Taksa chhunga iron control tu Hepcidin chungchang hi i zir mai ang u?

Hepcidin tih hming hi i hre tawh em? I la nei lo pawh a ni mai thei. Mahse hei hi kan taksaah hmun pawimawh tak a chang a ni. A dik tak chuan he Hepcidin hi kan taksaa iron awm zat control tu ber a ni. Chuvangin vawiin hian he Hepcidin chungchang hi han sawi ila, kan taksaah eng nge a tih tih te, awlsam tak leh friendly takin kan sawi dawn a ni.

Hepcidin chu eng nge ni? A awlsam zawngin...

Hepcidin hi kan taksaa hormone siam chhuah a ni. Hormone chu kan taksaa hnathawh zawng zawng thununtu leh thu hriatna phur chhuaktu, palai te tak te ang a ni. Chuvangin he hormone hepcidin an tih hi kan taksain iron a hman dan tur, taksain iron a mamawh zat leh a khawlkhawm tur zat tur a hril a ni.

Iron hi kan taksa tana mineral pawimawh tak a ni. Kan thisen sen (red blood cells)-a protein hemoglobin siam chhuahna atana thil pawimawh tak chu iron a ni tih i hria em? He hemoglobin hi oxygen nena inzawm a, kan taksa peng hrang hranga kan tissue leh organ hrang hranga phurtu a ni. Oxygen taxi ang maiin a che!

Chu mai ni lovin, kan taksa peng leh thinlunga oxygen petu protein myoglobin siam nan pawh iron a ngai a ni.

Chuvangin, he hepcidin hi "master of iron control" an ti fo thin. A chhan chu hemoglobin leh red blood cell siam ang chi thil pawimawh tak tak tih nan kan cell ten iron an mamawh zat a control vang a ni. Ngaihtuah teh, thir tlakchhamna kan neih chuan eng nge thleng ang? Iron tlakchhamna avanga thisen tlakchhamna (anemia) a lo awm thei. Chumi awmzia chu taksain thisen sen (red blood cells) a siam chhuak tawk lo tihna a ni. Kawng lehlamah chuan thir kan neih tam lutuk chuan engtin nge ni ang? Chu pawh chu taksa tan a tichhe hle a, rulhut ang maiin, a chang chuan nunna atana hlauhawm tak pawh a ni.

Khawiah nge he hepcidin hi kan taksaah hian siam chhuah a nih?

Hepcidin hi kan liver ah a lo chhuak ber a . A lo insiam tawh chuan kan thisenah a lut ta a ni.

Hepcidin hian eng nge a tih tak tak?

Hepcidin hi "iron regulation siamtu" a ni tih kan sawi tawh bawk. Chu chu kan taksaah iron homeostasis vawng reng turin a pui tihna a ni a, chu chu iron awm zat chu a level dik takah dah a ni tihna a ni a, a tlem lutuk lo va, a tam lutuk lo bawk.

Kan ei leh in atang hian iron kan hmu thin. Sa, sangha, thlai, leh nut ang chi ei tur atang hian iron kan hmu thin. Mahse, mineral dang ang lo takin kan taksa hian iron tam lutuk paih chhuahna tur kawng nghet tak a nei lo. Entirnan, sodium kan neih tam lutuk chuan zunah a chhuak ang. Mahse, iron hi kan taksa a\angin tlemte chauh a bo a, chu chu thisen hloh vang emaw, cell thih emaw a ni.

Chu ai chuan kan taksa hian thir a khawlkhawm zawk a, a tul huna hman tur a ni. Kan ruhro, kan ril, leh kan thin ang chi hmunah hian iron kan dah khawm a ni . Taksa chhunga iron awm zawng zawng zinga 70% vel chu a hmaa kan sawi tawh thisen sen (red blood cells)-a hemoglobin-ah hian a awm a ni.

Chuvangin, he hepcidin hi iron dahkhawmna, hmun khat atanga hmun danga sawn, leh hman lehna tura puitu process te nasa taka thlawptu a ni. Chu chu kan cell chhunga iron awm chu a tul huna a awm theih nan a control a, chubakah iron tam lutuk chu taksa tan harsatna a nih loh nan a control bawk.

