanyi nti basitula. Bazuula oba nga bamaze okuvaamu embuto enfunda eziwera oba omwana azaalibwa n’embeera y’obuzaale. Olwo omusawo ajja kulagira bakebere bazuule.
Ekigezo okuzuula kino kyangu nnyo. Kye kigezo kyangu eky'omusaayi . Omusaayi omutono gukuggyibwako era chromosomes eziri mu butoffaali bw’omusaayi zikeberebwa mu microscope. Okugezesebwa kuno kuyitibwa Karyotyping . Olwo kiyinza okulabibwa obulungi oba olina chromosomes zonna 46 mu nsengeka, oba olina emu entono (45), era oba waliwo chromosomes zonna ezikwatagana.
Bw’oba okimanyi nti waliwo omuntu mu maka go alina embeera eno ey’obuzaale, omusawo ayinza okukuwa amagezi ggwe ne munno mukebere kuno nga temunnagezaako kuzaala mwana.
Kya bulijjo okuwulira ng’otya n’okweraliikirira ng’otegedde embeera eno. Naye ekisinga obukulu kwe kufuna amawulire amatuufu n’okunoonya amagezi ag’omusawo ageetaagisa.
Obubaka Obutwala Awaka
- Robertsonian Translocation si bulwadde bwa kutya. Abantu abasinga obungi abalina (carriers) baba balamu ddala era babeera mu bulamu obwa bulijjo.
- Ekisinga okukosa kino kwe bulabe bw’okuyisa obuzaale ku mwana. Kyokka ne bw’oba oli musitula, okyalina emikisa mingi egy’okuzaala abaana abalamu.
- Bw’oba olina embuto ezitaggwaawo, ng’olina obuzibu mu kufuna embuto oba ng’olina endwadde z’obuzaale mu maka, kiba kya magezi okwogera n’omusawo wo ku ky’okukeberebwa nga karyotyping.
- Bw’oba olina ekibuuzo ekirala kyonna ku nsonga eno, tolwawo kubuuza musawo wo . Ajja kukuwa amawulire gonna, amagezi, n’okukusindikibwa okubudaabudibwa ku buzaale bwe kiba kyetaagisa.
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