Hepcidin hian a inrawlh ber a:

• Iron absorption controlling: Iron absorption chu kan ei leh in atanga iron kan thisenah kan intestine te tak te atanga kan luh dan a ni. Thisen a thlen hnuah chauh taksain thir hi a hmang thei a ni. Chuvangin, hepcidin hian thisenah iron engzat nge a luh tih leh engzat nge a dahkhawm tih a control a ni.
• Macrophages-a Iron Recycling: Macrophages hi thisen var chi khat, kan taksa tifaitu sipai ang mai a ni. Thisen sen hlui, thi mai tur tichhetu leh thisen sen thar tan hmun siamsaktu an ni. Kan ruhro hian ni 120 danah thisen sen thar a siam chhuak thin. Chuvangin, macrophage te hian heng thisen sen hlui te hi an tihchhiat hian an chhunga hemoglobin atanga iron chu an man ta a ni. Hepcidin hian chu iron chu macrophages chhungah dah a nih leh nih loh emaw, taksaa chhuah leh a nih leh nih loh a hril a ni.
• Iron dahkhawm chhuah: Iron hi kan liver cell ( hepatocytes an tih) leh kan small intestine cell ( enterocytes an tih) ah te a awm a. Hepcidin hian chu iron chu chu cell chhungah a awm reng leh awm loh emaw, hman tur atana chhuah a nih leh nih loh emaw a control a ni.

Engtin nge hepcidin hian iron absorption a control theih?

Thil ngaihnawm tak chu hepcidin hian eng process pawh initiate in iron absorption a regulate lo tih hi a ni. Chu ai chuan, iron absorption puitu process te chu a titawp zawk a ni.

Hepcidin hian protein pakhat ferroportin an tih nen hna a thawk a . He ferroportin hi kan taksaa "iron transporter" ang a ni. A hna chu a dahkhawlna hmun (macrophages, hepatocytes, enterocytes) atanga iron chhuah tir a, taksa cell inkara iron kal leh haw tir hi a ni. Ferroportin hi taksain iron a hman theih nan small intestine atanga thisenah a phur lut thin a ni.

Hepcidin hian he ferroportin hi a binding a. Tichuan ferroportin chu a chhe ta a ni. Chutiang a nih chuan ferroportin hmanga thisen chhunga phurh luh theih tur thir chu a dahna hmunah te chuan a tang ta vek a ni.

Hetiang hian han ngaihtuah teh:

* Hepcidin a pun chuan , ferroportin tan thisenah iron phurh luh a harsa thin. Chumi awmzia chu iron absorption a tlahniam tihna a ni.

* Hepcidin a tlem chuanFerroportin hian awlsam takin thisenah iron a phur lut thei a, chu chu iron absorption a tipung tihna a ni.

I hrethiam em? A awlsam hle mai, a ni lawm ni?

Eng thilin nge kan taksaa Hepcidin awm zat a nghawng?

I taksaa hepcidin i neih zat hi i taksain signal a thawn dan a zirin a innghat a ni. Chhan hrang hrang avangin i taksa hian hepcidin tam emaw tlem emaw siam turin signal a dawng thin.

Chutiang thil thenkhat chu hetiang hi a ni:

• Taksa chhunga iron awm zawng zawng: Taksain iron a neih tlem chuan taksain hepcidin siam tlem turin signal a pe a ni. Taksain iron a neih tam chuan taksain hepcidin tam zawk siam turin signal a pe a ni.
• Red blood cell production: Taksain thisen sen siam nan hemoglobin a mamawh tam chuan hepcidin level a tlahniam thin. Hei hi ferroportin hian iron a la chhuak thei a, cell thar siamnaah a pui thei a ni.
• Oxygen level hniam (Hypoxia): Hypoxia chu i tissue ten oxygen an hmuh tlem vang a ni. Oxygen level a hniam chuan taksain Hepcidin tihtlem turin taksa hnenah signal a pe thin. Hei hian Ferroportin a tichhuak a, chu chuan iron a tichhuak a, hemoglobin a siam a ni. Hemoglobin hi thisen sen (red blood cells) kaltlanga oxygen phurtu a ni.
• Hliam emaw, natna hrik emaw avanga inflammation: Hetiang hunah hian hepcidin level a sang chho thin. A chhan chu taksaa thir chhuah tur tihtawp nan a ni. Hriselna tha lo tam tak, bacteria ang chi te hian iron an hmang a, an thang lian thin. Chuvangin hepcidin tihpun, iron tihtlem hian chu hrik te chu iron an neih loh nan i titawp a ni. Smart, a dik em?

Hepcidin level a dik lo a nih chuan eng dinhmun nge lo awm?

Tunah chuan hepcidin hi a pawimawh zia i hre tawh ang. Chuvangin, a sang lutuk emaw, a hniam lutuk emaw chuan harsatna a thlen thei a ni.

Hepcidin a tam lutuk chuan taksain iron a hip lut thei lo a, chu chuan iron tlakchhamna ang chi dinhmun a thlen thei a ni.

If hepcidin is low , taksa hian iron tam lutuk a absorb thei a, chu chuan iron overload a thlen thei.

Hepcidin level hniam nena inzawm natna

Hepcidin level a hniam chuan a hnuaia dinhmunte hi hmuh theih a ni:

• Iron-deficiency anemia: Hei hi hepcidin tlahniam nena inzawm thisen tlakchhamna chi khat a ni. A châng chuan hepcidin level hi hriat theih loh a ni thei bawk. Hei hian taksain ferroportin a chhuah avangin thisenah iron phurh luh a tum tih a tilang a ni.
• Hemochromatosis hi a hring chhuak thei a ni:Hei hi genetic disease a ni. Cell chhunga mutations avang hian liver hian hepcidin a siam tlem hle. Chuvang chuan taksain iron a hip tam lutuk a ni. He iron tam lutuk hi thinlung, thin leh pancreas-ah te a awm ber a ni.
• Iron-loading anemias: Hei hi thisen tlakchhamna chi khat a ni. Mahse, hetiang hunah hian thir tlakchhamna a awm lo va, thir tam lutuk a awm zawk. Thisen sen siam chhuahna lama harsatna a awm avangin hepcidin siam chhuah a tlahniam a ni. Chuvang chuan ferroportin hian iron a tichhuak tam lutuk a ni.
• Hepatitis C: Hei hi virus (HCV) avanga thin (liver) a kai a ni. He virus hian taksain hepcidin a siam chhuah theihna a ti tlem a ni.
• Type 2 diabetes: Zirchianna thenkhatah chuan type 2 diabetes vei te hian hepcidin level a tlahniam a, chu chuan iron overload a thlen thin. Zunthlum damdawi hman tlanglawn tak Insulin hi a chhan a ni thei.

Hepcidin level sang zawk nena inzawm natna

Hepcidin level sang hi non-iron deficiency anemia nen a inzawm a ni. Chu chu iron tlakchhamna tel lova thisen tlakchhamna (anemia) a awm lo tihna a ni. Hengte hi genetic condition vang a ni thei a, chu chuan hepcidin siam tam lutuk a thlen thei a ni.

Hepcidin level hi anemias of inflammation emaw anemia of chronic disease (ACD) tih ang chi dinhmunah pawh a sang hle. ACD-ah chuan inflammation hian taksaah protein cytokine tih a tichhuak thin. He protein hian hepcidin level a tisang a ni.

ACD nena inzawm natna thenkhat chu:

• Infection rei tak awm thei
• Crohn natna a ni
• Ngawt
• Kidney natna rei tak awm thei

Chuvangin i hmu thei ang, Hepcidin hi kan taksaa iron hman dan control tu thil pawimawh tak a ni. Hepcidin hian iron chhuahna a titawp a, kan taksain hemoglobin leh thisen sen (red blood cells) a siam theihna chu a thunun a ni. Chutiang chuan Hepcidin hian taksa pum puia oxygen awm zat chu indirect takin a nghawng a ni. Hepcidin hian taksain iron a hip tam lutuk loh nan a titawp bawk. A chhan chu iron tam lutuk hian hun rei tak chhungin harsatna lian tak a thlen thei a ni.

He thawnthu atang hian kan hriat reng tur thil (Take-Home Message) .

Okay, chuti a nih chuan vawiin hian Hepcidin chungchang hi kan sawi nasa hle a ni lawm ni? A tawi zawngin:

• Hepcidin hi liver-a hormone siam chhuah a ni.
• Hei hi kan taksaa iron awm zat master regulator a ni. "Iron Lord" ang mai a ni.
• Hemoglobin siam nan iron kan mamawh a, chu chu taksa pum puia oxygen phurtu a ni.
• Hepcidin level, 1000 a ni.Iron lakluh, dahkhawm leh chhuah dan hi protein ferroportin an tih hmangin control a ni.
• Hepcidin a tlem chuan iron tam lutuk chu a hip lut thei a , chu chuan iron overload a thlen thei a ni . Hei hian hereditary hemochromatosis ang chi natna a thlen thei a ni.
• If hepcidin is increased , iron absorption a tlahniam thei a, chu chuan iron-deficiency anemia (a chang chuan inflammation avanga lo awm) a thlen thei.
• Hrisel taka awm tur chuan taksaa iron level leh Hepcidin level a inthlau a ngai a ni.

Chuvangin, iron lama harsatna i neih chuan, emaw, thisen tlakchham (anemia) ang chi symptom i neih chuan doctor pan a, thurawn lak a tha ber. Hetiang thil hi fimkhur a pawimawh hle bawk.

` Hepcidin, thir, thisen tlakchhamna, hormone, hemoglobin, thin, ferroportin